Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 24.04.2022
Attention! Information on this page is intended only for medical professionals! Information is collected in open sources and may contain significant errors! Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
Pantomed-20 For Delayed-Release
Oral Suspension and Pantomed-20 Delayed-Release Tablets are indicated for:
Short-Term Treatment Of Erosive Esophagitis Associated With Gastroesophageal Reflux Disease (GERD)
Pantomed-20 is indicated in adults and pediatric patients five years of age and older for the short-term treatment (up to 8 weeks) in the healing and symptomatic relief of erosive esophagitis. For those adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of Pantomed-20 may be considered. Safety of treatment beyond 8 weeks in pediatric patients has not been established.
Maintenance Of Healing Of Erosive Esophagitis
Pantomed-20 is indicated for maintenance of healing of erosive esophagitis and reduction in relapse rates of daytime and nighttime heartburn symptoms in adult patients with GERD. Controlled studies did not extend beyond 12 months.
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome
Pantomed-20 is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome.
Pantomed-20 is a proton pump inhibitor that decreases the amount of acid produced in the stomach.
Pantomed-20 is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Pantomed-20 is usually given for up to 8 weeks at a time while your esophagus heals.
Pantomed-20 is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.
Pantomed-20 is not for immediate relief of heartburn.
Pantomed-20 may also be used for purposes not listed in this medication guide.
Recommended Dosing Schedule
Pantomed-20 is supplied as delayed-release granules in packets for preparation of oral suspensions or as delayed-release tablets. The recommended dosages are outlined in Table 1.
Table 1: Recommended Dosing Schedule for Pantomed-20
Indication | Dose | Frequency |
Short-Term Treatment of Erosive Esophagitis Associated With GERD | ||
Adults | 40 mg | Once daily for up to 8 weeks* |
Children (5 years and older) | ||
≥ 15 kg to < 40 kg | 20 mg | Once daily for up to 8 weeks |
≥ 40 kg | 40 mg | |
Maintenance of Healing of Erosive Esophagitis | ||
Adults | 40 mg | Once daily*** |
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome | ||
Adults | 40 mg | Twice daily** |
* For adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of Pantomed-20 may be considered. ** Dosage regimens should be adjusted to individual patient needs and should continue for as long as clinically indicated. Doses up to 240 mg daily have been administered. *** Controlled studies did not extend beyond 12 months |
Administration Instructions
Directions for method of administration for each dosage form are presented in Table 2.
Table 2: Administration Instructions
Formulation | Route | Instructions* |
Delayed-Release Tablets | Oral | Swallowed whole, with or without food |
For Delayed-ReleaseOral Suspension | Oral | Administered in 1 teaspoonful of applesauce or apple juice approximately 30 minutes prior to a meal |
For Delayed-ReleaseOral Suspension | Nasogastric tube | See instructions below |
* Patients should be cautioned that Pantomed-20 Delayed-Release Tablets and Pantomed-20 For Delayed-ReleaseOral Suspension should not be split, chewed, or crushed. |
Pantomed-20 Delayed-Release Tablets
Pantomed-20 Delayed-Release Tablets should be swallowed whole, with or without food in the stomach. If patients are unable to swallow a 40 mg tablet, two 20 mg tablets may be taken. Concomitant administration of antacids does not affect the absorption of Pantomed-20 Delayed-Release Tablets.
Pantomed-20 For Delayed-Release
Oral Suspension
Pantomed-20 For Delayed-Release
Oral Suspension should only be administered approximately 30 minutes prior to a meal via oral administration in apple juice or applesauce or nasogastric tube in apple juice only. Because proper pH is necessary for stability, do not administer Pantomed-20 For Delayed-Release
Oral Suspension in liquids other than apple juice, or foods other than applesauce.
Do not divide the 40 mg Pantomed-20 For Delayed-Release
Oral Suspension packet to create a 20 mg dosage for pediatric patients who are unable to take the tablet formulation.
Pantomed-20 For Delayed-Release
Oral Suspension -Oral Administration in Applesauce
- Open packet.
- Sprinkle granules on one teaspoonful of applesauce. DO NOT USE OTHER FOODS OR CRUSH OR CHEW THE GRANULES.
- Take within 10 minutes of preparation.
- Take sips of water to make sure granules are washed down into the stomach. Repeat water sips as necessary.
Pantomed-20 For Delayed-Release
Oral Suspension -Oral Administration in Apple Juice
- Open packet.
- Empty granules into a small cup or teaspoon containing one teaspoon of apple juice.
- Stir for 5 seconds (granules will not dissolve) and swallow immediately.
- To make sure that the entire dose is taken, rinse the container once or twice with apple juice to remove any remaining granules. Swallow immediately.
Pantomed-20 For Delayed-Release
Oral Suspension -Nasogastric (NG) Tube or Gastrostomy Tube Administration
For patients who have a nasogastric tube or gastrostomy tube in place, Pantomed-20 For Delayed-Release
Oral Suspension can be given as follows:
- Remove the plunger from the barrel of a 2 ounce (60 mL) catheter-tip syringe. Discard the plunger.
- Connect the catheter tip of the syringe to a 16 French (or larger) tube.
- Hold the syringe attached to the tubing as high as possible while giving Pantomed-20 For Delayed-Release
Oral Suspension to prevent any bending of the tubing.
- Empty the contents of the packet into the barrel of the syringe.
- Add 10 mL (2 teaspoonfuls) of apple juice and gently tap and/or shake the barrel of the syringe to help rinse the syringe and tube. Repeat at least twice more using the same amount of apple juice (10 mL or 2 teaspoonfuls) each time. No granules should remain in the syringe.
How supplied
Dosage Forms And Strengths
Delayed-Release Tablets
- 40 mg, yellow oval biconvex tablets imprinted with Pantomed-20 (brown ink) on one side
- 20 mg, yellow oval biconvex tablets imprinted with P20 (brown ink) on one side
For Delayed-Release
Oral Suspension
- 40 mg, pale yellowish to dark brownish, enteric-coated granules in a unit dose packet
Storage And Handling
Pantomed-20 (Pantomed-20 sodium) Delayed-Release Tablets are supplied as 40 mg yellow, oval biconvex delayed-release tablets imprinted with Pantomed-20 (brown ink) on one side and are available as follows:
NDC 0008-0841-81, bottles of 90
NDC 0008-0841-99, carton of 10 Redipak® blister strips of 10 tablets each
Pantomed-20 (Pantomed-20 sodium) Delayed-Release Tablets are supplied as 20 mg yellow oval biconvex delayed-release tablets imprinted with P20 (brown ink) on one side and are available as follows:
NDC 0008-0843-81, bottles of 90
Pantomed-20 (Pantomed-20 sodium) For Delayed-Release
Oral Suspension
NDC 0008-0844-02, unit-dose carton of 30
Storage
Store Pantomed-20 For Delayed-Release
Oral Suspension and Pantomed-20 Delayed-Release Tablets at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F).
Distributed by : Wyeth Pharmaceuticals Inc, A subsidiary of Pfizer Inc., Philadelphia, PA 19101. under license from Takeda GmbH D78467 Konstanz, Germany. Revised: December 2014
See also:
What is the most important information I should know about Pantomed-20?
Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.
You should not use this medication if you are allergic to Pantomed-20 or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).
Pantomed-20 is not for immediate relief of heartburn symptoms.
Take this medication for the full prescribed length of time. Your symptoms may improve before the condition is fully treated.
Pantomed-20 should not be taken together with atazanavir (Reyataz) or nelfinavir (Viracept). Tell your doctor if you are taking either of these medications to treat HIV or AIDS.
Some conditions must be treated long-term with Pantomed-20. The chronic use of Pantomed-20 has caused stomach cancer in animal studies, but it is not known if this medication would have the same effects in humans. Talk with your doctor about your specific risk of developing stomach cancer.
Long-term treatment with Pantomed-20 may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Talk with your doctor if you need long-term Pantomed-20 treatment and you have concerns about vitamin B-12 deficiency.
Use Pantomed-20 suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Pantomed-20 suspension comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Pantomed-20 suspension refilled.
- Take Pantomed-20 suspension by mouth on an empty stomach about 30 minutes before a meal.
- Do not crush or chew Pantomed-20 suspension.
- Do not divide the contents of the packet to make a smaller dose.
- Only mix Pantomed-20 suspension with applesauce or apple juice. Do not mix with water or other liquids or foods.
- If you are mixing Pantomed-20 suspension with applesauce, sprinkle the contents of the packet onto 1 teaspoonful of applesauce. Swallow within 10 minutes after mixing. Take sips of water to make sure the granules are washed down into the stomach.
- If you are mixing Pantomed-20 suspension with apple juice, empty the contents of the packet into a small cup containing 5 mL (1 teaspoonful) apple juice. Stir for 5 seconds and then swallow immediately. To be sure you receive all the medicine, rinse the container once or twice with apple juice and swallow immediately.
- If the patient is taking Pantomed-20 suspension through a nasogastric (NG) tube or gastric tube, follow the instructions for use in the extra patient leaflet.
- You may take antacids while you are using Pantomed-20 suspension if you are directed to do so by your doctor.
- Continue to take Pantomed-20 suspension even if you feel well. Do not miss any doses.
- If you miss a dose of Pantomed-20 suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Pantomed-20 suspension.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Pantomed-20 is used to treat certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Pantomed-20 belongs to a class of drugs known as proton pump inhibitors (PPIs).
OTHER USES: This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to treat and prevent stomach and intestinal ulcers.
How to use Pantomed-20
Read the Medication Guide provided by your pharmacist before you start taking Pantomed-20 and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily. Dosage and length of treatment are based on your medical condition and response to treatment.
If you are taking the tablets, you may take them with or without food. Swallow the tablets whole. Do not split, crush, or chew the medication. Doing so may destroy the drug.
If you are taking the granules, take your dose 30 minutes before a meal. To take it by mouth, open the packet and mix the granules in applesauce or apple juice. Do not mix with other foods or liquids. Do not crush or chew the granules. Sprinkle the granules on 1 teaspoon (5 milliliters) of applesauce and swallow all of the mixture right away (within 10 minutes). Follow with sips of water. Or you can mix the granules with 1 teaspoon (5 milliliters) of apple juice in a small cup, stir for 5 seconds, and swallow all of the mixture right away. To make sure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules, and swallow the juice. Do not prepare the mixture ahead of time for later use.
If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it.
If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take Pantomed-20 at least 30 minutes before sucralfate.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better.
Tell your doctor if your condition persists or worsens. The risk of side effects goes up over time. Ask your doctor how long you should take this medication.
See also:
What other drugs will affect Pantomed-20?
Pantomed-20 is metabolized through the cytochrome P450 system, primarily the CYP2C19 and CYP3A4 isozymes, and subsequently undergoes Phase II conjugation.
Based on studies evaluating possible interactions of Pantomed-20 with other drugs, no dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam (and its active metabolite, desmethyldiazepam), diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, an oral contraceptive (levonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole, or amoxicillin. Clinically relevant interactions of Pantomed-20 with other drugs with the same metabolic pathways are not expected. Therefore, when coadministered with Pantomed-20, adjustment of the dosage of Pantomed-20 or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including Pantomed-20, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time.
Because of profound and long lasting inhibition of gastric acid secretion, Pantomed-20 may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (eg, ketoconazole, ampicillin esters, and iron salts).
Laboratory Tests
There have been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving most proton pump inhibitors, including Pantomed-20. An alternative confirmatory method should be considered to verify positive results.
See also:
What are the possible side effects of Pantomed-20?
The adverse reaction profiles for Pantomed-20 (Pantomed-20 sodium) For Delayed-Release
Oral Suspension and Pantomed-20 (Pantomed-20 sodium) Delayed-Release Tablets are similar.
Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Adults
Safety in nine randomized comparative US clinical trials in patients with GERD included 1,473 patients on oral Pantomed-20 (20 mg or 40 mg), 299 patients on an H2-receptor antagonist, 46 patients on another proton pump inhibitor, and 82 patients on placebo. The most frequently occurring adverse reactions are listed in Table 3.
Table 3: Adverse Reactions Reported in Clinical Trials of Adult Patients with GERD at a Frequency of > 2%
Pantomed-20 (n=1473) % | Comparators (n=345) % | Placebo (n=82) % | |
Headache | 12.2 | 12.8 | 8.5 |
Diarrhea | 8.8 | 9.6 | 4.9 |
Nausea | 7.0 | 5.2 | 9.8 |
Abdominal pain | 6.2 | 4.1 | 6.1 |
Vomiting | 4.3 | 3.5 | 2.4 |
Flatulence | 3.9 | 2.9 | 3.7 |
Dizziness | 3.0 | 2.9 | 1.2 |
Arthralgia | 2.8 | 1.4 | 1.2 |
Additional adverse reactions that were reported for Pantomed-20 in clinical trials with a frequency of ≤ 2% are listed below by body system:
Body as a Whole: allergic reaction, pyrexia, photosensitivity reaction, facial edema
Gastrointestinal: constipation, dry mouth, hepatitis
Hematologic: leukopenia, thrombocytopenia
Metabolic/Nutritional: elevated CK (creatine kinase), generalized edema, elevated triglycerides, liver enzymes elevated
Musculoskeletal: myalgia
Nervous: depression, vertigo
Skin and Appendages: urticaria, rash, pruritus
Special Senses: blurred vision
Pediatric Patients
Safety of Pantomed-20 in the treatment of Erosive Esophagitis (EE) associated with GERD was evaluated in pediatric patients ages 1 year through 16 years in three clinical trials. Safety trials involved pediatric patients with EE; however, as EE is uncommon in the pediatric population, 249 pediatric patients with endoscopically-proven or symptomatic GERD were also evaluated. All adult adverse reactions to Pantomed-20 are considered relevant to pediatric patients. In patients ages 1 year through 16 years, the most commonly reported ( > 4%) adverse reactions include: URI, headache, fever, diarrhea, vomiting, rash, and abdominal pain.
For safety information in patients less than 1 year of age see Use in Specific Populations.
Additional adverse reactions that were reported for Pantomed-20 in pediatric patients in clinical trials with a frequency of ≤ 4% are listed below by body system:
Body as a Whole: allergic reaction, facial edema
Gastrointestinal: constipation, flatulence, nausea
Metabolic/Nutritional: elevated triglycerides, elevated liver enzymes, elevated CK (creatine kinase)
Musculoskeletal: arthralgia, myalgia
Nervous: dizziness, vertigo
Skin and Appendages: urticaria
The following adverse reactions seen in adults in clinical trials were not reported in pediatric patients in clinical trials, but are considered relevant to pediatric patients: photosensitivity reaction, dry mouth, hepatitis, thrombocytopenia, generalized edema, depression, pruritus, leukopenia, and blurred vision.
Zollinger-Ellison Syndrome
In clinical studies of Zollinger-Ellison Syndrome, adverse reactions reported in 35 patients taking Pantomed-20 80 mg/day to 240 mg/day for up to 2 years were similar to those reported in adult patients with GERD.
Postmarketing Experience
The following adverse reactions have been identified during postapproval use of Pantomed-20. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
These adverse reactions are listed below by body system:
General Disorders and Administration Conditions: asthenia, fatigue, malaise
Hematologic: pancytopenia, agranulocytosis
Hepatobiliary Disorders: hepatocellular damage leading to jaundice and hepatic failure
Immune System Disorders: anaphylaxis (including anaphylactic shock)
Infections and Infestations: Clostridium difficile associated diarrhea
Investigations: weight changes
Metabolism and Nutritional Disorders: hyponatremia, hypomagnesemia
Musculoskeletal Disorders: rhabdomyolysis, bone fracture
Nervous: ageusia, dysgeusia
Psychiatric Disorders: hallucination, confusion, insomnia, somnolence
Renal and Urinary Disorders: interstitial nephritis
Skin and Subcutaneous Tissue Disorders: severe dermatologic reactions (some fatal), including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis (TEN, some fatal), and angioedema (Quincke's edema)
Each 20-mg tablet contains Pantoprazole sodium sesquihydrate 22.6 mg equivalent to Pantomed-20 20 mg.
Pantomed-20 also contains the following excipients: Crospovidone, yellow iron oxide E172, hypromellose 2910, methylacrylic acid-ethyl acrylate copolymer (1:1), polysorbate 80, sodium carbonate, titanium dioxide E171, triethyl citrate; mannitol (approximately 0.0036 BU), povidone K90, calcium stearate, povidone K25, propylene glycol, sodium lauryl sulfate; printing ink (for tablets only); microcrystalline cellulose, povidone, sodium dodecyl sulfate.
However, we will provide data for each active ingredient