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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 27.03.2022
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Top 20 medicines with the same components:
Ammonium chloride (Rexon) Injection, USP, after dilution in isotonic sodium chloride injection, may be indicated in the treatment of patients with (1) hypochloremic states and (2) metabolic alkalosis.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Diphenhydramine hydrochloride (Rexon) in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when Diphenhydramine hydrochloride (Rexon) in the oral form is impractical.
Antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
Motion sickness: For active treatment of motion sickness.
Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Prophylaxis & treatment of cystine & uric acid renal calculi. Urinary alkalizer in gout therapy. Treatment of acidosis in renal tubular disorders; chronic metabolic acidosis resulting from chronic renal insufficiency or the syndrome of renal tubular acidosis especially when administration of K salts is contraindicated. Prophylactic agent for acid-aspiration pneumonitis. Used in pre-anaesth medication as a non-particulate acid-neutralizing buffer of gastric acid to lessen the danger from acid-aspiration pneumonitis.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Oral
Productive cough
Adult: Usually used in combination preparations. Dose may range from 85-130 mg, taken 3-4 times daily.
Preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough. It may also relieve itching of the skin and allergic skin reactions. It is also used to treat and prevent motion sickness. It may also be used for other conditions as determined by your doctor.
Diphenhydramine hydrochloride (Rexon) is an antihistamine and anticholinergic. It works by blocking the action of histamine, reducing the symptoms of an allergic reaction. It also works in the brain to cause sedation.
Relieving minor pain caused by conditions such as arthritis, backache, bruising, bursitis, cramping, muscle strains or sprains, and tendonitis. It may also be used for other conditions as determined by your doctor.
Menthol (Rexon) lotion is a topical analgesic. It works by temporarily relieving minor pain.
Citric acid and Sodium citrate (Rexon) are both alkalinizing agents that make the urine less acidic.
The combination of citric acid and Sodium citrate (Rexon) is used to prevent gout or kidney stones, or metabolic acidosis in people with kidney problems.
Citric acid and Sodium citrate (Rexon) may also be used for other purposes not listed in this medication guide.
Ammonium chloride (Rexon) Injection, USP is administered intravenously and must be diluted before use. Solutions for intravenous infusion should not exceed a concentration of 1% to 2% of Ammonium chloride (Rexon).
Dosage is dependent upon the condition and tolerance of the patient. It is recommended that the contents of one to two vials (100 to 200 mEq) be added to 500 or 1000 mL of isotonic (0.9%) sodium chloride injection. The rate of intravenous infusion should not exceed 5 mL per minute in adults (approximately 3 hours for infusion of 1000 mL). Dosage should be monitored by repeated serum bicarbonate determinations.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.
A single oral dose of Diphenhydramine hydrochloride (Rexon) is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of Diphenhydramine hydrochloride (Rexon) is from four to six hours.
Always use a calibrated measuring device when administering Diphenhydramine hydrochloride (Rexon) to ensure the dose is measured and administered accurately.
Adults
Take 10 mL - 20 mL (25mg-50mg) three or four times daily. The nighttime sleep-aid dosage is 20 mL (50mg) at bedtime. Maximum daily dosage not to exceed 120 mL (300mg).
Pediatric Patients (over 20 lbs.)
Take 5 mL to 10 mL (12.5mg-25mg) three to four times daily. Maximum daily dosage not to exceed 120 mL (300mg). For physicians who wish to calculate the dose on the basis of body weight or surface area, the recommended dosage is 5 mg/kg/24 hours or 150 mg/m2/24 hours.
Data are not available on the use of Diphenhydramine hydrochloride (Rexon) as a nighttime sleep-aid in children under 12 years.
The basis for determining the most effective dosage regimen will be the response of the patient to medication and the condition under treatment.
In motion sickness, full dosage is recommended for prophylactic use, the first dose to be given 30 minutes before exposure to motion and similar doses before meals and upon retiring for the duration of exposure.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Related questions
- What is the difference between Diphenhydramine hydrochloride (Rexon) and Diphenhydramine hydrochloride (Rexon) citrate?
Medical Disclaimer
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
Adult: Add the contents of 1-2 sachets to a glass of cool water and mix. Sodium citrate (Rexon) may be taken up to 4 times daily. Do not take for >5 days unless advised to do so by the physician.
Adult : PO 85-130 mg 3-4 times/day.
Ammonium chloride (Rexon) is contraindicated in patients with severe impairment of renal or hepatic function.
Ammonium chloride (Rexon) should not be administered when metabolic alkalosis due to vomiting of hydrochloric acid is accompanied by loss of sodium (excretion of sodium bicarbonate in the urine).
See also:
What is the most important information I should know about Diphenhydramine hydrochloride (Rexon)?
Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
Antihistamines are also contraindicated in the following conditions: Hypersensitivity to Diphenhydramine hydrochloride (Rexon) and other antihistamines of similar chemical structure.
See also:
What is the most important information I should know about Menthol (Rexon)?
Not to be used in
No known conditions.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
See also:
What is the most important information I should know about Sodium citrate (Rexon)?
Renal failure or hypernatremia; in conjunction with hexamine mandelate or hexamine hippurate therapy because an acidic urine is needed.
Caution is advised in overt and occult cardiac failure. Concomitant use of urinary alkalinizers and quinolone antibiotics should be avoided. Crystalluria may be more likely to occur in alkaline urine.
Use Diphenhydramine hydrochloride (Rexon) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Diphenhydramine hydrochloride (Rexon) by mouth with or without food.
- Use Diphenhydramine hydrochloride (Rexon) exactly as directed on the package, unless instructed differently by your doctor. If you are taking Diphenhydramine hydrochloride (Rexon) without a prescription, follow any warnings and precautions on the label.
- For prevention of motion sickness: Take at least 30 minutes before activity or travel.
- If you miss a dose of Diphenhydramine hydrochloride (Rexon) and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Diphenhydramine hydrochloride (Rexon).
Use Menthol (Rexon) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before and right after using Menthol (Rexon) spray.
- Spray Menthol (Rexon) spray directly onto the affected area. Do not rub or massage the medicine into the skin.
- Do not wrap, bandage, or use a heating pad on the treated area.
- Do not apply Menthol (Rexon) spray more than 4 times daily.
- If you miss a dose of Menthol (Rexon) spray, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use Menthol (Rexon) spray.
Use Sodium citrate (Rexon) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Sodium citrate (Rexon) after meals and at bedtime, unless directed otherwise by your health care provider.
- Shake well before using.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Mix Sodium citrate (Rexon) with water before swallowing. Follow with additional water, if desired.
- If you miss a dose of Sodium citrate (Rexon), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Sodium citrate (Rexon).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Ammonium chloride (Rexon) is used for the relief of cough in the form of cough expectorant. It is also used as an injection to treat patients with hypochloremia and metabolic alkalosis.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis; adjunct to epinephrine in the treatment of anaphylaxis; insomnia, occasional; prevention or treatment of motion sickness; antitussive; management of parkinsonian syndrome including drug-induced extrapyramidal symptoms (dystonic reactions) alone or in combination with centrally acting anticholinergic agents
Guideline recommendations:
Anaphylaxis: Antihistamines are considered second-line treatment only after epinephrine administration in the adjunct management of anaphylaxis (AAAAI [Lieberman 2015]).
Insomnia: American Academy of Sleep Medicine guidelines for the treatment of chronic insomnia suggest Diphenhydramine hydrochloride (Rexon) not be used for sleep-onset or sleep-maintenance insomnia in adults due to the absence of evidence for clinically significant improvement (AASM [Sateia 2017]).
Off Label Uses
Angioedema, allergic (acute)
Clinical experience suggests the utility of Diphenhydramine hydrochloride (Rexon) in the management of allergic angioedema.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Pharmaceutical Aid
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Anticoagulant:
Concentrate (triCitrasol): Anticoagulant used in granulocytapheresis procedures
Solution: Anticoagulant for use with cytapheresis device only
Off Label Uses
Regional anticoagulation for continuous renal replacement therapy circuit
Data from several small randomized, controlled trials support the use of regional Sodium citrate (Rexon) to reduce the risk of clot formation in continuous renal replacement therapy (CRRT) circuits, thus prolonging circuit life and avoiding interruptions in therapy. It should be noted that patients with high bleeding risk, severe coagulopathy, metabolic abnormalities, or liver dysfunction were excluded from these trials.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Terpin hydrate (Rexon) helps to loosen mucus. Codeine suppresses a cough. This combination medication is used to control a cough associated with a cold or other respiratory illnesses.
In a treatment, patients should be monitored closely for signs of ammonia poisoning: pallor, sweating, irregular breathing, vomiting, bradycardia, arrhythmias, tremors, convulsions and coma.
Ammonium chloride (Rexon) should be used with caution in patients with heart and lung failure.
A longer-term correction of a hypochloraemia in patients with secondary metabolic alkalosis due to an intracellular potassium depletion can not be achieved by the sole administration of Ammonium chloride (Rexon). Concomitant administration of potassium is also necessary.
See also:
What other drugs will affect Diphenhydramine hydrochloride (Rexon)?
When Diphenhydramine hydrochloride (Rexon) applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of Diphenhydramine hydrochloride (Rexon) and MAO inhibitors increase the anticholinergic activity of Diphenhydramine hydrochloride (Rexon).
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.
Tell your doctor of any over-the-counter or prescription medication you may take including: blood thinners.
Do not start or stop any medicine without doctor or pharmacist approval.
See also:
What other drugs will affect Sodium citrate (Rexon)?
General: Alkalinization of the urine due to the use of Sodium citrate (Rexon), theoretically, may result in a decreased therapeutic effect of the following medications: Chlorpropamide, lithium, salicylates and tetracyclines. Alternatively, alkalinization of the urine due to the use of Sodium citrate (Rexon), theoretically, may result in an increased therapeutic effect of the following medications: Amphetamines, ephedrine/pseudoephedrine.
Antacids: Concurrent use of antacids with citrates may result in systemic alkalosis. Concomitant administration of antacids with Sodium citrate (Rexon) and sodium bicarbonate may promote the development of calcium stones in patients with uric acid stones and may also cause hypernatremia. Concurrent use of aluminum-containing antacids with citrate salts can increase aluminum absorption, possibly resulting in acute aluminum toxicity, especially in patients with renal insufficiency.
Quinolones: Citrates may reduce the solubility of ciprofloxacin, norfloxacin or ofloxacin in the urine. Patients should be observed for signs of crystalluria and nephrotoxicity.
Laxatives: Concurrent administration of citrates with laxatives may have an additive effect.
May potentiate other CNS depressants. Action may be prolonged by MAOIs.
See also:
What are the possible side effects of Ammonium chloride (Rexon)?
Rapid intravenous administration of Ammonium chloride (Rexon) may be accompanied by pain or irritation at the site of injection or along the venous route.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia (from large volume diluent).
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
See also:
What are the possible side effects of Diphenhydramine hydrochloride (Rexon)?
The most frequent adverse reactions are underscored.
- General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of the mouth, nose and throat.
- Cardiovascular System: Hypotension, headache, palpitations, tachycardia, extrasystoles.
- Hematologic System: Hemolytic anemia, thrombocytopenia, agranulocytosis.
- Nervous System: Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, neuritis, convulsions.
- GI System: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation.
- GU System: Urinary frequency, difficult urination, urinary retention, early menses.
- Respiratory System: Thickening of bronchial secretions, tightness of chest or throat and wheezing, nasal stuffiness.
To report SUSPECTED ADVERSE REACTIONS, contact Foxland Pharmaceuticals, Inc. at 1-844-430-7499 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
See also:
What are the possible side effects of Menthol (Rexon)?
May cause hypersensitivity reactions such as cutaneous dermatitis. Ingestion of large amount of Menthol (Rexon) may cause GI effects such as severe abdominal pain, nausea, vomiting, vertigo, ataxia, drowsiness and coma.
See also:
What are the possible side effects of Sodium citrate (Rexon)?
The tartrate component of Sodium citrate (Rexon) may be incompletely absorbed. Because of this Sodium citrate (Rexon) may be exert a mild laxative effect. Prolonged and excessive use may cause a systemic alkolosis and / or hypernatremia.
Vomiting, Nausea, Skin rash, Allergic reaction, Bradycardia, Confusion, Dizziness, Drowsiness, Shortness of breath, Epigastric pain, Loss of appetite, Mood changes, Rash
Diphenhydramine hydrochloride (Rexon) is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Menthol (Rexon) is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of Menthol (Rexon) occurring in nature is (-)-Menthol (Rexon), which is assigned the (1R,2S,5R) configuration. Menthol (Rexon) has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
Each 4 g of Sodium citrate (Rexon) contains sodium bicarbonate 1760 mg, anhydrous Sodium citrate (Rexon) 630 mg, anhydrous citric acid 720 mg and tartaric acid 890 mg.
It also contains the following excipients: Nature identical lemon flavor oil, terpeneless and sodium saccharin.
Sodium citrate (Rexon) consists of formulation and pleasantly flavored granules. When added to water, Sodium citrate (Rexon) effervesces and dissolves, forming a clear or orange-colored alkaline solution.