Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Top 20 medicines with the same components:
Symptoms of chronic venous insufficiency of various origins (edema of the lower extremities, calf muscle cramps, numbness, pain and feeling of heaviness in the legs, trophic changes);
- Varicose veins;
- Postthrombotic syndrome;
- Post-traumatic inflammation and postoperative swelling of soft tissues.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Relief of muscle & joint pain in various parts of the body eg shoulder, neck, waist, back, elbow & knee.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Heparin (Venostasin Gel) is an anticoagulant used principally in the treatment and prophylaxis of thromboembolic disorders (). It is often described as standard Heparin (Venostasin Gel) or unfractionated Heparin (Venostasin Gel) to distinguish it from low-molecular-weight heparins ().
Heparin (Venostasin Gel) inhibits clotting of blood in vitro and in vivo by enhancing the action of antithrombin III. Antithrombin III, which is present in plasma, inhibits the activity of activated clotting factors including thrombin (factor IIa) and activated factor X (factor Xa). Heparin (Venostasin Gel) increases the rate of this inhibition, but in a manner that is dependent on its dose. With normal therapeutic doses Heparin (Venostasin Gel) has an inhibitory effect on both thrombin and factor Xa. The inhibition of thrombin blocks the conversion of fibrinogen to fibrin, and the inhibition of factor Xa blocks the conversion of prothrombin to thrombin. The low doses that are given subcutaneously for the prophylaxis of thromboembolism have a selective effect on inhibition of factor Xa. Very high doses are reported to reduce the activity of antithrombin III. Heparin (Venostasin Gel) also has some effect on platelet function, inhibits the formation of a stable fibrin clot, and has an antilipidaemic effect
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Vitamin B1 (Venostasin Gel) deficiency
Heparin (Venostasin Gel) injection is an anticoagulant. It is used to decrease the clotting ability of the blood and help prevent harmful clots from forming in blood vessels. Heparin (Venostasin Gel) is sometimes called a blood thinner, although it does not actually thin the blood. Heparin (Venostasin Gel) will not dissolve blood clots that have already formed, but it may prevent the clots from becoming larger and causing more serious problems.
Heparin (Venostasin Gel) is used to prevent or treat certain blood vessel, heart, and lung conditions. Heparin (Venostasin Gel) is also used to prevent blood clotting during open-heart surgery, bypass surgery, kidney dialysis, and blood transfusions. It is used in low doses to prevent the formation of blood clots in certain patients, especially those who must have certain types of surgery or who must remain in bed for a long time. Heparin (Venostasin Gel) may also be used to diagnose and treat a serious blood condition called disseminated intravascular coagulation.
Heparin (Venostasin Gel) is available only with your doctor's prescription.
Thiamine is Vitamin B1 (Venostasin Gel). Thiamine is found in foods such as cereals, whole grains, meat, nuts, beans, and peas. Thiamine is important in the breakdown of carbohydrates from foods into products needed by the body.
Thiamine is used to treat or prevent Vitamin B1 (Venostasin Gel) deficiency. Thiamine injection is used to treat beriberi, a serious condition caused by prolonged lack of Vitamin B1 (Venostasin Gel).
Thiamine taken by mouth (oral) is available without a prescription. Injectable thiamine must be given by a healthcare professional.
Thiamine may also be used for purposes not listed in this medication guide.
Usual Adult Dose for Patency Maintenance of Indwelling
Intravenous Devices
Heparin (Venostasin Gel) flush, 10 or 100 units/mL, is injected as a single dose into an intravenous injection device using a volume of solution equivalent to that of the indwelling venipuncture device.
When using daily flushes of Heparin (Venostasin Gel) to maintain patency of single and double lumen central catheters, 10 units/mL is commonly used for younger infants (less than 10 kg) while 100 units/mL is used for older infants, children, and adults.
A single dose should be injected following venipuncture when the indwelling device is not to be used immediately. After each use of the indwelling venipuncture device for injection or infusion of medication, or withdrawal of blood samples, another dose should be injected to restore the effectiveness of the Heparin (Venostasin Gel) lock. The amount of Heparin (Venostasin Gel) solution is sufficient to prevent clotting within the lumen of indwelling venipuncture devices (usually not holding more than 0.2 to 0.3 mL) for up to twenty-four hours.
When the indwelling device is used to administer a drug which is incompatible with Heparin (Venostasin Gel), the entire Heparin (Venostasin Gel) lock set should be flushed with 0.9% Sodium Chloride Injection, USP before and after the medication is administered. Following the second flush, another dose of Heparin (Venostasin Gel) solution should be injected to restore the effectiveness of the Heparin (Venostasin Gel) lock. When the indwelling device is used for repeated withdrawal of blood samples for laboratory analyses and the presence of Heparin (Venostasin Gel) or saline is likely to interfere with or alter results of the desired blood tests, the in situ Heparin (Venostasin Gel) flush solution should be cleared from the device by aspirating and discarding 1 mL before the desired blood sample is drawn.
Usual Pediatric Dose for Patency Maintenance of Indwelling
Intravenous Devices
Arterial lines: Heparinize with a usual final concentration of 1 unit/mL; range: 0.5 to 2 units/mL; in order to avoid large total doses and systemic effects, use 0.5 unit/mL in low birth weight/premature newborns and in other patients receiving multiple lines containing Heparin (Venostasin Gel).
Peripheral arterial catheters in situ: Neonates and Children: Continuous IV infusion of Heparin (Venostasin Gel) at a final concentration of 5 units/mL at 1 mL/hour.
Umbilical artery catheter (UAC) prophylaxis: Neonates: Low-dose Heparin (Venostasin Gel) continuous IV infusion via the UAC with a Heparin (Venostasin Gel) concentration of 0.25 to 1 unit/mL.
Prophylaxis for cardiac catheterization via an artery: Neonates and Children: IV: Bolus: 100 to 150 units/kg; for prolonged procedures, further doses may be required.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Benzyl alcohol, a preservative in the multiple-dose vial preparations of Heparin (Venostasin Gel) Lock Flush Solution, USP has been associated with toxicity in neonates. Benzyl alcohol has been reported to be associated with a fetal "Gasping Syndrome" in premature infants. Data are unavailable on the toxicity of other preservatives in this age group. Preservative-free Heparin (Venostasin Gel) Lock Flush Solution, USP should be used for maintaining patency of intravenous injection devices in neonates.
Many concentrations of Heparin (Venostasin Gel) are available and range from 1 unit/mL to 20,000 units/mL. Carefully examine each prefilled syringe or vial prior to use to ensure that the correct concentration is chosen. Heparin (Venostasin Gel) lock flush solution is intended only to maintain patency of IV devices and is not to be used for anticoagulant therapy.
Dialysis
Data not available
Hypersensitivity to the drug.
Hypersensitivity to aspirin or to other NSAIDs.
See also:
What is the most important information I should know about Heparin (Venostasin Gel)?
Heparin (Venostasin Gel) injection should not be used to flush (clean out) an intravenous (IV) catheter. A separate Heparin (Venostasin Gel) product is available to use as catheter lock flush.
You should not use this medication if you are allergic to Heparin (Venostasin Gel), or if you have uncontrolled bleeding or a severe lack of platelets in your blood.
Before using Heparin (Venostasin Gel), tell your doctor if you have high blood pressure, an infection involving your heart, hemophilia or other bleeding disorder, a stomach or intestinal disorder, liver disease, or if you are on your period.
Heparin (Venostasin Gel) can cause you to have bleeding episodes while you are using it and for several weeks after you stop. Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.
Certain medicines can increase your risk of bleeding while you are using Heparin (Venostasin Gel), such as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), piroxicam (Feldene), and others.
Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Women over 60 years of age may be more likely to have bleeding episodes while using Heparin (Venostasin Gel).
See also:
What is the most important information I should know about Vitamin B1 (Venostasin Gel)?
Contraindications for Vitamin B1 (Venostasin Gel) (Vitamin B1 (Venostasin Gel))
Hypersensitivity to Vitamin B1 (Venostasin Gel) or any component of a product containing Vitamin B1 (Venostasin Gel).
Use Heparin (Venostasin Gel) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Heparin (Venostasin Gel) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Heparin (Venostasin Gel) at home, a health care provider will teach you how to use it. Be sure you understand how to use Heparin (Venostasin Gel). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Heparin (Venostasin Gel) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Heparin (Venostasin Gel), contact your doctor.
Ask your health care provider any questions you may have about how to use Heparin (Venostasin Gel).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Anticoagulation: Prophylaxis and treatment of thromboembolic disorders (eg, venous thromboembolism, pulmonary embolism) and thromboembolic complications associated with atrial fibrillation; prevention of clotting in arterial and cardiac surgery; as an anticoagulant for extracorporeal circulation and dialysis procedures.
Note: Heparin (Venostasin Gel) lock flush solution is intended only to maintain patency of IV devices and is not to be used for systemic anticoagulant therapy.
Off Label Uses
Antibiotic lock technique, adjunctive therapy (catheter-salvage strategy)
Based on the 2009 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection, antibiotic lock therapy may be used as salvage therapy for catheter-related infections in addition to systemic antibiotics when the catheter cannot be removed. Antibiotic lock solutions contain an appropriate antimicrobial and are usually mixed with Heparin (Venostasin Gel) or NS at a sufficient volume to fill the catheter lumen.
Mechanical heart valve, bridging anticoagulation (for interruptions in warfarin therapy)
Based on the 2017 American Heart Association/American College of Cardiology (AHA/ACC) focused update of the 2014 guideline for the management of patients with valvular heart disease, Heparin (Venostasin Gel) may be considered as bridge therapy during intervals of subtherapeutic anticoagulation for patients with mechanical mitral or tricuspid valve replacement. For patients with mechanical aortic valve replacement, bridging is not required unless an additional thromboembolic risk factor is present or the patient has an older-generation mechanical aortic valve.
Mechanical heart valve, postsurgical management (to transition to warfarin)
Data from a limited number of patients in case series and older randomized, controlled trials suggest that IV Heparin (Venostasin Gel) may be beneficial after surgical placement of a mechanical heart valve when transitioning to warfarin.
ST-elevation myocardial infarction
Based on the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction (STEMI), Heparin (Venostasin Gel) is effective and recommended for the treatment of patients presenting with STEMI managed by an invasive strategy with PCI, or by thrombolysis with fibrinolytic therapy.
The action of anticoagulants may be potentiated by this medicine
See also:
What other drugs will affect Heparin (Venostasin Gel)?
Drug Interactions:
Drug/ Laboratory Tests Interactions
Hyperaminotransferasemia: Significant elevations of aminotransferase (SGOT [S-AST] and SGPT [S-ALT]) levels have occurred in a high percentage of patients (and healthy subjects) who have received Heparin (Venostasin Gel) sodium. Since aminotransferase determinations are important in the differential diagnosis of myocardial infarction, liver disease and pulmonary emboli, rises that might be caused by drugs (Heparin (Venostasin Gel) sodium) should be interpreted with caution.
See also:
What other drugs will affect Vitamin B1 (Venostasin Gel)?
Interactions for Vitamin B1 (Venostasin Gel) (Vitamin B1 (Venostasin Gel))
Loop Diuretics,
Oral Contraceptives, Stavudine, Tricyclic Antidepressants
In occasional instances, there may be some disturbance of gastric or intestinal function. Hypersensitivity reactions such as urticaria may arise in isolated cases
Occasional itchiness, redness of the skin & allergic dermatitis.
See also:
What are the possible side effects of Heparin (Venostasin Gel)?
Postmarketing Experience
The following adverse reactions have been identified during post approval use of Heparin (Venostasin Gel) SODIUM INJECTION. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency.
- Hemorrhage – Hemorrhage is the chief complication that may result from Heparin (Venostasin Gel) therapy. Gastrointestinal or urinary tract bleeding during anticoagulant therapy may indicate the presence of an underlying occult lesion. Bleeding can occur at any site but certain specific hemorrhagic complications may be difficult to detect including:
- Adrenal hemorrhage, with resultant acute adrenal insufficiency, has occurred with Heparin (Venostasin Gel) therapy, including fatal cases.
- Ovarian (corpus luteum) hemorrhage developed in a number of women of reproductive age receiving short- or long-term Heparin (Venostasin Gel) therapy.
- Retroperitoneal hemorrhage.
- HIT and HITT, including delayed onset cases.
- Local irritation – Local irritation, erythema, mild pain, hematoma, or ulceration have occurred following deep subcutaneous (intrafat) injection of Heparin (Venostasin Gel) sodium. Because such reactions occur more frequently after intramuscular administration, the IM route is not recommended.
- Histamine-like reactions – Such reactions have been observed at the site of injection. Necrosis of the skin has been reported at the site of subcutaneous injection of Heparin (Venostasin Gel), occasionally requiring skin grafting.
- Hypersensitivity – Generalized hypersensitivity reactions have been reported with chills, fever, and urticaria as the most usual manifestations; asthma, rhinitis, lacrimation, headache, nausea and vomiting, and anaphylactoid reactions, including shock, occur less frequently. Itching and burning, especially on the plantar site of the feet, may occur.
- Elevations of serum aminotransferases – Significant elevations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels have occurred in patients who have received Heparin (Venostasin Gel).
- Others – Osteoporosis following long-term administration of high doses of Heparin (Venostasin Gel), cutaneous necrosis after systemic administration, suppression of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on discontinuation of Heparin (Venostasin Gel) sodium have been reported.
See also:
What are the possible side effects of Vitamin B1 (Venostasin Gel)?
Applies to thiamine: capsule, solution, tablet, tablet enteric coated
As well as its needed effects, thiamine (the active ingredient contained in Vitamin B1 (Venostasin Gel)) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking thiamine, check with your doctor immediately:
Rare - Soon after receiving injection only
- Coughing
- difficulty in swallowing
- hives
- itching of skin
- swelling of face, lips, or eyelids
- wheezing or difficulty in breathing
Heparin (Venostasin Gel) Cy 216, a highly sulfated glycosaminoglycan is widely used as an injectable anticoagulant. It has the highest negative charge density of any known biological molecule. Heparin (Venostasin Gel) Cy 216 acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. While Heparin (Venostasin Gel) does not break down clots that have already formed, it allows the body's natural clot lysis mechanisms to work normally to break down clots that have already formed. Heparin (Venostasin Gel) Cy 216 binds to and accelerates the activity of antithrombin III. By activating antithrombin III, Heparin (Venostasin Gel) preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so Heparin (Venostasin Gel) s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation.
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.