Ланотан

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Ланотан

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ланотан

Property Description
Active ingredient Latanoprost
Form Ophthalmic solution (Eye drops)
Pharmacological class Ocular hypotensive agent
General purpose Intraocular pressure reduction
Origin Synthetic (Prostanoid class)

What Type of Medicine is Ланотан?

Ланотан is defined as a potent ocular hypotensive agent belonging to the Prostaglandin F2alpha analogue class, which is a synthetic compound used to manage pressure within the eye. The active ingredient, Latanoprost, is a prostanoid derivative that functions chemically as an ester prodrug; this means the chemical requires enzymatic conversion upon absorption to become biologically active. Latanoprost is established as a first-line agent for pressure management for its effectiveness and long-term profile in adult patient populations.

Composition and Form: The Latanoprost Ophthalmic Solution

The medicine is manufactured exclusively as a sterile, water-based ophthalmic solution, designed for topical application as eye drops to the surface of the eye. This specific dosage form is critical for localized delivery, ensuring the medication's effect is concentrated within the ocular structures while minimizing systemic exposure. This design ensures that the treatment is focused directly in the eye, where the absorption mechanism occurs. Ланотан is a single-component product containing Latanoprost in an aqueous vehicle, distinguishing it from combination drops or non-aqueous formulations.

General Purpose: Managing Ocular Pressure

The primary function of the Latanoprost class of medicines is to achieve reliable intraocular pressure (IOP) reduction, making it essential for ocular hypertension management. The core mechanism involves acting as a selective agonist that subsequently increases the rate of aqueous humor outflow from the eye. This mechanism shows that the treatment works by promoting the eye's natural drainage process. A typical, neutral use scenario involves a patient requiring consistent, daily pressure maintenance. By increasing the eye’s fluid removal, the medicine supports the goal of maintaining a healthy, controlled pressure environment.

What side effects are possible with Ланотан?

The safety profile of this medicine is defined by adverse reactions classified according to their official frequency and grouped by the affected body system, as documented in government regulatory sources (e.g., FDA, EMA). The most frequently documented effects relate to the eye.

Frequency-Classified Adverse Reactions

Classification Examples of Officially Documented Effects
Very Common (ge 1/10) Increased iris pigmentation, conjunctival hyperaemia (redness), ocular irritation (stinging, burning), and changes to the eyelashes (length, thickness, pigmentation).
Common (ge 1/100 to < 1/10) Ocular pain, punctate keratitis (corneal damage), blepharitis, and headache.
Uncommon to Rare Eyelid oedema, photophobia, uveitis/iritis (intraocular inflammation), and cystoid macular oedema.

Serious Adverse Reactions and Safety Constraints

Official labeling identifies specific serious adverse reactions and safety considerations:

  • Serious reactions officially documented include macular oedema and uveitis/iritis. The exacerbation of conditions like asthma or angina has also been reported in regulatory literature.
  • Time-Related Pattern: The regulatory label notes that the increased iris pigmentation is typically a long-term effect that may start within the first year and is officially documented as potentially permanent. Eyelash changes are generally reversible upon treatment discontinuation.
  • Population Safety Notes: Caution is advised for patients who are aphakic or pseudophakic with specific capsule conditions, and use during pregnancy and lactation requires particular regulatory caution. Use is also restricted for patients with active intraocular inflammation.

This framework ensures that all known safety characteristics, based strictly on official regulatory classification, are transparently communicated.

Overdose and Emergency Response

The official regulatory documentation for Latanoprost (Ланотан) defines the overdose profile primarily based on its localized topical application.

Documented Overdose Manifestations

System Affected Observed Signs
Ocular System Transient ocular irritation and conjunctival hyperaemia (redness).
Systemic Risk Primarily associated with accidental oral ingestion of the solution.

Excessive topical application is expected to cause only these local and transient effects, with regulatory labeling noting that no other significant ocular side effects are typically known. Systemic effects, such as nausea, dizziness, or abdominal pain, are documented only as a result of massive theoretical exposure, which greatly exceeds typical use.

Emergency Action and Required Help-Seeking

The critical regulatory mandate for overdose is tied to ingestion. Immediate medical attention or contacting a poison control center is explicitly required if the eye solution is accidentally swallowed. For medical assessment following ingestion, official documents state that one bottle contains approximately 125 micrograms of Latanoprost. Management for overdose is defined as strictly symptomatic and supportive treatment because no specific antidote is known. No differentiated overdose guidance for specific populations (e.g., pediatric or elderly patients) is provided in the official labeling.

Therapeutic Uses of Ланотан

What Ланотан Treats: Main Uses and Benefits


The therapeutic use of Ланотан is relevant for managing the symptoms of high fluid pressure within the eye, which is a key factor in several major ocular conditions. The medication is commonly used to help with pressure associated with glaucoma and ocular hypertension.

This medication is primarily used to address the pathological state of elevated Intraocular Pressure (IOP), which is the measurable characteristic of conditions including Primary Open-Angle Glaucoma and Ocular Hypertension. The therapeutic application is aligned with the management of symptoms that create noticeable physiological strain and may support the patient during difficult episodes related to optic nerve health. It is typically applied in clinical settings that involve chronic management of ocular pressure for adult and elderly patients.

By addressing this high pressure, Ланотан is applied in situations where supportive management of a key risk factor is needed, helping to ease the overall symptom load related to ocular stress.

Quick Fact: Relief for Elevated IOP
This medication helps address symptom clusters related to fluid pressure, which supports general well-being and the management of symptoms linked to organ-specific functional stress.

Regulatory References

  1. NIH MedlinePlus overview of Latanoprost

Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Ланотан — Official Regulatory Information

Ланотан (Latanoprost) is an ophthalmic solution for reducing elevated intraocular pressure and is generally prescribed for adults and paediatric patients with ocular hypertension or glaucoma. However, its use is governed by strict regulatory eligibility rules.


Populations and Conditions for Use

Classification Population / Condition
Contraindicated Individuals with a known Hypersensitivity to Latanoprost or any other component in the medicine.
Use Restricted / Caution Patients with an active eye infection or inflammation (such as active Herpes simplex keratitis) must not use the medicine. Use requires caution for patients with a history of intraocular inflammation (iritis/uveitis), a history of herpetic keratitis, or those who are aphakic or pseudophakic with a torn posterior lens capsule, as these conditions may be exacerbated.
Age Restriction Adults and older children are eligible. The medicine is not recommended for preterm infants (less than 36 weeks gestational age) due to a lack of data, and data is very limited for infants under one year of age.
Pregnancy/Lactation Use during pregnancy and breastfeeding is generally not recommended as the safety of Latanoprost for the unborn child or nursing infant has not been conclusively established in humans.

Eligibility Summary

Regulatory documents define eligibility based on the absolute exclusion of patients with known allergies to the product. Use is permitted for a broad age range, but is restricted in the youngest paediatric groups and requires special consideration in patients with specific pre-existing ocular conditions that could be worsened by the medicine. Patients must also remove contact lenses before application and wait at least 15 minutes before reinsertion.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Latanoprost (Ланотан) is structured around localized constraints due to its ophthalmic route of administration.

Property Description
Medicinal product categories with documented interactions: Topical Ophthalmic Drug Products; Prostaglandin F2\alpha analogues.
Mechanistic basis of interactions: Pharmacodynamic conflict (paradoxical IOP elevation); Chemical Incompatibility. Minimal systemic pharmacokinetic relevance is noted.
Interaction-related restrictions: The combined use of two or more prostaglandins, or prostaglandin analogues, is formally not recommended.
Timing-based interaction rules: All other topical ophthalmic drug products must be administered at least five (5) minutes apart from Latanoprost.
Population-specific interaction notes: The product has not been adequately studied in patients with impaired renal and/or hepatic function.

Official Interaction Statements

  • Prostaglandin Analogues: Co-administration with other prostaglandin analogues is not recommended because this combination may lead to a paradoxical elevation in intraocular pressure, reducing the intended ocular hypotensive effect.
  • Chemical Incompatibility: Precipitation occurs in vitro when Latanoprost ophthalmic solution is physically mixed with eye drops that contain the preservative thimerosal.

Connection to the Overall Interaction Profile

Regulatory documents define the interaction structure primarily through constraints related to the ocular environment. The official profile consists of a formal "not recommended" classification against co-administering other prostaglandin agents, a mandatory five-minute timing separation rule for all other eye drops, and a noted in vitro chemical incompatibility with thimerosal-containing solutions. Systemic metabolic interactions are not explicitly documented.

Mechanism of Action

Targeting Ocular Drainage with Prostaglandin Agonism

Ланотан is administered as an inactive prodrug that undergoes rapid enzymatic conversion by esterases in the cornea into its biologically active acid form. The active acid functions as a selective agonist for the Prostaglandin F (FP) receptors located on cells, primarily within the ciliary muscle of the eye. Activating these G-protein-coupled receptors initiates the intracellular cascade that regulates tissue composition.


Enhancing Uveoscleral Outflow

Receptor binding triggers the upregulation of Matrix Metalloproteinases (MMPs), enzymes that mediate the breakdown and reorganization of the extracellular matrix within the ciliary muscle. This tissue remodeling process enhances the permeability and outflow of aqueous humor through the unconventional uveoscleral pathway, resulting in the adjustment of intraocular fluid dynamics and the reduction of Intraocular Pressure (IOP).


Localized Tissue Modulation

This prostaglandin-like activity extends to local cellular processes, leading to the modulation of melanocyte activity (melanin synthesis) and alteration of the hair follicle growth cycle in the periocular region.

Dosage and Administration Information

How to Use Ланотан: Administration Guidelines

Ланотан, which contains the active ingredient Latanoprost, is prescribed for continuous, long-term management of elevated intraocular pressure. Its usage follows a specific regimen.


Administration Scope

Usage Element Instruction
Route of Administration Topical application to the eye (ocular route)
Dosing Schedule One drop instilled into the affected eye(s)
Frequency and Timing Once daily (QD), optimally administered in the evening
Maximum Use Constraint Dosage must not exceed once daily; more frequent use may diminish the IOP-lowering effect

Procedural and Population Rules

Treatment is intended to be continuous for chronic conditions, and if a dose is missed, treatment resumes with the next scheduled evening dose without doubling the amount. The administration routine includes specific procedural steps:

  • Contact Lenses: Soft contact lenses must be removed prior to instillation and may be reinserted 15 minutes after administration.
  • Concomitant Drops: If using other topical ophthalmic drugs, they should be administered at least five (5) minutes apart to prevent dilution and ensure adequate absorption.

For older adults, no dosage adjustment is typically required, reflecting a consistent usage pattern across adult patient populations. These instructions describe the protocol for the drug's intended action.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Ланотан

Evidence from Controlled Trials for Glaucoma and Ocular Hypertension

The research foundation for Ланотан has primarily relied on large-scale, randomized controlled trials (RCTs) and comprehensive systematic reviews that specifically examine its use for managing Primary Open-Angle Glaucoma and Ocular Hypertension. These studies focused heavily on adult populations. The main goal of this research was to track the absolute and relative changes in Intraocular Pressure (IOP) from the start of the study, and to monitor the IOP measurements over the short and intermediate term.

In these studies, findings describe patterns observed where research monitored changes in Intraocular Pressure (IOP), a primary focus of the trials. Comparative trials described patterns where the IOP measurements with Latanoprost were tracked against measurements reported for older classes of medicine, such as beta-blockers. Systematic reviews documented the structure of the evidence base, noting the presence of controlled trials that utilized IOP measurement as an endpoint in these indications.


Study Landscape in Pediatric Populations and Key Evidence Gaps

Research has also explored the use of this medicine in pediatric patients, including children from 4 years of age up to adolescence, who have elevated IOP related to various forms of pediatric glaucoma. These were often smaller, specialized comparative studies. Research examined outcomes related to physiological strain or stress, including IOP measurements from baseline and overall tolerability.

Data show patterns related to IOP measurements in these younger patient cohorts, although the consistency and magnitude of these measurements were observed in some studies to be heterogeneous. The research base, which contains many short-term RCTs, still contains certain gaps and uncertainties. Follow-up durations were limited in many of the core efficacy trials, meaning long-term effects are not fully established based on the most rigorous study designs. Evidence quality varies across studies, and data for certain groups remain insufficient.

Key Studies & References

  1. Latanoprost for elevated intraocular pressure
  2. Latanoprost for the treatment of pediatric glaucoma and ocular hypertension: a comprehensive review of clinical studies
  3. NIH MedlinePlus: Latanoprost Ophthalmic (Medical Encyclopedia)

Frequently Asked Questions (FAQ)

Common questions about Ланотан (FAQ)


Q: How quickly should I expect to notice any change after starting Ланотан?

A: According to official regulatory documents, the reduction of elevated intraocular pressure typically begins approximately 3 to 4 hours after the medicine is administered. The maximum pressure-lowering effect is usually reached within 8 to 12 hours of application. This information helps establish general expectations for the onset of the medicine’s action.


Q: What happens if I stop taking Ланотан suddenly?

A: The official product information indicates that if the use of this medicine is discontinued, the intraocular pressure (IOP) is generally expected to return to its pre-treatment, elevated level over time. Because the medicine is intended for continuous management of a chronic condition, a discussion with a healthcare provider is generally recommended before stopping treatment.


Q: Can children or teenagers use Ланотан?

A: Official information indicates the medicine is generally used in adults and older children with elevated intraocular pressure. While some pediatric patients are eligible, the safety and effectiveness have not been fully established across all young age groups, particularly in infants and preterm infants.


Q: Does alcohol affect how Ланотан works?

A: Since this medicine is a topical eye drop with minimal systemic absorption, official prescribing information does not typically document a specific interaction or contraindication related to systemic alcohol consumption.


Q: Is there a generic version of Ланотан available, and is it exactly the same?

A: Yes, the active ingredient, Latanoprost, is available in generic versions that have been approved by regulatory agencies. Generic products are required to demonstrate therapeutic equivalence to the brand-name product, meaning they are approved as therapeutically equivalent.


Q: What does 'not recommended' mean for a certain group of patients in the drug leaflet?

A: The term 'not recommended' in official regulatory documents generally indicates that there is insufficient scientific data to fully support use in that population, or that a known safety or efficacy risk exists. This suggests that the potential risks may not be fully justified by the potential benefits in that group.


Q: Can I crush or split the Ланотан tablet?

A: The medicine is manufactured only as a sterile ophthalmic solution, which means it is in the form of eye drops. It is administered as a liquid drop to the eye and is not available in any tablet or pill form that can be crushed or split.


Q: Is Ланотан used for anything besides the main condition mentioned?

A: The medicine is officially indicated for the specific purpose of reducing elevated intraocular pressure in patients diagnosed with open-angle glaucoma or ocular hypertension. Some international regulatory labels may also include its use for chronic angle-closure glaucoma following specific surgical procedures.


Q: Why is Ланотан sometimes prescribed if another similar drug didn't work?

A: Official clinical guidelines describe this medicine as a first-line agent for managing intraocular pressure due to its established mechanism and effectiveness profile. Its use is a common, established strategy when other initial treatments have not proven sufficient or appropriate for achieving the target pressure.


Q: Does Ланотан help with sleep or mood, even if that's not its main use?

A: The documented adverse effects are primarily related to the eye due to the medicine's topical application. While reported systemic side effects in clinical trials have included headache or flu-like symptoms, systemic mood or sleep disturbances are not listed among the commonly reported effects.


Q: Are there any common foods or supplements that are known to interfere with Ланотан?

A: Official prescribing information does not document any specific interactions between this eye medicine and common foods or nutritional supplements.


Q: Do older adults typically need a different approach when using Ланотан?

A: Official labeling states that no overall differences in safety or effectiveness have been observed between elderly and younger adult patients. For this reason, dosage adjustment is not typically required solely based on a patient’s advanced age.


Q: What should I do if I miss a dose of Ланотан?

A: Official patient information describes that if a dose is missed, the recommended procedure is to skip the missed dose entirely. Treatment should then continue with the next scheduled evening dose, as dosing must not exceed once daily.


Q: Is there a risk of becoming dependent on Ланотан?

A: The medicine is not classified as a controlled substance by the U.S. Drug Enforcement Administration (DEA) or equivalent international regulatory bodies.


Q: How long is the typical duration of treatment with Ланотан?

A: The medicine is intended for long-term or chronic management of elevated eye pressure. Due to the chronic nature of the underlying condition, many patients may continue to use the medicine indefinitely to maintain a controlled pressure environment.


Q: Why are people told not to drive or operate machinery sometimes when they start Ланотан?

A: Warnings related to driving or operating machinery are given because the medicine can potentially cause temporary ocular side effects, such as blurred vision or dizziness, which can temporarily impair a person's ability to safely perform these activities.


Q: Does taking Ланотан at a specific time of day matter?

A: The medicine is directed to be taken once daily. Official documents indicate that the optimal pressure-lowering effect is obtained if the medicine is administered in the evening.


Q: Are there any long-term effects of taking Ланотан for many years?

A: The most noted long-term effect documented in regulatory documents is the potential for a gradual, permanent increase in the amount of brown pigment in the iris (eye color), which may begin within the first year of use and progress over time.


Q: Is it safe to use Ланотан if I have a history of liver problems?

A: Specific official guidelines for dosage adjustment in patients with hepatic (liver) impairment are generally not available. Use of the medicine in these patients is often advised with caution by regulators, as data regarding its effects in this group is limited.


Q: Can Ланотан affect birth control or fertility?

A: Animal studies conducted on the medicine have not found it to have an effect on male or female fertility. Additionally, the official prescribing information does not document an interaction with hormonal birth control methods.


Q: What were the main findings of the major studies on Ланотан?

A: Clinical trials consistently demonstrated that the medicine effectively reduced elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. The research foundation is built on measuring the magnitude of this pressure reduction.


Q: How is the effectiveness of Ланотан measured in clinical trials?

A: Effectiveness is measured by documenting and monitoring the absolute and relative changes in Intraocular Pressure (IOP) from the start of the study. This measurement is typically taken using a validated pressure-measuring instrument like the Goldmann applanation tonometer.


Q: Are there different forms of Ланотан (e.g., tablet, liquid)?

A: The medicine is only available as a sterile ophthalmic solution, which is a liquid intended for application as eye drops. Other dosage forms, such as oral tablets or capsules, are not available for this product.


Q: What is the official classification of Ланотан (e.g., controlled substance)?

A: The medicine is officially classified as an ocular hypotensive agent belonging to the Prostaglandin F2alpha analogue class. It is not classified as a controlled substance in the United States or many other jurisdictions.


Q: Does Ланотан interact with herbal supplements like St. John's Wort?

A: Official prescribing information focuses primarily on interactions with other eye drops or prostaglandin analogues. The information does not list a specific interaction with St. John's Wort or other common herbal supplements.


Q: How does Ланотан affect my heart rate or blood pressure?

A: Due to its localized application to the eye and subsequent minimal systemic absorption into the bloodstream, the medicine is not typically associated with changes in heart rate or blood pressure for most patients. Documented adverse reactions are primarily confined to the ocular system.


Q: Why is the drug name 'Ланотан' spelled differently sometimes in discussions?

A: Variations in spelling or the use of other names (e.g., brand names like Xalatan) are typically due to different brand identities, generic spellings, or the way the active ingredient, Latanoprost, is marketed in various countries or specific product forms.


Q: Are there specific storage requirements for keeping Ланотан effective?

A: Yes, to ensure the medicine maintains its effectiveness, unopened bottles must be stored under refrigeration between 2 C and 8 C. Once the bottle is opened, it may be stored at room temperature for a maximum of six weeks.


Q: What are the major contraindications for using Ланотан?

A: The medicine is formally contraindicated for individuals with a known hypersensitivity, or severe allergy, to the active ingredient, Latanoprost, or any of the other components in the solution.


Q: Does using Ланотан require regular blood tests or monitoring?

A: Regular monitoring by a healthcare professional is required to check the intraocular pressure and watch for possible ocular side effects, such as changes in iris pigmentation. However, routine blood tests are not typically required for monitoring this medicine.


Q: What are the most common reasons why doctors decide to stop a patient's treatment with Ланотан?

A: Reasons for discontinuing treatment, based on clinical trial criteria, often relate to the failure to achieve the desired reduction in intraocular pressure (IOP). Other reasons include the development of specific adverse reactions such as severe eye inflammation or patient hypersensitivity to the medicine.


Q: Does having kidney problems prevent someone from using Ланотан?

A: Specific official guidelines for dosage adjustment in patients with renal (kidney) impairment are generally not available. Use in these patients is often advised with caution by regulators due to limited data in this population.


Q: Is it necessary to have a special diet while taking Ланотан?

A: Official regulatory documents do not specify or recommend that patients adhere to a special diet while using this medicine.

How should Ланотан be stored and disposed of?

Storage and Disposal Requirements for Latanoprost

Storage Condition Requirement
Unopened Bottle Must be stored under refrigeration between 2 C and 8 C (36 F to 46 F). Do not freeze.
In-Use (Opened) May be stored at room temperature up to 25 C (77 F) for a maximum of 6 weeks (42 days).

All latanoprost solution, both unopened and opened, must be kept in the original container and protected from light. The container must be kept tightly closed to prevent contamination. The medicine must be kept out of the sight and reach of children.

For disposal, any unused or expired product should be discarded according to local regulations for pharmaceutical waste. Do not dispose of the medicine via wastewater or household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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