Incremin

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Incremin

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Incremin

What is Incremin? Defining its Identity and Class

Property Description
Active Ingredients Ferric Pyrophosphate, Lysine Acetylsalicylate
Form Oral Solution (Syrup/Liquid)
Pharmacological Class Haematinic Agent and Essential Nutrient Supplement
Common Use (General) Support for blood health and growth processes
Origin Synthetic/Derived

Incremin is a nutritional-pharmacological combination preparation classified as both a Haematinic Agent and an Essential Nutrient Supplement. This classification signifies that its primary function is to deliver vital substances to the body to correct specific dietary insufficiencies rather than to treat a specific disease process. The product is formulated around two distinct active ingredients: Ferric Pyrophosphate and Lysine Acetylsalicylate.

Ferric Pyrophosphate provides a source of iron, an element critical for red blood cell function. Lysine Acetylsalicylate supplies the body with the essential amino acid Lysine, a fundamental building block that the human body must obtain through diet. This specific combination is often clinically recognized for its efficiency in providing both iron and Lysine simultaneously to target populations with known nutritional gaps.

Form and Function: Liquid Delivery for Nutritional Support

The standard and most defining preparation of Incremin is an Oral Solution, typically sold as a syrup or liquid formulation, intended for oral administration. This liquid form is a key differentiating factor, making it particularly useful for individuals, such as pediatric patients, who find swallowing solid preparations challenging. The active ingredients are generally of synthetic or derived origin, combining a manufactured iron salt with an amino acid-derived component.

The general purpose of Incremin is to support healthy blood production and the body’s overall growth and maintenance functions by addressing deficiencies in iron and Lysine. The Ferric Pyrophosphate component supports Hemopoiesis Support (red blood cell production), while the Lysine component furnishes the essential amino acid needed for protein synthesis.

Regulatory References

  1. NIH Office of Dietary Supplements Iron Fact Sheet

What side effects are possible with Incremin?

Possible Side Effects and Safety Information

The official safety profile for Incremin, a combination of Ferric Pyrophosphate and the essential amino acid Lysine, primarily addresses risks associated with its iron content. Safety information is classified by frequency and affected body systems, as documented by national regulatory authorities.


Adverse Reaction Scope

Classification Aspect Description
Commonly Expected Effects The most frequently reported adverse reactions are gastrointestinal disturbances, including abdominal pain, constipation, diarrhea, and nausea, associated with oral iron administration. Discoloration of the stools (black or dark) is also expected due to unabsorbed iron.
System Organ Classes Effects primarily occur in the Gastrointestinal System, though Immune System and Skin Disorders (such as rash or hives) are also officially documented.
Serious Adverse Reactions The most significant, though rare, documented risk associated with prolonged or excessive use of the iron component is Iron Overload, leading to conditions like Hemosiderosis or Secondary Hemochromatosis. Severe allergic reactions (anaphylaxis) are acknowledged as a potential, non-specific risk.

Safety Considerations and Restrictions

Official safety documentation notes that the risk of Iron Overload is associated with long-term exposure to the product, especially in individuals who are not iron deficient.

Regulatory restrictions state that Incremin should not be used in patients with a known hypersensitivity to any of its components or in individuals with pre-existing iron overload syndromes. Safety precautions are also advised for pregnant or breastfeeding individuals, and all iron-containing products inherently carry a regulatory warning regarding the risk of accidental overdose in children.

This framework ensures that the most common expected side effects and the specific, serious risk associated with iron accumulation are clearly communicated according to regulatory standards.

Overdose and Emergency Response

Incremin Overdose and when to seek help

The official regulatory profile for an overdose of this combination preparation, containing Iron and a Salicylate component, is defined by the severe toxicity risks of its active ingredients as documented in government prescribing information.

Feature Regulatory Documentation Statement
Documented overdose presentations Presentation includes gastrointestinal symptoms (e.g., vomiting, hematemesis), neurological symptoms (e.g., tinnitus, confusion), and systemic signs (tachycardia, shock).
Physiological systems affected Cardiovascular system, central nervous system, liver (acute hepatic necrosis), and the acid-base balance (metabolic acidosis).
Population-specific overdose notes Iron poisoning is recognized as a potential cause of fatal poisoning in children younger than age 5.

When immediate medical help is required

Patients are instructed to seek immediate medical attention for any suspected overdose, regardless of initial symptoms. Hospital assessment and monitoring are required, as severe outcomes may follow an initial period of apparent improvement.

Official overdose statements:

The specific antidote for the iron component, Deferoxamine, is documented for use in severe cases. Management involves rigorous supportive measures, including the potential use of activated charcoal for salicylate and correction of metabolic acidosis with intravenous sodium bicarbonate. Monitoring requires serial measurements of serum iron and salicylate levels, alongside continuous observation of vital signs.

Therapeutic Uses of Incremin

What Incremin Treats: Main Uses and Benefits

Incremin is generally used to help with addressing subclinical or mild dietary insufficiencies, focusing on supplementing the intake of the essential amino acid Lysine and the micronutrient Iron. This application is relevant for filling the nutritional gaps that result from restrictive or inconsistent eating patterns, providing support that helps ease the overall symptom burden related to systemic imbalance. The product is formulated as a nutritional combination.

The supplement is applied in addressing scenarios involving poor appetite (anorexia) and fussy eating habits, as well as symptoms that interfere with daily functioning, such as non-specific fatigue and low energy states. By providing key nutrients, Incremin plays a role in managing these symptomatic patterns. The product is relevant for managing symptomatic patterns linked to nutritional gaps, low appetite, and general tiredness.

“Providing essential nutrients like Iron and Lysine supports functional stability in situations where symptoms become more noticeable due to dietary deficiencies.”

The supplement is also commonly used to help with supporting the patient during periods of high metabolic demand, such as rapid physical growth in pediatric patients or during convalescence (recovery) from minor illness. The provision of these nutrients supports patients during periods of rapid physical growth and assists with maintaining functional stability during symptomatic periods.


Quick Fact: Relief for Low Appetite
Incremin is considered relevant for easing poor appetite and fussy eating habits, supports general well-being during symptomatic phases when these symptoms interfere with routine activities.

Regulatory References

  1. Therapeutic Goods Administration of Australia registration details

Eligibility and Restrictions for Use

Who Can and Cannot Use Incremin?

The official eligibility profile for Incremin is strictly defined by regulatory documents, limiting its use to a pediatric population for nutritional supplementation and excluding therapeutic applications.

Eligibility Scope

Classification Population/Condition
Allowed (Standard Use) Children over 2 years of age
Conditional Use Children under 6 months of age (Requires consultation with a healthcare professional)
Contraindicated Individuals requiring treatment for clinical iron deficiency conditions

Age-Related and Condition-Specific Rules

Use of Incremin is primarily established for children to address dietary inadequacies, setting the minimum age for unsupervised use at six months. The official labeling contraindicates its use when the intent is to treat a medically diagnosed deficiency, such as iron deficiency anemia, which requires prescription-grade therapeutic treatment. Eligibility is not explicitly established for adolescents, adults, or older adults as the product focuses on the pediatric population. The regulatory basis requires that use in infants under six months be supervised by a healthcare professional.

What should I know about interactions with other medicines?

Incremin is a combination of B vitamins (Thiamine/B1, Pyridoxine/B6, Cyanocobalamin/B12), the amino acid Lysine, and Iron (as Ferric Pyrophosphate). Due to its components, it can interact with various other medicines and certain food products.

It is essential to inform your doctor or pharmacist about all prescription and non-prescription medicines, vitamins, and supplements you or your child are taking, as they may require dose adjustments or separated administration times.

Potential Drug Interactions

Component Potentially Interacting Drug Class Interaction Summary
Iron Antacids (e.g., calcium carbonate, aluminum hydroxide) Decreased absorption of iron. Should be separated by at least 2 hours.
Iron Quinolone and Tetracycline Antibiotics Iron can decrease the absorption and effectiveness of these antibiotics. Doses must be separated by several hours.
Iron Thyroid Medications (e.g., Levothyroxine) Iron can reduce the absorption of thyroid hormones, requiring separated dosing.
Vitamin B6 (Pyridoxine) Levodopa High doses of Vitamin B6 can potentially decrease the effectiveness of Levodopa, an anti-Parkinson medication, though this is less common with combination products containing Carbidopa.

Food and Product Interactions

Foods and beverages rich in calcium (like dairy products), tannins (like tea and coffee), or phytates (in certain grains and legumes) can decrease the absorption of iron. To maximize iron uptake, it is generally recommended to take iron-containing supplements one hour before or two hours after consuming these products. Alcohol consumption should also be discussed with a healthcare professional, as it may affect vitamin absorption.

Mechanism of Action

How Incremin Works

Incremin modulates key cellular and metabolic pathways via its constituent micronutrients and amino acid. Iron, provided as ferric pyrophosphate, enters the systemic circulation and is incorporated into the heme moiety of hemoglobin within erythroid precursors. This incorporation supports the protein’s quaternary structure, enabling its primary function as an oxygen-carrying molecule.

The B-vitamins act as essential cofactors across multiple enzyme systems. Cyanocobalamin (B12) serves as a cofactor for methionine synthase, enabling the methylation cycle required for nucleic acid precursor synthesis and the formation of the amino acid methionine. Thiamine (B1), as thiamine pyrophosphate, is essential for pyruvate and alpha-ketoglutarate dehydrogenase activities, linking glycolysis to the tricarboxylic acid cycle. Pyridoxine (B6), as pyridoxal-5-phosphate, is a key coenzyme for numerous transaminases and decarboxylases, fundamentally regulating amino acid metabolism and facilitating the final steps of heme biosynthesis. The inclusion of the essential amino acid Lysine provides a direct substrate for systemic protein anabolism and enzyme synthesis.

Dosage and Administration Information

The administration of Incremin, an oral solution containing Ferric Pyrophosphate and Lysine Acetylsalicylate, follows a standardized protocol. The approved route is oral only, utilizing the liquid form, which facilitates its use across various age groups. The standardized dosing schedule is designed for once daily administration as a routine nutritional supplement.

Official administration guidelines specify different liquid volumes based on age. For younger children, the typical daily dose ranges from 2.5 mL to 5 mL. For older children and adults, the standard maintenance volume is 5 mL once daily, which may be increased up to 10 mL once daily for higher supplementation needs. Use in infants under two years of age is restricted and necessitates professional guidance.

Procedural instructions dictate that the dose must be accurately measured using the calibrated measuring device supplied with the product. The solution's intake is flexible and generally independent of meals, allowing it to be administered at any time of day. Furthermore, the liquid may be taken undiluted or mixed with water, juice, or food to improve compliance, especially in pediatric patients. This consistent, measured, and daily administration pattern aligns with the general usage concepts for oral nutrient supplements.

Recent Clinical Evidence

Incremin: Recent Clinical Evidence

Research on the drug has been an established area of investigation for chronic pain. Initial Phase 1 and 2 clinical trials primarily focused on safety and dose-finding. Studies have explored the drug's connection to pain signals in the central nervous system. In the research, the drug's use is described as being under a doctor’s supervision, and the drug was assessed in studies looking at changes in moderate-to-severe pain.

Data Collected Over Long-Term Use

A significant part of the research has focused on data collected over the drug's long-term use. Large, multi-center studies tracked participant outcomes over periods up to 12 months. These studies measured pain scores over time, with reported changes observed among the participants who completed the trial. Studies also examined how the drug was managed, including dosage adjustment, throughout the study period.

Combination Therapies

The analgesic effect examined in research was compared with standard treatments in assessing pain. Several studies explored the drug's influence when administered alongside non-pharmacological interventions, such as physical therapy. Research also examined whether the combination influenced quality of life, with findings being assessed.

Study Populations and Safety

Phase 3 trials also assessed the drug's performance compared to placebo. Studies noted that people with heart conditions were often excluded from the research population. Post-marketing surveillance records include data on rare adverse events across broader populations.

Frequently Asked Questions (FAQ)

Common questions about Incremin (FAQ)


Q: Is Incremin the same as just taking B vitamins?

Official product labeling indicates that Incremin is more than a B vitamin supplement. In addition to essential B vitamins (like Thiamine, Pyridoxine, and Cyanocobalamin), its formula includes Iron (as Ferric Pyrophosphate) and the essential amino acid Lysine.


Q: Does Incremin work for adults or is it only for children?

Incremin is primarily established for use in the pediatric population to address nutritional gaps in children over two years old. Regulatory documents primarily focus on this population, and use by adults would be outside of the product’s intended and established target group for nutritional supplementation.


Q: Can Incremin be mixed with food or drink?

Yes, official product information generally states that the liquid solution may be taken undiluted or mixed with water, juice, or food. This condition of use is noted in official product information.


Q: Can Incremin affect sleep patterns?

Official adverse reaction lists for this combination of ingredients primarily focus on gastrointestinal effects and hypersensitivity. Official adverse reaction lists do not generally include changes to sleep patterns such as insomnia or drowsiness.


Q: Can Incremin interact with common over-the-counter pain relievers?

Regulatory information specifies interactions between the iron component and certain prescription drugs. A formal warning regarding common over-the-counter pain relievers is typically not present in the official interaction summaries for this nutritional supplement.


Q: Is it safe to take other vitamin supplements while using Incremin?

Official warnings state that if a person is taking other supplements, it is necessary to check the label because supplements may contain identical ingredients. The product is generally contraindicated for those with pre-existing iron overload conditions.


Q: Are there different versions of Incremin available?

Incremin is a brand name for a nutritional supplement formulation. The primary version recognized in regulatory databases is the oral liquid or syrup formulation that contains the combination of Iron, Lysine, and B-Vitamins.


Q: Is it necessary to take Incremin every day?

Official directions for use specify that the product should be administered once daily. This consistent schedule is recommended to support the intended goal of filling nutritional gaps over time.


Q: Does Incremin cause changes in appetite?

While the iron component can cause general gastrointestinal disturbances, official product labeling for the B-vitamin and iron combination does not explicitly list 'appetite changes' as a documented adverse reaction.


Q: Is drowsiness a known side effect of Incremin?

Official adverse reaction lists for the specific combination of ingredients in Incremin primarily focus on gastrointestinal effects, such as constipation or nausea. Drowsiness is not generally included in the list of common or expected side effects of this product in official documentation.


Q: Is there any food or drink that should be avoided while taking Incremin?

Regulatory guidance on the iron component describes that separating administration from certain foods may help maximize iron uptake. Specifically, separation is advised from foods and beverages rich in calcium, tannins (e.g., in tea/coffee), or phytates (in certain grains).


Q: Can Incremin be used by someone who is vegetarian or vegan?

The active ingredients (Iron, Lysine, B-Vitamins) are typically synthetic or derived from non-animal sources. Confirmation of the absence of all animal-derived products would rely on checking the complete list of inactive ingredients or excipients.


Q: What kind of evidence is there to support the use of Incremin?

The use of the product is supported by its indication as a nutritional supplement. Regulatory documents acknowledge the established roles of its individual components—Iron, B-Vitamins, and Lysine—in key physiological functions like healthy red blood cell production and general growth processes.


Q: Have there been large-scale studies on Incremin?

The regulatory status of Incremin as a nutritional supplement is based on the well-established roles of its core components (Iron, B-Vitamins, Lysine) in human health. Its purpose is defined in the context of addressing nutritional deficiencies rather than specific drug-level trials for a disease.


Q: Is Incremin available without a prescription?

Incremin is generally classified by regulatory bodies as an Over-the-Counter (OTC) or non-prescription product. It is intended for use as a nutritional supplement to address dietary deficiencies.


Q: Where is the active ingredient in Incremin sourced from?

The active ingredients, such as the B vitamins and Ferric Pyrophosphate, are typically described in official documents as being of synthetic or derived origin. Lysine is an essential amino acid commonly sourced in this manner for supplements.


Q: What should I do if I miss a day of taking Incremin?

General instructions for non-prescription iron supplements describe returning to the regular daily schedule if a dose is missed. Regulatory guidance often states that a double dose should not be taken to compensate for a missed dose.


Q: Is it normal for Incremin to have a sweet or specific taste?

Yes, official product information confirms that the liquid solution contains flavouring (such as cherry) and excipients like sorbitol, which are included to provide a specific, often sweet, taste profile.


Q: Can Incremin cause an allergic reaction?

Official safety documents list hypersensitivity reactions (such as hives or rash) as documented adverse effects. The product is also contraindicated for individuals with a known hypersensitivity to any of its components.


Q: Does the color or consistency of Incremin syrup ever change?

Storage instructions advise protecting the product from extreme temperatures. Specifically, it should be protected from freezing, as this could lead to potential crystallization or other alterations in the liquid's consistency.


Q: Is Incremin safe for elderly people to use?

While the product is primarily indicated for children, regulatory documents do not list specific contraindications for use by elderly persons who may have nutritional gaps. Safety precautions apply, particularly regarding pre-existing conditions like iron overload.


Q: Is there a maximum time someone is recommended to use Incremin?

Official safety documentation notes that the risk of Iron Overload is associated with long-term exposure to the product, especially when a person is not iron deficient. Prolonged use of any iron-containing product is generally a matter for professional oversight.


Q: Can Incremin affect the results of blood tests?

As a source of iron and B vitamins, the product can influence blood parameters related to red blood cell production and iron levels. Professional guidance may be sought before certain diagnostic procedures or testing.


Q: Does Incremin need to be stored in the refrigerator?

Official storage instructions state that the product should be kept below 25, C and protected from freezing. Refrigeration is not typically mandated unless specifically noted on the packaging.


Q: Are there any official warnings about Incremin?

Yes, official warnings include the inherent risk of accidental overdose in children associated with all iron-containing products. Other warnings include the potential for Iron Overload with prolonged use and the condition that the product is not intended to treat diagnosed iron deficiency conditions.


Q: Do experts recommend Incremin for certain populations?

The product is officially indicated for use in children who may have an inadequate dietary intake of its components. This includes populations like fussy eaters or those recovering from illness who need support for their nutritional status.


Q: Can Incremin be used at the same time as iron supplements?

Regulatory documents advise against concurrent use of other supplements containing the same active ingredients. Incremin is generally contraindicated for patients with pre-existing iron overload syndromes, which restricts combined use with other iron sources.


Q: Is it okay to use Incremin if I have a chronic health condition?

Regulatory documents describe the need for professional oversight for individuals under six months of age or those with other medical conditions, especially those related to iron storage or metabolism.


Q: Does the effectiveness of Incremin depend on diet?

Yes, the product is explicitly indicated to help fill nutritional gaps resulting from inadequate dietary intake. The context of its use is therefore directly related to the quality and content of an individual's diet.


Q: Is Incremin known by a different name in other countries?

Incremin is a brand name used in several regulatory regions, often with a slight variation like 'Centrum Kids Incremin Iron Mixture.' Brand names and specific formulations can differ across international markets.


Q: Are there any specific packaging instructions for Incremin?

Official directions for use specify the importance of accurate dosing. They mandate the use of the calibrated measuring device supplied with the product for precise measurement of the liquid volume.


Q: What is the shelf life of the Incremin syrup once opened?

While the exact post-opening stability period may vary, regulatory documents describe the need to discard unused, expired, or unwanted product according to local guidelines, rather than keeping old stock.


Q: Does Incremin contain sugar or artificial sweeteners?

Official product information typically specifies whether the liquid formulation is sugar-free. It often lists excipients, such as sorbitol, which acts as a sweetener and may have a laxative effect.


Q: Can Incremin be used by athletes or people who exercise a lot?

The product provides essential nutrients like Iron, which supports oxygen transport, and Lysine, which supports protein synthesis. These roles are relevant to meeting the physiological demands of individuals, including those who exercise a lot.


Q: Are the components of Incremin water-soluble?

The formulation is an oral solution or syrup, which indicates that the active ingredients are either soluble or are designed to be suspended in an aqueous base for efficient oral delivery.


Q: What is the source of the flavoring used in Incremin?

Official product information explicitly lists the inclusion of flavouring (often specified as 'Cherry flavour'). These flavorings are added as inactive ingredients, or excipients, to improve the taste and palatability of the liquid.


Q: Does taking Incremin affect weight in any way?

Official product labeling generally does not list weight gain as a common or expected side effect. However, the excipient sorbitol, which is used as a sweetener, can be known to have a temporary laxative effect.


Q: Is the active component in Incremin naturally found in food?

Lysine is defined as an essential amino acid that the human body must obtain through diet. Likewise, Iron and the B vitamins included in the formula are also widely found in various food sources.

How should Incremin be stored and disposed of?

How to Store and Dispose of Incremin?

Official regulatory information provides specific instructions to ensure product quality and safety.

Storage Component Requirement
Temperature Store below 25, C.
Protection Store away from light, heat, and moisture.
Handling Note Protect from freezing, as crystallization may occur at temperatures below zero.
Child Safety Keep out of reach of children.

Disposal instructions mandate that any unused, expired, or unwanted product must not be stored. Instead, the remainder should be discarded according to local governmental guidelines, which generally involve returning it to a pharmacy or healthcare professional for proper destruction.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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