Synaleve Tablets

Moderate to severe pain of any origin: tension headache, migraine, dental pain, post-op pain, dysmenorrhoea, cancer pain, low back pain, fever & also symptomatic relief from colds and cough.

Renal & hepatic failure. Pregnancy & lactation.

Acetaminophen (Synaleve Tablets) is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen (Synaleve Tablets) [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen (Synaleve Tablets) and may decrease the action of Acetaminophen (Synaleve Tablets). Doses of Acetaminophen (Synaleve Tablets) greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen (Synaleve Tablets) to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of Acetaminophen (Synaleve Tablets) by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen (Synaleve Tablets) should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.

Acetaminophen (Synaleve Tablets) doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen (Synaleve Tablets) should be avoided during warfarin therapy

Very rarely (and usually mild) skin rashes and palpitations. Sedation and dizziness may occur after the intake of the yellow (night) tablet. In this case it is not advisable for patients who drive or operate machinery at night. Therefore the yellow tablet is recommended at bedtime.