Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 2020-03-26
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Quick Lotion is indicated for patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
- Apply Quick Lotion on DRY hair in amount just sufficient to thoroughly wet the hair and scalp. Pay particular attention to the back of the head and neck while applying Quick Lotion. Wash hands after appl ying to scalp.
- Allow hair to dry naturally - use no electric heat sou rce, and allow hair to remain uncovered.
- After 8 to 12 hours, the hair should be shampooed.
- Rinse and use a fine - toothed (nit) comb to remove dead lice and eggs.
- If lice are still present after 7 - 9 days, repeat with a second application of Quick Lotion.
Further treatment is generally not necess ary. Other family members should be evaluated by a physician to determine if infested, and if so, receive treatment.
Quick Lotion is contraindicated for neonates and infants because their scalps are more permeable and may have increased absorption of malathion. Quick Lotion should also not be used on individuals known to be sensitive to malathion or any of the ingredients in the vehicle.
- Quick Lotion is flammable. The lotion and wet hair should not be exposed to open flames or electric heat sources, including hair dryers and electric curlers. Do not smoke while applying lotion or while hair is wet. Allow hair to dry naturally and to remain uncovered after application of Quick Lotion.
- Quick Lotion should only be used on children under the direct supervision of an adult.
- If Quick Lotion comes into contact with the eyes, flush immediately with water. Consult a physician if eye irritation persists.
- If skin irritation occurs, discontinue use of product until irritation clears. Reapply the Quick Lotion, and if irritation reoccurs, consult a physician.
- Chemical burns including second-degree burns and stinging sensations may occur with the use of Quick Lotion.
Keep out of reach of children. Close eyes tightly during product application. If accidentally placed in the eye, flush immediately with water. Use only on scalp hair.
There are no special laboratory tests needed in order to use this medication.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Carcinogenesis, mutagenesis and impairment of fertility have not been studied with Quick Lotion (0.5% pharmaceutical grade malathion). However, followi ng long-term oral administration of technical grade malathion to rodents via dietary supplementation, increased incidences of hepatocellular neoplastic lesions were observed in B6C3F1 mice dosed for 18 months at malathion doses greater than 1500 mg/kg/day, and in female F344 rats dosed for 2 years at malathion doses greater than 4 00 mg/kg/day. These tumors occurred only in association with severe hepatic toxicity and chronic suppression of acetylcholinesterase activity, or at doses causing excessive mortality. Based on body surface area, doses at which carcinogenic effects were observed in rodents following life-time exposures to malathion were approximately 14- to 26-fold greater than the maximum dose anticipated in a 10 kg child following a single use of Quick Lotion, assumi ng 100% bioavailability. Actual systemic exposures are expected to be less than 10% of the administered dose.
The malathion of greater than pharmaceutical-grade purity used in Quick Lotion has not been tested for genotoxicity. The technical-grade malathion (95% pure) was found to be negative in Salmonella typhimurium, equivocally positive in the mouse lymphoma cell assay, and positive in in vitro chromosomal aberration and sister chromatid exchange assays. Fifteen separate in vitro gene mutation studies with malathion of unknown purity have reported negative results, while three studies reported malathion to be mutagenic in bacterial cells. Both technical grade (94–96.5%) and purified (98-99%) malathion have been reported to cause chromosomal aberrations and sist er chromatid exchanges in vitro in human and hamster cell lines. In vivo chromosomal aberration and micronucleus studies of technical-grade malathion are reported to be positive, whereas an in vivo chromosomal aberration study of > 99% pure malathion was reported to be negative. Furthermore, mice exposed to malathion in their drinking wate r for 7 weeks demonstrated no evidence of chromosome damage in bone marrow cells, spermatogonia, or primary spermatocytes. Lack of details makes independent evaluation of the results of these assays impossible. Ashby and Purchase have suggested that impurities may be responsible for some of the observed genetic activity of malathion.
Reproduction studies performed with malathion in rats at doses over 180 fold greater than those anticipated in a 60 kg adult (based on body surface area and assuming 100% bioavailability) revealed no evidence of impaired fertility.
Pregnancy Category B. There was no evidence of teratogenicity in studies in rats and rabbits at doses up to 900 mg/kg/day and 100 mg/kg/day malathion, respectively. A study in rats failed to show any gross fetal abnormalities attributable to feeding malathion up to 2,500 ppm (~ 200 mg/kg/day) in the diet during a three - generation evaluation period. These doses were approximately 40 to 180 times higher than the dose anticipated in a 60 kg adult (based on body surface area and assuming 100% bioavailability). Because animal reproduction studies are not always predictive of human responses, this drug should be used (or handled) during pregnancy only if clearly needed.
Malathion in an acetone vehicle has been reported to be absorbed through human skin to the extent of 8% of the applied dose. However, percutaneous absorption from the Quick® (malathion) Lotion, 0.5% formulation has not been studied, and it is not known whether malathion is excreted in human milk. Because many drugs are excreted in h uman milk, caution should be exercised when Quick Lotion is administered to (or handled by) a nursing mother.
The safety and effectiveness of Quick Lotion in children less than 6 years of age has not been established via well-controlled trials.
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Malathion has been shown to be irritating to the skin and scalp. Other adverse reactions reported ar e chemical burns including second-degree burns. Accidental contact with the eyes can result in mild conjun ctivitis. It is not known if Quick Lotion has the potential to cause contact allergic sensitization.
Consideratio n should be given, as part of the treatment program, to the high concentration of isopropyl alcohol in the vehicle.
Malathion, although a weaker cholinesterase inhibitor than some other organophosphates, may be expected to exhibit the same symptoms of cholinesterase depletion after accidental ingestion orally. If accidentall y swallowed, vomiting should be induced promptly or the stomach lavaged with 5% sodium bicarbonate solution.
Severe respiratory distress is the major and most serious symptom of organophosphate poisoning re quiring artificial respiration, and atropine may be needed to counteract the symptoms of cholinesterase depletion.
Repeat analyses o f serum and RBC cholinesterase may assist in establishing the diagnosis and formulating a long - ra nge prognosis.