Procart

Glucosamine sulphate (Procart) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since Glucosamine sulphate (Procart) is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental Glucosamine sulphate (Procart) may help to rebuild cartilage and treat arthritis.

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, Vitamin C (Procart), functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C (Procart) is considered an antioxidant.

Vitamin D3 (Procart) (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from cholecalciferol in having a double bond between C22 and C23 and a methyl group at C24.

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Vitamin E (Procart)&

Osteoarthritis & rheumatoid arthritis.

For systemic use of Vitamin C (Procart): prevention and treatment of hypo- and avitaminosis of Vitamin C (Procart); providing increased need for Vitamin C (Procart) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Vitamin D3 (Procart) has an important role in energize the intestinal absorption for calcium and phosphor, to regulate their metabolism and balance in blood. It helps bone calcification. Deficiency of Vitamin D3 (Procart) in the body causes deficiency of the calcium in the bone, weakness of its resistance and deformity.

Oral

Vitamin E (Procart) deficiency

Adult: 40-50 mg of d-α tocopherol daily.

Child: Neonate: 10 mg/kg once daily; 1 mth-18 yr: 2-10 mg/kg/day, up to 20 mg/kg.

Oral

Supplementation in cystic fibrosis

Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.

Child: As α- tocopheryl acetate: 1 mth-1 yr 50 mg once daily; 1-12 yr 100 mg once daily; 12-18 yr 200 mg once daily. Dose to be adjusted as needed.

Oral

Abetalipoproteinaemia

Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.

Child: Neonate: 100 mg/kg once daily; 1 mth-18 yr: 50-100 mg/kg once daily.

Glucosamine sulphate (Procart) is sugar protein that helps your body build cartilage (the hard connective tissue located mainly on the bones near your joints).

Glucosamine sulphate (Procart) is a naturally occurring substance found in bones, bone marrow, shellfish and fungus.

Glucosamine sulphate (Procart) has been used in alternative medicine as an aid to relieving joint pain, swelling, and stiffness caused by arthritis.

Not all uses for Glucosamine sulphate (Procart) have been approved by the FDA. Glucosamine sulphate (Procart) should not be used in place of medication prescribed for you by your doctor.

Glucosamine sulphate (Procart) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Glucosamine sulphate (Procart) may also be used for purposes not listed in this product guide.

Ascorbic acid (Vitamin C (Procart)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Vitamin C (Procart) is important for bones and connective tissues, muscles, and blood vessels. Vitamin C (Procart) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid is used to treat and prevent Vitamin C (Procart) deficiency.

Ascorbic acid may also be used for purposes not listed in this medication guide.

Cholecalciferol is a Vitamin D3 (Procart). Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Cholecalciferol is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones.

Cholecalciferol may also be used for purposes not listed in this medication guide.

Vitamin E (Procart) is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E (Procart) is a fat-soluble vitamin important for many processes in the body.

Vitamin E (Procart) is used to treat or prevent Vitamin E (Procart) deficiency. People with certain diseases may need extra Vitamin E (Procart).

Vitamin E (Procart) may also be used for purposes not listed in this medication guide.

Adults: 1 capsule twice daily.

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions Vitamin C (Procart) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used ascorbic acid drugs in appropriate dosage forms.

1 tab daily.

Usual Adult Dose for Vitamin E (Procart) Deficiency

Treatment: 60 to 75 units orally once daily.

Prevention: 30 units orally once daily.

Usual Adult Dose for Tardive Dyskinesia

600 to 1600 units orally per day.

Usual Adult Dose for Sickle Cell Anemia

450 units orally per day.

Usual Adult Dose for Alzheimer's Disease

1000 units orally twice daily.

Usual Adult Dose for Dietary Supplement

Oral liquid formulation (Vitamin E (Procart)): 200 units (10 mL) orally once daily.

Usual Pediatric Dose for Vitamin E (Procart) Deficiency

1 unit/kg/day orally of water-miscible Vitamin E (Procart).

Usual Pediatric Dose for Retinopathy Prophylaxis

Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy: 15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (may need as high as 100 units/kg/day). Note: AAP considers this use investigational and routine use is not recommended.

Usual Pediatric Dose for Cystic Fibrosis

100 to 400 units/day orally.

Usual Pediatric Dose for Dietary Supplement

Dosing: 1 unit Vitamin E (Procart) = 1 mg dl-alpha-tocopherol acetate.

Oral:

Adequate Intake (AI):

1 to less than 6 months: 4 units daily

6 to less than 12 months: 5 units daily

Recommended Daily Allowance (RDA):

1 to 3 years: 6 units daily

4 to 8 years: 7 units daily

9 to 13 years: 11 units daily

13 years and Older: 15 units daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Although no longer available in the U.S., Vitamin E (Procart) injectable administered intravenously to premature infants may result in a potentially fatal syndrome consisting of thrombocytopenia, hepatomegaly, splenomegaly, ascites, and renal, hepatic, and pulmonary dysfunction.

Oral administration of large doses (200 mg per day) of a hyperosmolar Vitamin E (Procart) preparation to low-birthweight infants has been associated with the development of necrotizing enterocolitis.

Dialysis

Data not available

Other Comments

The oral liquid formulation (Vitamin E (Procart) [R]) is intended to enhance absorption in patients with conditions associated with malabsorption (e.g., Crohn's disease, ulcerative colitis ) or for patients who have difficulty swallowing capsules.

The oral liquid formulation (Vitamin E (Procart) [R]) may be taken directly or mixed with water or other beverage. It must be shaken well prior to each use and refrigerated after opening.

See also:
What is the most important information I should know about Glucosamine sulphate (Procart)?

Hypersensitivity to chondroitin sulphate, Glucosamine sulphate (Procart) sulphate or to any of the excipients of Glucosamine sulphate (Procart).

Glucosamine sulphate (Procart) contains sorbitol 1163 mg as excipient. Therefore, patients with rare hereditary problems of fructose intolerance should not take Glucosamine sulphate (Procart).

Glucosamine sulphate (Procart) is not indicated for the treatment of acute painful symptoms.

Since Glucosamine sulphate (Procart) is derived from seafood (shellfish), Glucosamine sulphate (Procart) should not be given to patients who are allergic to shellfish.

AV-block II and III degree, sinoatrial block, SSS, bradycardia (HR < 40 bpm), hypotension (in case of myocardial infarction, systolic blood pressure less than 100 mm Hg), cardiogenic shock, congestive heart failure IIB-III stages, acute heart failure, Prinzmetal's angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenolol.

Contraindications for vitamin D analogues (Vitamin D2, Vitamin D3 (Procart), Calcitriol, and Calcidiol)

Vitamin D should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Use of vitamin D in patients with known hypersensitivity to vitamin D (or drugs of the same class) or any of the inactive ingredients is contraindicated.

See also:
What is the most important information I should know about Vitamin E (Procart)?

Hypersensitivity to Vitamin E (Procart) or any component of the formulation

Use Glucosamine sulphate (Procart) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Dosing depends on the use and the source of the product.
• Use as directed on the package, unless instructed otherwise by your doctor.
• This product may take several weeks to months to work.
• If you miss taking a dose of Glucosamine sulphate (Procart) for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Glucosamine sulphate (Procart).

Glucosamine sulphate (Procart) is used in addition to other drugs to relieve joint pain, swelling and stiffness due to arthritis.

Ascorbic acid (Vitamin C (Procart)) is used to prevent or treat low levels of Vitamin C (Procart) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra ascorbic acid. Low levels of Vitamin C (Procart) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Vitamin C (Procart) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Vitamin C (Procart)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

Vitamin D3 (Procart) is used for the prevention and treatment of vitamin D deficiency. Vitamin D3 (Procart) is important for absorption of calcium in the body. It is also used to prevent bone disorders such as osteomalacia and rickets.

This supplement is used to prevent or treat a lack of Vitamin E (Procart) in the body. A low body level of Vitamin E (Procart) is rare. Most people who eat a normal diet do not need extra Vitamin E (Procart). However, Vitamin E (Procart) supplements are used in premature newborns and in people who have problems absorbing enough Vitamin E (Procart) from their diets. Vitamin E (Procart) is important in protecting your body's cells from damage. It is known as an antioxidant.

How to use Vitamin E (Procart)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using a liquid form of this product, carefully measure your dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than recommended. Taking too much Vitamin E (Procart) may increase your risk of side effects.

High doses of Vitamin E (Procart) (400 units or more per day) may increase the chance of rare but very serious side effects. There is no proof that high doses of Vitamin E (Procart) help to prevent or treat heart disease. There is very little evidence that it helps prevent or treat Alzheimer's disease. In some people, taking these high doses may even be harmful. Talk to your doctor or pharmacist and discuss the risks and benefits before taking Vitamin E (Procart) supplements.

If your doctor prescribes this product for Vitamin E (Procart) deficiency, use it regularly to get the most benefit from it. To help you remember, take it at the same time each day. You should see improvement of symptoms such as numbness/tingling of the hands/feet and weakness. If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

See also:
What other drugs will affect Glucosamine sulphate (Procart)?

No formal drug interaction studies have been performed, however, the physicochemical and pharmacokinetic properties of Glucosamine sulphate (Procart) sulphate suggest a low potential for interactions.

However, interactions between the active ingredients of Glucosamine sulphate (Procart) and other drug substances may occur ie, between Glucosamine sulphate (Procart) sulphate and coumarinic anticoagulants, Glucosamine sulphate (Procart) sulphate and tetracyclines, chondroitin sulphate and platelet antiaggregant drugs.

In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.

In an application of Vitamin C (Procart) with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.

Vitamin C (Procart) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of ascorbic acid in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

Interactions for vitamin D analogues (Vitamin D2, Vitamin D3 (Procart), Calcitriol, and Calcidiol)

Cholestyramine

Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; as such it may impair intestinal absorption of any of vitamin D

Phenytoin/Phenobarbital

The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism. Since blood level of calcitriol/ergocalcitriol will be reduced, higher doses of Rocaltrol may be necessary if these drugs are administered simultaneously

Thiazides

Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary

Digitalis

Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias

Ketoconazole

Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. Reductions in serum endogenous vitamin D concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with vitamin D have not been investigated

Corticosteroids

A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption

Phosphate-Binding Agents

Since vitamin D also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration

Vitamin D

The coadministration of any of the vitamin D analogues should be avoided as this could create possible additive effects and hypercalcemia

Calcium Supplements

Uncontrolled intake of additional calcium-containing preparations should be avoided

Magnesium

Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

See also:
What other drugs will affect Vitamin E (Procart)?

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): Vitamin E (Procart) (Systemic) may enhance the antiplatelet effect of Agents with Antiplatelet Properties. Monitor therapy

Anticoagulants: Vitamin E (Procart) (Systemic) may enhance the anticoagulant effect of Anticoagulants. Monitor therapy

CycloSPORINE (Systemic): Vitamin E (Procart) (Systemic) may decrease the serum concentration of CycloSPORINE (Systemic). Monitor therapy

Ibrutinib: Vitamin E (Procart) (Systemic) may enhance the antiplatelet effect of Ibrutinib. Monitor therapy

Orlistat: May decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of orlistat. Similar precautions do not apply to parenterally administered fat soluble vitamins. Consider therapy modification

Tipranavir: May enhance the adverse/toxic effect of Vitamin E (Procart) (Systemic). Management: Patients taking tipranavir oral solution are advised to avoid taking additional Vitamin E (Procart), beyond the amounts contained in a multivitamin product. This interaction does not apply to tipranavir capsules. Consider therapy modification

See also:
What are the possible side effects of Glucosamine sulphate (Procart)?

The clinical trials have shown the good tolerability of Glucosamine sulphate (Procart). Undesiderable effects have been observed in a low proportion of patients. They were transient, of minor entity and included: Cardiovascular: Peripheral oedema, tachycardia were reported in a few patients following larger clinical trials investigating oral administration in osteoarthritis. Causal relationship has not been established. Central Nervous System: Drowsiness, headache, somnolence, insomnia have been observed rarely during therapy. Gastrointestinal: Nausea, vomiting, diarrhoea, dyspepsia or epigastric pain, flatulence, constipation, heartburn and anorexia have been described rarely during oral therapy with Glucosamine sulphate (Procart). Skin: Skin reactions eg, cutaneous rash, erythema, pruritus have been reported with therapeutic administration of Glucosamine sulphate (Procart). Occasionally contact dermatitis, papular rash, urticaria and eczema may occur.

Isolated cases of hair loss, allergic reactions, visual disturbances and oedema were observed.

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

As well as its needed effects, ascorbic acid (the active ingredient contained in Vitamin C (Procart)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ascorbic acid, check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some ascorbic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

Applies to cholecalciferol: oral capsule, oral capsule liquid filled, oral solution, oral tablet, oral tablet chewable, oral wafer

As well as its needed effects, cholecalciferol (the active ingredient contained in Vitamin D3 (Procart)) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking cholecalciferol, check with your doctor immediately:

Incidence not known:

• Cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives or itching
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• skin rash
• tightness in the chest
• unusual tiredness or weakness

See also:
What are the possible side effects of Vitamin E (Procart)?

Applies to Vitamin E (Procart): oral capsule, oral capsule liquid filled, oral liquid, oral powder for solution, oral solution, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by Vitamin E (Procart) (the active ingredient contained in Vitamin E (Procart)). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Vitamin E (Procart), check with your doctor or nurse as soon as possible:

With doses greater than 400 Units a day and long-term use

• Blurred vision
• diarrhea
• dizziness
• headache
• nausea or stomach cramps
• unusual tiredness or weakness