Mavidol TR

•For short-term management (? 7 days) of different painful conditions that requires analgesia at opioid level e.g.: Major abdominal operations-Orthopaedic operations-Dental operations -Gynecological operations; Therapy should be initiated with IV or IM and continuation of treatment with oral Ketorolac (Mavidol TR), if necessary.

•For management of severe painful conditions e.g.: Cancer pain, Renal colic,........etc.

N.B.: The total combined duration of use of Ketorolac (Mavidol TR) tromethamine is not to exceed ? 7 days because of potential increase of severity of adverse reactions associated with therapeutic doses. Patients should be switched to alternative analgesics as soon as possible. - As an eye drops: indicated to patients suffering from:

The temporarily relief of ocular itching due to seasonal allergic conjunctivitis.

Postoperative inflammation due to cataract extraction.

Known hypersensitivity to Ketorolac (Mavidol TR) or other NSAIDs, history of asthma, severe heart failure, peptic ulcer, coagulation disorders, and during pregnancy and lactation.

Ketorelac should not be used with other NSAIDs and Probenecid because of the potential for additive side-effects.

*Ketorolac (Mavidol TR) reduces the diuretic response to frusemide by approximately 20%, in renal impairment.

*Caution is advised when: Methotrexate or Lithium is administered concurrently with Ketorolac (Mavidol TR).

Side effects may include: GIT upsets, Dizziness, Vertigo, Rash, Pruritus, Sweating, Tinnitus, Headache, Dyspnea, Oliguria, Insomnia, Flushing, Bradycardia, and Weight Gain. Ophtlamic Adverse effects: Transient stinging & burning sensation on instillation are most frequent.

Ocular irritation, allergic reactions, superficial infections, superficial keratitis are very few reported, eye dryness, corneal infiltrates, corneal ulcer, & visual disturbance are rare.