Components:
Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 17.04.2022
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Top 20 medicines with the same components:
Oral
Oedema
Adult: Initially, 40 mg daily in the morning, reduced to 20 mg daily according to response. Max: 80 mg daily.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.
Reconstitution: Ref: See PI.
Oral
Hypertension
Adult: 20 mg daily as a single dose in the morning.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.
Oral
Oedema
Adult: Initially, 40 mg daily in the morning, reduced to 20 mg daily according to response. Max: 80 mg daily.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.
Reconstitution: Ref: See PI.
Oral
Hypertension
Adult: 20 mg daily as a single dose in the morning.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.
Hypersensitivity to sulphonamide. Untreated Addison's disease. Severe renal failure; severe electrolyte deficiency; precomatose states associated with cirrhosis; lactation.
Not recommended combinations
Xipamid AAA-Pharma lowers the renal clearance of lithium which can lead to lithium intoxication. (This interaction is classified as medium.)
Combinations requiring special precautions
The product information requests special precautions for these combinations:
The antihypertensive effect can be increased by ACE inhibitors, barbiturates, phenothiazines, tricyclic antidepressants, alcohol, etc. (Classified as minor.)
NSAIDs can reduce the antihypertensive and diuretic effects. Xipamid AAA-Pharma increases the neurotoxicity of high doses of salicylates. (Classified as minor.)
Toxicity of cardiac glycosides is increased due to hypokalemia and hypomagnesemia.(Classified as minor.)
Antiarrhythmic agents (classes Ia and III), phenothiazines and other antipsychotics increase the risk of torsade de pointes due to hypokalemia.
Interactions not included in the product information
Xipamid AAA-Pharma can reduce the effect of antidiabetics.
The biological or clinical side effects are largely dose-dependent and can be reduced by finding the lowest effective dose, especially in hypertension.
Thiazides and related can cause:
In biological terms:
- A hypokalemia with potassium depletion, particularly in cases of intensive diuresis, and particularly acute in certain populations at risk.
- Hyponatremia with hypovolemia to cause dehydration and orthostatic hypotension, or a delirium. The concomitant loss of chloride ions can cause a secondary compensatory metabolic alkalosis: the incidence and magnitude of this effect is weak.
- Elevated serum uric acid and blood glucose during treatment: the use of these diuretics is discussed thoroughly in patients with diabetes and gout.
- An increase in serum lipids in high doses.
- Hematological disorders, much more rare, thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia.
- Hypercalcemia exceptional.
In clinical terms:
- In cases of liver failure, possibility of occurrence of hepatic encephalopathy.
- Possibility of aggravation of a preexisting lupus erythematosus, necrotizing vasculitis, toxic epidermal necrolysis exceptional.
- Nausea, constipation, dizziness, asthenia, paresthesia, headache and rarely encountered most often yielding a reduction in dosage.
- Exceptionally: pancreatitis, visual disturbances in early treatment
Xipamid AAA-Pharma is a sulfonamide diuretic drug marketed by Eli Lilly. It is used for the treatment of oedema and hypertension.