Постинор

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Постинор

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Постинор

Property Description
Active Ingredient Levonorgestrel
Form Oral Tablet
Pharmacological Class Progestogen-only Contraceptive
Common Use Emergency prevention of pregnancy
Origin Synthetic (progestogen)

Постинор is a specific pharmaceutical preparation classified as an emergency contraceptive, intended for use following unprotected intercourse or contraceptive failure. It belongs to the progestogen-only pharmacological class, a category of medicines whose use in acute intervention is established. This means its primary mechanism relies solely on the effect of a synthetic hormone, distinguishing it from combined hormonal pills.

Composition, Origin, and Physical Form

The core component in the medicine is Levonorgestrel, an established synthetic progestogen. Постинор is supplied as an oral tablet, establishing the oral route of administration for rapid systemic absorption. It is commercially positioned as a focused, non-continuous contraceptive solution for women of reproductive age who require immediate action, and it is typically categorized as a prescription-only medicine (Rx) due to the necessity of timely, appropriate medical guidance.

General Purpose and Mechanism Principle

The singular general purpose of Постинор is the immediate prevention of an unplanned pregnancy following a specific event. The core principle involves leveraging the potent progestogenic effect to rapidly interfere with the reproductive process before conception is established. The Levonorgestrel acts predominantly by disrupting the timing of the menstrual cycle, primarily causing inhibition or delay of ovulation. Secondary, supportive actions include temporary alteration of the endometrium (uterine lining), ensuring the medicine functions as a preventive measure that specifically targets pre-fertilization events, which is the cornerstone of its clinical recognition.

What side effects are possible with Постинор?

Possible Side Effects and Safety Information

Adverse reactions to Levonorgestrel, the active component in Postinor, are formally classified by government regulatory authorities based on their frequency. These effects are typically transient and relate primarily to the nervous, gastrointestinal, and reproductive systems.

Frequency-Classified Adverse Reactions

Side effects are categorized according to standard regulatory frequency tiers:

  • Very Common (occurring in 1/10 patients): Nausea, Headache, Lower abdominal pain, Fatigue, Dizziness, Bleeding not related to menses (spotting), and Breast tenderness.
  • Common (occurring in 1/100 to <1/10 patients): Vomiting, Diarrhoea, Dysmenorrhoea (painful menstruation), and Delay of menses (more than seven days).
  • Very Rare (occurring in <1/10,000 patients): Urticaria, Rash, Pruritus, and Face oedema.

Serious Adverse Reactions and Safety Constraints

The regulatory safety profile includes specific warnings about serious potential complications. Ectopic pregnancy is a critical safety consideration noted in official labeling if the medicine fails to prevent conception; severe abdominal or pelvic pain following administration requires immediate attention. Thromboembolic events (blood clots) are also documented as a very rare, post-marketing safety concern.

Safety limitations explicitly stated in regulatory documents include severe hepatic dysfunction, as the metabolism of Levonorgestrel may be significantly impaired. The medicine is also restricted for use in cases of known or suspected pregnancy and undiagnosed abnormal genital bleeding. Furthermore, the label states the medicine provides no protection against sexually transmitted diseases.

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory information for Levonorgestrel (Постинор) overdosage is based on the acute toxicity profile documented in authoritative government sources.


Documented Overdose Profile

Element Official Regulatory Documentation
Severity Classification Overdose is not likely to be life-threatening; serious undesirable effects have not been reported following acute ingestion of large doses.
Documented Manifestations The clinical signs of overdose are generally limited to nausea and abnormal uterine bleeding (withdrawal bleeding).
Management Measures Treatment should be symptomatic and supportive, reflecting that no specific antidote is available.

Emergency Actions Mandated by Regulators

When overdosage is suspected, the official regulatory guidance requires immediate medical help or contact with a Poison Control Center (e.g., 1-800-222-1222). This action is mandated because, while acute toxicity is low, professional medical advice is necessary for risk evaluation and patient monitoring.

Monitoring of vital signs may be required if the presentation necessitates clinical observation. The documentation does not specify unique population-specific overdose risks for pediatric, elderly, or impaired patient groups.

Therapeutic Uses of Постинор

What Постинор Treats: Main Uses and Benefits

Постинор is a specific pharmacological intervention applied in clinical settings that involve the acute, time-sensitive risk of conception. The medication is commonly used after events such as unprotected sexual intercourse or a recognized failure of another birth control method, which are situations marked by increased physiological stress.

This intervention provides a supportive post-coital protective measure that helps reduce the likelihood of an unplanned pregnancy. It is considered relevant for managing the acute psychological burden and tension that arises from the unexpected need for supportive action. The general benefit may assist with maintaining functional stability and provides back-up support during episodic scenarios. The primary purpose is to offer a supportive back-up option when primary contraception has failed.


Quick Fact: Relief for Acute Uncertainty

The medication is commonly used to help manage the overall symptom load related to anxiety, providing supportive relief when the risk of unintended pregnancy affects functional stability.

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Постинор — official regulatory information

Classification Populations
Populations for whom use is allowed Adults and adolescents ge 16 years of age (availability may vary by jurisdiction and age).
Populations for whom use is not recommended Patients with a known or suspected history of ectopic pregnancy or salpingitis. Patients with severe hepatic dysfunction (severe liver problems). Individuals with severe malabsorption syndromes (e.g., Crohn's disease) where drug absorption may be compromised. Use is also not recommended for young women under 16 years of age without medical supervision.
Populations for whom use is contraindicated Women with a known or suspected pregnancy. Patients with hypersensitivity to the active substance, levonorgestrel, or to any of the excipients. Individuals with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption (due to lactose content).
Age-related eligibility rules Indicated for use by adults and adolescents ge 16 years of age. Not indicated for use before the first menstrual bleeding (menarche). Not intended for use in postmenopausal women.
Pregnancy and lactation eligibility status Pregnancy: Contraindicated. It does not terminate an existing pregnancy. Lactation: Levonorgestrel passes into breast milk; use is not recommended or requires special consideration (e.g., timing administration relative to a nursing period).

Official eligibility statements:

  • The medicine is contraindicated if a woman is already pregnant or has a known allergy to levonorgestrel or its excipients.
  • Use is not recommended in the presence of severe liver dysfunction or malabsorption syndromes.
  • Eligibility is subject to age restrictions, though these vary by country, with common guidance specifying suitability for adolescents and adults ge 16 years.

Connection to the overall eligibility profile: The regulatory profile strictly limits the use of this emergency contraceptive based on absolute contraindications such as pre-existing pregnancy and known allergies. Further restrictions and special warnings are applied to populations with certain clinical conditions, including severe liver issues or malabsorption, or those at risk of ectopic pregnancy. This structure ensures the medicine is used only when the regulatory-defined eligibility criteria are met.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for Levonorgestrel (Постинор) establishes that the most significant interactions are those that reduce the efficacy of the medication.

Documented Exposure-Modifying Interactions

The primary interaction mechanism documented across authoritative government sources is the induction of hepatic enzymes, notably Cytochrome P450 3A4 (CYP3A4). Co-administration of strong enzyme-inducing substances accelerates the metabolism and clearance of Levonorgestrel, resulting in a clinically significant decrease in plasma concentrations and, consequently, reduced effectiveness.

Product Category Specific Examples Explicitly Listed in Regulatory Documents
Anticonvulsants Phenytoin, Phenobarbital, Primidone, Carbamazepine, Felbamate
Anti-Tuberculosis Rifampicin, Rifabutin
Antivirals (NNRTIs) Efavirenz (documented to reduce the Levonorgestrel AUC by \sim 50% )
Anti-Fungals Griseofulvin
Herbal Products St. John's Wort (Hypericum perforatum)

Interaction Classification and Constraints

Official regulatory labels do not classify any combination as formally "contraindicated." Instead, the profile centers on the risk of treatment failure due to reduced drug exposure when co-administered with any listed inducer. No mandatory time-separation requirements are documented for these interactions, nor are there population-specific cautions for individuals with conditions like hepatic impairment.

Mechanism of Action

How Postinor Works: Mechanism of Action

Central Control of the Hormonal Axis

The drug's primary mechanism involves acting as an agonist (activating) binding to Progesterone Receptors (PR) in the hypothalamus and pituitary gland, key control centers of the reproductive system. This interaction initiates a negative feedback loop within the HPO axis that suppresses the secretion of GnRH and inhibits the mid-cycle surge of Luteinizing Hormone (LH). This central suppression contributes to the prevention or delay of the final maturation and rupture of the ovarian follicle, resulting in the physiological consequence of anovulation or delayed ovulation.

Localized Barrier Effects

A secondary mechanistic domain involves the drug's peripheral action on the cervix. This activity results in an increase in the viscosity and density of the cervical mucus. This physical change creates an environment that impedes the motility and transport of sperm. This peripheral action provides a secondary physiological mechanism that limits sperm transport.

Temporal Constraint on the Mechanism

The drug's activity is constrained by the physiological timeline of the neuroendocrine cascade it modulates. The mechanism of ovulation suppression is maximally effective when administered before the natural LH surge begins. If administration occurs after the LH surge has peaked, the mechanism is overridden, resulting in the inability of the molecule to engage the neuroendocrine cascade necessary for ovulation suppression.

Dosage and Administration Information

How to Use Постинор (Levonorgestrel)

The administration of this medication is strictly defined as a time-sensitive, single course of treatment, adhering to specific parameters established in prescribing information. The approved administration route is oral.

Dosing Regimen and Timing

The standard adult dosing regimen is a single 1.5 mg tablet of Levonorgestrel taken as one administration. Alternatively, the regimen may consist of two 0.75 mg tablets, with the second dose taken 12 hours after the first. This treatment is defined by a critical time constraint: it must be administered as soon as possible following unprotected intercourse or contraceptive failure, and no later than 72 hours (three days) after the event. The medicine is not indicated for continuous or routine use.

Administration Conditions

Condition Instruction
Ingestion The tablet is swallowed whole with water.
Food Intake May be taken with or without food.
Vomiting If vomiting occurs within three hours of taking the dose, standard instructions advise that another full tablet should be taken immediately.
Cycle Timing The tablet may be used at any time during the menstrual cycle, provided menstrual bleeding is not overdue.

Adjustments and Restrictions

While there are no specific dose adjustments for healthy adolescents, the medicine is not recommended for patients with severe hepatic impairment. In cases where the patient has used hepatic enzyme-inducing drugs within the preceding four weeks, established guidance advises a double dose (3 mg total) if non-hormonal barrier methods are not used. The medicine's use is confined to this acute application and must not be used as a primary or ongoing method of contraception.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Postinor (Постинор)

Evidence for Use in Emergency Contraception

Postinor (levonorgestrel) was evaluated in research exploring research scenarios involving unprotected sexual intercourse or contraceptive failure. Research in this area has primarily involved Randomized Controlled Trials (RCTs) and Comparative Effectiveness Studies. These trials, along with large-scale observational studies and combined analyses of multiple study results have contributed to the evidence landscape.

The primary measurement axis examined by researchers was pregnancy incidence in women who received the intervention, which was compared to a calculated baseline rate. Studies also monitored the patterns of subsequent menstrual cycles among the observed populations. Findings describe the frequency of observed pregnancies across the different study groups, and the evidence contributes to the broader evidence landscape.

Comparative Studies and Timing of Use

Research has also explored the outcomes of Postinor compared to other agents used for emergency contraception, such as ulipristal acetate. These comparative effectiveness studies describe how the measured outcomes differed between the two types of interventions when used by different study groups. Research reports that outcomes varied across studies. Data show patterns related to pregnancy incidence that were monitored against baseline rates. Findings describe group patterns, not personal outcomes.

A major focus of research has been on the time elapsed between unprotected intercourse and the use of the emergency contraceptive. Studies have monitored how the observed pregnancy incidence changes across defined time intervals, such as within 24 hours, 48 hours, or up to 72 hours. Research describes that administering the intervention sooner was associated with varying measured outcomes than waiting for a longer duration. Evidence remains limited and heterogeneous for interventions delivered after the initial 72-hour window.

Long-Term Studies and Follow-up

Postinor was studied for its use as a single emergency intervention, meaning most available data focuses on short-term outcomes, primarily until the next menstrual period. Follow-up durations were limited in the primary effectiveness trials. Available long-term outcomes for women who used Postinor are limited. There is limited information for long-term outcomes, such as the potential long-term health implications in the years following a single or infrequent use. Research is ongoing, and future studies may contribute to better understanding symptom patterns over time.

What Is Still Uncertain About Postinor

Despite decades of research, several aspects of Postinor's evidence landscape contain gaps or limitations. Findings highlight what is known and what is still uncertain.

  • Repeat Use: Data for women who use Postinor repeatedly, either frequently or multiple times within a single cycle, are still emerging. Evidence is limited regarding the consistency of outcomes and potential changes in symptom patterns with habitual use.
  • Study Application: Research provides context but not individual predictions, meaning study results reflect the specific conditions under which they were conducted, and research does not determine whether an individual will respond similarly. Results apply only to the populations studied in the research.

Key Studies & References

  1. Levonorgestrel - StatPearls [Internet] (Authoritative summary of EC evidence, timing, and BMI data)
  2. Emergency contraception: Oral and intrauterine options (RACGP Clinical Guidelines on efficacy, timing, and BMI for LNG)

Frequently Asked Questions (FAQ)

Common questions about Постинор (FAQ)


Q: Is it possible to take Постинор if I am breastfeeding?

Regulatory documents state that the active substance, levonorgestrel, passes into breast milk. While the overall risk to the infant is considered low, official guidance describes a recommendation to take the tablet immediately after a feeding and to use an alternative method to feed the infant for at least 8 hours after administration.


Q: What is the difference between Постинор and a medical abortion pill?

Постинор is classified as an emergency contraceptive and is intended only to prevent pregnancy, primarily by preventing or delaying ovulation. Official product information strictly states that it is contraindicated and will not interrupt an established pregnancy, which is the function of a medical abortion pill.


Q: What is the mechanism of action of the active component?

The drug's primary action is described as the inhibition or delay of the body's release of the egg (ovulation) by suppressing certain hormones. Regulatory information also indicates that it may temporarily alter the cervical mucus, which can impede sperm movement.


Q: Is Постинор considered a reliable method of contraception when used regularly?

No. Official guidance clearly states that this medicine is an occasional method for use in an emergency situation. It is not intended for use as a primary or ongoing method of routine contraception.


Q: What are the common misunderstandings about how Постинор works?

A key point highlighted in official documentation is that this emergency contraceptive works by targeting pre-fertilization events, such as blocking ovulation. It is strictly contraindicated if a woman is already pregnant, as it cannot interrupt an existing pregnancy.


Q: What does the patient leaflet say about overdose?

Regulatory documents state that no serious harmful effects have been reported following an acute overdose of the active ingredient. Patients who receive more than the recommended dose may experience side effects such as nausea and withdrawal bleeding.


Q: What are the documented infrequent but serious side effects?

The regulatory safety profile notes that if the medication fails to prevent conception, there is a risk of ectopic pregnancy (a pregnancy outside the uterus); such an event is a critical safety consideration noted in official labeling. Very rare, post-marketing reports of thromboembolic events (blood clots) are also documented.


Q: Is Постинор the same as other 'morning after' pills?

Постинор is a specific brand name for an emergency contraceptive that uses the active ingredient levonorgestrel. This is one type of 'morning after' pill. Other emergency contraceptive pills, such as those containing ulipristal acetate, have different active ingredients and may have different administration guidelines.


Q: Can Постинор be purchased without a prescription in some countries?

The regulatory status and accessibility of levonorgestrel-based emergency contraception vary significantly by country. In many regions, the product is available to all ages over the counter (OTC) without the need for a prescription.


Q: Is it normal to experience nausea after taking Постинор?

Yes. Nausea is classified in official regulatory documents as a very common side effect. This means it is among the side effects most frequently reported by patients and may occur in 1 in 10 or more patients.


Q: Can taking Постинор affect future fertility?

Official data and regulatory documents do not suggest a long-term effect on future fertility after using this medicine. The rapid return of normal fertility is the reason regulatory information emphasizes the need for reliable regular contraception.


Q: What age groups is Постинор generally considered appropriate for?

The medication is indicated for use by adults and adolescents who have begun menstruating. Official guidance generally supports its use from the age of 16 and above, but local laws determine the exact age of availability and necessity for medical supervision.


Q: How long does the drug stay in the body after taking it?

Regulatory pharmacokinetic data shows the active substance, levonorgestrel, has a half-life of approximately 26 to 28 hours. The half-life is the time it takes for the amount of drug in the body to be reduced by half.


Q: Can the drug be used if someone is already taking hormonal birth control?

Yes. Regulatory labeling states that taking this emergency contraceptive does not typically contraindicate the continuation of a patient’s regular hormonal birth control method.


Q: What are the signs that Постинор may not have worked?

Official guidance advises performing a pregnancy test if the next menstrual period is delayed by more than seven days past the expected start date. A period that is unusually light or heavy compared to normal may also warrant testing.


Q: Does body weight influence how effective Постинор is described to be?

Regulatory documents include a warning that limited and inconclusive data suggest a possible reduction in effectiveness in women who have a high body weight or Body Mass Index (BMI).


Q: Can alcohol consumption interact with Постинор?

Official regulatory documents do not list alcohol as a substance that reduces the efficacy of the drug. However, alcohol consumption may potentially worsen common central nervous system side effects like nausea or dizziness.


Q: Can people with liver conditions use Постинор?

The medication is not recommended for patients who have severe hepatic dysfunction (severe liver problems). This restriction is in place because the body’s ability to process and clear the active ingredient may be significantly impaired.


Q: Does the time of day a person takes Постинор matter?

No. Official administration instructions state that the tablet can be used at any time during the menstrual cycle. The critical factor emphasized is taking it as soon as possible after the event of unprotected intercourse.


Q: Is the medication known to interact with herbal supplements?

Yes. The herbal product St. John's Wort (Hypericum perforatum) is explicitly listed in official documents as a substance that can reduce the effectiveness of the medicine by speeding up its breakdown in the body.


Q: What is the general duration of action of the active ingredient?

The drug's action is primarily an acute, short-term effect concentrated in the period immediately following administration to prevent or delay ovulation. The half-life of the substance is about 26 to 28 hours, but the critical window for its contraceptive effect is much shorter.


Q: How does Постинор affect the uterine lining?

Official documents indicate that a secondary mechanism involves the temporary alteration of the endometrium (the uterine lining). This change is intended to support the medication’s primary role as a preventive measure targeting pre-fertilization events.


Q: Is there any research on long-term effects of occasional use of Постинор?

Regulatory guidance stresses that the drug is for a single emergency intervention. Consequently, available research primarily focuses on short-term outcomes, and there is limited information regarding potential long-term health implications after a single or infrequent use.


Q: Can a person be allergic to any component in Постинор?

Yes. The medicine is contraindicated for women with a known hypersensitivity (allergy) to the active substance, levonorgestrel, or to any of the non-active components (excipients), such as lactose.


Q: Does Постинор interact with medications for epilepsy?

Yes. Certain anticonvulsant medications, such as phenytoin, phenobarbital, and carbamazepine, are explicitly listed in regulatory documents. These drugs can significantly reduce the effectiveness of the medicine by accelerating its breakdown.


Q: Can a person experience fatigue after taking Постинор?

Yes. Fatigue is listed in official regulatory documents as a very common side effect. This means it is a frequently reported experience among patients using the medication.


Q: Are there specific diet restrictions when taking Постинор?

No. Official administration instructions state that the tablet may be taken with or without food, indicating that specific diet restrictions are not required.


Q: Can taking other medications at the same time make the side effects of Постинор worse?

Regulatory warnings primarily focus on interactions that reduce efficacy. The label explicitly notes the potential for levonorgestrel to increase the toxicity of one specific drug, cyclosporin, by inhibiting its metabolism, but generally does not address the potentiation of its own side effects.


Q: What is the half-life of the active substance in Постинор?

Regulatory pharmacokinetic data states that the half-life (the time required for half the dose to be eliminated from the body) of the active substance, levonorgestrel, is approximately 26 to 28 hours.


Q: Is there a maximum number of times someone can use Постинор per year according to guidelines?

Official guidance stresses that the drug is an occasional method and not intended for routine use. However, regulatory documents do not specify an absolute maximum number of times it can be used per year.


Q: Can people with gastrointestinal conditions use Постинор?

The medication is not recommended for patients with severe malabsorption syndromes, such as Crohn's disease. This is because severe malabsorption may compromise the uptake of the drug, leading to reduced effectiveness.


Q: Is Постинор known to be effective if taken near ovulation?

The drug's primary mechanism is to inhibit or delay ovulation. Regulatory documents indicate that the mechanism is maximally effective when administered before the body's natural ovulation trigger begins and is overridden if administered after that trigger has peaked.

How should Постинор be stored and disposed of?

How to Store and Dispose of Postinor (Levonorgestrel)

Official regulatory documentation outlines specific requirements for the storage and disposal of levonorgestrel tablets to maintain product stability and ensure safety.


Storage Conditions

The medication must be stored at controlled room temperature, which is defined as 20 C to 25 C (68 F to 77 F). The product must be kept in its original container and stored out of the reach of children. Temperatures should not consistently fall outside the acceptable range of 15 C to 30 C.


Disposal Requirements

Unused or expired medication must not be flushed down the toilet or disposed of in wastewater. The preferred disposal method is using a designated medicine take-back program. If a program is unavailable, the product should be mixed with an undesirable substance, placed in a sealed bag or container, and discarded in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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