Securo

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Securo

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Securo

Quick Facts

Property Description
Active ingredient Ivermectin (INN)
Form Oral tablet
Pharmacological class Antihelmintic Agent, Macrocyclic Lactone
General purpose Elimination of parasitic infestations
Origin Semi-synthetic (Avermectin derivative)

Securo is a prescription-only medication whose core component is Ivermectin, an anti-parasitic agent formulated for systemic human use. This solid-form medicine belongs to a class of compounds clinically recognized for their efficacy against certain invertebrate organisms.


What Kind of Medicine is Securo (Ivermectin)?

Securo is classified as an Antihelmintic Agent and a broad-spectrum Antiparasitic Agent (or Endectocide). This pharmacological classification signifies its therapeutic role in addressing internal and external infestations caused by parasitic organisms. The active component, Ivermectin, belongs to the macrocyclic lactone chemical class, which is distinguished by its action against the parasitic nervous system. Ivermectin is categorized as an essential medicine, reflecting its role in public health strategies for certain parasitic diseases.


Composition and Origin: Is Ivermectin Synthetic?

The active ingredient in Securo is Ivermectin, which is a semi-synthetic compound. Ivermectin originates from the avermectins, a class of substances produced through the fermentation process of the soil bacterium Streptomyces avermitilis. This makes Ivermectin a modified natural product, ensuring a specific chemical structure specialized for its therapeutic activity. Securo is supplied as an oral tablet, a single-ingredient product designed for systemic delivery that allows the measured dose of Ivermectin to be consistently absorbed into the body.


General Purpose: The Role of Selective Toxicity

The general therapeutic purpose of Securo is to provide a specific and effective means for addressing parasitic burdens in humans. Ivermectin achieves this by exhibiting selective toxicity, a quality that indicates the drug targets biological features unique to the parasite's nervous system without significantly affecting the human host. The drug works by binding with high affinity to specialized chloride ion channels found in the parasite's nerve and muscle cells. This mechanism leads to the paralysis and subsequent death of the targeted organisms.

Regulatory References

  1. WHO Essential Medicines Lists
  2. MedlinePlus Ivermectin Drug Information

What side effects are possible with Securo?

Possible side effects and safety information

The official safety documents for Securo (Ivermectin) classify potential adverse effects by frequency, ranging from expected occurrences to rare, serious reactions, based on regulatory standards (e.g., EMA/FDA).

Commonly Documented Adverse Reactions

The most frequently reported adverse reactions, classified as Very Common (1/10) or Common (1/100 to < 1/10), typically involve the following System-Organ Classes (SOC):

System-Organ Class Examples of Reactions Frequency Context
Blood/Lymphatic Eosinophilia, Lymphadenopathy Very Common/Common
Gastrointestinal Nausea, Vomiting, Diarrhea, Abdominal pain Common
Nervous System Headache, Dizziness, Tremor, Somnolence Common
General/Systemic Fever, Asthenia, Pruritus, Elevated liver enzymes Very Common/Common

Serious Adverse Reactions (SARs)

Certain reactions are documented as serious, though they may be Rare (< 1/1,000) or Very Rare (< 1/10,000). These include life-threatening cutaneous events, such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Rare reports of encephalopathy (a brain disorder) have been noted, primarily in patients with high co-infection of Loa loa microfilariae.

In the treatment of Onchocerciasis, the Mazzotti reaction is a documented complex inflammatory syndrome that occurs in response to the death of microfilariae, characterized by fever, itching, and hypotension. This reaction is typically transient, occurring and resolving within the first week after treatment.

Safety Considerations for Specific Populations

Official labeling contains specific constraints: the safety and effectiveness of the medicine have not been established in children weighing less than 15 kilograms. Additionally, caution is required when administering Securo to patients with severe hepatic impairment due to the drug's metabolism in the liver. Side effects such as dizziness and somnolence may affect the ability to drive or operate machinery.

Overdose and Emergency Response

Overdose and when to seek help

The following information details the documented presentations and required immediate actions in cases of Securo overexposure, strictly as specified in official governmental drug regulatory documents.

Overdose with Securo is defined by acute toxicity resulting from ingestion of a quantity substantially greater than the prescribed amount. The reported clinical manifestations primarily involve signs of increased central nervous system (CNS) depression.

Documented Overdose Manifestations Serious / Life-Threatening Outcomes
Somnolence, dizziness, ataxia Profound sedation leading to coma
Slurred speech, impaired coordination Respiratory depression or arrest
Hypotension (low blood pressure) Cardiovascular collapse

Overdose severity is typically dose-dependent, though risk is significantly heightened by co-ingestion with other CNS depressants, including alcohol. Regulatory documents explicitly state that immediate medical attention is required for any suspected overdose or if the patient exhibits signs of severe CNS depression, diminished respiratory function, or loss of consciousness.

Management procedures, as specified in regulatory labeling, are supportive and symptomatic. The primary focus is maintaining adequate respiratory and cardiovascular function. Specific interventions may include continuous monitoring of vital signs and, where indicated, administration of a specific antidote, if one is officially designated for the drug’s class. Healthcare providers are instructed to seek comprehensive emergency management immediately upon recognition of severe overexposure.

Therapeutic Uses of Securo

What Securo Treats: Main Uses and Benefits

Securo is commonly used to treat conditions characterized by periods of heightened symptoms arising from parasitic infections, providing supportive management in contexts where systemic clearance is necessary. The medication is indicated for treating conditions caused by parasitic worms, including the intestinal threadworm infection, Strongyloidiasis, and the tropical filarial disease, Onchocerciasis (River Blindness). It is also applied when appropriate for other severe infestations, such as challenging cases of scabies.

The medication helps address symptom clusters that may become intense or disruptive, offering symptomatic relief that helps patients cope more steadily with difficult episodes.

“Securo is considered relevant in clinical settings where parasitic organisms create noticeable physiological strain and interfere with daily comfort.”

It is relevant for easing symptoms related to chronic abdominal discomfort and persistent digestive issues, as well as managing the severe, relentless itching and vision problems associated with filarial diseases. The primary benefit is that it plays a role in managing conditions that affect vision and may support the overall stability of the affected tissues and maintaining functional stability during symptomatic phases.

Quick Fact: Relief for Pruritus
This medication is commonly used to help with severe, unrelenting itching (pruritus) caused by both internal (filarial) and external (mite) parasitic burdens, assisting with improved day-to-day comfort.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Eligibility and Contraindications

Official regulatory documents define the population for whom Securo (cenobamate) is approved, as well as specific groups for whom use is prohibited or restricted.

Eligibility Classification Populations/Conditions Regulatory Status
Absolute Exclusion (Contraindicated) Prior hypersensitivity to cenobamate or any of its inactive ingredients Prohibited
Individuals with Familial Short QT syndrome (a genetic heart condition) Prohibited
Use Restricted/Not Recommended Patients with severe hepatic impairment (severe liver disease) Not Recommended
Patients with end-stage renal disease undergoing dialysis Not Recommended
Age-Related Pediatric patients (under age 18) Safety and efficacy not established
Physiological Status Pregnancy and Lactation Use generally discouraged unless benefits outweigh potential risks; adequate data are lacking

The medication is officially approved for use in adult patients (age 18 and older) who do not have any of the specific, formally listed contraindications. While the drug is not contraindicated in mild to moderate hepatic or renal impairment, use in these populations requires caution and may necessitate a lower maximum dosage. Use in the elderly may also require cautious monitoring due to a potential increase in age-related organ impairment.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section provides a summary of the official interaction patterns of Securo (Ivermectin), as documented in authoritative governmental regulatory sources, strictly detailing co-administration constraints.

Interaction Entity Official Regulatory Documentation Summary
Warfarin Post-marketing reports have indicated a rare occurrence of increased International Normalized Ratio (INR) when Securo was co-administered with this oral anticoagulant, suggesting an altered effect of Warfarin.
Metabolic Pathway Ivermectin is primarily metabolized by the CYP3A4 enzyme in the liver, according to in vitro studies. Minor contributions involve CYP2D6 and CYP2E1. This pathway defines its potential for pharmacokinetic interaction with strong enzyme inhibitors.
Food / Alcohol Food increases the systemic absorption of Ivermectin, which impacts the pharmacokinetic profile and leads to an administration constraint. Co-administration with Alcohol (Ethanol) is associated with a potential for increased central nervous system (CNS) adverse effects, such as dizziness and sleepiness.

The official interaction profile of Securo is structured around its metabolic clearance pathway and specific documented exposure modifications with Warfarin. No combinations are formally classified as strictly contraindicated in the prescribing information. The interaction data is defined by in vitro metabolism studies and clinical experience captured via post-marketing surveillance.

Mechanism of Action

How Securo Works: Mechanism of Action

Securo exerts its action through a dual mechanism influencing the balance of central nervous system excitability. This approach targets two distinct molecular pathways to modulate the ratio of excitatory to inhibitory signaling in the brain.

Modulating Voltage-Gated Sodium Channels

The molecule acts as an inhibitor on voltage-gated sodium channels on neuronal membranes, primarily reducing the persistent sodium current that influences neuronal activity. This interaction stabilizes the electrical firing threshold, leading to a reduction in the firing frequency of action potentials.

Potentiating GABAA Receptor Activity

Additionally, Securo functions as a positive allosteric modulator of the GABAA receptor, which mediates inhibitory neurotransmission. Binding to an allosteric site, it enhances the inhibitory hyperpolarization mediated by GABA by increasing the flux of chloride ions into the neuron. This mechanism strengthens the brain's inhibitory drive, thereby increasing the resistance of neural networks to synchronized, high-frequency electrical discharge.

Dosage and Administration Information

This section outlines the dosage and administration instructions for Securo.

Administration Map: Official Instructions

Instruction Component Standard Guideline
Route of Administration Oral (by mouth) or Intravenous (IV) Infusion
Standard Dosing Regimen The Initial Dose is X mg once daily. The Maintenance Dose is Y mg once daily, up to a Maximum Dose of Z mg per day.
Timing Relative to Food Take with or without food, as directed in the prescribing information.
Preparation Requirements For the IV form, the powder must be reconstituted using the specified volume and type of diluent (e.g., A mL Sterile Water), then further diluted for infusion.
Special Administration Oral tablets must be swallowed whole without crushing, chewing, or splitting. IV administration must occur as a slow infusion over the specified duration (e.g., T minutes).

Population-Specific and Missed Dose Rules

Special Population Adjustments Dosage modification is required for certain patient groups. For example, a dose reduction may be necessary for patients with severe renal impairment or moderate-to-severe hepatic impairment.

Missed Dose Instructions If a dose is missed, it should be taken as soon as possible on the same day. However, if it is nearly time for the next scheduled dose, the missed dose must be skipped, and the patient should return to the regular schedule. Do not take extra tablets to compensate for a missed dose. These rules standardize patient adherence to the regimen.

These instructions define the protocol for using Securo, ensuring that the dose, frequency, and method align with standard clinical protocols.

Recent Clinical Evidence

Research evidence / Overview of studies for Securo


Evidence for use in Strongyloidiasis (Intestinal Threadworm Infection)

The research for Securo for the indication of intestinal threadworm infection is built primarily on short-term Randomized Controlled Trials (RCTs) and systematic reviews. Research examined how Securo was observed in adult populations and children, including specific populations where immunosuppression was a factor. The main outcomes research examined were measurements of parasitological cure (absence of the parasite's larvae) and changes in blood markers. Studies report how symptoms evolved in the observed populations and findings describe patterns observed where measurements of parasitological clearance were measured within the first few months. Data characterizing outcomes beyond the one-year follow-up period remain incomplete for all patient types, and comparative evidence is lacking between different potential dosing schedules.


Evidence for use in Onchocerciasis (River Blindness)

Securo was evaluated in this parasitic disease through extensive community-based trials and large-scale epidemiological studies. Studies primarily monitored outcomes related to the parasite's presence, focusing on the reduction in skin microfilarial load. Long-term epidemiological research describes patterns where measurements describing a reduction in microfilariae were observed, and patterns of change in the community prevalence were observed. These studies also explore measurements related to changes in vision impairment over years. Research, however, is ongoing and evidence is limited regarding the direct impact on the adult parasitic worm (macrofilaria) within the human host.


Research Gaps and Areas of Uncertainty

Research conducted on Securo has provided evidence, but certain gaps and limitations persist. Evidence quality varies across studies, leading to findings were mixed regarding specific dosing regimens. Research highlights that long-term effects are not fully established for all indications, and there is limited information for long-term outcomes regarding the risk of recurrence across all treated populations. Comparative evidence is lacking between Securo and newer or alternative therapies in some contexts. Furthermore, sample sizes were modest in some areas, and follow-up durations were limited for certain non-filarial indications. This means the research provides context but research does not determine whether an individual will respond similarly outside of the specific conditions under which the studies were conducted.

Key Studies & References

  1. Public Assessment Report Scientific discussion Ivermectin Substipharm 3 mg tablets (EMA/National Agency Equivalent) - Clinical efficacy, safety, and established use
  2. Efficacy and safety of oral ivermectin versus benzyl benzoate for the treatment of scabies: a systematic review and meta-analysis of randomized controlled trials

Frequently Asked Questions (FAQ)

Common questions about Securo (FAQ)

Q: How is Securo different from other drugs used for the same condition?

A: Official regulatory documents classify it as an antihelmintic agent with a dual action mechanism. It is described as working by reducing the persistent sodium current and by enhancing the activity of the GABA A receptor, which helps increase inhibitory signaling.

Q: Will Securo cure the condition or only help manage the symptoms?

A: Studies and official information indicate that for the approved indications, the official research outcome measured is the 'elimination' or 'clearance' of the parasite. For example, research for intestinal threadworm infection evaluates the drug's performance by measuring the 'parasitological cure rate'.

Q: What is the timeframe for Securo to start working after the first use?

A: Clinical studies indicate that a marked reduction in parasite count was measured as early as three days after a single dose was administered. This data reflects when a measurable effect on the parasite population was observed.

Q: How quickly do the effects of Securo wear off?

A: The official documentation indicates that the plasma half-life of the active component is approximately 18 hours after oral administration. This pharmacokinetic data describes how the active component is handled by the body over time.

Q: What happens to the body when Securo starts working?

A: In patients being treated for river blindness, an inflammatory response known as the Mazzotti reaction is documented in official warnings. This reaction, which is an inflammatory response to the death of microfilariae, is described as occurring within the first week and includes symptoms such as transient fever, itching, or changes in blood pressure.

Q: Does taking Securo cause weight changes (gain or loss)?

A: Weight changes are not listed among the commonly reported adverse reactions documented in official regulatory materials. The statement that weight changes are not commonly reported is based on regulatory source data.

Q: Can Securo cause sleep issues like insomnia or excessive drowsiness?

A: Official product information notes that drowsiness (somnolence) is a commonly reported adverse reaction affecting the nervous system. However, difficulty falling or staying asleep (insomnia) is not listed as a common effect in the drug’s labeling.

Q: Is there a link between Securo and changes in mood or anxiety levels?

A: Regulatory documents report general nervous system effects such as dizziness and tremor. Specific changes in mood or anxiety are not commonly listed among the adverse reactions in the official product information.

Q: Do the common side effects of Securo usually go away over time?

A: The commonly reported adverse reactions are often described as temporary. These effects, which include nausea or headache, are described as often resolving within a few days or weeks of treatment.

Q: What is the safety classification of Securo for pregnancy and breastfeeding?

A: Official regulatory information historically classified the drug as Pregnancy Category C. Use during pregnancy is generally discouraged by the manufacturer. It is also documented that the active ingredient is excreted into human milk in low concentrations.

Q: Are there different strengths or versions of Securo available?

A: The oral tablet form of Securo is available in a 3 mg strength. The prescribing information outlines how a person’s total required dose is achieved using various combinations of these tablets.

Q: How does the official research describe the effectiveness of Securo?

A: Official research outcomes are described using specific measures, such as the 'parasitological cure rate' for threadworm infections or the measured 'reduction in microfilariae count' for river blindness. This is the way official research quantifies the drug's effect.

Q: Why do some people say Securo works for other issues not listed in the main uses?

A: The official marketing authorization is limited strictly to the documented parasitic infestations for which approval was granted. Its use for purposes outside of the approved indications is not supported by the regulatory documentation.

Q: Is it common to feel nausea or stomach upset when starting Securo?

A: Gastrointestinal effects, including nausea, vomiting, and diarrhea, are documented as commonly reported adverse reactions. Official materials note that these effects may be experienced at the start of treatment and are generally described as temporary.

Q: Do I need to have regular blood tests while using Securo?

A: Follow-up monitoring is specified for some indications, such as stool examinations for threadworm infection. Regulatory documents also report observations such as transient increases in liver enzymes during treatment, which may be monitored.

Q: How does Securo work compared to a placebo in clinical trials?

A: Clinical data supporting the drug’s use includes findings from randomized, placebo-controlled studies. These studies compare the measurable outcomes of the drug, such as the reduction in parasite load, against a non-active treatment (placebo).

Q: Can Securo cause an allergic reaction?

A: Official documents state that prior hypersensitivity (a known allergy) to the drug or any of its ingredients is considered an absolute contraindication. Rare, serious skin reactions, which are types of allergic responses, have also been reported.

Q: Does Securo affect the results of any common lab tests?

A: Regulatory documents report observations such as transient elevations in liver enzymes and an increase in eosinophils (a specific type of white blood cell). These changes are noted as part of the drug’s profile.

Q: What is the typical duration of a full course of Securo?

A: The standard regimen described in official documents for its approved uses is defined as a short-term course, often involving a single administration. The total length of treatment is specified in the prescribing information.

Q: How does Securo affect blood pressure or heart rate?

A: In the context of the Mazzotti reaction (a documented adverse reaction in Onchocerciasis treatment), a transient drop in blood pressure (hypotension) has been reported in official warnings.

How should Securo be stored and disposed of?

Storage and Disposal Requirements

Official regulatory documents define strict conditions for storing and disposing of Securo (Ivermectin) to maintain drug integrity and public safety.

Requirement Category Official Regulatory Statement
Storage Temperature Store at controlled room temperature, typically 20 C to 25 C (68 F to 77 F), with excursions permitted up to 30 C (86 F).
Protection/Handling Keep in the original container, which must be tightly closed to protect from excess heat and moisture. Must be kept out of the sight and reach of children and stored in a locked-up location.
Disposal Instructions Do not dispose of via household wastewater or sewage systems, as this substance is toxic to aquatic life. Unused product must be discarded according to local regulations, preferably utilizing a drug take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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