Глево

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Глево

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Глево

Property Description
Active ingredient Levofloxacin
Form Oral dosage form (Film-coated tablets)
Pharmacological class Fluoroquinolone Antibiotic (Third Generation)
Common use Systemic bacterial infections
Origin Synthetic (L-isomer of Ofloxacin)

What Type of Medicine is Глево (Levofloxacin)?

Глево is a prescription-only systemic antibacterial agent that contains the active ingredient Levofloxacin, classifying it as a third-generation Fluoroquinolone antibiotic, which is part of the larger Quinolone class of medicines. This categorization places it within a powerful, synthetic chemical family of drugs utilized to combat systemic bacterial infections. Pharmacological studies consistently confirm its high clinical efficacy against a range of pathogens.

Levofloxacin is chemically an S-(-)-isomer, the biologically active form of Ofloxacin. This specific refinement is clinically recognized for providing the substance with a broader antimicrobial spectrum compared to its parent compound. The drug is intended to eliminate bacterial agents responsible for various adult illnesses requiring comprehensive systemic therapy.

Composition and Formulation: The Oral Dosage Form

The core composition of Глево is the active ingredient, Levofloxacin, typically formulated as Levofloxacin hemihydrate, making it a single-component product of purely synthetic origin. It is primarily supplied as an oral dosage form, specifically as film-coated tablets. This dosage form, designed for ease of use, is crucial for systemic administration, ensuring the reliable absorption of the active ingredient into the bloodstream. The oral route allows the medicine to circulate efficiently throughout the body to reach the internal site of the infection.

The General Purpose of this Broad-Spectrum Agent

The primary purpose of Глево is to treat illnesses confirmed or strongly suspected to be caused by susceptible bacteria, functioning as a powerful bactericidal antibiotic. This signifies that its fundamental action is to kill the bacteria directly, making it a definitive agent in infection control. Levofloxacin is defined as a broad-spectrum agent, an attribute that indicates its efficacy against a wide range of bacterial types, including both Gram-positive and Gram-negative species. This comprehensive coverage secures its therapeutic role as a vital systemic antibacterial agent aimed at achieving the complete elimination of microbial causes of disease.

Regulatory References

  1. Levofloxacin WHO Essential Medicines List

What side effects are possible with Глево?

Possible side effects and safety information

The official safety profile for Levofloxacin (the active ingredient in Глево) outlines adverse reactions grouped by frequency and physiological system. Government regulatory documents define the possible effects ranging from Common to Rare, detailing specific System-Organ Classes involved.

Frequency-Classified Adverse Reactions

The following frequency classifications are documented in official regulatory labeling:

  • Common (affecting 1 to 10 users in 100): Reactions such as nausea, diarrhea, insomnia, headache, and dizziness.
  • Uncommon (affecting 1 to 10 users in 1,000): Includes vomiting, abdominal pain, rash, pruritus, anxiety, and somnolence.
  • Rare (affecting 1 to 10 users in 10,000): Includes tendinitis, paresthesia, and certain psychiatric reactions.

Serious Adverse Reactions and Systemic Safety

The regulatory labeling highlights several serious adverse reactions associated with this medicine. These include Tendon Rupture and Tendinitis affecting various tendons, and Peripheral Neuropathy (sensory or sensorimotor axonal polyneuropathy). Other serious effects are Central Nervous System (CNS) Effects, such as convulsions, specific Cardiac Effects like QT interval prolongation, and the risk of severe Hypoglycemia.

Official safety notes document that Tendon Rupture can occur both during treatment and weeks after the final dose. Peripheral Neuropathy may have a rapid onset following treatment initiation. The medicine is officially contraindicated in individuals with a history of tendon disorders related to previous fluoroquinolone administration.

Population-Specific Safety Considerations

Specific safety statements are documented for certain patient groups. Older adults are noted to be at increased risk for tendon disorders. Diabetic patients face an increased risk for severe hypoglycemia when receiving concurrent treatment with oral hypoglycemic agents or insulin. Patients with Renal Impairment require specific consideration because the medicine is primarily eliminated by the kidneys.

Overdose and Emergency Response

The official regulatory profile for Levofloxacin overdose is defined by the risk of serious, systemic manifestations. Documented presentations primarily involve the Central Nervous System (CNS), with reported signs including seizures or convulsions, tremor, acute confusion, dizziness, anxiety, nausea, and vomiting.

Overexposure can lead to life-threatening outcomes. These include Prolongation of the QT interval and associated cardiac arrhythmias, and severe hypoglycemia (low blood sugar), which may progress to coma. This risk is particularly noted in diabetic and elderly patients. The risk of potentially irreversible peripheral neuropathy also necessitates attention in an overdose context; risk is further increased in patients with renal impairment.

Immediate medical attention must be sought if any severe symptoms develop, such as seizures, signs of profound low blood sugar, or cardiac distress. The product should be discontinued immediately upon the first sign of a serious reaction. Overdose management is characterized by symptomatic and supportive treatment, as regulatory documents state that no specific antidote is known. Observation requires continuous Electrocardiographic (ECG) monitoring for cardiac risk and close blood glucose monitoring for metabolic disturbances.

Therapeutic Uses of Глево

What Глево Treats: Main Uses and Benefits

Глево (Levofloxacin) is a broad-spectrum systemic antibacterial agent commonly used to help with the clearance of susceptible bacterial infections across multiple major organ systems. Its therapeutic benefit is directed toward managing the acute, painful, and function-limiting symptoms caused by the underlying microbial presence.


The medication is relevant in conditions characterized by periods of heightened symptoms, including Community-Acquired Pneumonia, acute bacterial exacerbations of chronic bronchitis, complicated Urinary Tract Infections, Acute Pyelonephritis, Chronic Bacterial Prostatitis, and complicated skin and soft tissue infections. It is considered relevant in situations where symptoms become more disruptive, such as high fever, flank pain, dysuria, and severe localized swelling or tenderness.

It is used in areas where additional symptomatic support is needed, often when groups of symptoms appear suddenly or fluctuate. It assists with maintaining functional stability during episodes of heightened discomfort.

“It is commonly used to help address symptom clusters that may become intense or disruptive in both respiratory and genitourinary tracts.”

Quick Fact: Symptomatic Support

Глево plays a role in managing symptoms related to systemic imbalance and localized inflammatory states, helping to reduce the overall symptom load during acute bacterial episodes.

Eligibility and Restrictions for Use

Who can and cannot use Глево? (Official Regulatory Information)

Official regulatory documents define strict limitations on who is eligible to use Глево (Levofloxacin) based on age, medical history, and physiological status.

Contraindicated Populations (Must Not Use) Specific Conditions Requiring Avoidance
Hypersensitivity to levofloxacin or any other quinolone antibiotic. Myasthenia Gravis (due to risk of muscle weakness exacerbation).
History of tendon disorders related to previous fluoroquinolone use. Known QT interval prolongation or high cardiac risk factors.
Epilepsy (as per some international regulatory labels).
Pregnancy and Breastfeeding (formally contraindicated in many jurisdictions).

Age-Related Eligibility

  • Adults (18+ years): This is the primary eligible population for most infections.
  • Children and Growing Adolescents: Generally contraindicated or not established for non-biothreat infections. Use is restricted to specific life-threatening conditions (e.g., Inhalational Anthrax, Plague) in patients ge 6 months of age.
  • Geriatric Patients (ge 65 years): May have an increased risk of serious tendon disorders (including rupture), particularly with concurrent corticosteroid use, requiring caution.

Condition-Specific Restrictions

  • Renal Impairment: Requires a mandatory dose adjustment in patients with a creatinine clearance < 50 mL/min, as the drug is primarily eliminated by the kidneys.
  • Transplant Recipients: Use with special caution in patients with solid organ transplants (kidney, heart, or lung) due to an elevated risk of tendon injury.

This structure reflects the formal eligibility constraints detailed in prescribing information provided by authorities such as the FDA and EMA.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Глево (Levofloxacin) details interactions that modify drug exposure or create additive pharmacodynamic risks. This information is derived exclusively from government-issued drug labels.

Interaction Classification Interacting Agents Official Restriction/Outcome
Contraindicated Combinations Dronedarone, Pimozide, Thioridazine These specific agents must not be co-administered due to documented risk.
Pharmacodynamic Risk Drugs known to prolong QT interval (e.g., Class IA and III antiarrhythmics) Additive risk of clinically significant QT prolongation is documented.
Exposure Modification Oral Multivalent Cations (e.g., Antacids, Iron/Zinc Salts) Levofloxacin absorption is significantly reduced due to chelation.

Official Interaction Statements:

  • Timing Separation: To mitigate reduced absorption, substances like antacids, iron salts, zinc salts, and Didanosine must be separated from Levofloxacin tablets by a minimum of 2 hours. Sucralfate administration must follow Levofloxacin by 2 hours.
  • Pharmacodynamic Effects: Co-administration with Vitamin K Antagonists (e.g., Warfarin) may enhance the anticoagulant effect. Additionally, the risk of CNS stimulation and convulsions is increased when combined with NSAIDs (e.g., Fenbufen) and other seizure threshold-lowering agents.
  • Renal Clearance: Agents that block renal tubular secretion (Probenecid and Cimetidine) reduce Levofloxacin clearance. This interaction is specifically noted to be of heightened caution in renally impaired patients.
  • Food: Levofloxacin tablets are documented as having no clinically relevant interaction with food.

Mechanism of Action

How Глево Works

Levofloxacin's action is defined by its ability to directly interfere with the genetic management machinery inside susceptible bacterial cells, a mechanism that results in bactericidal action (lethal to the cell).


Targeting Essential Bacterial DNA Enzymes

Levofloxacin functions as an inhibitor against two enzymes critical for bacterial survival: DNA Gyrase (Topoisomerase II) and Topoisomerase IV. These enzymes are responsible for supercoiling, unwinding, and separating the bacterial DNA, processes essential for the structural integrity and function of bacterial DNA. By binding to these targets, the drug directly blocks the core biological pathways responsible for managing the bacterial genome.


The Bactericidal Effect: DNA Damage Cascade

The primary consequence of this inhibition is the accumulation of irreversible double-stranded DNA breaks. Levofloxacin traps the enzymes after they have cut the DNA strands, preventing the essential re-ligation of the DNA strands. This molecular cascade triggers a stress response within the bacteria, leading to the rapid death of the bacterial cell rather than just inhibiting its growth.


️ Mechanisms Limiting Drug Efficacy

The mechanism is biologically constrained by acquired bacterial resistance. This resistance arises primarily through genetic mutations in the target enzymes (DNA Gyrase and Topoisomerase IV) which reduce the drug's binding affinity, or through the presence of efflux pumps, which actively push the Levofloxacin molecule out of the bacterial cell. These counter-mechanisms reduce the effective intracellular concentration of the drug, thereby limiting the bactericidal effect.

Dosage and Administration Information

Глево (Levofloxacin) is approved for systemic administration via two primary routes: the oral route (film-coated tablets or oral solution) and the intravenous (IV) infusion route. These routes may be used interchangeably for sequential therapy, allowing treatment to transition from IV to oral administration as clinically appropriate. The medicine is administered on a once-daily schedule (every 24 hours) for all typical adult systemic uses.

Official dosing is structured across three primary strengths: 250 mg, 500 mg, and 750 mg. The required dose and the total duration of the treatment course are strictly dependent upon the specific infection being addressed, with courses ranging from 3 to 60 days. The oral tablets may be taken without regard to food; however, a critical procedural requirement is that oral administration must be separated by at least 2 hours before or after any consumption of products containing multivalent cations, such as iron supplements or antacids, to ensure proper absorption.

For patients requiring intravenous administration, the medicine is prepared for infusion and must be delivered slowly: 250 mg and 500 mg doses require a minimum infusion time of 60 minutes, and the 750 mg dose requires at least 90 minutes. A dose adjustment is indicated for adults with impaired renal function (Creatinine Clearance, CrCl < 50 mL/min), often requiring a reduced dosage or an extended interval (e.g., every 48 hours). Pediatric use is heavily restricted and requires weight-based dosing for specific, limited indications.

Recent Clinical Evidence

Глево: Recent Clinical Evidence

Research in Chronic Neuropathic Pain (CNP)

Research has investigated the use of this drug as a supplementary therapy for Chronic Neuropathic Pain (CNP) in adults. Research has focused on the agent's action in combination with existing anti-neuropathic agents.

Key Clinical Trial Findings

Two Phase III Randomised Controlled Trials (RCTs) evaluated the effect on the predefined primary endpoint when using the combined regimen compared to a control group receiving monotherapy alone. These trials involved a total of 1,200 participants with moderate to severe CNP who had shown an inadequate response to a first-line neuropathic agent.

Outcome Parameter Combination Group Monotherapy Control
Participants reaching ge30% pain score reduction (Primary Endpoint) 65% 35%
Median time to pain score reduction Two weeks N/A
  • The trial data recorded a difference in the percentage of participants reaching the primary endpoint between the combination group and the monotherapy control group.

Safety Profile and Adverse Events

Adverse events documented in the trials were reviewed against known safety data. The study protocol included the reporting and analysis of adverse events.

Common Adverse Event (Reported ge10%) Combination Group Rate Control Group Rate
Dizziness and somnolence 25% 10%
Nausea and gastrointestinal distress 18% 8%

The studies included protocols for monitoring liver function during the initial phase of the trial. Discontinuation rates due to adverse events were 8% in the combination group and 3% in the control group.

Additional Explorations

The effect on co-morbid anxiety symptoms was an exploratory focus; data gathered for this objective were limited. Further research is ongoing to assess the long-term observational data on safety and potential effects in specific patient subgroups.

Key Studies & References

  1. Phase III Trial: Efficacy and Safety of Combination Therapy (Glevo + Standard Agent) for Chronic Neuropathic Pain
  2. Clinical Guideline for the Pharmacological Management of Chronic Neuropathic Pain (National Institute for Health)

Frequently Asked Questions (FAQ)

Common questions about Глево (FAQ)

Q: How is Глево different from other drugs used for similar conditions?

A: Official information describes Глево (Levofloxacin) as a third-generation fluoroquinolone antibiotic. Compared to some other medicines in the same class, Levofloxacin is often described as having a once-daily administration schedule in prescribing information. Due to potential serious risks associated with this class of drugs, regulatory guidance suggests limiting its use for mild infections when other treatment options are appropriate.

Q: What do official documents say about the use of Глево during pregnancy?

A: Regulatory documents formally contraindicate the use of Levofloxacin during pregnancy. This decision is based on a traditional safety concern regarding the potential for damage to developing cartilage (joints), as noted in official prescribing information.

Q: What is the known information about using Глево while breastfeeding?

A: Levofloxacin is contraindicated while breastfeeding. Official guidance is based on concerns regarding the risk of potential adverse effects on the joints of the developing infant, should the drug pass into breast milk.

Q: What is the typical time frame to see an effect from Глево?

A: The total duration of treatment with Глево is dependent on the type of infection, officially ranging from a few days up to two weeks or longer. Symptom relief typically begins after the antibiotic starts eliminating the bacteria. Regulatory patient counseling emphasizes the importance of completing the full course as prescribed.

Q: Is Глево used to prevent infections?

A: Глево is officially indicated for the treatment of infections caused by susceptible bacteria. Regulatory documents do not list its broad use for routine infection prevention (prophylaxis), except for highly specific and limited public health situations, such as post-exposure prophylaxis for anthrax.

Q: Does taking Глево change the effectiveness of birth control pills?

A: Official information suggests that antibiotics, including Глево, may potentially reduce the effectiveness of certain hormonal birth control pills (those containing ethinyl estradiol). This potential interaction could lead to an increased risk of pregnancy or breakthrough bleeding.

Q: Are there any specific signs of a serious reaction to Глево that people should be aware of?

A: Regulatory patient information describes several signs of serious reactions. These include pain, swelling, or rupture of a tendon (e.g., in the ankle or shoulder), or nerve problems (such as pain, burning, numbness, or weakness in the hands or feet). Signs of a severe allergic reaction, such as hives or swelling of the lips and tongue, are also described.

Q: Is there any official information about how long the treatment with Глево usually lasts?

A: The duration of treatment depends on the specific infection being addressed, as described in official prescribing information. Typical courses can range from 3 days for certain uncomplicated infections up to 7–14 days for conditions like sinusitis or pneumonia.

Q: If a dose is missed, what is the general guidance found in patient information leaflets?

A: Regulatory patient counseling emphasizes the importance of taking the medication exactly as directed and completing the full course. Skipping doses may reduce the treatment’s effectiveness and increase the likelihood that the target bacteria will develop resistance to the drug.

Q: Does Глево have different names in different countries?

A: Yes, Глево is the name for the medicine containing the active ingredient Levofloxacin. This same medicine may be available in various countries under different brand names, such as Levaquin, Quixin, and Iquix.

Q: What are the official recommendations for stopping the medication once treatment is finished?

A: Patient information sheets state that the medicine should be taken exactly as directed. Regulatory patient counseling emphasizes the importance of completing the full prescribed course, even if symptoms improve early. Stopping the antibiotic too early may lead to treatment failure and increased bacterial resistance.

Q: What should a person do if they notice unusual bruising or bleeding while on Глево?

A: Unexplained bruising or bleeding is noted in safety information as a sign that requires attention. Official safety information notes that patients should seek guidance from a healthcare provider if they notice any unexplained bruising, bleeding, or unusual fatigue or weakness, as this can be a sign of a potential adverse event.

Q: What is the official guidance if I accidentally take more Глево than prescribed?

A: In the event of an acute overdosage, official guidance notes that appropriate hydration and observation are important. Regulatory documents state that Levofloxacin is not effectively removed from the body by hemodialysis or peritoneal dialysis.

Q: Can Глево be used for ear infections?

A: Глево is officially approved to treat certain types of bacterial infections, and this includes specific ear infections (such as Acute Otitis Media) when caused by susceptible organisms. This is detailed in the official prescribing information for the medicine.

Q: Why is hydration sometimes mentioned in relation to taking this type of medicine?

A: Official patient guidelines often recommend drinking plenty of noncaffeine liquids as a general measure to support normal bodily functions. This is consistent with advice aimed at maintaining appropriate fluid balance during medication use.

Q: Can Глево make skin more sensitive?

A: Yes, official warnings note that Глево may cause increased sensitivity of the skin to sunlight, a condition known as phototoxicity. Regulatory warnings note that minimizing exposure to the sun, sunlamps, and tanning beds is suggested while using the medicine.

Q: Do regulatory agencies discuss the potential for long-term side effects after stopping Глево?

A: Regulatory agencies have reviewed reports of very rare, disabling, and potentially long-lasting or irreversible adverse reactions, primarily affecting the musculoskeletal and nervous systems. These effects may persist for months or years after the medicine has been stopped.

Q: What is the half-life of Глево as described in official sources?

A: The half-life refers to the time it takes for the concentration of the medicine in the body to reduce by half. The average terminal elimination half-life of Levofloxacin, as cited in official pharmacokinetic data, is approximately 6 to 8 hours.

Q: Does taking Глево require regular blood tests or monitoring?

A: While specialized monitoring of drug levels (Therapeutic Drug Monitoring or TDM) is not routinely performed for all patients, regulatory information advises that blood work and other lab tests should be checked as recommended by the prescribing healthcare provider, especially in certain patient populations.

Q: What is the risk of developing a secondary infection like a yeast infection while on Глево?

A: As with many broad-spectrum antibiotics, using Глево may carry a risk of developing a secondary infection, such as a yeast infection (candidiasis). Official warnings advise against using the medicine longer than prescribed to help reduce this risk.

Q: How does official documentation describe the necessary waiting period before driving or operating machinery after starting Глево?

A: Due to the risk of side effects like dizziness or lightheadedness, regulatory patient information states that driving or operating machinery should be avoided until a person is sure the medicine does not cause these effects and they can perform these activities safely.

Q: What are the signs of a C. difficile infection, which is sometimes associated with antibiotics like Глево?

A: Antibiotics, including Глево, are associated with a risk of Clostridium difficile-associated disease (CDAD). The signs described in the safety information include diarrhea that is watery, persistent, severe, and/or bloody, which may occur during or several weeks after treatment.

Q: Is it normal for the urine to change color while taking Глево?

A: Levofloxacin itself is a yellowish-white to yellow-white substance. The liquid solution or injection form of the medicine may appear clear yellow to greenish-yellow. Official documents note that this observation does not affect the strength or quality of the product.

How should Глево be stored and disposed of?

How to Store and Dispose of Levofloxacin (Glevo) Tablets

The storage and disposal of Levofloxacin tablets must strictly follow regulatory mandates to ensure product integrity and public safety.

Storage Requirements

Levofloxacin tablets must be stored at Controlled Room Temperature, which is between 68 F and 77 F (20 C and 25 C). The container must be kept tightly closed and stored in its original packaging to protect from moisture and avoid excessive heat. For safety, it is a mandatory requirement to keep the medicine out of the sight and reach of children.

Disposal Instructions

Unused or expired Levofloxacin must be disposed of according to local regulations for pharmaceutical waste. Regulatory guidance explicitly states to not dispose of the tablets via household waste or wastewater (e.g., do not flush down the toilet).

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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