Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 16.04.2022
Attention! Information on this page is intended only for medical professionals! Information is collected in open sources and may contain significant errors! Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
Intra-articular
Inflammatory joint diseases
Adult: 0.8-4 mg depending on the size of the affected joint. For soft-tissue inj, 2-6 mg may be used. May repeat inj every 3-5 days to every 2-3 wk.
Intravenous
Prophylaxis of nausea and vomiting associated with cytotoxic therapy
Adult: Prevention: 10-20 mg 15-30 minutes before admin of chemotherapy on each treatment day. For continuous infusion regimen: 10 mg every 12 hr on each treatment day. For midly emetogenic regimen: 4 mg every 4-6 hr.
Intravenous
Unresponsive shock
Adult: As phosphate: Initially, 40 mg or 1-6 mg/kg as a single IV inj, may repeat every 2-6 hr. Continue high-dose treatment only until patient's condition has stabilised and not to be continued beyond 48-72 hr.
Intravenous
Bacterial meningitis
Adult: 0.15 mg/kg 4 times daily, to be given 10-20 min before or with the 1st dose of anti-infective treatment. Treatment should be given for the first 2-4 days of the anti-infective treatment.
Child: As phosphate: 2 mth-18 yr: 150 mcg/kg every 6 hr for 4 days, starting before or with 1st dose of antibacterial treatment.
Ophthalmic
Ocular inflammation
Adult: As 0.1% suspension: Apply 1-2 drops into the affected eye/s 4-6 times daily in mild disease, up to hrly admin in more severe disease. As 0.05% ointment: Apply 0.5-1 inch ribbon of ointment into the conjunctival sac(s) up to 4 times daily. Reduce to once daily dosing once conditon has improved.
Oral
Anti-inflammatory
Adult: 0.75-9 mg daily in 2-4 divided doses; may also be given via IM/IV admin.
Child: 1 mth-18 yr: 10-100 mcg/kg daily in 1-2 divided doses via oral admin, adjusted according to response; up to 300 micrograms/kg daily may be used in emergency situations.
Oral
Screening test for Cushing's syndrome
Adult: 0.5 mg every 6 hr for 48 hr after determining baseline 24-hr urinary 17-hydroxycorticosteroid (17-OHCS) concentrations. During the second 24 hr of dexamethasone admin, urine is collected and analysed for 17-OHCS. Alternatively, after a baseline plasma cortisol determination, 1 mg may be given at 11 pm and plasma cortisol determined at 8 am the next morning. Plasma cortisol and urinary output of 17-OHCS are depressed after dexamethasone admin in normal individuals but remain at basal levels in patients with Cushing's syndrome.
Oral
Acute exacerbations in multiple sclerosis
Adult: 30 mg daily for 1 wk followed by 4-12 mg daily for 1 mth.
Child: 1 mth-12 yr: 100-400 mcg/kg daily in 1-2 divided doses; 12-18 yr: Initially 0.5-24 mg daily. Max. 24 mg daily.
Parenteral
Cerebral oedema caused by malignancy
Adult: As phosphate: 10 mg IV followed by 4 mg IM every 6 hr until response is achieved, usually after 12-24 hr. May reduce dosage after 2-4 days then gradually discontinued over 5-7 days. In severe cases, an initial dose of 50 mg IV may be given on day 1, with 8 mg every 2 hr, reduced gradually over 7-13 days. Maintenance dose: 2 mg 2-3 times daily.
Child: As phosphate: <35 kg: Initially 20 mg, then 4 mg every 3 hr for 3 days, then 4 mg every 6 hr for 1 day, then 2 mg every 6 hr for 4 days, then decrease by 1 mg daily. >35 kg: Initially 25 mg, then 4 mg every 2 hr for 3 days, then 4 mg every 4 hr for 1 day, then 4 mg every 6 hr for 4 days, then decrease by 2 mg daily. Doses are given via IV inj.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Parenteral
Susceptible infections
Adult: 4-6 mg/kg once daily or in equally divided doses given every 8 or 12 hr. Life-threatening infections: Increase to up to 7.5 mg/kg daily every 8 hr. All doses may be given as IM, slow IV (over 3-5 min) or as 50-200 ml infusion over 0.5-2 hr. Treatment is usually given for 7-14 days.
Child: Premature infants and neonates <1 wk: 6 mg/kg daily in divided doses every 12 hr. Infants and neonates >1 wk: 7.5-9 mg/kg daily in divided doses every 8 hr. Older children: 6-7.5 mg/kg daily in divided doses every 8 hr. Alternative regimen: Neonates <6 wk: 4-6.5 mg/kg daily in divided doses every 12 hr. Older infants and children: 5.5-8 mg/kg daily in divided doses every 8 or 12 hr.
Renal impairment: Dose reduction or lengthening of interval between doses may be necessary.
Haemodialysis: 50% of initial loading dose is required after dialysis.
Incompatibility: Do not mix in the same syringe with penicillins or cephalosporins.
Parenteral
Urinary tract infections
Adult: 150 mg as a single daily dose for 5 days. Complicated UTI: 3-4 mg/kg daily in divided doses every 12 hr. All doses may be given as IM, slow IV (over 3-5 min) or as a 50-200 ml infusion over 0.5-2 hr. Treatment is usually given for 7-14 days.
Renal impairment: Dose reduction or lengthening of interval between doses may be necessary.
Haemodialysis: 50% of initial loading dose is required after dialysis.
Incompatibility: Do not mix in the same syringe with penicillins or cephalosporins.
Dexamethasone intravitreal implant is used to treat an eye disease called macular edema (swelling of the back of the eye). Macular edema occurs when a blood vessel in the eye is clogged. This causes vision changes that must be treated right away. Dexamethasone is a corticosteroid (steroid medicine) that helps reduce the swelling in the eye.
Dexamethasone intravitreal implant is also used to treat an eye disease called uveitis (swelling in the middle part of the eye). dexamethasone is also used to treat diabetic macular edema in patients with artificial lens implant or are scheduled for cataract surgery.
dexamethasone is to be given only by or under the supervision of your doctor.
Generic name: dexamethasone 0.5mg in 5mL
Dosage form: elixir
See also:
- Dexamethasone tablet
Medically reviewed on October 1, 2017.
For oral administration: DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.
The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue Dexamethasone® Elixir and transfer the patient to other therapy.
After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.
Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.
If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually.
The following milligram equivalents facilitate changing to Dexamethasone® Elixir from other glucocorticoids:
Dexamethasone suppression tests
- Tests for Cushing's syndrome.
Give 1 mg of Dexamethasone orally at 11:00 p.m. Blood is drawn for plasma cortisol determination at 8:00 a.m. the following morning.
For greater accuracy, give 0.5 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.
- Test to distinguish Cushing's syndrome due to pituitary ACTH excess from Cushing's syndrome due to other causes.
Give 2 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Dexamethasone (dexamethasone)
- Dexamethasone Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- 14 Reviews
- Drug class: glucocorticoids
Consumer resources
- Dexamethasone (Advanced Reading)
Other brands: Dexamethasone Intensol, Dexasone, Dexacen-4, Dexamethasone,... +7 more
Professional resources
- Dexamethasone (FDA)
- Dexamethasone Elixir (FDA)
- Dexamethasone sodium phosphate (AHFS Monograph)
Related treatment guides
- Addison's Disease
- Adrenal Insufficiency
- Adrenocortical Insufficiency
- Adrenogenital Syndrome
- ... +54 more
Applies to the following strengths: 100 mg/mL
Usual Adult Dose for:
- Bacterial Infection
- Urinary Tract Infection
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dose Adjustments
- Precautions
- Dialysis
- Other Comments
Usual Adult Dose for Bacterial Infection
Serious systemic infections: 4 to 6.5 mg/kg/day in divided doses every 8 to 12 hours.
Usual Adult Dose for Urinary Tract Infection
Complicated: 3 to 4 mg/kg/day in 2 divided doses every 12 hours.
Renal Dose Adjustments
CrCl 20 to 40 mL/min: The usual dose should be administered every 24 hours.
CrCl 40 to 60 mL/min: The usual dose should be administered every 12 hours.
Liver Dose Adjustments
No adjustment required
Dose Adjustments
The dosage in obese patients should be based on lean body mass. In patients with extensive body surface burns, altered pharmacokinetics may result in reduced serum levels of aminoglycosides. Measurement of netilmicin serum levels is particularly important as a basis for dosage adjustment in such patients.
Precautions
Administration of injections preserved with benzyl alcohol has been associated with toxicity in neonates. Caution should be used when netilmicin is administered to neonates and children.
Although prolonged courses of netilmicin injection have been well tolerated, it is particularly important that patients treated for longer than the usual period be carefully monitored for changes in renal, auditory, and vestibular functions.
Dialysis
In adults, a dose of 2 mg/kg at the end of each dialysis period is recommended until the results of tests measuring netilmicin serum levels become available. Dosage should then be appropriately adjusted based on these tests.
Other Comments
Generally, each individual dose should not exceed 3.25 mg/kg. It is desirable to limit the duration of treatment with aminoglycosides to short-term whenever feasible. The usual duration of treatment for all patients is 7 to 14 days. In complicated infections, a longer course of therapy may be necessary. It is desirable to measure both peak and trough serum levels of netilmicin to determine the adequacy and safety of the administered dosage. When such measurements are feasible, they should be carried out periodically during therapy. Peak serum levels are expected to range from 4 to 12 mcg/mL. Dosage should be adjusted to attain the desired peak and trough levels and to avoid prolonged peak serum levels above 16 mcg/mL. When monitoring trough levels (just prior to the next dose), dosage should be adjusted so that levels above 4 mcg/mL are avoided. Interpatient variation of aminoglycoside serum levels occurs in patients with normal or abnormal renal function. Generally, desirable peak and trough levels will be in the range of 6 to 10 and 0.5 to 2 mcg/mL, respectively.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about netilmicin
- Netilmicin Side Effects
- During Pregnancy
- Drug Interactions
- Drug class: aminoglycosides
Related treatment guides
- Urinary Tract Infection
- Bacterial Infection
See also:
What is the most important information I should know about Dexamethasone?
You should not use this medication if you are allergic to dexamethasone, or if you have a fungal infection anywhere in your body.
Before taking dexamethasone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
Do not receive a "live" vaccine while you are taking dexamethasone. Vaccines may not work as well while you are taking a steroid.
Do not stop using dexamethasone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Wear a medical alert tag or carry an ID card stating that you take dexamethasone. Any medical care provider who treats you should know that you are using a steroid.
Patients with a history of hypersentivity to aminoglycosides or those with impaired renal function should avoid this medication.
Use Dexamethasone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- If your doctor prescribed more than 1 eye medicine, find out the best order for using each medicine.
- Remove contact lenses before using Dexamethasone.
- Shake well before each use.
- To use Dexamethasone in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
- To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
- If you miss a dose of Dexamethasone, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Dexamethasone.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. It is also used to test for an adrenal gland disorder (Cushing's syndrome). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions. Dexamethasone is a corticosteroid hormone (glucocorticoid). This injectable form of dexamethasone is used when a similar drug cannot be taken by mouth or when a very fast response is needed, especially in patients with severe medical conditions. Talk to your doctor about the risks and benefits of dexamethasone, especially if it is to be injected near your spine (epidural). Rare but serious side effects may occur with epidural use.
This drug may also be used with other medications as a replacement for certain hormones.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This drug may also be used to prevent nausea and vomiting caused by cancer chemotherapy.
How to use Dexamethasone injection
This medication is given by injection into a vein, muscle, joint, or skin wound as directed by your doctor. Follow your doctor's directions carefully. Dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often than prescribed without consulting your doctor. Some patients (especially newborns) should receive the preservative-free form of this drug. In these patients, when mixing this form of the drug, be sure to use IV fluid that is also preservative-free. Use these mixtures within 24 hours.
If this medication is injected into a joint, be careful how much pressure you put on that joint, even if it is feeling better. Ask your doctor how much you can move/use the joint while it is healing.
If you have been using this medication for a long time, do not suddenly stop using it without your doctor's approval. Your dose may need to be gradually decreased to reduce symptoms such as weakness, weight loss, nausea, or extreme tiredness.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
Tell your doctor if your condition persists or worsens.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Netilmicin is used to treat complicated urinary tract infection, skin infection, stomach or intestinal infection.
See also:
What other drugs will affect Dexamethasone?
Tablet/Forte Tablet: Barbiturates, Phenytoin, Ephedrine, Carbamazepine, Rifampicin and Other Drugs that Stimulate Hepatic Metabolism: May lessen the effect of dexamethasone due to enhancement of dexamethasone metabolism. Increase in dexamethasone dosage may be required.
CYP3A4 Inhibitors eg, Ketoconazole and Macrolide Antibiotics: May increase plasma concentrations of corticosteroids.
Indinavir, Erythromycin and Other Drugs Metabolized by CYP3A4: Dexamethasone is a moderate inducer of CYP3A4 and may increase clearance of these drugs, resulting in decreased plasma concentrations.
Oral Contraceptives and Estrogen:
Aspirin: Concomitant use of aspirin or other nonsteroidal anti-inflammatory agents (NSAIDs) and corticosteroids increases the risk of gastrointestinal adverse effects. Use aspirin cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Concomitant administration of dexamethasone and aspirin may also cause changes in salicylate plasma protein-binding and its rate of metabolism. These changes cause lowering of plasma salicylate levels.
Warfarin: Co-administration of corticosteroids and warfarin usually results in decreased response to warfarin, although there have been conflicting results.
Monitor coagulation indices frequently to maintain the desired anticoagulant effect.
Potassium-Depleting Agents eg, Diuretics and Amphotericin-B: Observe patients closely for the development of hypokalemia. Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.
Anticholinesterase Agents: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, withdraw anticholinesterase agents at least 24 hrs before initiating corticosteroid therapy.
Antacids: Large doses of antacids cause alteration in corticosteroid absorption.
Insulin: Concomitant administration of dexamethasone and insulin generally requires higher doses of insulin.
Ketoconazole: Decreases the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.
Thalidomide: Toxic epidermal necrolysis has been reported when dexamethasone was used concomitantly with thalidomide.
Indomethacin: May cause false negative results in the dexamethasone suppression test (DST).
Other Interactions: Toxoids and Live or Inactivated Vaccines: Patients on prolonged corticosteroid therapy may exhibit diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.
Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. If possible, postpone routine administration of vaccines or toxoids until corticosteroid therapy is discontinued.
Antidiabetic Agents: Dosage adjustment of antidiabetic agents may be required because corticosteroids may increase blood glucose concentrations.
Skin Tests: Corticosteroids may suppress reactions to skin tests.
Netilmicin should not be administered concomitantly with potent loop diuretics such as furosemide and ethacrynic acid as the potential for ototoxicity is enhanced by the combination.
See also:
What are the possible side effects of Dexamethasone?
Applies to dexamethasone: oral elixir, oral solution, oral tablet
Along with its needed effects, dexamethasone (the active ingredient contained in Dexamethasone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dexamethasone:
More common
- Aggression
- agitation
- anxiety
- blurred vision
- decrease in the amount of urine
- dizziness
- fast, slow, pounding, or irregular heartbeat or pulse
- headache
- irritability
- mental depression
- mood changes
- nervousness
- noisy, rattling breathing
- numbness or tingling in the arms or legs
- pounding in the ears
- shortness of breath
- swelling of the fingers, hands, feet, or lower legs
- trouble thinking, speaking, or walking
- troubled breathing at rest
- weight gain
- Abdominal cramping and/or burning (severe)
- abdominal pain
- backache
- bloody, black, or tarry stools
- cough or hoarseness
- darkening of skin
- decrease in height
- decreased vision
- diarrhea
- dry mouth
- eye pain
- eye tearing
- facial hair growth in females
- fainting
- fatigue
- fever or chills
- flushed, dry skin
- fractures
- fruit-like breath odor
- full or round face, neck, or trunk
- heartburn and/or indigestion (severe and continuous)
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- loss of sexual desire or ability
- lower back or side pain
- menstrual irregularities
- muscle pain or tenderness
- muscle wasting or weakness
- nausea
- pain in back, ribs, arms, or legs
- painful or difficult urination
- skin rash
- sleeplessness
- sweating
- trouble healing
- trouble sleeping
- unexplained weight loss
- unusual tiredness or weakness
- vision changes
- vomiting
- vomiting of material that looks like coffee grounds
Some side effects of dexamethasone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Increased appetite
- Abnormal fat deposits on the face, neck, and trunk
- acne
- dry scalp
- lightening of normal skin color
- red face
- reddish purple lines on the arms, face, legs, trunk, or groin
- swelling of the stomach area
- thinning of the scalp hair
Headache, malaise, visual disturbances, disorientation, tachycardia, hypotension, palpitations, thrombocytosis, paraesthesia, rash, chills, fever, fluid retention, vomiting, diarrhoea. Increased blood sugar; increased alkaline phosphatase; increased liver enzymes, bilirubin; increased potassium; other abnormal LFTs; decreased haemoglobin, WBCs and platelets; eosinophilia, anaemia and increase in prothrombin time.
Potentially Fatal: Nephrotoxicity; ototoxicity; anaphylaxis.
Each gram of Dexamethasone oral paste contains dexamethasone 1 mg and sodium polyacryle 300 mg. Dexamethasone is a paste for application to the oral mucosa, containing dexamethasone with a potent anti-inflammatory action as the active ingredient. The use of sodium polyacrylate which has a potent adhesive and coating activity on the moist surface as the base is greatly contributory to the prolonged action of dexamethasone and the protection of wound surface: Dexamethasone is thus effective against inflammatory diseases of the oral cavity.
Dexamethasone is 9α-Fluoro-11β, 17α, 21-trihydroxy-16α-methyl-pregna-1, 4-diene-3, 20-dione. It has a molecular formula C22H29FO5 and a molecular weight of 392.47.
Dexamethasone occurs as white to light yellow crystals or a crystalline powder. It is sparingly soluble in methanol, in ethanol, in acetone or in dioxane, slightly soluble in chloroform, and practically insoluble in ether.
Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. [PubChem] Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect of netilmiicin is not fully understood.