Cardicor

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cardicor

Quick Facts

Property Description
Active Ingredient Bisoprolol fumarate
Form Film-coated tablet (Oral administration)
Pharmacological Class beta1 Selective Beta-Blocker (Cardioselective)
General Purpose Achieve long-term cardiovascular stability
Origin Synthetic chemical compound

What Type of Medicine is Cardicor? (Identity and Classification)

Cardicor is a prescription-only medication primarily used to stabilize the cardiovascular system. Its active ingredient is Bisoprolol fumarate, a synthetic compound classified as a beta1 selective beta-adrenergic receptor blocking agent, widely known as a cardioselective beta-blocker. This classification is clinically recognized for providing a targeted action profile, meaning the drug mainly focuses its sympatholytic agent effects on the receptors predominantly located in the heart.


Composition, Origin, and Form: A Cardioselective Agent

The Bisoprolol molecule is entirely manufactured chemically, supplied as a single active ingredient product in the form of a film-coated tablet for oral administration. The specific chemical architecture of Bisoprolol contributes to a relatively long elimination half-life, a factor that supports its suitability for once-daily dosing, which is a practical differentiating factor for patient adherence. Furthermore, its high cardioselectivity is a key trait that separates it from non-selective beta-blockers by preferentially modulating heart receptors.


General Purpose: What Does Cardicor Help to Achieve?

The fundamental purpose of Cardicor is to promote cardiovascular stability by protecting the heart from sympathetic overstimulation. By selectively inhibiting nerve signals, the drug produces a decrease in both the heart's pumping force (myocardial contractility) and its speed (heart rate). This effect is utilized to reduce the heart's overall workload and oxygen demand. Clinically, this mechanism is central to supporting efficient heart function in adults managing chronic circulatory conditions.

What side effects are possible with Cardicor?

Possible Side Effects and Safety Information

The official safety profile of Cardicor (Bisoprolol) classifies documented adverse reactions according to their frequency and the physiological system affected.

Frequency-Classified Adverse Reactions

  • Very Common (Affecting more than 1 in 10 patients): Bradycardia (slowed heart rate) has been reported in patients treated for chronic heart failure.
  • Common (Affecting between 1 in 10 and 1 in 100 patients): Common effects include dizziness and headache, which regulatory documents note occur especially at the beginning of therapy. Other common effects include fatigue, asthenia (weakness), and gastrointestinal complaints such as nausea, vomiting, diarrhea, and constipation. Hypotension (low blood pressure) and a feeling of coldness or numbness in the extremities are also officially classified as common.
  • Uncommon: These include sleep disorders, depression, muscular weakness, and cramps. AV-conduction disturbances and bronchospasm (particularly in patients with asthma or obstructive airway disease) are also noted as uncommon.
  • Rare: Effects such as hepatitis, syncope (fainting), nightmares, hallucinations, and erectile dysfunction are classified as rare in the regulatory documentation.

Serious Adverse Reactions and Safety Constraints

The label documents the potential for serious reactions, including the worsening of pre-existing heart failure and severe bradycardia. The medicine is formally contraindicated in several serious conditions, including acute heart failure/decompensation, cardiogenic shock, and second or third degree AV block (without a pacemaker), establishing strict limitations on its use.

Population-Specific Safety Notes

The regulatory label specifies that the medicine is not recommended for the pediatric population due to lack of experience. Additionally, patients with renal or hepatic impairment require particular caution due to the drug’s elimination characteristics. The label also notes that Bisoprolol may potentially mask symptoms of hypoglycemia in diabetic patients and may provoke or worsen psoriasis in susceptible individuals, requiring careful assessment.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes Cardicor (Bisoprolol) overdose by listing severe clinical manifestations that require immediate intervention.

Documented Overdose Manifestations

System Officially Documented Signs
Cardiovascular Bradycardia (abnormally slow heart rate), hypotension (low blood pressure), atrioventricular (AV) conduction disturbances.
Systemic/Other Bronchospasm, hypoglycemia, and CNS depression including confusion or coma.

Required Emergency Actions

The presence of any suspected overdose or severe manifestation mandates immediate medical attention. Regulatory guidance requires patients or caregivers to contact emergency services or a Poison Control Center right away. Discontinuation of Cardicor therapy is necessary, but this must be followed immediately by seeking professional emergency care, as defined in official prescribing information.

Overdose can lead to severe outcomes such as cardiogenic shock or severe worsening of heart failure. No specific antidote for Bisoprolol is known; therefore, management involves symptomatic and supportive treatment, including the use of therapeutic agents such as Atropine or Glucagon, and continuous vital sign and cardiac monitoring, as documented in regulatory guidelines. Specific concern is noted for hypoglycemia in pediatric patients.

Therapeutic Uses of Cardicor

What Cardicor Treats: Main Uses and Benefits

Therapeutic Domains

The primary uses of Cardicor (Bisoprolol) are applied across therapeutic domains where additional symptomatic support is needed for chronic conditions. The medication is commonly used to help manage hypertension (high blood pressure), chronic stable angina (chest pain), and stable chronic heart failure—conditions where supportive symptom management is considered relevant.

The medication is applied for essential, long-term support in patients diagnosed with stable chronic heart failure with reduced function. The medication contributes to improved comfort during periods of symptomatic discomfort, which may assist with maintaining functional stability. It is also used for managing high blood pressure and relieving symptomatic discomfort related to chronic stable chest pain.


Quick Fact: Support for Key Symptom Domains
Main Conditions Hypertension, Chronic Stable Angina, Stable Chronic Heart Failure
Symptom Support Helps address symptoms related to high circulatory pressure and chronic chest discomfort
Patient Benefit May assist with maintaining functional stability and contributes to easing overall symptom load

Eligibility and Restrictions for Use

Who Can and Cannot Use Cardicor?

The population eligibility for Cardicor (Bisoprolol fumarate) is strictly defined by government regulatory documents, which list groups for whom the medicine is contraindicated (must not be used) and groups requiring conditional use.


Absolute Contraindications

Cardicor is contraindicated in patients with:

  • Acute cardiac failure or decompensation.
  • Cardiogenic shock.
  • Second- or third-degree AV block (without a pacemaker).
  • Marked sinus bradycardia (slow heart rate).
  • Severe bronchial asthma or severe COPD.
  • Severe forms of Raynaud’s syndrome or peripheral arterial occlusive disease.

Restrictions and Limitations

Population Group Regulatory Status
Children/Adolescents (<18) Not recommended; safety and efficacy are not established.
Pregnancy/Lactation Not recommended; use only if potential benefit justifies the risk to the fetus.
Severe Renal/Hepatic Impairment Maximum daily dose must not exceed 10 mg.
Diabetes Mellitus Use with caution, as symptoms of hypoglycemia may be masked.

Adult patients without these specific contraindications or restrictions are eligible for use under standard labeled conditions.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Cardicor (Bisoprolol fumarate) has specific officially documented interaction patterns based on regulatory labeling, classified by the potential for additive effects or altered clearance.

Official Regulatory Classifications

Classification Interacting Agents (Examples)
Contraindicated Other beta-blocking agents (including topical use)
Use with Caution Calcium antagonists (Verapamil, Diltiazem type), Class I Antiarrhythmics, Digitalis glycosides, Catecholamine-depleting drugs

Documented Interaction Constraints

Official labeling defines constraints across pharmacodynamic and pharmacokinetic dimensions.

  • Pharmacodynamic Risk: Combining Cardicor with Verapamil or Diltiazem types of calcium antagonists carries a risk of negatively affecting myocardial contractility and AV conduction, requiring caution.
  • Kinetic Effect: The antibiotic Rifampin increases the metabolic clearance of Bisoprolol, which results in a shortened elimination half-life, a pharmacokinetic effect noted in official documents.
  • Administration Sequence: If therapy involving Clonidine and Cardicor is stopped, Bisoprolol must be discontinued for several days before the withdrawal of Clonidine is permitted, a mandated procedural sequence.
  • Specific Populations: The half-life is officially documented as significantly slower and more variable in individuals with liver cirrhosis and approximately three times longer in severe renal disease (creatinine clearance < 40 mL/min).

Mechanism of Action

Cardicor (Bisoprolol) is a highly selective beta1-adrenergic receptor antagonist. Its mechanism of action centers on modulating the sympathetic nervous system's influence on cardiac and renal function by binding to these receptors.

Selectively Targeting beta1-Adrenergic Receptors

Cardicor acts as a selective antagonist for beta-1 adrenergic receptors (beta1ARs), which are densely expressed in the cardiac muscle. By competing with endogenous catecholamines (like norepinephrine), it prevents the activation of the downstream cAMP/PKA signaling cascade in cardiac tissue. This engagement mechanism effectively reduces the beta1AR-mediated increase in heart rate and contractility resulting from sympathetic stimulation.


Modulating Cardiac and Electrical Function

The blockade of beta1ARs on the heart directly decreases heart rate (negative chronotropy) and diminishes the force of myocardial contraction (negative inotropy). This suppression modifies the early molecular steps within the beta1AR signaling cascade and results in decreased automaticity and conduction velocity, contributing to lower myocardial oxygen consumption.


Regulating Renin Release and Vascular Tone

Cardicor also influences physiological processes outside the heart. It supports the regulation of the renin-angiotensin-aldosterone system (RAAS) activity by blocking beta1ARs on the juxtaglomerular cells in the kidney, thereby suppressing renin release. This effect modifies the activity of the RAAS pathway, impacting downstream signaling that regulates vascular tone and systemic blood pressure.

Dosage and Administration Information

Cardicor (bisoprolol fumarate) is administered exclusively through the oral route via a film-coated tablet, which is typically taken once daily in the morning. The tablet may be taken either with or without food, but must be swallowed whole with liquid and should not be crushed or chewed. The duration of therapy is generally long-term for chronic conditions. Any cessation of treatment must follow a gradual, planned reduction in dose (tapering) over approximately one week, as abrupt withdrawal is to be avoided.


Official Dosing Regimens

For hypertension and chronic stable angina, the usual starting dose is 5 mg once daily, with a maximum recommended dose of 20 mg once daily.

For stable chronic heart failure, the medicine requires a specific titration protocol:

  • Treatment begins at a low starting dose of 1.25 mg once daily.
  • The dose is gradually doubled at weekly intervals based on tolerance, up to a maximum maintenance dose of 10 mg once daily.

Population-Specific Use

Dose adjustment is required for patients with severe kidney or liver impairment, where the maximum daily dose should not exceed 10 mg. For older adults, initial dosage adjustment is typically not necessary.

Recent Clinical Evidence

Research evidence / Overview of studies for Cardicor (Bisoprolol Fumarate)


Evidence for use in Hypertension (High Blood Pressure)

Research examining Cardicor in individuals with high blood pressure was conducted primarily through short-term clinical trials. These studies focused on measurements of blood pressure levels, monitoring outcomes related to physiological strain or stress. The participants in this research were generally adults with documented high blood pressure.

Findings describe patterns observed in the studies where research highlights changes measured during the study period, such as measured measurements of blood pressure metrics. It appears to relate to reported changes measured in these short-term physiological measurements. Findings varied across studies, and the overall evidence contributes to understanding symptom patterns related to blood pressure regulation.

Long-term outcomes are not well characterized regarding potential durability of measured change or related systemic outcomes over many years. Follow-up durations were limited in many of the initial trials. Furthermore, the evidence quality varies across studies.


Evidence for use in Chronic Stable Angina Pectoris

Cardicor was evaluated in research for individuals with chronic stable angina pectoris, a condition involving periods of heightened symptoms such as chest discomfort. Researchers explored outcomes related to physical discomfort, such as measurements of exercise tolerance and patient-reported outcomes describing perceived discomfort.

Research so far indicates that during the study periods, changes in measured outcomes like exercise capacity was observed in some studies. These changes may relate to how the condition manifests and how patients reported their experience. The studies report how symptoms evolved in the observed populations.

Certainty remains low for long-term outcomes beyond the duration of the trials. Sample sizes were modest in many of the initial reports, which suggests that the results are drawn from modest sample sizes. There is limited information for long-term outcomes.


What is still uncertain about Cardicor

There are several areas where the research evidence remains incomplete or uncertain. Comparative evidence is lacking for many aspects, and long-term effects are not fully established across all measured outcomes, as follow-up durations were limited in much of the core evidence. Existing data highlights what is known — and what is still uncertain about how the drug may be associated with outcomes. Research is ongoing to address these gaps.

Frequently Asked Questions (FAQ)

Common questions about Cardicor (FAQ)

Q: What is the difference between Cardicor and other common heart medicines?

A: Official information describes Cardicor as a selective beta-blocker, meaning its primary action is targeted at receptors predominantly located in the heart. This selectivity is noted in regulatory summaries as describing a mechanism of action that differs from other medicine classes used for the heart, such as calcium channel blockers.


Q: What happens if I miss taking a dose of Cardicor?

A: General administration guidance states that if a dose is missed, it should be taken as soon as it is remembered. If it is almost time for the next scheduled dose, regulatory documents suggest taking only that single dose. Official regulatory documentation indicates that double or extra doses should not be taken.


Q: Is it common for Cardicor to cause dizziness?

A: Dizziness is officially classified in regulatory documents as a Common adverse reaction, meaning it has been reported to affect between 1 in 10 and 1 in 100 patients. This effect is noted in official documents to occur particularly during the initial phase of therapy.


Q: How does Cardicor affect a person's heart rate?

A: The drug's mechanism of action is described as involving a direct decrease in the heart rate (negative chronotropy). Bradycardia (a slowed heart rate) is classified as a Very Common adverse reaction in regulatory safety profiles for patients managing chronic heart failure.


Q: What is the maximum duration Cardicor has been studied for?

A: Regulatory summaries mention that for certain uses, blood pressure reductions were observed to be sustained for over a year in some longer-duration studies. The limited follow-up periods suggest core evidence largely covers a short to medium duration.


Q: Why is Cardicor listed with safety precautions?

A: Safety precautions are necessary because regulatory documents specify the potential for Serious Adverse Reactions, including the worsening of pre-existing heart failure and severe bradycardia (slowed heart rate). The medicine is also formally contraindicated in several acute medical conditions.


Q: How does Cardicor specifically help the heart function?

A: The medicine is described as helping the heart function by selectively blocking overstimulating nerve signals. This action reduces the heart rate and diminishes the force of myocardial contraction, which decreases the heart's overall workload and oxygen demand.


Q: How quickly does Cardicor start working after the first dose?

A: Information based on regulatory review indicates that the blood pressure-lowering effect may begin within about 2 hours after the first dose. However, achieving the full therapeutic effect may require a period of 2 to 6 weeks of consistent use.


Q: Is it normal to feel tired when starting Cardicor?

A: Fatigue and asthenia (a feeling of weakness) are classified in official regulatory documents as Common adverse reactions. These effects may occur in up to 1 in 10 patients, particularly during the initial phase of starting the therapy.


Q: Can Cardicor affect my ability to drive or operate machinery?

A: Official warnings state that the medicine may cause some people to become less alert due to potential side effects such as dizziness or headache. Official guidance recommends caution, and if these effects occur, driving or operating machinery should be avoided.


Q: Can taking Cardicor affect my blood sugar levels?

A: Regulatory documentation notes that Cardicor may mask the symptoms of hypoglycemia (low blood sugar), such as a rapid pulse rate, especially in diabetic patients. Official adverse reaction data also indicates that changes in blood sugar levels have been reported.


Q: Can I take Cardicor if I drink alcohol occasionally?

A: Regulatory-based patient guidance advises caution, as consuming alcohol can increase the blood pressure-lowering effect of the drug. Regulatory-based patient guidance indicates that this may be associated with an increased risk of side effects like dizziness or fainting.


Q: Does Cardicor have known interactions with common over-the-counter pain relievers?

A: Guidance based on regulatory review states that Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen, may reduce how well Cardicor works. Regulatory review states that this combination may be associated with a reduced effect of Cardicor in lowering blood pressure.


Q: What should I know about Cardicor if I also take supplements like vitamins?

A: Official regulatory-based information suggests there is limited evidence available regarding the use of supplements (including vitamins) with Cardicor, as they are not formally tested in the same way as prescription medicines.


Q: Is Cardicor typically prescribed to younger adults?

A: The medicine is generally prescribed to adults aged 18 and over who do not have any listed contraindications. Official labeling states the medicine is not recommended for the pediatric population (under 18) because safety and efficacy have not been established.


Q: What information is available about Cardicor use during pregnancy?

A: Regulatory guidance states that the medicine is not recommended during pregnancy unless the potential benefit is determined to justify the potential risk to the fetus. Official documentation notes that beta-blockers may be associated with decreased placental blood flow.


Q: What kind of evidence supports the use of Cardicor for its main purpose?

A: The evidence supporting the medicine's main uses is primarily based on short-term clinical trials. These studies focused on measuring outcomes such as blood pressure levels, exercise tolerance, and patient-reported outcomes describing perceived discomfort.


Q: What are the signs of a serious side effect from Cardicor?

A: Official safety documents indicate that signs of serious side effects include symptoms of worsening heart failure (such as trouble breathing, rapid weight gain, or swelling of the legs/feet) and bronchospasm (such as tightness in the chest or wheezing).


Q: Is Cardicor known to interact with herbal remedies, such as St. John's wort?

A: Guidance based on regulatory review indicates there is very little official information available about taking specific herbal remedies (including St. John's wort) with Cardicor, as they are not formally tested like prescription medications.


Q: Can Cardicor cause changes in mood or anxiety?

A: Official adverse reaction lists include anxiety (Common), sleep disorders and depression (Uncommon), and nightmares and hallucinations (Rare). These listings indicate potential effects on mood and central nervous system function have been reported.


Q: How does Cardicor affect blood pressure readings?

A: Cardicor is described as lowering blood pressure readings through two main actions: it decreases the heart's pumping force and it suppresses the release of renin from the kidneys. Renin is a key part of the body's system that regulates systemic blood pressure.


Q: Is it possible to be allergic to an ingredient in Cardicor?

A: The medicine is formally contraindicated if a person has a history of hypersensitivity or an allergic reaction to the active substance (bisoprolol fumarate) or to any of the inactive ingredients (excipients) listed on the official label.


Q: Can Cardicor affect cholesterol levels?

A: Official adverse reaction data includes reports of changes in cholesterol levels and an increase in triglycerides as observed metabolic side effects. These have been classified in regulatory documents as rare to common.


Q: What is still uncertain about Cardicor?

A: Regulatory-based evidence summaries indicate that comparative evidence is lacking for many aspects, and long-term effects are not fully established across all measured outcomes. This is attributed to the limited follow-up durations used in much of the core clinical evidence.


Q: Are there any dietary restrictions mentioned in the official guidance for Cardicor?

A: Official guidance states that there are no specific food or drink restrictions, other than advising caution regarding the consumption of alcohol. The medicine may be taken with or without food.


Q: Does Cardicor interact with grapefruit juice?

A: Information based on regulatory review states that Cardicor does not have a known interaction with grapefruit or grapefruit juice, unlike some other types of blood pressure medications.


Q: Is there a link between Cardicor and weight gain or loss?

A: Official adverse reaction data includes reports of weight changes (gain or loss) as a reported side effect. Some regulatory-based reviews indicate weight gain is not a common side effect when compared to older types of beta-blockers.


Q: Are there any large-scale studies on the long-term effects of Cardicor?

A: Regulatory summaries indicate that long-term outcomes are not well characterized and that initial core evidence involved modest sample sizes and limited follow-up durations. This suggests that large-scale, multi-year evidence is not central to the core approval data.


Q: If I have kidney problems, can I still use Cardicor?

A: Regulatory documents indicate that dose adjustment is required for patients with severe kidney impairment. For patients with severe kidney impairment, the maximum daily dose specified in labeling is 10 mg.


Q: If I have a history of liver problems, is Cardicor still an option?

A: Regulatory documents indicate that dose adjustment is required for patients with severe liver impairment. For patients with severe liver impairment, the maximum daily dose specified in labeling is 10 mg. The official label notes that the drug’s elimination is significantly slower and more variable in individuals with conditions such as liver cirrhosis.


Q: Is Cardicor safe for people with diabetes?

A: Regulatory documents state that Cardicor should be used with caution in patients with diabetes mellitus. This is because the medicine may potentially mask symptoms of hypoglycemia (low blood sugar), such as a rapid pulse rate.

How should Cardicor be stored and disposed of?

How to Store and Dispose of Cardicor (Bisoprolol Fumarate)


Official regulatory documents define specific storage and disposal requirements for Cardicor tablets.

Required Storage Conditions

Tablet Strength Required Maximum Temperature
1.25 mg, 2.5 mg, 3.75 mg Below 25 °C
5 mg, 7.5 mg, 10 mg (Standard Pack) Below 30 °C

The shelf life of the tablets is either 3 years or 5 years, which depends on the specific strength and the packaging format. The product must be kept out of the sight and reach of children to prevent accidental ingestion.

Disposal Instructions

Regulatory labeling specifies that no special requirements are necessary for the disposal of any unused or expired Cardicor. The unused medicine or waste material derived from the product must be disposed of in accordance with local requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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