Аксеф

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Аксеф

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Аксеф

The medicine Аксеф (Axef) is a pharmaceutical preparation classified as a semisynthetic antibiotic specifically used as an antimicrobial agent to combat systemic bacterial infections. It is identified by its active substance, Cefuroxime, and belongs to the cephalosporin family, a subgroup of the broader beta-lactam class of drugs.


Quick Facts: Аксеф (Cefuroxime)

Property Description
Active Ingredient Cefuroxime / Cefuroxime axetil
Form Oral (tablet, suspension) and Parenteral (injection)
Pharmacological Class Second-Generation Cephalosporin Antibiotic
Common Use Treating systemic bacterial infections
Origin Semisynthetic beta-lactam compound

Аксеф: Definition and Pharmacological Classification

Аксеф is a second-generation cephalosporin antibiotic. This classification places it within a structurally advanced group of compounds, enabling it to possess a wide spectrum of activity against both gram-positive and gram-negative bacteria, while also possessing enhanced stability against certain bacterial enzymes compared to first-generation agents. Pharmacological profiles indicate that Cefuroxime demonstrates antimicrobial action against susceptible pathogens, supporting its use in treating various infections. The active compound is recognized as an essential medicine and is structurally a beta-lactam compound.

Compositional Forms and Mechanism

The active agent exists in two primary chemical forms to suit different patient needs: Cefuroxime for parenteral delivery, such as intravenous or intramuscular injection/infusion, and Cefuroxime axetil for oral preparations, including film-coated tablets and granules for oral suspension. Cefuroxime axetil functions as an orally active prodrug, which the body absorbs and then converts into the active Cefuroxime compound. Regardless of the form, Аксеф acts as a bactericidal agent intended to resolve infection. It achieves this by causing the destruction of susceptible bacteria through the inhibition of bacterial cell wall synthesis, which is the mechanism by which it addresses the underlying infectious process.

Regulatory References

  1. WHO Essential Medicines List (Cefuroxime)
  2. WHO Model List
  3. EMA Cefuroxime Axetil Referral
  4. EMA Cefuroxime Axetil Prodrug Information

What side effects are possible with Аксеф?

Possible Side Effects and Safety Information

This section describes the adverse reactions and safety constraints for Аксеф (Cefuroxime Axetil), as documented in authoritative regulatory sources.


Frequency-Classified Adverse Reactions

Adverse reactions are formally grouped by how often they occur:

  • Common (ge 1/100 to < 1/10): These include Candida overgrowth, headache, dizziness, diarrhea, nausea, and transient increases in liver enzymes.
  • Uncommon (ge 1/1,000 to < 1/100): Vomiting, abdominal pain, skin rash, and urticaria.
  • Rare to Very Rare: Serious reactions such as pseudomembranous colitis and severe skin reactions (Stevens-Johnson syndrome and Toxic epidermal necrolysis).

System-Organ-Class (SOC) Groupings

Side effects are classified by the part of the body affected, including Gastrointestinal Disorders, Blood and Lymphatic System Disorders (e.g., eosinophilia, thrombocytopenia), Nervous System Disorders, and Immune System Disorders.


Serious Adverse Reactions

Documented clinically significant adverse reactions include Anaphylaxis (a severe allergic reaction), Hemolytic Anemia, and the potential for Convulsions or Encephalopathy, particularly in patients with pre-existing renal impairment where dosage is not adjusted.


Safety Constraints and Considerations

  • Contraindications: Аксеф is contraindicated in patients with a history of severe hypersensitivity to any cephalosporin or other beta-lactam antibiotics (e.g., penicillins).
  • Population Specifics: Dosage adjustment is explicitly required for patients with significant renal impairment (creatinine clearance < 30 ml/min). Use during pregnancy and lactation requires caution, and the label notes excretion into breast milk.
  • Other Notes: The potential for superinfection (e.g., Candida) is noted with use. Аксеф may also interfere with certain laboratory tests, causing a false positive Coombs' test and interference with non-enzymatic urinary glucose tests.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdosage of the active substance Cefuroxime is primarily associated with the risk of neurological toxicity resulting from excessive serum levels. The official regulatory documents cite potential neurological sequelae that may include encephalopathy, convulsions (seizures), and coma as severe manifestations of overexposure.

A notable risk factor for increased toxicity is renal impairment. Overdose symptoms are more likely to occur if the standard dose is not appropriately reduced in patients with markedly impaired kidney function, as this slows the body’s ability to excrete the drug.

Required Emergency Action

In any case of suspected overdose, official guidance dictates that the individual must seek immediate medical attention.

When Urgent Help is Required (Label-Derived Phrasing):

  • Call emergency services (e.g., 911) immediately if the affected person has collapsed, is experiencing trouble breathing, or cannot be awakened.
  • Contact the poison control helpline.

Management and Procedural Notes

The regulatory information states that no specific antidote is known for Cefuroxime overdose. Management involves symptomatic and supportive treatment. Procedures such as haemodialysis and peritoneal dialysis are documented as methods that can effectively reduce the concentration of Cefuroxime in the body.

Therapeutic Uses of Аксеф

Main Uses and Therapeutic Benefits of Аксеф (Cefuroxime)

Аксеф (Cefuroxime) is commonly used across therapeutic domains to manage bacterial infections presenting with symptoms related to heightened physiological activity that interfere with daily functioning. It is applied in addressing the underlying infectious cause. It may assist in easing the overall symptom load and support general well-being during symptomatic phases. The medication is utilized across a wide range of bacterial illnesses.

The therapeutic scope encompasses infections such as bacterial pneumonia, acute sinusitis, otitis media (ear infection), and tonsillitis, alongside severe systemic conditions like septicemia and site-specific illnesses like early Lyme disease and uncomplicated urinary tract infections. Applied in clinical settings that involve acute or unstable symptom patterns, it provides supportive relief when symptoms interfere with routine activities.

“Аксеф is relevant in contexts where groups of symptoms, including fever, pain, and inflammation, may be part of symptomatic management.”

Its application often occurs during phases when symptoms become more noticeable, providing short-term symptomatic assistance. This approach may contribute to improved day-to-day comfort and assists with maintaining functional stability when symptoms are particularly disruptive.


Quick Fact: Relief for Acute Discomfort
Аксеф is applied when appropriate for conditions characterized by periods of heightened symptoms where symptoms create noticeable physiological strain on the respiratory system or affected tissues.

Regulatory References

  1. NIH StatPearls overview on Cefuroxime

Eligibility and Restrictions for Use

Who can and cannot use Аксеф?

The eligibility for using Аксеф (Cefuroxime) is strictly defined by regulatory documents, focusing on patient status and allergy history.

Absolute Non-Eligibility (Contraindications): Use is strictly prohibited for individuals with known severe hypersensitivity to cephalosporin antibiotics or a history of severe allergic reactions to any other β-lactam antibacterial agent, such as penicillins.

Age and Developmental Stage: The oral formulation is generally approved for adults, adolescents, and pediatric patients ≥ 3 months. Use is not established in infants younger than 3 months. Geriatric patients do not typically require dose adjustment based on age alone.

Conditional and Restricted Use:

  • Renal Impairment: Patients with marked renal impairment (Creatinine Clearance ≤ 30 mL/min) require a mandated reduced dosage regimen, as the medicine is eliminated by the kidney.
  • Comorbidities: The oral suspension is contraindicated in patients with Phenylketonuria (PKU) due to its composition. Tablets are unsuitable for patients unable to swallow them whole.
  • Pregnancy/Lactation: Use during pregnancy and breastfeeding is permitted only after a thorough conditional risk-benefit assessment, as the medicine is excreted in breast milk.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Cefuroxime (Аксеф) is structured by pharmacokinetic changes, pharmacodynamic effects, and specific regulatory constraints.

Pharmacokinetic and Pharmacodynamic Interactions

Interacting Substance/Class Official Interaction Description Classification
Probenecid Co-administration is not recommended as it inhibits renal tubular secretion, significantly increasing the Cefuroxime plasma concentration (AUC and C max). Renal Clearance Competition
Drugs that reduce gastric acidity (e.g., Antacids, PPIs) Lower the bioavailability of Cefuroxime axetil due to reduced dissolution. This effect can cancel the enhanced absorption achieved after food. Absorption Reduction
Oral Anticoagulants (e.g., Warfarin) Concomitant use may give rise to an increased International Normalized Ratio (INR). Coagulation Effect
Combined Oral Contraceptives May have reduced efficacy because Cefuroxime can affect gut flora, leading to lower estrogen reabsorption. Efficacy Reduction

Administration and Test Constraints

The Cefuroxime axetil oral suspension form must be taken with meals for proper absorption. Additionally, Cefuroxime can cause false positive results for glucose in urine tests using copper reduction methods and false negative results in the ferricyanide test for blood glucose. A false positive Direct Coombs test has also been reported.

Mechanism of Action

Аксеф is a selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme. The mechanism involves high-affinity binding to the active site of COX-2, which is structurally induced upon local cellular irritation and inflammation. This targeted interaction competitively prevents the conversion of the enzyme's substrate, arachidonic acid, into unstable prostaglandin precursors.

The subsequent decrease in intermediate metabolites, primarily prostaglandin G2 and H2, results in the modulation of the pro-inflammatory signaling cascade at the cellular level. This localized biochemical effect restricts the biosynthesis and release of downstream prostanoid mediators, such as prostacyclin and thromboxanes. The overall effect is the confinement of excessive localized biochemical signaling in the affected tissue, which represents the pure pharmacodynamic action.

Dosage and Administration Information

How to Use Аксеф (Cefuroxime): Official Administration Guidelines

The usage of Аксеф, which contains the antibiotic Cefuroxime, is defined by official protocols, allowing for flexible administration based on patient needs and clinical status. The medicine is available for both oral administration, as Cefuroxime axetil tablets and suspensions, and parenteral delivery via intravenous (IV) or intramuscular (IM) injection/infusion as Cefuroxime sodium.


Standard Dosing and Frequency

Standard oral regimens typically require the administration of Cefuroxime axetil twice daily (every 12 hours). Parenteral dosing, used for moderate to severe infections, is typically administered every 8 hours in doses ranging from 750 mg to 1.5 g. Treatment duration is determined by the specific infection but commonly ranges from 5 to 10 days, with longer courses up to 21 days reserved for conditions like Early Lyme disease.


Administration Requirements

The oral form (Cefuroxime axetil) must be taken with food to ensure its proper absorption into the body. Conversely, the parenteral powder for injection must be reconstituted using specific official diluents before IV or IM use. When administered intramuscularly, the dosage should not exceed 750 mg per single injection site.


Population-Specific Adjustments

Clinical instructions mandate dosage modification for adults with impaired renal function, specifically when the creatinine clearance (CrCl) is le 20 mL/min. No dose adjustment is generally required solely based on hepatic function. Following the established protocol, patients often transition from initial IV/IM therapy to the oral form, known as sequential therapy, upon evidence of clinical improvement.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Аксеф (Cefuroxime)

This overview summarizes the official research evidence, including findings from clinical trials and meta-analyses, to provide a descriptive look at the established study contexts for Cefuroxime. It focuses on what types of studies exist and what their reported outcomes suggest, without providing advice or interpreting individual results.


Evidence for Use in Respiratory and Ear/Throat Infections

Research has explored the use of Cefuroxime in contexts related to systemic or functional imbalance, such as lower respiratory tract infections (LRTIs). Examples of conditions studied in this category are community-acquired pneumonia and acute exacerbations of chronic bronchitis. These studies typically use short-term Randomized Controlled Trials (RCTs) to compare Cefuroxime against other standard antibiotic treatments. Researchers monitored outcomes like clinical response (noting measurements of resolution or non-resolution) and the monitoring of the target bacteria (bacteriological clearance). Comparative trials reported that the outcomes measured were consistent with those observed in groups receiving other agents studied in this context.

Similarly, studies explored the medicine's use for upper respiratory tract infections (URTIs), including acute otitis media (AOM), pharyngitis, tonsillitis, and acute sinusitis. Research highlights changes measured during the study period for conditions like pharyngitis. Findings were mixed in some trials for non-severe sinusitis when compared to a placebo, which highlights the challenge in trial design of distinguishing outcomes related to bacterial causes from those related to self-limiting, potentially viral illnesses.


Evidence for Use in Specific Systemic and Skin Infections

Аксеф was studied for and is commonly recognized in research regarding early Lyme disease, which typically presents as a localized rash known as erythema migrans. Research utilized RCTs comparing Cefuroxime to other established oral treatments studied for this specific stage of the illness. Outcomes tracked were the measurement of changes in the rash and monitoring for the subsequent development of complications like neurological or cardiac issues. Research has explored its application in uncomplicated urinary tract infections (UTIs) and certain skin and soft tissue infections (SSTIs).

For severe, systemic infections, the primary evidence often relies on historical RCTs and observational data. The studies monitored physiological strain and overall patient outcomes, including measures of stability and overall outcome. Comparative evidence is lacking in modern settings, as current hospital guidelines often prioritize newer agents or specific combination therapies for the most severe cases.


What is Still Uncertain About Аксеф Research

While Cefuroxime was studied for a wide range of common infections, evidence is limited for long-term outcomes across most indications, as the focus is appropriately on treating the acute phase of the infection. Data for certain subgroups remain insufficient, such as those encompassing defined patient groups or those with complex co-morbidities.

Key Studies & References

  1. WHO Model List of Essential Medicines
  2. Cefuroxime Axetil: An Overview of the Evidence and Mechanisms (NIH StatPearls)
  3. Efficacy and Safety of Cefuroxime Axetil in the Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis

Frequently Asked Questions (FAQ)

Common questions about Аксеф (FAQ)

Q: What is the main difference between Аксеф and other common antibiotics?

A: According to the official product information, Аксеф is classified as a second-generation cephalosporin antibiotic. This classification means it belongs to a specific structural family that is distinct from other common antibiotics, such as penicillins or macrolides.


Q: Can Аксеф be taken for a cold or the flu?

A: Regulatory documents state that Аксеф is an antibacterial medicine used to treat infections caused by bacteria. Therefore, it is not indicated for use against viral illnesses, such as the common cold or influenza (the flu).


Q: Does Аксеф cause drowsiness or affect my ability to drive?

A: Official documents advise that the ability to safely drive or operate machinery may be affected if side effects like dizziness or headache occur. While dizziness is a common side effect, drowsiness itself is not typically listed as a frequent effect.


Q: What should I do if I miss a dose of Аксеф?

A: Regulatory labels generally contain instructions about managing missed doses. If a dose is missed, the patient information typically advises taking it as soon as it is remembered, unless the time for the next scheduled dose is already near.


Q: How do I know if the side effects I'm feeling are serious?

A: Official safety documents describe serious adverse reactions that have been reported, which include severe allergic reactions like anaphylaxis (swelling or difficulty breathing). Other serious reactions noted are severe skin reactions (like Stevens-Johnson syndrome) and neurological effects such as convulsions.


Q: Are there any common foods or drinks that should be avoided when taking Аксеф?

A: Regulatory documents specify that the oral form of Аксеф must be taken with food to ensure its proper absorption into the body. However, official information does not list any specific common foods or non-alcoholic drinks that must be strictly avoided during treatment.


Q: How long does Аксеф stay in your system after you stop taking it?

A: According to the official pharmacokinetics data, the medicine is described as being rapidly excreted from the body. It is primarily eliminated through the kidneys, and its plasma half-life is typically stated as approximately 1.2 to 1.5 hours in most adults.


Q: What are the possible long-term effects of taking Аксеф?

A: Because this medicine is typically used for short-term treatment of acute infections, official documents note that there is limited data available on long-term effects. Adverse reactions described include the potential for conditions like pseudomembranous colitis or fungal superinfections, which may occur during or after treatment.


Q: What happens if I drink alcohol while taking Аксеф?

A: Official regulatory documents and interaction lists do not describe a specific interaction or warning between the active substance, Cefuroxime, and alcohol consumption.


Q: Why is the full course of Аксеф needed even if symptoms improve quickly?

A: The regulatory guidelines for antibiotic use emphasize the importance of taking the full prescribed course of medicine, even if symptoms begin to improve quickly. This practice is supported to help ensure that the infection is completely resolved and to maintain the medicine’s overall effectiveness.


Q: What are the common signs of an allergic reaction to Аксеф?

A: Official documents describe signs of allergic reactions ranging from mild events like skin rash and hives (urticaria). Rare, severe reactions noted include anaphylaxis, which involves serious symptoms like swelling of the face, throat, or difficulty breathing.


Q: Is there any research about Аксеф's use in specific patient groups?

A: Regulatory documents provide specific details on its use in certain populations, including children 3 months of age and geriatric patients. Furthermore, they outline mandated dosage adjustments for patients with impaired renal function due to how the medicine is eliminated from the body.


Q: Do studies suggest that Аксеф is effective for all types of bacterial infections?

A: Studies and official product information describe Аксеф as having a wide spectrum of activity against many types of bacteria. However, its use is restricted to treating infections where the causative bacteria are known or suspected to be susceptible to Cefuroxime.


Q: How should Аксеф be stored, and does it expire?

A: Official regulatory documents specify the shelf life of the product, which defines when it expires. The documents also outline detailed storage requirements for its various forms, including control of temperature and protection from light and moisture.


Q: Why is Аксеф prescribed over an injection?

A: The choice between the oral and injection forms is described as being related to the severity and type of infection being treated. The medicine is also used in a process known as sequential therapy, where treatment may begin with an injection and transition to the oral form upon evidence of improvement.


Q: Can I stop taking Аксеф if I develop diarrhea?

A: While diarrhea is listed as a common side effect in regulatory documents, the occurrence of severe, persistent diarrhea is noted in regulatory warnings as a potential sign of a rare, serious intestinal condition called pseudomembranous colitis.


Q: Does Аксеф interact with antacids or iron supplements?

A: Official documents note that medicines that reduce gastric acidity, such as antacids, can affect the absorption of the oral form of Аксеф. However, regulatory interaction lists do not typically include a specific warning regarding iron supplements.


Q: Are there any known drug interactions with common heart medications?

A: Official documents describe an interaction with oral anticoagulants, which are often used to prevent blood clots in people with certain heart conditions. This interaction may result in an increased International Normalized Ratio (INR), which is a measure of blood clotting time.


Q: Is it possible to develop a resistance to Аксеф over time?

A: Regulatory documents and official product information address the potential for bacteria to develop resistance to the medicine. This is a general characteristic of antibiotics that influences their long-term effectiveness.


Q: Do official documents mention any connection between Аксеф and tendon issues?

A: The regulatory adverse reaction profile for Аксеф (Cefuroxime) does not list tendon disorders such as tendonitis or tendon rupture as an expected adverse effect.


Q: What is known about the research phases and approval history of Аксеф?

A: The medicine has an established history, reflected by its inclusion on the World Health Organization Model List of Essential Medicines. Furthermore, regulatory documents cite various historical clinical trials and studies supporting its current approved uses.


Q: Why do some people experience stomach upset with Аксеф?

A: Official documents describe that Cefuroxime acts by disrupting bacterial cell wall synthesis, which is its method of fighting infection. This action may inadvertently affect the normal balance of the gut flora, which can lead to common gastrointestinal side effects like diarrhea and nausea.


Q: Can Аксеф cause changes in mood or behavior?

A: Adverse reactions noted in the regulatory documents are listed for the nervous system, including common effects like dizziness and headache. While rare, serious effects like convulsions are noted, official documents do not list specific changes in mood or behavior as expected effects.


Q: What types of bacteria is Аксеф most effective against, according to research?

A: Official documents list a range of susceptible bacteria against which Аксеф is effective, according to laboratory and clinical research. Examples of these bacteria include Streptococcus pneumoniae and Haemophilus influenzae.


Q: Is there a maximum duration of time that a person should take Аксеф?

A: Official regulatory documents provide a range of typical treatment durations, often 5 to 10 days. They also provide specific maximum durations for certain conditions, such as up to 21 days for Early Lyme disease, but no single absolute maximum duration for all approved uses.


Q: Are there restrictions on exposure to sunlight while taking Аксеф?

A: The regulatory adverse reaction profile for Аксеф (Cefuroxime) does not list photosensitivity as an expected side effect. Consequently, the official product information does not contain a specific sun exposure restriction warning.


Q: Can people with a history of seizures take Аксеф?

A: The regulatory label notes the potential for convulsions as a rare side effect, particularly in patients with existing impaired renal function where dosage is not adjusted. The official documents do not provide specific guidance on eligibility solely based on a pre-existing seizure history.


Q: What should I do if I accidentally take two doses of Аксеф close together?

A: Regulatory documents describe that taking a quantity exceeding the prescribed dose has been associated with the potential for neurological effects. These effects include a reported risk of convulsions, particularly in individuals who may have pre-existing kidney issues.


Q: Is Аксеф a sulfa drug?

A: Аксеф (Cefuroxime) is classified as a cephalosporin and a beta-lactam antibiotic. The official pharmacological classification confirms that it is not a sulfonamide (sulfa) drug.


Q: Does taking Аксеф affect blood sugar levels?

A: Official documents specify that the medicine is documented to interfere with certain non-enzymatic urinary glucose tests, potentially leading to false positive results. The information does not state that Аксеф physiologically affects the body's actual blood sugar levels.

How should Аксеф be stored and disposed of?

How to Store and Dispose of Аксеф

Official storage and disposal requirements for Аксеф (Cefuroxime) are strictly defined by the regulatory status of its form (oral or parenteral).

Labeled Storage Component Official Regulatory Requirement
Parenteral Powder Temperature Must not be stored above 25 C for the dry powder form.
Protection Requirements The powder vial must be kept in the outer carton to protect from light. Oral tablets must be stored in the original packaging to protect from moisture.
Stability After Reconstitution Solutions for injection have a short, limited stability period, typically 24 hours at 2 to 8 C (refrigerated), after which they must be discarded.
Handling Prohibition Thawed frozen solutions for infusion must not be refrozen.
Disposal Instructions Any unused medicinal product or waste material must be disposed of in accordance with local requirements. Do not dispose of via household waste or wastewater.

The regulatory profile dictates that the environment must be controlled to maintain product integrity, with specific constraints for both temperature and light/moisture exposure. Unused products, especially time-limited solutions, must be discarded according to mandated local pharmaceutical waste rules.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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