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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 30.03.2022
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Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) is indicated for the treatment of the following infections:
Strongyloidiasis of the intestinal tract. Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis.
This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of Ivermectin (Guardian Complete Worming).
Onchocerciasis. Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) is indicated for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus.
This indication is based on randomized, double-blind, placebo-controlled and comparative studies conducted in 1427 patients in onchocerciasis-endemic areas of West Africa. The comparative studies used diethylcarbamazine citrate (DEC-C).
NOTE: Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) has no activity against adult Onchocerca volvulus parasites. The adult parasites reside in subcutaneous nodules which are infrequently palpable. Surgical excision of these nodules (nodulectomy) may be considered in the management of patients with onchocerciasis, since this procedure will eliminate the microfilariae-producing adult parasites.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Oral
Trichuris trichiura
Adult: 10-20 mg/kg as single dose; with pyrantel: 10-20 mg/kg as single dose
Child: 10-20 mg/kg as single dose; with pyrantel: 10-20 mg/kg as single dose
Oral
Enterobiasis; Hookworm infections; Trichostrongylus orientalis
Adult: With pyrantel: 10-20 mg/kg as single dose
Child: With pyrantel; 10-20 mg/kg as single dose
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Praziquantel (Guardian Complete Worming) (Praziquantel (Guardian Complete Worming)) is indicated for the treatment of infections due to: all species of schistosoma (for example, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium), and infections due to the liver flukes, Clonorchis sinensis/Opisthorchis viverrini (approval of this indication was based on studies in which the two species were not differentiated).
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Oral
Single or mixed infections due to susceptible worms
Adult: 10 mg/kg as a single dose.
Child: 10 mg/kg as a single dose.
Oral
Ascariasis
Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.
Oral
Necatoriasis
Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.
Oral
Enterobiasis
Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.
Oral
Trichinosis
Adult: 10 mg/kg daily for 5 days.
Ivermectin (Guardian Complete Worming) is used in the treatment of certain worm infections. It is used to treat river blindness (onchocerciasis) and a certain type of diarrhea (strongyloidiasis). It may also be used for some other kinds of worm infections.
Ivermectin (Guardian Complete Worming) appears to work by paralyzing and then killing the offspring of adult worms. It may also slow down the rate at which adult worms reproduce. This results in fewer worms in the skin, blood, and eyes.
Ivermectin (Guardian Complete Worming) is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Ivermectin (Guardian Complete Worming) is used in certain patients with the following medical condition:
- Bancroft's filariasis
- Scabies
Praziquantel (Guardian Complete Worming) is used to treat infections caused by parasites such as liver flukes (worms) or schistosoma (blood fluke). These infections are also known as snail fever, schistosomiasis, or bilharziasis. Praziquantel (Guardian Complete Worming) may also be used for other worm infections as determined by your doctor. However, it will not work for pinworms or other roundworms.
Praziquantel (Guardian Complete Worming) belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Praziquantel (Guardian Complete Worming) works by causing severe spasms and paralysis of the worms' muscles. Some kinds of worms are then passed in the stool. However, you may not notice them since they are sometimes completely destroyed in the intestine.
Praziquantel (Guardian Complete Worming) is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in the product labeling, Praziquantel (Guardian Complete Worming) is used in certain patients with the following medical conditions:
- Some kinds of fluke infections.
- Some kinds of tapeworm infections.
Pyrantel (Guardian Complete Worming) belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.
Pyrantel (Guardian Complete Worming) is used to treat pinworms (enterobiasis; oxyuriasis).
Pyrantel (Guardian Complete Worming) may also be used for other worm infections as determined by your doctor.
Pyrantel (Guardian Complete Worming) works by paralyzing the worms. They are then passed in the stool.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Pyrantel (Guardian Complete Worming) is used in certain patients with the following medical condition:
- Common roundworm infection
- Hookworm infection
- More than one worm infection at a time
For patients taking Pyrantel (Guardian Complete Worming) for hookworm infection :
- Anemia (iron-poor blood) may occur in patients with hookworm infections. Therefore, your doctor may want you to take iron supplements to help clear up the anemia. If so, it is important to take iron every day while you are being treated for hookworms. Do not miss any doses. Your doctor may also want you to keep taking iron supplements for up to 6 months after you stop taking Pyrantel (Guardian Complete Worming). If you have any questions about this, check with your doctor.
Strongyloidiasis
The recommended dosage of Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) for the treatment of strongyloidiasis is a single oral dose designed to provide approximately 200 mcg of Ivermectin (Guardian Complete Worming) per kg of body weight. See Table 1 for dosage guidelines. Patients should take tablets on an empty stomach with water. In general, additional doses are not necessary. However, follow-up stool examinations should be performed to verify eradication of infection.
Table 1: Dosage Guidelines for Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) for Strongyloidiasis
Body Weight (kg) | SingleOral DoseNumber of 3-mg Tablets |
15-24 | 1 tablet |
25-35 | 2 tablets |
36-50 | 3 tablets |
51-65 | 4 tablets |
66-79 | 5 tablets |
≥ 80 | 200 mcg/kg |
Onchocerciasis
The recommended dosage of Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) for the treatment of onchocerciasis is a single oral dose designed to provide approximately 150 mcg of Ivermectin (Guardian Complete Worming) per kg of body weight. See Table 2 for dosage guidelines. Patients should take tablets on an empty stomach with water. In mass distribution campaigns in international treatment programs, the most commonly used dose interval is 12 months. For the treatment of individual patients, retreatment may be considered at intervals as short as 3 months.
Table 2: Dosage Guidelines for Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) for Onchocerciasis
Body Weight (kg) | SingleOral DoseNumber of 3-mg Tablets |
15-25 | 1 tablet |
26-44 | 2 tablets |
45-64 | 3 tablets |
65-84 | 4 tablets |
≥ 85 | 150 mcg/kg |
How supplied
No. 8495 — Tablets Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) 3 mg are white, round, flat, bevel-edged tablets coded MSD on one side and 32 on the other side. They are supplied as follows:
NDC 0006-0032-20 unit dose packages of 20.
Storage
Store at temperatures below 30°C (86°F).
Dist. by: MERCK & CO., INC,Whitehouse Station, NJ 08889, USA. Manufactured by: MSD BV Waarderweg 39 2031 BN Haarlem Netherlands. Issued 2009
Oral
Trichuris trichiura
Adult: 10-20 mg/kg as single dose; with pyrantel: 10-20 mg/kg as single dose
Child: 10-20 mg/kg as single dose; with pyrantel: 10-20 mg/kg as single dose
Oral
Enterobiasis; Hookworm infections; Trichostrongylus orientalis
Adult: With pyrantel: 10-20 mg/kg as single dose
Child: With pyrantel; 10-20 mg/kg as single dose
The dosage recommended for the treatment of schistosomiasis is: 20 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The recommended dose for clonorchiasis and opisthorchiasis is: 25 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The tablets should be washed down unchewed with water during meals. Keeping the tablets or segments thereof in the mouth can reveal a bitter taste which can promote gagging or vomiting.
How supplied
Praziquantel (Guardian Complete Worming) (Praziquantel (Guardian Complete Worming)) is supplied as a 600 mg white to orange tinged, film-coated, oblong tablet with three scores. The tablet is coded with “BAYER” on one side and “LG” on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient's bodyweight.
Segments are broken off by pressing the score (notch) with thumbnails. If ¼ of a tablet is required, this is best achieved by breaking the segment from the outer end.
Praziquantel (Guardian Complete Worming) (Praziquantel (Guardian Complete Worming)) is available in bottles of 6 tablets.
Strength | NDC | |
Bottles of 6 | 600 mg | 0085-1747-01 |
Store below 86°F (30°C).
Manufactured by: Bayer HealthCare Pharmaceuticals Inc. Wayne, NJ 07470. Made in Germany. Distributed and Marketed by: Schering Corporation, a subsidiary of Whitehouse Station, NJ 08889, USA. Revised: 08/10.
Usual Adult Dose for Enterobiasis
11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.
Usual Adult Dose for Pinworm Infection (Enterobius vermicularis)
11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.
Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma)
11 mg/kg base (maximum 1 g) orally daily for 3 days.
Usual Adult Dose for Ascariasis
11 mg/kg base (maximum 1 g) orally once.
Usual Adult Dose for Trichostrongylosis
11 mg/kg base (maximum 1 g) orally once.
Usual Adult Dose for Moniliformis Infection
11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.
Usual Pediatric Dose for Enterobiasis
>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.
Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis)
>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.
Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma)
>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.
Usual Pediatric Dose for Ascariasis
>=2 years: 11 mg/kg base (maximum 1 g) orally once.
Usual Pediatric Dose for Trichostrongylosis
>=2 years: 11 mg/kg base (maximum 1 g) orally once.
Usual Pediatric Dose for Moniliformis Infection
>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Pyrantel (Guardian Complete Worming) is contraindicated in patients with hepatic disease.
Dose Adjustments
In the treatment of ascariasis, Pyrantel (Guardian Complete Worming) may be used only if it has been determined that the worm load will not worsen obstruction.
Precautions
Pyrantel (Guardian Complete Worming) is contraindicated in patients with hepatic disease.
When one individual in a household has pinworms, the entire household should be treated unless otherwise advised. Pinworm infections are easily transmitted to others in the same household.
Pyrantel (Guardian Complete Worming) should be used with caution in patients with severe malnutrition or anemia. Supportive therapy is recommended for anemic, dehydrated, or malnourished patients prior to administration of the drug.
Other medications are known to antagonize the anthelmintic effect of Pyrantel (Guardian Complete Worming). Patients should be advised to consult with their physician before initiating any drug therapy while receiving Pyrantel (Guardian Complete Worming).
Dialysis
Data not available
Other Comments
The dose should be taken as a single oral dose. It may be taken alone or with milk or fruit juice.
Pyrantel (Guardian Complete Worming) pamoate 2.9 g is approximately equivalent to 1 g of Pyrantel (Guardian Complete Worming) (base).
See also:
What is the most important information I should know about Ivermectin (Guardian Complete Worming)?
Before taking Ivermectin (Guardian Complete Worming), tell your doctor about any other medical conditions that you have, especially liver disease. If you have liver problems, you may not be able to use Ivermectin (Guardian Complete Worming), or you may need a dosage adjustment or special tests during treatment.
Treatment with Ivermectin (Guardian Complete Worming) usually involves taking a single dose, which should be taken on an empty stomach with a full glass of water.
To be sure this medication is helping your condition, a sample of your stool (bowel movement) will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.
Avoid drinking alcohol, which can increase some of the side effects of Ivermectin (Guardian Complete Worming).
You may need to be retreated with Ivermectin (Guardian Complete Worming) several months to a year after your single dose.
Call your doctor at once if you have any problems with your eyes or your vision.
See also:
What is the most important information I should know about Praziquantel (Guardian Complete Worming)?
Praziquantel (Guardian Complete Worming) (Praziquantel (Guardian Complete Worming)) is contraindicated in patients who previously have shown hypersensitivity to the drug or any of the excipients. Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound.
Concomitant administration with strong Cytochrome P450 (P450) inducers, such as rifampin, is contraindicated since therapeutically effective blood levels of Praziquantel (Guardian Complete Worming) may not be achieved. In patients receiving rifampin who need immediate treatment for schistosomiasis, alternative agents for schistosomiasis should be considered. However, if treatment with Praziquantel (Guardian Complete Worming) is necessary, rifampin should be discontinued 4 weeks before administration of Praziquantel (Guardian Complete Worming). Treatment with rifampin can then be restarted one day after completion of Praziquantel (Guardian Complete Worming) treatment.
See also:
What is the most important information I should know about Pyrantel (Guardian Complete Worming)?
This medicine is contraindicated in patients with known hypersensitivity to the benzimidazole class of compounds or any components of this medicine.
Use Ivermectin (Guardian Complete Worming) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet and instructions for use is available with Ivermectin (Guardian Complete Worming). Talk to your pharmacist if you have questions about this information.
- Be sure you understand how to use Ivermectin (Guardian Complete Worming). Ask your health care provider if you have questions or if you are unsure how to use it.
- If the patient is a child, an adult should apply Ivermectin (Guardian Complete Worming).
- Your hair and scalp should be completely dry before you apply Ivermectin (Guardian Complete Worming).
- Apply Ivermectin (Guardian Complete Worming) directly to dry hair, starting with the hair closest to the scalp. Work it outward, toward the ends of your hair. Use enough medicine to completely cover the hair and scalp (up to 1 tube).
- Rub Ivermectin (Guardian Complete Worming) throughout your hair. Be sure that each hair is coated with medicine from the scalp to the tip.
- After Ivermectin (Guardian Complete Worming) is applied, leave it on your hair and scalp for 10 minutes (use a timer or clock).
- After 10 minutes, completely rinse Ivermectin (Guardian Complete Worming) using only water.
- Wash your hands immediately after using Ivermectin (Guardian Complete Worming).
- Ivermectin (Guardian Complete Worming) is for a single use only. Throw away the tube and any unused medicine out of reach of children and away from pets.
- Only one dose of Ivermectin (Guardian Complete Worming) is required. If you forget to use Ivermectin (Guardian Complete Worming), use it as soon as you remember.
Ask your health care provider any questions you may have about how to use Ivermectin (Guardian Complete Worming).
Use Praziquantel (Guardian Complete Worming) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Praziquantel (Guardian Complete Worming) with a full glass of water during meals.
- Do not crush or chew before swallowing.
- Take your doses at least 4 hours apart but not more than 6 hours apart unless directed otherwise by your doctor.
- If you miss a dose of Praziquantel (Guardian Complete Worming), take it as soon as possible. If it less than 4 hours until your next dose, contact your doctor to see if you need to establish a new dosing schedule.
Ask your health care provider any questions you may have about how to use Praziquantel (Guardian Complete Worming).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use Pyrantel (Guardian Complete Worming) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Pyrantel (Guardian Complete Worming) may be taken on an empty stomach or with food, milk, or juice.
- Shake well before using a dose of Pyrantel (Guardian Complete Worming).
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Wear tight underwear both day and night while taking Pyrantel (Guardian Complete Worming).
- Pyrantel (Guardian Complete Worming) is usually prescribed as a single dose.
- Only one dose of Pyrantel (Guardian Complete Worming) is required. If you forget to take Pyrantel (Guardian Complete Worming), take it as soon as you remember.
Ask your health care provider any questions you may have about how to use Pyrantel (Guardian Complete Worming).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Onchocerciasis: Treatment of onchocerciasis due to the immature form of Onchocerca volvulus.
Limitations of use: Ivermectin (Guardian Complete Worming) has no activity against adult Onchocerca volvulus parasites. The adult parasites reside in subcutaneous nodules which are infrequently palpable. Surgical excision may be considered as removal of these nodules will eliminate the microfilariae-producing adult parasites.
Strongyloidiasis, intestinal: Treatment of intestinal (eg, nondisseminated) strongyloidiasis due to Strongyloides stercoralis.
Off Label Uses
Ascariasis
Data from two clinical trials in patients with intestinal helminths supports the use of Ivermectin (Guardian Complete Worming) in the treatment of Ascaris lumbricoides infection. Additional trials may be necessary to further define the role of Ivermectin (Guardian Complete Worming) in this condition.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Helminths: Treatment of infections in patients ≥1 year caused by the following: All species of Schistosoma (eg, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium) and the liver flukes Clonorchis sinensis/Opisthorchis viverrini
Off Label Uses
Neurocysticercosis, parenchymal
Data from the phase II and phase III portions of a randomized, double blind, placebo-controlled study supports the use of Praziquantel (Guardian Complete Worming) (in combination with albendazole) in the treatment of parenchymal neurocysticercosis.
See also:
What other drugs will affect Ivermectin (Guardian Complete Worming)?
With simultaneous use of Ivermectin (Guardian Complete Worming) Ind-Swift with theophylline, aminophylline, caffeine, there is an increase in their concentration in blood plasma and thus increases the risk of toxic effects.
Erythromycin increases the concentrations of cyclosporine in the blood plasma and may increase the risk of nephrotoxicity.
Drugs that block tubular secretion prolongs T1/2 of erythromycin.
Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).
Ivermectin (Guardian Complete Worming) Ind-Swift reduces the bactericidal action of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems).
With simultaneous use of erythromycin increases the concentration of theophylline.
At the same time receiving chemotherapy, which is carried metabolism in the liver (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, dizopiramid, lovastatin, bromocriptine), may increase the concentration of these drugs in plasma (an inhibitor of microsomal liver enzymes).
IV injection of erythromycin increases the effects of ethanol (accelerating gastric emptying and decrease the duration of alcohol dehydrogenase in the gastric mucosa).
Erythromycin reduces the clearance of triazolam and midazolam and therefore may increase the pharmacological effects of benzodiazepines.
At the same time taking with terfenadine or astemizole may develop arrhythmias (fibrillation and ventricular flutter, ventricular tachycardia, until death); with dihydroergotamine or non hydrated ergot alkaloids may vasoconstriction to spasm, dysesthesia.
With simultaneous application Ivermectin (Guardian Complete Worming) Ind-Swift slows elimination (increases the effect) of methylprednisolone, felodipine and anticoagulants of cumarine series.
In a joint appointment with lovastatin increased rhabdomyolysis.
Erythromycin increases the bioavailability of digoxin.
Erythromycin reduces the effectiveness of hormonal contraceptives.
See also:
What other drugs will affect Praziquantel (Guardian Complete Worming)?
Concomitant administration of rifampin, a strong P450 inducer, with Praziquantel (Guardian Complete Worming) is contraindicated and must be avoided. In a crossover study with a 2-week washout period, 10 healthy subjects ingested a single 40 mg/kg dose of Praziquantel (Guardian Complete Worming) following pre-treatment with oral rifampin (600 mg daily for 5 days). Plasma Praziquantel (Guardian Complete Worming) concentrations were undetectable in 7 out of 10 subjects. When a single 40 mg/kg dose of Praziquantel (Guardian Complete Worming) was administered to these healthy subjects two weeks after discontinuation of rifampin, the mean Praziquantel (Guardian Complete Worming) AUC and Cmax were 23% and 35% lower, respectively, than when Praziquantel (Guardian Complete Worming) was given alone. In patients receiving rifampin, for example, as part of a combination regimen for the treatment of tuberculosis, alternative agents for schistosomiasis should be considered. However, if treatment with Praziquantel (Guardian Complete Worming) is necessary, treatment with rifampin should be discontinued 4 weeks before administration of Praziquantel (Guardian Complete Worming). Treatment with rifampin can then be restarted one day after completion of Praziquantel (Guardian Complete Worming) treatment.
Concomitant administration of other drugs that increase the activity of drug metabolizing liver enzymes (P450 inducers), for example, antiepileptic drugs (phenytoin, phenobarbital and carbamazepine), and dexamethasone, may also reduce plasma levels of Praziquantel (Guardian Complete Worming). Concomitant administration of drugs that decrease the activity of drug metabolizing liver enzymes (P 450 inhibitors), for example, cimetidine, ketoconazole, itraconazole, erythromycin may increase plasma levels of Praziquantel (Guardian Complete Worming).
Chloroquine, when taken simultaneously, may lead to lower concentrations of Praziquantel (Guardian Complete Worming) in blood. The mechanism of this drug-drug interaction is unclear.
Grapefruit juice was reported to produce a 1.6-fold increase in the Cmax and a 1.9-fold increase in the AUC of Praziquantel (Guardian Complete Worming). However, the effect of this exposure increase on the therapeutic effect and safety of Praziquantel (Guardian Complete Worming) has not been systematically evaluated.
See also:
What other drugs will affect Pyrantel (Guardian Complete Worming)?
• Dexamethasone
Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.
• Pyrantel (Guardian Complete Worming)
• Cimetidine
Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.
• Theophylline
The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.
See also:
What are the possible side effects of Ivermectin (Guardian Complete Worming)?
Strongyloidiasis
In four clinical studies involving a total of 109 patients given either one or two doses of 170 to 200 mcg/kg of Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)), the following adverse reactions were reported as possibly, probably, or definitely related to Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) :
Body as a Whole: asthenia/fatigue (0.9%), abdominal pain (0.9%)
Gastrointestinal: anorexia (0.9%), constipation (0.9%), diarrhea (1.8%), nausea (1.8%), vomiting (0.9%)
Nervous System/Psychiatric: dizziness (2.8%), somnolence (0.9%), vertigo (0.9%), tremor (0.9%)
Skin: pruritus (2.8%), rash (0.9%), and urticaria (0.9%).
In comparative trials, patients treated with Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) experienced more abdominal distention and chest discomfort than patients treated with albendazole. However, Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) was better tolerated than thiabendazole in comparative studies involving 37 patients treated with thiabendazole.
The Mazzotti-type and ophthalmologic reactions associated with the treatment of onchocerciasis or the disease itself would not be expected to occur in strongyloidiasis patients treated with Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)).
Laboratory Test Findings
In clinical trials involving 109 patients given either one or two doses of 170 to 200 mcg/kg Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)), the following laboratory abnormalities were seen regardless of drug relationship: elevation in ALT and/or AST (2%), decrease in leukocyte count (3%). Leukopenia and anemia were seen in one patient.
Onchocerciasis
In clinical trials involving 963 adult patients treated with 100 to 200 mcg/kg Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)), worsening of the following Mazzotti reactions during the first 4 days post-treatment were reported: arthralgia/synovitis (9.3%), axillary lymph node enlargement and tenderness (11.0% and 4.4%, respectively), cervical lymph node enlargement and tenderness (5.3% and 1.2%, respectively), inguinal lymph node enlargement and tenderness (12.6% and 13.9%, respectively), other lymph node enlargement and tenderness (3.0% and 1.9%, respectively), pruritus (27.5%), skin involvement including edema, papular and pustular or frank urticarial rash (22.7%), and fever (22.6%).
In clinical trials, ophthalmological conditions were examined in 963 adult patients before treatment, at day 3, and months 3 and 6 after treatment with 100 to 200 mcg/kg Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)). Changes observed were primarily deterioration from baseline 3 days post-treatment. Most changes either returned to baseline condition or improved over baseline severity at the month 3 and 6 visits. The percentages of patients with worsening of the following conditions at day 3, month 3 and 6, respectively, were: limbitis: 5.5%, 4.8%, and 3.5% and punctate opacity: 1.8%, 1.8%, and 1.4%. The corresponding percentages for patients treated with placebo were: limbitis: 6.2%, 9.9%, and 9.4% and punctate opacity: 2.0%, 6.4%, and 7.2%.
In clinical trials involving 963 adult patients who received 100 to 200 mcg/kg Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)), the following clinical adverse reactions were reported as possibly, probably, or definitely related to the drug in ≥ 1% of the patients: facial edema (1.2%), peripheral edema (3.2%), orthostatic hypotension (1.1%), and tachycardia (3.5%). Drug-related headache and myalgia occurred in < 1% of patients (0.2% and 0.4%, respectively). However, these were the most common adverse experiences reported overall during these trials regardless of causality (22.3% and 19.7%, respectively).
A similar safety profile was observed in an open study in pediatric patients ages 6 to 13.
The following ophthalmological side effects do occur due to the disease itself but have also been reported after treatment with Ivermectin (Guardian Complete Worming) (Ivermectin (Guardian Complete Worming)) : abnormal sensation in the eyes, eyelid edema, anterior uveitis, conjunctivitis, limbitis, keratitis, and chorioretinitis or choroiditis. These have rarely been severe or associated with loss of vision and have generally resolved without corticosteroid treatment.
Laboratory Test Findings
In controlled clinical trials, the following laboratory adverse experiences were reported as possibly, probably, or definitely related to the drug in ≥ 1% of the patients: eosinophilia (3%) and hemoglobin increase (1%).
Post-Marketing Experience
The following adverse reactions have been reported since the drug was registered overseas:
Onchocerciasis
Conjunctival hemorrhage
All Indications
Hypotension (mainly orthostatic hypotension), worsening of bronchial asthma, toxic epidermal necrolysis, Stevens-Johnson syndrome, seizures, hepatitis, elevation of liver enzymes, and elevation of bilirubin.
Headache, abdominal pain, diarrhoea
See also:
What are the possible side effects of Praziquantel (Guardian Complete Worming)?
Applies to Praziquantel (Guardian Complete Worming): oral tablet
In addition to its needed effects, some unwanted effects may be caused by Praziquantel (Guardian Complete Worming) (the active ingredient contained in Praziquantel (Guardian Complete Worming)). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Praziquantel (Guardian Complete Worming):
Incidence not known:
- Abdominal or stomach discomfort with or without nausea
- abdominal or stomach pain
- black, tarry stools
- bloody diarrhea
- chest pain or discomfort
- chills
- convulsions
- cough
- dizziness
- fainting
- fast, slow, or irregular heartbeat
- fever
- hives
- hoarseness
- irritation
- itching
- joint pain, stiffness, or swelling
- lightheadedness, dizziness, or fainting
- painful or difficult urination
- rash
- redness of the skin
- severe abdominal or stomach pain
- shortness of breath
- slow or irregular heartbeat
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sweating
- swelling of the eyelids, face, lips, hands, or feet
- swollen glands
- tightness in the chest
- troubled breathing or swallowing
- unusual bleeding or bruising
- unusual tiredness or weakness
- wheezing
Minor Side Effects
Some of the side effects that can occur with Praziquantel (Guardian Complete Worming) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Drowsiness
- increased sweating
- general feeling of discomfort or illness
- nausea or vomiting
- Skin rash, hives, or itching
- Difficulty with moving
- dizziness or lightheadedness
- feeling of constant movement of self or surroundings
- headache
- hives or welts
- joint pain
- lack or loss of strength
- loss of appetite
- muscle aching or cramping
- muscle pains or stiffness
- redness of the skin
- sensation of spinning
- sleepiness or unusual drowsiness
- swollen joints
- weight loss
See also:
What are the possible side effects of Pyrantel (Guardian Complete Worming)?
Applies to Pyrantel (Guardian Complete Worming): oral suspension, oral tablet, oral tablet chewable
In addition to its needed effects, some unwanted effects may be caused by Pyrantel (Guardian Complete Worming) (the active ingredient contained in Pyrantel (Guardian Complete Worming)). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Pyrantel (Guardian Complete Worming), check with your doctor or nurse as soon as possible:
Rare
- Skin rash
Minor Side Effects
Some of the side effects that can occur with Pyrantel (Guardian Complete Worming) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:
- Abdominal or stomach cramps or pain
- diarrhea
- dizziness
- drowsiness
- headache
- irritability
- loss of appetite
- nausea or vomiting
- trouble in sleeping
Ivermectin (Guardian Complete Worming) is a broad-spectrum anti-parasite medication. It was first marketed under the name Ivermectin (Guardian Complete Worming)® and used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older, and marketed under the name Sklice™ as well. Ivermectin (Guardian Complete Worming) is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).
An anthelmintic used in most schistosome and many cestode infestations. [PubChem]
Pyrantel (Guardian Complete Worming) is an antinematodal thiophene