Components:
Method of action:
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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 27.03.2022
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Phillips' Milk of Magnesia
Magnesium Hydroxide BP 415 mg per 5 ml suspension.
Oral Suspension.
Milk of Magnesia is indicated as an antacid for the symptomatic relief of stomach discomfort, indigestion, hyperacidity, heartburn and flatulence; and as a laxative for constipation.
Use a 5 ml spoon or the dosing cup provided.
Doses may be taken with milk or water if desired.
Do not exceed the stated dose.
As an antacid:
| Adults: | 5-10 ml (one or two 5 ml spoonfuls or fill the dosing cup to the first or second line). Repeat as necessary to a maximum of 60 ml in 24 hours. |
| Children aged 3-12 years: | 5 ml (one spoonful or first line in dosing cup). Repeat as necessary to a maximum of 30 ml in 24 hours. |
As a laxative:
| Adults: | 30-45 ml at bedtime. Repeat nightly, reducing dose each night until constipation is relieved. |
| Children aged over 3 years: | 5-10 ml at bedtime. |
| Children aged under 3 years: | to be given only on the advice of a doctor. |
| Elderly: | As adult dose. |
Hypersensitivity to any of the ingredients.
Adequate fluid intake should be maintained during use. If diarrhoea occurs especially in children or the elderly, discontinue use immediately. In case of renal impairment a doctor should be consulted as hypermagnesaemia may occur. If symptoms persist or worsen, a doctor or pharmacist should be consulted.
Do not use as a laxative for more than three consecutive days, or as an antacid for more than fourteen consecutive days.
If a laxative dose is needed every day or if there is a persistent abdominal pain further medical advice should be sought.
Users taking medicines either physician prescribed or self-prescribed should consult a doctor or pharmacist before use.
Keep out of the reach and sight of children.
Magnesium hydroxide may interfere locally with the absorption of other drugs taken orally by increasing gastric pH. This can be avoided by giving other drugs 2-3 hours before the administration of magnesium hydroxide on the advice of a doctor.
Milk of Magnesia may interact with tetracycline, digoxin, dicoumerol and cimetidine. Magnesium hydroxide may increase the absorption of ibuprofen and decrease the absorption of penicallamine, bisphosphates, ketoconazole and tetracycline.
The excretion of salicylates will be increased by changes in urinary pH.
Co-administration of sodium polystyrene sulphonate results in a relative excess of bicarbonate ions, which are absorbed, and may lead to metabolic alkylosis.
For Magnesium hydroxide no clinical data on exposed pregnancies are available.
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development.
Magnesium crosses the placenta and is excreted in small amounts in breast milk. Use during pregnancy and lactation should be avoided unless on the advice of a doctor.
Magnesium hydroxide is unlikely to cause any effects on the ability to drive and use machines.
Diarrhoea may occur which is dose related.
In patients with impaired renal function there may be sufficient accumulation of magnesium to produce toxic effects.
Symptoms of overdose include gastrointestinal irritation and watery diarrhoea. Magnesium poisoning may produce hypermagnesaemia, symptoms of which include nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, loss of tendon reflexes, muscle weakness, respiratory depression, cardiac arrhythmias, coma and cardiac arrest.
Treatment
Treatment consists of the intravenous administration of calcium gluconate injection 10% in a dose of 10-20ml to counteract respiratory depression or heart block. If renal function is normal, adequate fluids should be given to assist removal of magnesium from the body. Dialysis may be necessary in patients with renal impairment or severe hypermagnesaemia.
Magnesium hydroxide is practically insoluble in water and solution is not effected until the hydroxide reacts with hydrochloric acid in the stomach to form magnesium chloride. Its neutralising action is almost equal to that of sodium bicarbonate. When the dose is in excess of that required to neutralise the acid the intragastric pH may reach pH 8 or 9. Acid rebound following magnesium hydroxide is clinically insignificant.
Magnesium hydroxide has an indirect cathartic effect resulting from water retention in the intestinal lumen.
Magnesium hydroxide exerts its antacid therapeutic effect rapidly within the gastro-intestinal tract following oral administration and this action is therefore independent of pharmacokinetic properties. Following oral administration, about one third to half the magnesium is absorbed very slowly from the small intestine. Magnesium salts are excreted mainly in the urine with small amounts in the faeces and saliva.
Magnesium hydroxide has been used for many years and no further data are presented in this section.
Sodium Hydrogen Carbonate EP, Oil of Peppermint EP, Glycerol EP, Sodium Saccharin EP, Purified Water EP.
None.
36 months; after opening, 6 months.
Store below 25°C. Do not freeze.
Blue HDPE bottles with white HDPE screw turn tamper evident inner cap and external click on dosing cap. Pack size 100ml and 200ml.
Shake bottle well before use. Use within 6 months of opening.
Omega Pharma Ltd.
1st Floor
32 Vauxhall Bridge Road
LONDON, SW1V 2SA
United Kingdom
PL 02855/0072
22nd March 1999
9th July 2013
