Ascor

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Ascor

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ascor

The pharmaceutical preparation Ascor is a high-concentration source of Vitamin C, whose active ingredient is Sodium Ascorbate, a salt derived from L-Ascorbic Acid. This medicine is formally classified as an essential water-soluble vitamin and functions as an Antiscorbutic agent.


Quick Facts

Property Description
Active Ingredient Sodium Ascorbate
Form Sterile Solution
Pharmacological Class Vitamin; Antiscorbutic Agent
Common Use Treating/Preventing severe Vitamin C deficiency
Origin Synthetic derivative (Sodium Salt)
Route Parenteral (Injection)

Classification, Composition, and Form

Ascor's active component, Sodium Ascorbate, is a synthetic derivative manufactured to be the sodium salt of Ascorbic Acid. This chemical configuration increases the molecule’s solubility and stability, making it suitable for medicinal preparations that require precise delivery. Ascor is typically provided as a sterile solution, representing a single-entity product.

This liquid form is designed for the parenteral route of administration—meaning it is injected, usually intravenously or intramuscularly. This parenteral solution ensures complete bioavailability of the vitamin, bypassing potential issues with absorption in the gastrointestinal tract. The route is often preferred for target patient groups experiencing severe gastrointestinal malabsorption or critical care needs, representing a key point of differentiation from widely available oral Vitamin C products.


General Purpose and Core Physiological Role

The primary purpose of Ascor is the rapid and reliable replenishment of Vitamin C to address or prevent severe deficiencies, such as Scurvy or profound Hypovitaminosis C.

The substance’s general benefit stems from its fundamental biochemical role as an essential redox agent and cofactor. Sodium Ascorbate supports numerous metabolic processes, performing essential antioxidant action and acting as a cofactor required for the synthesis of collagen. This clinically recognized function means the medicine is necessary for the formation and maintenance of healthy skin, bone, and connective tissues, sustaining essential physiological function.

Regulatory References

  1. Sodium ascorbate - WHO JECFA
  2. Vitamin C (Ascorbic Acid) - StatPearls - NCBI Bookshelf

What side effects are possible with Ascor?

Possible Side Effects and Safety Information

The safety profile of this medicine is based on information from government regulatory documents, outlining formally documented adverse reactions and safety considerations.


Serious Adverse Reactions and Risk Factors

Administration is associated with several serious, clinically significant risks, particularly with high doses or prolonged exposure:

  • Kidney Problems: Acute and chronic oxalate nephropathy (kidney damage) and nephrolithiasis (kidney stone formation) have been documented. This risk is greater with prolonged administration of high doses and in patients with pre-existing renal impairment or a history of kidney stones.
  • Severe Hemolysis: For patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, there is an increased risk of severe hemolysis, which is the destruction of red blood cells.

Other Documented Adverse Reactions

Adverse reactions that are most commonly documented involve the infusion site. Other reactions are linked to the speed of administration.

Adverse Reaction Type Examples
Most Common Pain and swelling at the site of infusion.
Linked to Rapid IV Administration Temporary faintness, nausea, lethargy, flushing, dizziness, and headache.

Safety Restrictions and Monitoring

The medicine is not indicated for prolonged administration. The maximum recommended duration of daily treatment is one week.

  • Population-Specific Risk: Monitoring of hemoglobin and blood counts is noted for G6PD deficient patients, and monitoring of renal function is noted for patients at high risk of oxalate nephropathy.
  • Laboratory Interference: The medicine acts as a strong reducing agent and may interfere with many laboratory tests based on oxidation-reduction reactions, including blood and urine glucose testing, potentially affecting the accuracy of diagnostic results.

Overdose and Emergency Response

Overdose of Ascor (Sodium Ascorbate Injection) is associated with officially documented clinical manifestations. These include gastrointestinal effects such as nausea, vomiting, and diarrhea, along with signs like headache, fatigue, disturbed sleep, facial flushing, and rash. Rapid administration may cause temporary faintness or dizziness. The official regulatory labeling notes that prolonged high-dose exposure carries a risk of severe or life-threatening outcomes, including acute or chronic oxalate nephropathy and nephrolithiasis. There is also a risk of severe hemolysis in patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency.

Emergency Action and When to Seek Help

If an overdose is suspected, the immediate action mandated by regulators is to discontinue administration of the product. Urgent medical attention must be sought for any adverse symptoms related to an overdose. No specific antidote is officially known or documented; therefore, management focuses on providing symptomatic and supportive care. Monitoring of renal function and blood counts is required in high-risk groups, such as geriatric patients, those with kidney disease, and pediatric patients under two years of age.

Therapeutic Uses of Ascor

What Ascor Treats: Main Uses and Benefits

Ascor is a high-concentration, injectable source of Vitamin C, generally reserved for conditions where short-term symptomatic assistance and support may be clinically necessary. Its therapeutic scope is considered relevant for severe deficiency and clinical situations of high metabolic demand.

The medication is relevant for the management of Scurvy. It also plays a role in managing symptoms related to severe systemic deficiency and other symptoms that interfere with daily comfort, such as those related to tissue integrity and hemorrhagic manifestations, including easy bleeding, bruising, and poor wound healing. In these contexts, Ascor supports the management of systemic imbalance and assists in addressing associated decline.

“The injectable route is commonly used in acute settings or when absorption is compromised, applied when appropriate for support.”

The use of this injectable solution is commonly used in clinical settings that involve acute or unstable symptom patterns, such as following major surgery, severe trauma, or in patients with severe gastrointestinal malabsorption. This provides supportive relief when symptoms interfere with routine activities.

Quick Fact: Relief for Tissue Integrity
Supports the structural integrity of tissues, contributing to easing the burden of chronic fragility symptoms like bleeding gums and poor healing.

Eligibility and Restrictions for Use

The eligibility for Ascor (Sodium Ascorbate Injection) is strictly defined by official regulatory labeling, establishing patient groups for whom use is permitted, restricted, or excluded. The medicine is indicated for Adults and Pediatric Patients age 5 months and older for the short-term treatment of scurvy when oral administration is not possible or is insufficient. Use is not indicated for children younger than 5 months.


Official Eligibility Status

Population Status Classification
Contraindicated Known hypersensitivity to the drug or any component.
Allowed Adults and children age 5 months and older.
Not Indicated Pediatric patients under 5 months of age.

Populations Requiring Conditional Use

Use requires close monitoring for several populations due to increased risk:

  • Renal Impairment: Patients with renal disease or a history of oxalate kidney stones are at increased risk of oxalate nephropathy.
  • Age: Geriatric patients and pediatric patients less than 2 years of age require renal function monitoring due to similar risks.
  • Hematologic: Patients with G6PD Deficiency must use a reduced dose and undergo mandatory blood count monitoring due to the risk of severe hemolysis.
  • Pregnancy/Lactation: Use must not exceed the U.S. Recommended Dietary Allowance (RDA) for the patient’s condition.

What should I know about interactions with other medicines?

The official regulatory profile for Ascor documents interaction patterns that result from its properties as a strong reducing agent and its effect on urinary acidity. The restrictions and requirements established in government-approved labeling must be observed.

Interaction Type Interacting Substances / Restrictions
Exposure Modification Ascor may cause acidification of the urine, potentially leading to decreased serum levels of certain basic drugs, including Amphetamine and Fluphenazine, by increasing their renal excretion.
Pharmacodynamic / Efficacy The activity of some antibiotics, such as Erythromycin, Doxycycline, and Lincomycin, may be decreased. Warfarin requires continued monitoring when co-administered due to suggested interference with anticoagulation effects.

Interaction-Related Constraints:

The preparation must not be physically mixed with solutions containing elemental reducing compounds (e.g., Copper) due to incompatibility. The regulatory profile also documents that Bleomycin is subject to inactivation in vitro. A crucial timing constraint applies to diagnostic procedures: Laboratory tests based on oxidation-reduction reactions (such as those for blood glucose, nitrite, and bilirubin) must be delayed until 24 hours after infusion to prevent analytical interference and ensure accurate results. This structure defines the mandatory restrictions and monitoring requirements established in government-approved labeling.

Mechanism of Action

The mechanism of Ascor centers on the active L-Ascorbate anion's indispensable role as an Fe^2+-dependent enzyme cofactor and a reducing agent across three fundamental biological domains.


Cofactor Role in Structural Protein Synthesis

Ascorbate acts as a cofactor for the essential Prolyl and Lysyl Hydroxylase enzymes, maintaining the active Fe^2+ state required for the hydroxylation of collagen precursors. This process is necessary to form the stable, triple-helix structure of collagen , directly enabling the formation of stable connective tissues and the integrity of capillary walls system-wide.


Cofactor for Metabolic and Neurotransmitter Synthesis

The active molecule functions as a reducing cofactor for Dopamine beta-Hydroxylase (DBH), ensuring the efficient metabolic conversion of dopamine to the critical neurotransmitter norepinephrine. The generation of norepinephrine provides systemic signaling to the neuroendocrine and sympathetic nervous systems.


Regulating Cellular Redox Balance

The active molecule functions as an antioxidant, directly neutralizing and scavenging various Reactive Oxygen Species (ROS) throughout the aqueous cellular environment. This modulation of redox state influences the integrity and function of cell membranes and the vascular endothelium against oxidative damage.

Dosage and Administration Information

Instruction Map: How to use Ascor — Administration Guidelines

This map summarizes the instructions for the administration of Ascor (Ascorbic Acid Injection). The use of this medicine is reserved for a controlled setting due to its required preparation and parenteral route.

Feature Detail
Route of administration Slow Intravenous (IV) Infusion only. The concentrate must not be administered undiluted.
Dosing schedule Administered once daily. The standard dose is 200 mg for adults and pediatric patients 11 years and older.
Preparation requirements Mandatory dilution in a suitable solution, such as 5% Dextrose Injection or Sterile Water for Injection. The final solution must be isotonic with a concentration between 1 and 25 mg/mL.
Age-group rules Dosing is tiered by age: 100 mg once daily for children 1 to < 11 years, and 50 mg once daily for infants 5 months to < 12 months. For high-risk groups (e.g., pregnant women), the dose must not exceed the Recommended Dietary Allowance (RDA).
Course duration The maximum recommended duration for initial treatment is one week (seven days) of daily use. Retreatment is permitted if symptoms persist.

Instruction Classifications (High-Level)

Classification Detail
Administration method type Parenteral (Intravenous Infusion).
Frequency pattern Daily (Once daily) for a short-term course.
Use-context constraints Requires a controlled clinical setting (ISO Class 5 work area) for preparation.

Connection to the overall use protocol

The established instructions define a highly controlled protocol, including the precise administration route as a slow intravenous infusion and mandating specific preparatory steps like dilution and osmolarity adjustment. This structure sets a clear daily dosage for acute, short-term treatment that must not exceed one week, with explicit dose adjustments based on the patient's age group and physiological status.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Ascor

Evidence for the Core Regulatory Use: Severe Deficiency and Scurvy

The research base used for the regulatory classification of Ascor (injectable Vitamin C) for addressing severe Vitamin C deficiency, known as scurvy, includes studies spanning many decades. This evidence is built upon historical human volunteer studies that were used in research exploring how symptoms change over time when dietary Vitamin C is restricted. Researchers also utilized numerous case reports and case series documenting the symptoms and physical changes observed in individuals diagnosed with frank scurvy. These studies monitored physiological strain or stress and provided evidence contributing to understanding symptom patterns of the deficiency.

Because scurvy is a condition characterized by fluctuating or episodic manifestations, the official research record documented how the body was studied after the administration of the vitamin. Findings describe patterns observed in the studies related to the resolution of classic symptoms, such as bleeding gums, easy bruising, and fatigue. The evidence contributes to the broader evidence landscape by describing how Vitamin C was studied as an essential antiscorbutic agent for human health.

Research on Clinical Outcomes and Biomarkers

Studies conducted during periods of increased symptom activity monitored two main areas of measurement. First, research examined the reversal of physical signs, monitoring the physical outcomes related to systemic imbalance, such as the healing of skin lesions and the reduction of hemorrhagic manifestations. Second, studies monitored physiological strain or stress by tracking biomarker shifts, specifically measuring the restoration of plasma Vitamin C concentrations, indicating the body's uptake of the nutrient. These findings describe patterns observed in the studies as changes were measured during the study period.

Identified Gaps and Uncertainties in the Research Record

The research base for Ascor, while definitive for its core purpose, does contain recognized gaps. For the core indication (scurvy), the evidence is based on established historical knowledge rather than modern Randomized Controlled Trials (RCTs). In the contextual area of high-dose critical care research, data are still emerging, and certainty remains low due to variability and heterogeneity (differences) in dosing strategies and compounds used. Research into the use of this treatment in conditions outside of severe deficiency remains an area where certainty remains low.

Key Studies & References

  1. History of Vitamin C (Ascorbic Acid) Deficiency and Discovery of its Role in Scurvy (Supporting Historical Evidence)

Frequently Asked Questions (FAQ)

Common questions about Ascor (FAQ)


Q: Is Ascor the same kind of medicine as [similar drug name]?

Official product information describes Ascor as an essential water-soluble vitamin and an antiscorbutic agent. This classification defines its fundamental function as replenishing vitamin C levels in the body to address severe deficiencies. Its recognized function is distinct from that of other pharmaceutical classes.


Q: Can Ascor be used to treat things other than its main use?

The officially indicated use for Ascor is strictly limited to treating or preventing severe vitamin C deficiency, known as scurvy. Research has explored its use in other areas, such as critical care settings. However, official certainty regarding these non-approved uses remains limited, as data is still emerging.


Q: How long does it typically take to see any effect from Ascor?

Studies that examined the treatment monitored the pattern of symptom resolution over time. Findings documented the reversal of classic deficiency signs, such as the healing of bleeding gums, reduction in bruising, and a decrease in fatigue. These changes were tracked alongside the restoration of plasma vitamin C levels.


Q: Is Ascor safe for older adults (seniors)?

Official eligibility status indicates that geriatric patients are a population noted for conditional use. Due to an identified risk of oxalate nephropathy (kidney damage), close monitoring of renal function is specified in regulatory documents during the course of treatment. This monitoring assists healthcare professionals in assessing risk.


Q: What are the possible signs of an allergic reaction to Ascor?

The medicine is contraindicated for individuals with a known hypersensitivity to the drug or any of its components. Signs of a severe hypersensitivity reaction may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Hypersensitivity is a factor that must be assessed before use.


Q: Can Ascor be taken by people with kidney problems?

Official documents note that patients with kidney problems, including renal impairment or a history of kidney stones, are identified as having an increased risk of oxalate nephropathy (a type of kidney damage). For these populations, close monitoring of renal function during the treatment period is specified in regulatory documents.


Q: Are there any studies looking at Ascor in women who are pregnant?

Regulatory labeling addresses use during pregnancy and lactation by requiring that the dose must not exceed the U.S. Recommended Dietary Allowance (RDA). High-dose use is assigned to FDA Pregnancy Category C, while use at RDA levels is classified as Pregnancy Category A.


Q: Why might a person need to stop taking Ascor?

Reasons for stopping the medicine are defined by the official protocol. This includes reaching the maximum recommended duration of one week, a confirmed hypersensitivity to the drug, or the development of a severe adverse reaction such as severe hemolysis or kidney problems.


Q: Can Ascor be taken by people who have diabetes?

Official warnings state that Ascor can interfere with certain laboratory tests that rely on oxidation-reduction reactions. This is particularly relevant for diabetes management, as it may cause inaccurate readings on some blood and urine glucose meters. This potential for interference requires review of the patient's monitoring practices.


Q: What are the results of the most recent research on Ascor?

Recent and emerging research has focused on the deficiency and consumption of vitamin C in critically ill patients, where there is an increased risk of vitamin depletion. Research themes currently examine the impact of Ascor in managing deficiency in these patient groups. The core regulatory use, however, remains the treatment of severe vitamin C deficiency.


Q: How do I know if Ascor is working for me?

Studies on the core indication monitored the reversal of classic physical signs associated with severe deficiency. These included improvements in bleeding gums, reduction of bruising, and a decrease in fatigue. These observed changes were tracked alongside the restoration of plasma vitamin C levels.


Q: Can I drink alcohol while using Ascor?

Official product information notes that alcohol consumption reduces the levels of ascorbic acid in the body. Additionally, chronic use may interfere with the disulfiram-alcohol reaction, which is relevant if other medicines are being taken concurrently.


Q: What happens if I forget to take Ascor one day?

Since Ascor is administered as an intravenous infusion in a controlled clinical setting, it is not a medicine taken independently by the patient. If concerns about a missed administration arise, contact with the healthcare provider is necessary for guidance. The administration is managed by a healthcare team.


Q: Are there any food or drinks I should avoid while on Ascor?

Official labeling does not list general food or drink restrictions. However, because the drug is the sodium salt of Ascorbic Acid, high doses are identified for caution in regulatory documents and may require monitoring for patients who are following a sodium-restricted diet.


Q: Does Ascor interact with common pain relievers like ibuprofen?

Official regulatory sources and drug interaction data do not generally document a known interaction between Ascorbic Acid and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. The regulatory label focuses on specific prescription drug interactions where efficacy or exposure may be modified.


Q: Is it safe to take Ascor with vitamins or supplements?

Official regulatory information documents the potential for interaction, particularly with supplements containing iron. The drug can increase the absorption of iron, which may require monitoring in certain patients.


Q: Is there a generic version of Ascor available?

Yes, according to official labeling and drug data, the generic name for the active ingredient in Ascor is Ascorbic Acid Injection. It is typically provided as a sterile solution designed for the parenteral (injection) route of administration.


Q: How long does Ascor stay in your system?

Pharmacokinetic data from official sources indicate that the active substance has a short plasma half-life. It is typically described as ranging from 30 minutes to 4 hours.


Q: Does Ascor interact with birth control pills?

Official interaction data documents the potential for the active substance to increase the serum levels of estrogens, which are a component of some oral contraceptives.


Q: How does the FDA classify the safety of Ascor?

The FDA assigns different classifications based on the amount administered. The drug is classified as Pregnancy Category A when used at Recommended Dietary Allowance (RDA) levels, but is classified as Pregnancy Category C when administered in high doses.


Q: Can I drive or operate machinery while taking Ascor?

Official product information describes the medicine as being unlikely to affect a patient's ability to drive or use heavy machinery. However, regulatory documents note that side effects linked to rapid administration, such as dizziness or faintness, may occur.


Q: Does Ascor interact with cold and flu medicines?

Regulatory labeling lists specific, documented drug interactions with agents like amphetamine and certain antibiotics. It typically does not provide comprehensive warnings for general categories of over-the-counter medicines such as cold and flu remedies.

How should Ascor be stored and disposed of?

Ascor (Ascorbic Acid Injection) vials must be stored under refrigeration, typically between 2 C and 8 C (36 F and 46 F), and should be protected from light by keeping them in the carton until use. The product is light-sensitive and contains no preservative.

Upon initial entry into the Pharmacy Bulk Package (PBP) vial, the contents must be fully dispensed within four hours, and any remaining, unused portion must be immediately discarded. Caution is advised when withdrawing the contents, as pressure may develop within the vial upon storage.

For disposal of the unused medication and related supplies, follow all institutional, local, state, and federal regulations regarding medical waste. This ensures proper handling and minimization of environmental impact. Do not dispose of this medication in household waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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