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Medicamente revisado por Oliinyk Elizabeth Ivanovna, Farmácia Última atualização em 30.03.2022
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20 principais medicamentos com os mesmos componentes:
Trimepranol (solução oftalmológica de metipranolol) A solução oftalmológica é indicada no tratamento de pressão intra-ocular elevada em pacientes com hipertensão ocular ou glaucoma de ângulo aberto.
The recommended dose is one drop of Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution in the affected eye(s) twice a day.
If the patient's IOP is not at a satisfactory level on this regimen, use of more frequent administration or a larger dose of Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution is not known to be of benefit. Concomitant therapy to lower intraocular pressure can be instituted.
In clinical trials, Trimepranol® (metipranolol ophthalmic solution) Ophthalmic Solution was safely used during concomitant therapy with pilocarpine, epinephrine or acetazolamide.
Hypersensitivity to any component of this product.
Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution is contraindicated in patients with bronchial asthma or a history of bronchial asthma, or severe chronic obstructive pulmonary disease; symptomatic sinus bradycardia; greater than a first degree atrioventricular block; cardiogenic shock; or overt cardiac failure.
WARNINGS
As with other topically applied ophthalmic drugs, this drug may be absorbed systemically. Thus, the same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely, death in association with cardiac failure, have been reported following topical application of beta-adrenergic blocking agents (see CONTRAINDICATIONS).
Since Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution had a minor effect on heart rate and blood pressure in clinical studies, caution should be observed in treating patients with a history of cardiac failure. Treatment with Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution should be discontinued at the first evidence of cardiac failure.
Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution, or other beta-blockers, should not, in general, be administered to patients with chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity (see CONTRAINDICATIONS). However, if the drug is necessary in such patients, then it should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta2 receptors.
PRECAUTIONS
General
Because of potential effects of beta-adrenergic receptor blocking agents relative to blood pressure and pulse, these agents should be used with caution in patients with cerebrovascular insufficiency. If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapy with Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution, alternative therapy should be considered.
Some authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents in patients undergoing elective surgery. If necessary during surgery, the effects of beta-adrenergic receptor blocking agents may be reversed by sufficient doses of such agonists as isoproterenol, dopamine, dobutamine or levarterenol.
While Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution has demonstrated a low potential for systemic effect, it should be used with caution in patients with diabetes (especially labile diabetes) because of possible masking of signs and symptoms of acute hypoglycemia.
Beta-adrenergic receptor blocking agents may mask certain signs and symptoms of hyperthyroidism, and their abrupt withdrawal might precipitate a thyroid storm.
Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms (e.g., diplopia, ptosis, and generalized weakness).
Risk of anaphylactic reaction: While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Lifetime studies with metipranolol have been conducted in mice at oral doses of 5, 50, and 100 mg/kg/day and in rats at oral doses of up to 70 mg/kg/day. Metipranolol demonstrated no carcinogenic effect. In the mouse study, female animals receiving the low, but not the intermediate or high dose, had an increased number of pulmonary adenomas. The significance of this observation is unknown. In a variety of in vitro and in vivo bacterial and mammalian cell assays, metipranolol was nonmutagenic.
Reproduction and fertility studies of metipranolol in rats and mice showed no adverse effect on male fertility at oral doses of up to 50 mg/kg/day, and female fertility at oral doses of up to 25 mg/kg/day.
Pregnancy-Teratogenic effects
Pregnancy Category C
No drug related effects were reported for the segment II teratology study in fetal rats after administration, during organogenesis, to dams of up to 50 mg/kg/day. Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution has been shown to increase fetal resorption, fetal death, and delayed development when administered orally to rabbits at 50 mg/kg/day during organogenesis.
There are no adequate and well-controlled studies in pregnant women. Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers
It is not known whether Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Trimepranol (metipranolol ophthalmic solution) Ophthalmic Solution is administered to nursing women.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Geriatric Use
No overall differences in safety or effectiveness have been observed between elderly and younger patients.
Em ensaios clínicos, o uso de Trimepranol (solução oftálmica de metipranolol) A solução oftálmica foi associada ao desconforto local transitório.
Outras reações adversas oculares, como visão anormal, blefarite, visão turva, dor de testa, conjuntivite, edema, dermatite palpebral, fotofobia, lacrimejamento e uveíte foram relatadas em um pequeno número de pacientes.
Outras reações adversas sistêmicas, como reação alérgica, angina, ansiedade, artrite, astenia, fibrilação atrial, bradicardia, bronquite, tosse, depressão, tontura, dispnéia, epistaxe, dor de cabeça, hipertensão, mialgia, infarto do miocárdio, náusea, nervosismo, palpitações, erupção cutânea, rinite e sonolência também foram relatados em pequenos números.
Nenhuma informação está disponível sobre a superdosagem de Trimepranol (solução oftálmica de metipranolol) Solução oftálmica em humanos. Os sintomas que podem ser esperados com uma overdose de um agente bloqueador dos receptores beta-adrenérgicos administrado sistemicamente são bradicardia, hipotensão e insuficiência cardíaca aguda.