Laticort

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Laticort

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Laticort

Laticort is a prescribed topical medication containing the active substance Hydrocortisone butyrate, which belongs to the powerful pharmacological class of glucocorticoids or corticosteroids. This preparation is a synthetic derivative, specifically designed for localized application to manage skin inflammation and irritation.


Quick Facts

Property Description
Active Ingredient Hydrocortisone butyrate
Form Cream, Ointment
Pharmacological Class Glucocorticoid (Corticosteroid)
General Purpose Anti-inflammatory and antipruritic action
Origin Synthetic derivative

Laticort's Composition and Classification

Laticort's effectiveness stems from Hydrocortisone butyrate (INN), an ester of hydrocortisone chemically modified to enhance its ability to penetrate the skin's protective barriers. This modification is clinically recognized for increasing its anti-inflammatory action compared to the parent compound, concentrating its therapeutic effects at the site of application. The medication is exclusively applied via the topical/cutaneous route of administration, supplied as a cream or an ointment.

Therapeutic Class and General Purpose

As a topical glucocorticoid, Laticort's primary action is to act as a powerful anti-inflammatory and antipruritic agent. Hydrocortisone butyrate is classified as a medium-potency corticosteroid, establishing its therapeutic strength for stabilizing inflammatory skin processes. Laticort's general purpose is to suppress the localized immune processes that cause symptoms of irritation, thereby providing significant symptomatic relief from the discomfort associated with swelling, heat, and persistent itching.

Regulatory References

  1. Topical Corticosteroid Potency Ratings (AAFP)
  2. European Public Assessment Report (EPAR) definition

What side effects are possible with Laticort?

Possible Side Effects and Safety Information for Laticort

Laticort, a formulation of hydrocortisone butyrate, is a topical corticosteroid associated with both local and, less commonly, systemic adverse reactions, particularly with prolonged or widespread use.

Common Adverse Reactions (Local Site Reactions)

Reactions most frequently observed at the application site include mild burning, itching, irritation, and dryness. Other common skin effects can involve acneiform eruptions, inflammation of the hair follicles (folliculitis), and unusual hair growth (hypertrichosis).

Serious and Clinically Significant Risks

  • Skin Atrophy: Extended or excessive use can lead to permanent changes such as thinning of the skin (atrophy), easy bruising, and the development of stretch marks (striae).
  • Systemic Effects: Although rare with appropriate use, significant systemic absorption can occur when applied over large surface areas, to broken skin, or under occlusive dressings. This may lead to reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, potentially causing glucocorticosteroid insufficiency or manifestations of Cushing's syndrome.
  • Ocular Risks: Use near the eyes carries a risk of cataracts and glaucoma.

Population-Specific and Safety Restrictions

  • Pediatric Patients: Children are generally more susceptible to systemic toxicity, including HPA axis suppression, due to a larger skin surface area to body mass ratio. Dosage and duration must be carefully monitored.
  • Pre-existing Conditions: Caution is advised in patients with pre-existing conditions like diabetes, glaucoma, or those with large sores or infections at the application site, as use may exacerbate these conditions or mask signs of infection. The medication is contraindicated for certain skin infections (e.g., fungal, viral) and conditions like rosacea or perioral dermatitis.
  • Exposure Patterns: Prolonged continuous therapy is generally not recommended to mitigate the risk of both local irreversible skin changes and systemic adverse effects.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose with Laticort (hydrocortisone butyrate) is primarily associated with the systemic absorption that can occur from the prolonged use of high doses over large body surface areas. Because Laticort is a topical corticosteroid, the risk centers on the potential for the body to absorb too much of the medication, leading to systemic effects.

Documented Overdose Symptoms

The established presentation of excessive exposure is hypercortisolism, or chronic toxicity, which may manifest as Cushing's syndrome. Other documented clinical signs of systemic absorption include hyperglycemia (elevated blood sugar) and glucosuria (sugar in the urine).

Special Considerations and Emergency Actions

Consideration Information for Patients
Pediatric Patients Children may be more susceptible to systemic toxicity from topical corticosteroids due to their higher skin surface area to body mass ratio.
Emergency Action If symptoms suggestive of hypercortisolism appear, the treatment should be discontinued gradually under medical supervision. The symptoms are generally reversible. The approach to management is by providing appropriate symptomatic treatment.

When to Seek Medical Help: You should contact a healthcare professional if you or a child using Laticort develops signs of systemic toxicity, such as unexplained weight gain, puffiness in the face, or changes in blood sugar levels. Immediate, gradual withdrawal of the medication is necessary to manage chronic toxicity.

Therapeutic Uses of Laticort

What Laticort Treats: Main Uses and Benefits

The medication is used for managing the symptoms of various inflammatory skin conditions. This medication is applied in situations involving certain distressing symptoms, specifically for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Laticort is relevant for easing symptoms associated with chronic disorders, such as atopic dermatitis (eczema) and localized psoriasis, as well as acute episodes of contact dermatitis.


The primary benefit is to provide support that helps ease the overall symptom load. It is commonly used when short-term symptomatic assistance is needed, and may assist with addressing symptoms that may become intense or disruptive, such as itching, visible redness, and localized swelling. This contributes to improved comfort during periods of heightened symptoms, helping to maintain a sense of stability when symptoms become more disruptive during flare-ups.

It is applied in situations involving recurrent or episodic manifestations across adult patients and is relevant for easing symptoms in pediatric patients with mild to moderate atopic dermatitis.

Quick Fact: Symptomatic Support
Laticort is commonly used to help with symptoms that create noticeable physiological strain, primarily itching and inflammation (redness and swelling), during acute flare-ups of conditions like eczema.

Regulatory References

  1. NIH DailyMed drug label

Eligibility and Restrictions for Use

Regulatory documents define specific populations that are eligible to use Laticort (hydrocortisone butyrate) and those who must not use it due to safety and absorption concerns.

Who Cannot Use This Medicine (Contraindications)

Laticort is contraindicated for any individual with a history of hypersensitivity or an allergic reaction to its active substance or any other component in the formulation. Furthermore, its use is generally advised against or restricted in the presence of certain concurrent conditions, such as untreated viral, fungal, bacterial, parasitic, or tubercular skin infections in the treatment area, or on skin affected by rosacea, acne vulgaris, or perioral dermatitis.

Populations Requiring Special Consideration

Population Eligibility Restriction Official Status
Pediatric Age Not established for infants under 3 months of age. Use in all children requires caution due to a higher risk of systemic absorption (HPA axis suppression). Not Established / Caution
Pregnancy Use only if the potential benefit justifies the potential risk to the fetus. Avoid extensive use or prolonged periods. Use with Caution
Lactation Advised to use on the smallest area for the shortest duration possible. Avoid applying to areas at risk for direct infant contact. Use with Caution

Additionally, use under occlusive dressings (including diapers or plastic pants) or on the face, underarms, or groin is generally not recommended unless directed and closely monitored by a healthcare provider.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Laticort (Hydrocortisone butyrate topical) is generally characterized by an absence of specific drug-drug interactions. Authoritative government documents, such as the FDA Prescribing Information, explicitly state that there are no known drug interactions documented for this topical formulation. This regulatory classification indicates that Laticort does not formally interact with specific medications via common metabolic pathways, such as the cytochrome P450 (CYP) enzyme system, nor are there any known transporter-mediated interaction concerns.


Pharmacodynamic Interaction Profile

While specific drug interactions are not documented, the regulatory profile does include an important pharmacodynamic caution related to the class of medicine.

The co-administration of Laticort with other corticosteroid-containing products, whether topical or systemic, may result in an additive effect. This documented interaction pattern can lead to an increase in total systemic corticosteroid exposure.

Interaction Category Documented Regulatory Restriction
Corticosteroid Co-use May increase total systemic corticosteroid exposure.
Food / Alcohol / Herbal No explicitly documented interactions with food, alcohol, or supplements.
Timing Rules No mandatory separation rules are formally listed.

Population-Specific Note

Regulatory documents also include a specific note regarding the interaction-related exposure risk in certain populations. Pediatric patients are identified as potentially more susceptible to the systemic effects (such as HPA axis suppression) that can result from this increased exposure, due to their larger skin-surface-to-body-mass ratio.

Mechanism of Action

Receptor Activation and Transcriptional Suppression

This mechanism begins when the molecule acts as an agonist for the Glucocorticoid Receptor ( GRalpha) inside the cell. The resulting complex translocates to the nucleus to perform Transrepression, physically blocking pro-inflammatory transcription factors like NF-kappa B and AP-1. This action results in the suppression of genes encoding pro-inflammatory cytokines ( IL-1, TNF-alpha) and other mediators.


Upstream Blockade of Inflammatory Pathways

A crucial consequence of the nuclear action is Transactivation, where the drug-receptor complex stimulates the production of the anti-inflammatory protein, Lipocortin-1. This protein subsequently inhibits the enzyme Phospholipase A2 ( PLA2). By blocking PLA2, the mechanism prevents the release of Arachidonic Acid, thereby blocking the synthesis of powerful downstream inflammatory mediators like prostaglandins and leukotrienes. This collective molecular cascade limits the production of mediators associated with tissue edema, localized warmth, and nociceptive signaling.


Localized Microvascular Modulation

The drug's action also includes the modulation of localized vascular tone. It functionally antagonizes vasodilatory mediators and induces vasoconstriction in the dermal microvasculature. This physiological change results in localized vasoconstriction and decreased capillary permeability, limiting the extravasation of fluid and cellular components into the tissue. This localized effect modulates vascular dynamics and limits the physiological processes associated with tissue swelling and localized hyperaemia.

Dosage and Administration Information

How Laticort is Used: Official Administration and Dosing

Laticort, a prescribed medication containing Hydrocortisone butyrate 0.1%, must be administered strictly according to official guidelines to ensure proper use.


Official Route and Dosage

The approved and mandatory route of administration for Laticort is topical (cutaneous use). This medication is supplied as a cream, ointment, lotion, or topical solution, all at a concentration of 0.1%. It is explicitly not approved for oral, ophthalmic (eye), or intravaginal use.

Standard Dosing and Frequency

For all approved uses, Laticort is applied as a thin layer to the affected skin areas and must be rubbed in gently. The application frequency is based on the condition being treated:

Indication/Population Application Frequency
Adults (Corticosteroid-Responsive Dermatoses) 2 or 3 times daily
Adults and Pediatrics (Atopic Dermatitis) 2 times daily

Procedural and Time-Specific Constraints

The treatment should be discontinued once control of the skin condition is achieved. Generally, if no improvement is seen within two weeks, the diagnosis requires reevaluation.

  • Occlusion Constraint: The treated area must not be bandaged, covered, or wrapped as to be occlusive unless specifically directed by a healthcare provider. Avoid use in the diaper area, as diapers can act as occlusive dressings.
  • Pediatric Use: Use is established for children 3 months of age and older. Safety and efficacy are not established for infants under 3 months.
  • Restricted Areas: Avoid applying to the face, underarms, or groin unless advised by a healthcare provider.

These official instructions define the standardized application amount, frequency, and time limitations for administering Laticort.

Recent Clinical Evidence

Research Evidence / Overview of Studies for The Medication

This overview describes the types of studies that have examined The Medication, what researchers have observed so far, and where limitations or uncertainties in the evidence still exist. This information reflects group patterns observed in research and does not provide individual predictions or clinical advice.


Evidence for use in Community-Acquired Pneumonia (CAP)

Research has explored The Medication's use in individuals diagnosed with CAP, a condition characterized by periods of heightened symptoms. Studies have included randomized controlled trials (RCTs) and observational research. Researchers were interested in outcomes related to systemic imbalance, such as achieving measured clinical endpoints, whether bacterial eradication was observed, and the duration of a hospital stay. The populations evaluated included adults and children, often grouped based on disease severity. Long-term effects are not fully established regarding the status of patients after the acute infection has passed, as follow-up durations were limited.


Evidence for use in Acute Bacterial Exacerbation of COPD (AB-COPD)

The Medication was studied for its use during an acute bacterial worsening of Chronic Obstructive Pulmonary Disease (COPD). Studies included short-term RCTs for acute treatment and longer observational cohort studies for extended use. Research examined outcomes reflecting daily functioning, such as changes in breathlessness and sputum, and the time until another acute episode occurred. Studies monitored how symptoms evolved in the observed populations, and research also examined the incidence of adverse outcomes, such as cardiac events, in prolonged-use cohorts. Comparative evidence is lacking, and data for certain groups remain insufficient.


Areas where the research remains uncertain

Evidence highlights what is known—and what is still uncertain—about this medication. For many uses, the long-term effects are not fully established, as follow-up durations were limited. Sample sizes were modest in some older studies, and data for certain groups (such as the immunocompromised or those with specific comorbidities) remain insufficient. Furthermore, subgroup findings are uncertain for many unique populations, including pregnant individuals. Research describes patterns related to clinical endpoints, but findings describe group patterns, not personal outcomes.

Frequently Asked Questions (FAQ)

Common questions about Laticort (FAQ)

Q: Is Laticort the same as other steroid creams I've used before?

According to the official product information and classification from the European Medicines Agency (EMA), the active ingredient in Laticort, hydrocortisone butyrate, is classified as a medium-potency topical corticosteroid. This classification is used to standardize the therapeutic strength compared to other medications in the same class.

Q: Are there different strengths or versions of Laticort available?

Official regulatory labeling indicates that the active ingredient in Laticort is supplied only at a concentration of 0.1%. While it is available in various forms, such as a cream, ointment, lotion, or topical solution, the concentration remains consistent across all official forms.

Q: Are there any specific signs of an allergic reaction to Laticort that I should know about?

Regulatory documents advise against using the medication if there is a known hypersensitivity to any component in the formulation. While mild irritation is a common local side effect, severe symptoms, such as extensive rash, swelling, or difficulty breathing, are documented as potential signs of serious hypersensitivity.

Q: Does Laticort affect the rest of the body, or is its action localized to the skin?

Laticort is designed primarily for localized action on the skin to reduce inflammation. However, official regulatory warnings note that systemic absorption (entering the bloodstream) can occur, especially with extensive or prolonged use. This systemic exposure may lead to risks such as hypothalamic-pituitary-adrenal (HPA) axis suppression.

Q: Is Laticort generally used for short periods or long periods of time?

The use of this medication is generally intended for short periods. Regulatory instructions state that treatment should cease once the condition is controlled. Official warnings specifically advise against prolonged continuous therapy to help mitigate the risk of local and systemic side effects.

Q: What does 'topical corticosteroid' mean in simple terms?

A topical corticosteroid is a medicine from the glucocorticoid class that is applied only to the surface of the skin (topically). The general purpose of these agents is to reduce localized inflammation, swelling, and itching associated with skin conditions.

Q: Can Laticort be used on open cuts or broken skin?

Official safety warnings indicate the need for caution if the medication is applied to broken skin or large open sores due to the potential for increased absorption into the body. Furthermore, the medication is contraindicated (advised against) for use on untreated infections of the skin.

Q: Is it true that Laticort can suppress the immune response in the skin?

The medication functions by suppressing the localized immune processes that cause symptoms like irritation and inflammation. The mechanism involves blocking the production of pro-inflammatory mediators and compounds in the skin.

Q: Does applying more Laticort make it work faster?

Official instructions state that Laticort should be applied as a thin layer to the affected area. Regulatory documentation warns that using excessive amounts increases the risk of potential side effects, but does not suggest that it increases the speed or effectiveness of the drug's action.

Q: Are there warnings about using Laticort for conditions other than the approved uses?

The regulatory labeling specifies the approved skin conditions for which Laticort is indicated. Use is specifically advised against or restricted for conditions that are not approved uses, such as rosacea, perioral dermatitis, and untreated infections.

Q: Is Laticort absorbed into the bloodstream?

Yes, systemic absorption of the active ingredient can occur through the skin. Official warnings note that the risk of significant absorption is highest when Laticort is used over large surface areas, on broken skin, or when applied under an occlusive dressing.

Q: Why do official documents warn against bandaging the area after applying Laticort?

Official documents warn against covering or bandaging the treated area (occlusion) because doing so significantly increases the amount of medication absorbed systemically. This increased absorption raises the risk of serious, systemic side effects, such as HPA axis suppression.

Q: What are the general rules for stopping the use of Laticort?

Regulatory instructions state that treatment should cease once control of the skin condition is achieved. For cases involving prolonged or extensive use, official warnings related to the risk of HPA axis suppression note that abrupt cessation in such cases may need medical supervision.

Q: What should be done if Laticort gets into the eyes?

Regulatory documents explicitly state Laticort is not approved for use in the eyes. Since use near the eyes carries specific risks like cataracts and glaucoma, if accidental exposure occurs, official product information suggests rinsing the area thoroughly.

Q: How is Laticort's safety profile generally described in official sources?

The general regulatory safety profile focuses on the risk of local side effects at the application site, such as irritation or skin changes. The primary serious concern identified is the potential for systemic effects (HPA axis suppression) if the drug is used extensively or improperly.

Q: Where can I find research on Laticort's use in diverse populations?

Official information regarding clinical studies, including data on effectiveness, safety, and limitations in certain populations, can typically be found within the Clinical Studies or Use in Specific Populations sections of official regulatory labeling.

Q: What is the difference between Laticort cream and Laticort ointment?

The different formulations of Laticort, such as cream and ointment, use different bases. Official regulatory documents list these as separate dosage forms, and ointment formulations are generally recognized as being more occlusive or potent than creams.

Q: Is Laticort considered a preventative treatment?

Laticort is classified as an anti-inflammatory and antipruritic agent. Its official purpose is to suppress the symptoms of existing inflammatory skin processes, and it is not intended or classified as a treatment to prevent conditions from occurring.

Q: Why might Laticort stop working for a condition over time?

Prolonged continuous use of topical corticosteroids can sometimes result in the skin developing a reduced response to the medication over time. Official guidelines advise against continuous prolonged therapy and indicate that treatment should cease once the condition is controlled.

Q: Is Laticort addictive in the way some people describe steroid use?

Official warnings relate to the potential for systemic absorption and HPA axis suppression with extensive or prolonged use. This physiological risk may require medical supervision when treatment is discontinued, but the term "addictive" is not used in official regulatory documentation.

Q: Does Laticort contain any ingredients that cause allergic reactions commonly?

Laticort contains inactive ingredients (excipients) in addition to the active substance, and official documents provide a complete list of these components. Regulatory documents contraindicate the use of Laticort for anyone with a known hypersensitivity to the active substance or any component in the formulation.

Q: Is the term 'off-label' use of Laticort defined in regulatory documents?

Regulatory documents define the medication's approved uses, known as indications, in the labeling. Any use for a condition or in a way not described in the official indications section is considered outside of the approved scope.

How should Laticort be stored and disposed of?

How to Store and Dispose of Laticort

Laticort (hydrocortisone butyrate) must be stored under specific environmental and temperature conditions as defined in its official regulatory labeling to ensure stability.


Storage Requirements

Store the medication at Controlled Room Temperature, which is 20 C to 25 C (68 F to 77 F), with permitted excursions. It is required to be kept out of the sight and reach of children and protected from freezing, excess heat, and moisture. The medicine should be stored in a closed container.


Disposal Instructions

Do not flush Laticort down the sink or toilet. Unused or expired medication should be disposed of by taking it to an authorized drug take-back program. If a take-back program is unavailable, mix the medicine with an undesirable substance (such as coffee grounds) and place it in a sealed container before discarding it in the household trash, following local regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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