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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 24.03.2022
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Metoclopramide (Plasil Enzimatico) increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.
Metoclopramide (Plasil Enzimatico) is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.
Metoclopramide (Plasil Enzimatico) is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.
You should not take this medication if you are allergic to Metoclopramide (Plasil Enzimatico), or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).
Before taking Metoclopramide (Plasil Enzimatico), tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Metoclopramide (Plasil Enzimatico).
Tell your doctor about all other medications you use, especially:
acetaminophen (Tylenol);
cyclosporine (Gengraf, Neoral, Sandimmune);
digoxin (digitalis, Lanoxin);
glycopyrrolate (Robinul);
levodopa (Larodopa, Atamet, Parcopa, Sinemet);
mepenzolate (Cantil);
tetracycline (Brodspec, Panmycin, Robitet, Sumycin, Tetracap, and others);
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bladder or urinary medications such as darifenacin (Enablex), tolterodine (Detrol), or solifenacin (Vesicare);
bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.
Get emergency medical help if you have any of these signs of an allergic reaction to Metoclopramide (Plasil Enzimatico): hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Metoclopramide (Plasil Enzimatico) and call your doctor at once if you have any of these serious side effects:
tremors, or restless muscle movements in your eyes, tongue, jaw, or neck;
mask-like appearance of the face;
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
depressed mood, thoughts of suicide or hurting yourself;
hallucinations, anxiety, agitation, jittery feeling, trouble staying still;
swelling, fluid retention;
jaundice (yellowing of your skin or eyes); or
seizure (convulsions).
Less serious Metoclopramide (Plasil Enzimatico) side effects may include:
feeling restless, drowsy, tired, or dizzy;
headache, sleep problems (insomnia);
nausea, vomiting, diarrhea;
breast tenderness or swelling;
changes in your menstrual periods; or
urinating more than usual.