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Микофин

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Микофин

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Method of action: Antifungal Broad Spectrum

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Микофин

Property Description
Active ingredient Terbinafine Hydrochloride
Form Tablets, cream, solution, spray
Pharmacological Class Allylamine Antifungal
Origin Synthetic
Action Type Fungicidal

1. What Type of Medicine is Микофин? (Definition & Class)

Микофин is a medication containing the single active ingredient Terbinafine Hydrochloride, a synthetic compound belonging to the highly effective allylamine class of antifungal drugs. This classification is clinically recognized for its focused action against the key organisms responsible for many dermatophytosis conditions. Terbinafine is structurally distinct from other common antifungal families, such as the azoles, which dictates its unique pharmacological behavior and overall efficacy profile.

2. Composition and Forms: Systemic versus Topical (Composition & Forms)

The product's identity is defined by Terbinafine Hydrochloride as its sole active component. This substance is prepared for both oral (systemic) and topical administration. The oral form, typically a tablet, allows the medication to reach infections in keratinized tissues. For localized infections, Микофин is available in topical forms, including a cream, a solution, and a spray, which use an inert base to deliver the agent directly to the surface. This dual form strategy provides adaptability in treatment across various infection sites and severity.

3. General Purpose of Allylamine Antifungals (General Benefit)

The fundamental purpose of Микофин is to provide a decisive fungicidal action against susceptible fungal organisms. This means the drug is specifically designed to actively eliminate the fungal cells, a mechanism that distinguishes it from many fungistatic agents. Its targeted mechanism, which involves disrupting a critical fungal enzyme, results in the destruction of the fungal cell membrane. This confirmed activity underpins the drug's general therapeutic role in achieving the sustained clearance of fungal pathogens.

Regulatory References

  1. Terbinafine LiverTox Entry
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What side effects are possible with Микофин?

Possible side effects and safety information

The safety profile of Микофин (Terbinafine Hydrochloride) is categorized according to frequency and the major organ systems affected, as documented in official government regulatory information.


Frequency-Classified Adverse Reactions

The most commonly documented adverse reactions, classified as Very Common in regulatory documents, include headache, gastrointestinal symptoms (such as diarrhea, dyspepsia, nausea, and abdominal pain), rash, urticaria, and musculoskeletal pain (arthralgia and myalgia). Reactions classified as Common include dizziness and fatigue. Uncommon reactions include taste disturbances (such as ageusia or hypogeusia) and anxiety.

Serious Adverse Reactions and Safety Constraints

Official labeling documents serious, rare adverse reactions that require discontinuation. These include hepatic failure (sometimes requiring liver transplantation), severe dermatological reactions (such as Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis), and serious haematological disorders (such as neutropenia or agranulocytosis).

The medication is not recommended for patients with pre-existing chronic or active liver disease. For individuals with renal impairment, caution is necessary, and a dose adjustment may be officially considered. Time-related safety patterns note that liver injury can occur at any point during treatment, and taste disturbances have been reported to be prolonged or, in rare cases, permanent. Treatment must be discontinued upon any clinical or biochemical evidence of liver injury or other severe reactions.

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Overdose and Emergency Response

Overdose and when to seek help

The official regulatory profile for Микофин (Terbinafine) establishes the expected clinical presentation in the event of an acute overdose of the oral tablet. Clinical experience regarding overdose is limited, but reported ingestions of up to 5 grams have been documented.

The acute manifestations of overdose reported in regulatory documents primarily involve gastrointestinal and central nervous system effects. The documented symptoms include:

  • Gastrointestinal: Nausea, vomiting, stomach pain, or epigastric pain.
  • General/CNS: Headache, dizziness, rash, and frequent urination.

The management protocol described in prescribing information is strictly supportive, as no specific antidote is known for this medication. Recommended treatment focuses on eliminating the unabsorbed active substance, typically by the administration of activated charcoal, and providing symptomatic supportive therapy as required by the patient’s clinical status.

When to Seek Immediate Medical Attention

Urgent medical assistance is required for any suspected overdose. Emergency services must be contacted immediately if the patient has collapsed, had a seizure, is experiencing trouble breathing, or cannot be awakened.

A specific note in the labeling clarifies that due to the minimal systemic absorption of the topical forms (cream, solution, or spray), an overdose resulting from these products is considered extremely unlikely.

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Therapeutic Uses of Микофин

What Микофин Treats: Main Uses and Benefits

Systemic Treatment of Deep Fungal Infections

This medication is primarily used across domains where additional symptomatic support is needed for deep-seated fungal infections that penetrate the keratinized tissues, particularly the fingernails and toenails, and fungal infections of the scalp. Oral therapy is commonly applied when symptoms are driven by microbial growth in areas inaccessible to surface treatments. It is commonly used across conditions presenting with acute or recurrent episodes, such as onychomycosis, tinea capitis, tinea corporis (ringworm), and tinea cruris (jock itch). It is relevant for the management goal of achieving fungal clearance from within the keratinized tissues, which may assist with the long-term goal of tissue restoration and easing scalp symptoms.


Relief from Disruptive Skin Symptoms

Микофин is also commonly used to help with symptom clusters associated with widespread or recurrent tinea infections of the skin. It is applied in addressing symptoms related to inflammatory or irritative states, including intense itching, burning, scaling, and redness. This application is relevant when supportive symptom management is appropriate and contributes to improved comfort during periods of heightened symptoms. The medicine is applied in clinical settings that involve recurrent or episodic manifestations, where fungal infections have been chronic or resistant to prior localized management.


Quick Fact: Relief for Pruritus and Dystrophy

The medication plays a role in managing symptoms that interfere with daily comfort, focusing on alleviating pruritus (itching) and assisting with the symptomatic management of structurally damaged keratin tissues (nails and skin).

Regulatory References

  1. NIH MedlinePlus Drug Information
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Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Микофин (Oral Terbinafine)

This eligibility map details the official population criteria for using systemic (oral) Terbinafine, as defined by government regulatory documents.


Eligibility Scope

Classification Population or Condition
Contraindicated Chronic or active liver disease; History of hypersensitivity to Terbinafine or its components.
Not Recommended Patients with severe renal impairment (creatinine clearance <50 mL/min); Pregnancy and lactation (excreted in breast milk).

Age-Related Eligibility Rules

  • Adults (18+): Generally eligible, provided no contraindications exist.
  • Pediatrics: For onychomycosis, safety and efficacy are not established in patients younger than 18 years. For tinea capitis, eligibility is established in children 4 years and older (country-dependent). Use in children under 2 years of age is generally not recommended due to limited data.
  • Older Adults: No specific restrictions, but renal and hepatic function should be considered.

Condition-Specific Considerations

Use requires caution in patients with pre-existing Lupus Erythematosus or Psoriasis, as precipitation or exacerbation of these conditions has been reported in post-marketing experience. The official eligibility profile is structured by these explicit exclusions, which govern whether a patient may proceed with treatment, strictly based on regulatory assessment of population-specific risks.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for oral Mikofin (Terbinafine) is primarily defined by its documented effect on drug metabolism. Terbinafine is recognized as a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) isozyme.

Pharmacokinetic Interactions

This potent inhibition can significantly increase the systemic exposure of other co-administered medicinal products that are primarily metabolized by CYP2D6. For instance, co-administration with Desipramine (a CYP2D6 substrate) is documented to result in a substantial increase in its systemic concentration (AUC).

Conversely, other medicines can affect Terbinafine itself. Dual inhibitors of CYP2C9 and CYP3A4, such as Fluconazole, are documented to increase Terbinafine's own plasma concentration by reducing its clearance. Conversely, enzyme inducers like Rifampin are known to substantially decrease Terbinafine concentrations.

Other Documented Interactions

Type Entity Official Outcome
Drug-Substance Caffeine Decreased clearance
Drug-Drug Ciclosporin Increased clearance
Drug-Food Tablets Absorption is not affected by food intake

Interaction-Related Restriction

Systemic use of oral Terbinafine is formally contraindicated in patients with chronic or active hepatic disease. This restriction is based on the drug's metabolism and the risk associated with reduced clearance in this specific patient population.

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Mechanism of Action

The action of Микофин centers on its selective ability to non- competitively inhibit the enzyme Squalene Epoxidase within fungal cells, which is an essential metabolic step in the creation of ergosterol. This mechanism acts within the domain of enzyme-mediated metabolic disruption, preventing the fungal cell from manufacturing the primary sterol necessary for the structural integrity and function of its cell membrane. By blocking Squalene Epoxidase, the drug initiates a cascade characterized by two simultaneous effects: a critical deficiency of ergosterol and a buildup of the toxic substance squalene inside the cell. This dual molecular action structurally compromises the fungal cell membrane, which quickly results in cell lysis and death, achieving a fungicidal physiological action. The drug demonstrates enzymatic selectivity, targeting the fungal epoxidase with high affinity, ensuring significant selectivity over the analogous human enzyme involved in cholesterol synthesis. However, this targeted mechanism is subject to constraints, including the potential for acquired resistance due to mutations in the fungal SQLE gene, and physiological constraints related to the slow turnover rate of highly keratinized tissues.

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Dosage and Administration Information

Микофин (Terbinafine) is administered through two primary official routes: oral for systemic treatment and topical for localized cutaneous infections. This distinction defines the appropriate form for treating deep-seated versus superficial fungal growth.

The standard adult systemic regimen is a single, fixed dose. The authorized oral dose is 250 mg once daily for all approved indications. Pediatric dosing for the oral granule formulation is calculated strictly based on body weight, with defined once-daily ranges (e.g., 125 mg to 250 mg) applied for conditions like tinea capitis.

The duration of oral therapy is tied to the site of infection. For instance, the course for fingernail onychomycosis is typically 6 weeks, while the treatment for toenail infections generally requires 12 weeks of continuous use. Topical preparations (creams, solutions) are applied as a thin layer, usually once or twice daily.

Administration must adhere to specific contextual instructions. The 250 mg oral tablet may be taken with or without food. However, the oral granule formulation must be mixed exclusively with soft, non-acidic foods and swallowed immediately without chewing. Use is not recommended in patients with significantly impaired renal function (creatinine clearance leq 50 mL/min) or pre-existing chronic liver disease. This structured approach, defined by route, dose, frequency, and duration, forms the complete usage protocol.

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Recent Clinical Evidence

Research evidence / Overview of studies for Микофин (Terbinafine)

This section summarizes the official research evidence concerning the clinical evaluation of Terbinafine (Микофин), focusing only on the types of studies conducted, what outcomes were monitored, and what the collective findings describe. This is a neutral overview and does not contain clinical advice or recommendations.


Evidence for Use in Onychomycosis (Fungal Nail Infection)

The systemic (oral tablet) form of the medication was studied for its use in fungal infections of the fingernails and toenails. The evidence consists primarily of Randomized Controlled Trials (RCTs) that examined the oral tablet form's use. Trials monitored the effect on fungal presence through mycological clearance and the change in the physical appearance of the nail via clinical improvement criteria. The research highlights that final outcome assessments were often conducted over an extended follow-up duration of up to a year or longer after treatment finished.


Evidence for Use in Tinea Capitis (Fungal Scalp Infection)

The oral form of the medication was studied for its application in fungal infections of the scalp, mainly in children. Research in this area explores short-term symptom changes, often comparing Terbinafine to other systemic therapies. Studies monitored for mycological clearance and documented the change in clinical signs such as scaling, hair loss, and inflammation using composite predefined treatment criteria. Research describes patterns where the observed outcomes can be related to the specific fungal species causing the infection.


Evidence in Special Populations and Research Gaps

Research has explored the use of the oral medication in specific subgroups, including older adults and patients with pre-existing conditions like diabetes, although the evidence base for these groups is limited compared to data for otherwise healthy adults. For conditions like tinea capitis, data for certain groups remain insufficient, especially for infants and toddlers.

What Is Still Uncertain About Микофин Research

There is variability in how trials define key endpoints, such as clinical improvement criteria, which can make synthesizing evidence across studies challenging. Furthermore, the evidence includes findings related to the impact of emerging patterns of antifungal resistance in certain fungal species; data are still emerging in this area. The collective findings provide context but not individual predictions.

Key Studies & References

  1. Terbinafine: LiverTox Clinical and Research Information (NIH/NCBI)
  2. Terbinafine Oral Medication Drug Information (NIH MedlinePlus)
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Frequently Asked Questions (FAQ)

Common questions about Микофин (FAQ)

Q: Can Микофин be taken with common pain relievers?

A: Official information describes that Mikofin can significantly affect the body’s processing of certain other medications, specifically those metabolized by the enzyme CYP2D6. This includes some antidepressants and certain pain medicines. However, official regulatory documents do not generally include warnings or contraindications related to common, non-opioid pain relievers like ibuprofen.

Q: Can women who are planning to become pregnant use Микофин?

A: While formal data on using this medication during the planning phase of pregnancy is limited, regulatory assessments often suggest that treatment for non-urgent conditions may be postponed until after the pregnancy is completed. This is a factor described in official documents to consider during the planning phase.

Q: What happens if I forget to use Микофин?

A: According to official patient instructions, a missed dose of the tablet form may be taken as soon as it is remembered. If the next scheduled dose is due in less than four hours, the missed dose should be skipped entirely. The instructions advise resuming the regular schedule and indicate that a double dose should not be taken to compensate for a missed dose.

Q: Does Микофин cause drowsiness or affect driving?

A: Official product information documents dizziness as a common adverse reaction, which may potentially impact concentration. While regulatory documents for the oral form generally state there are no data suggesting the drug affects the ability to drive or use machines, caution related to driving or operating machinery may be necessary for individuals experiencing side effects like dizziness.

Q: What if Микофин doesn't seem to be working for me?

A: The drug is known to build up quickly in the affected tissues. However, due to the slow replacement cycle of highly keratinized tissues (like nails), the physical change or clinical improvement may take several weeks or even months to become fully apparent. Final outcome assessments in clinical studies are often conducted long after the course of therapy is completed.

Q: Are there warnings about taking Микофин with alcohol?

A: Official sources do not describe a specific interaction between Mikofin and alcohol. However, the drug is documented to carry a rare risk of liver problems (hepatotoxicity). To minimize the potential for additive liver risk, official information may suggest limiting or avoiding alcohol consumption.

Q: Can Микофин be used for problems other than [main condition]?

A: Official regulatory documents list specific, approved indications for the oral form of the drug, such as certain fungal infections of the nails (onychomycosis) and scalp (tinea capitis). The product is not officially authorized by regulatory agencies for uses beyond these defined indications.

Q: Does Микофин start working immediately?

A: The active substance is absorbed relatively quickly into the bloodstream and diffuses rapidly into the target tissues like the skin and nails. The drug's mechanism to eliminate fungal cells begins upon reaching the infection site, but the clearance of the infection and visible physical improvement occur slowly because it takes time for the infected tissue to grow out.

Q: How long does the effect of Микофин last?

A: The drug is eliminated slowly from the body’s tissues, including the skin and nails, following the final dose. This slow elimination is documented in pharmacokinetics and results in the medication continuing to have a residual effect for some time after completing the treatment course.

Q: Is it normal to feel [mild, non-serious symptom] when first taking Микофин?

A: Official documents classify certain mild reactions as Very Common or Common events observed in clinical trials, such as headache, diarrhea, nausea, and rash. The occurrence of these frequently documented effects upon initiating treatment is described in the drug's safety profile.

Q: Are there any foods or drinks that should be avoided while using Микофин?

A: For the oral tablet form, official labeling states it may be taken with or without food as its absorption is not affected. If using the oral granule formulation, however, it must be mixed only with soft, non-acidic foods (like pudding or mashed potatoes) and swallowed immediately.

Q: Is Микофин safe for people with [common long-term condition, e.g., high blood pressure]?

A: Official documents list specific populations and conditions where use is cautioned or strictly advised against, notably including chronic liver disease, severe renal impairment, Lupus, and Psoriasis. Official labeling generally does not include specific warnings or contraindications related to common conditions like high blood pressure.

Q: Is there a generic version of Микофин available?

A: Yes, the active ingredient in Микофин is Terbinafine, and it is widely available in a generic form. The product is also marketed globally under various brand names.

Q: Where does Микофин work in the body?

A: Following oral administration, official information indicates the drug is absorbed and distributed to the skin, sebum, and concentrates in the hair follicles and nail plate. This concentration allows the medicine to reach the site of the fungal infection directly in the affected tissues where its action is needed.

Q: Does Микофин interact with herbal supplements?

A: Official regulatory documents focus primarily on interactions with other prescription drugs via the CYP2D6 pathway. However, some interaction databases suggest that certain herbal supplements, such as Echinacea, may alter the blood levels of Terbinafine.

Q: Is Микофин a strong medicine?

A: In medical terms, the drug is classified as an allylamine antifungal and is described by regulatory documents as having a fungicidal action against certain dermatophytes. This classification means the drug is designed to actively kill, rather than just suppress or inhibit the growth of, the fungal cells.

Q: What is the risk of addiction or dependence?

A: Official adverse reaction reports and warnings for this medication do not classify it as a drug associated with abuse or dependence potential. However, regulatory documents highlight the potential for it to interact with certain other central nervous system (CNS) medications.

Q: What is the proper way to stop using Микофин?

A: The duration of oral therapy is set by official guidelines (e.g., 6 or 12 weeks for nails) to achieve clearance. Official documentation describes the duration of the course to achieve clearance and notes that irregular use or stopping treatment prematurely may be associated with the risk of recurrence.

Q: What is the difference between [different forms/strengths] of Микофин?

A: The product is available in two primary forms: the oral tablet, which is used for systemic treatment to reach deep infections like those in the nails, and topical forms (creams, solutions), which are applied directly to the skin for localized surface infections. These forms have different uses and are not generally interchangeable for all conditions.

Q: Can I use Микофин if I am allergic to other similar medicines?

A: Official documents explicitly contraindicate use if there is a known history of hypersensitivity or severe allergic reaction specifically to oral Terbinafine or any of its components. There is no explicit regulatory warning for potential cross-reactivity with other distinct classes of antifungal medicines.

Q: Are there different brand names for Микофин?

A: Yes, the active ingredient, Terbinafine, is sold globally under various brand names. The most well-known brand name for this medication is Lamisil.

Q: Does the efficacy of Микофин change over time?

A: Regulatory overviews of research evidence note that studies have examined the emergence of patterns of antifungal resistance in certain fungal species over time. This is an area where collective research findings are still being gathered.

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How should Микофин be stored and disposed of?

How to Store and Dispose of Mykofin (Terbinafine)

Official Storage Requirements

Mykofin (Terbinafine) tablets must be stored at controlled room temperature, specifically between 20 C and 25 C (68 F and 77 F). Topical forms, such as the cream and spray, must be stored below 30 C and should not be frozen.

All forms of the medication must be stored in the original, tightly closed container and kept protected from light. To ensure safety, the product must be stored out of the sight and reach of children.

Disposal Instructions

Official regulatory guidelines require that any unused or expired Mykofin must be handled as pharmaceutical waste. Do not dispose of this medicine in household trash or pour it into wastewater. Disposal must be conducted in accordance with local and national requirements, often by taking the product to a pharmacist or designated collection site.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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