Tincture of Iodine

Intramuscular

Tincture of Iodine deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): Up to 45 yr: 380 mg Tincture of Iodine, as single IM doses to provide adequate protection from Tincture of Iodine deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Tincture of Iodine each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): 380 mg Tincture of Iodine, as single IM doses to provide adequate protection from Tincture of Iodine deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Tincture of Iodine, as iodised oil (480 mg/ml Tincture of Iodine).

Oral

Grave's disease

Child: Neonates: 1 drop of strong Tincture of Iodine solution every 8 hr.

Oral

Radiation protection against radioactive Tincture of Iodine

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Tincture of Iodine solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Oral

Tincture of Iodine deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): 400 mg Tincture of Iodine once yrly. Pregnant patient: 200 mg Tincture of Iodine as a single dose. Moderate to severe: 300-480 mg Tincture of Iodine each yr or 100-300 mg Tincture of Iodine every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): Infants up to 1 yr: Single dose of 100 mg Tincture of Iodine; 1-5 yr: 200 mg Tincture of Iodine; >6 yr: 400 mg Tincture of Iodine.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Topical Tincture of Iodine is used to prevent and treat infections that may occur in minor scrapes and cuts. It works by killing bacteria that can cause infections.

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Tincture of Iodine solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.

Oral

Grave's disease

Child: Neonates: 1 drop of strong Tincture of Iodine solution every 8 hr.

Oral

Radiation protection against radioactive Tincture of Iodine

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.

Oral

Tincture of Iodine deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): 400 mg Tincture of Iodine once yrly. Pregnant patient: 200 mg Tincture of Iodine as a single dose. Moderate to severe: 300-480 mg Tincture of Iodine each yr or 100-300 mg Tincture of Iodine every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): Infants up to 1 yr: Single dose of 100 mg Tincture of Iodine; 1-5 yr: 200 mg Tincture of Iodine; >6 yr: 400 mg Tincture of Iodine.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Intramuscular

Tincture of Iodine deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): Up to 45 yr: 380 mg Tincture of Iodine, as single IM doses to provide adequate protection from Tincture of Iodine deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Tincture of Iodine each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Tincture of Iodine): 380 mg Tincture of Iodine, as single IM doses to provide adequate protection from Tincture of Iodine deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Tincture of Iodine, as iodised oil (480 mg/ml Tincture of Iodine).

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Allergy to Tincture of Iodine,

- Class III patients with Okuda

- Extrahepatic metastases,

- Respiratory or renal insufficiencies severe

- Cons-indications for hepatic arteriography,

- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,

- Pregnant woman: Tincture of Iodine should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Tincture of Iodine. Contraception must be instituted and prosecuted in the administration at least a year.

- Breastfeeding: Breastfeeding should be stopped.

Use: Labeled Indications

Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively

There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.

this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.

Since Tincture of Iodine may be absorbed systemically, the result of tests of the thyroid function can be influenced.

See also:
What are the possible side effects of Tincture of Iodine?

Tincture of Iodine and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.

Inhalation of Tincture of Iodine vapour is very irritating to mucous membranes.

Tincture of Iodine and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.

Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.

Tincture of Iodine as oral and topical/cutaneous formulations is prescribed for the treatment of Tincture of Iodine deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Tincture of Iodine, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.