Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 1969-12-31
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Moderate to severe pain of any origin: tension headache, migraine, dental pain, post-op pain, dysmenorrhoea, cancer pain, low back pain, fever & also symptomatic relief from colds and cough.
Renal & hepatic failure. Pregnancy & lactation.
Acetaminophen is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize acetaminophen [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of acetaminophen and may decrease the action of acetaminophen. Doses of acetaminophen greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for acetaminophen to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing its absorption into the body from the intestine. Therefore, acetaminophen should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of acetaminophen should be avoided during warfarin therapy
Very rarely (and usually mild) skin rashes and palpitations. Sedation and dizziness may occur after the intake of the yellow (night) tablet. In this case it is not advisable for patients who drive or operate machinery at night. Therefore the yellow tablet is recommended at bedtime.