Corticetine

Corticetine

Dexamethasone, Framycetin

bacterial diseases of the anterior segment of the eye (blepharitis, conjunctivitis, keratitis (without damage to the epithelium), iridocyclitis, scleritis, episcleritis),

infected eczema of the eyelid skin,

otitis media of the outer ear.

Diseases of the eye: with a mild course of the infectious process, 1-2 drops of the drug are instilled into the conjunctival sac of the eye every 4 hours. In the case of a severe infectious process, the drug is instilled every hour. As the inflammatory phenomena decrease, the frequency of instillations of the drug decreases.

Diseases of the ear: instill 2-3 drops 3-4 times a day, in the external auditory canal, you can lay a gauze swab moistened with a solution.

The duration of use of the drug should not exceed 7 days, except in cases of obvious positive dynamics of the disease (GCS can mask hidden infections, and long-term use of antimicrobial components of the drug-contribute to the development of a stable flora).

increased individual sensitivity to any of the components of the drug,

viral or fungal infections, tuberculosis, purulent inflammation of the eyes, trachoma,

violation of the integrity of the corneal epithelium and thinning of the sclera,

herpetic keratitis (tree-shaped corneal ulcer) (possible increase in the size of the ulcer and significant visual impairment),

glaucoma,

perforation of the tympanic membrane (penetration of the drug into the middle ear can lead to the development of ototoxic effects),

pregnancy,

breast-feeding period,

infants.

With caution: young children (especially when the drug is prescribed in large doses and for a long time — the risk of developing systemic effects and suppression of adrenal function).

Allergic reactions are usually of a delayed type, manifested by irritation, burning, pain, itching, and dermatitis.

With long-term use of local GCS, it is possible:

- increased IOP with the development of the glaucoma symptom complex (damage to the optic nerve, decreased visual acuity and the appearance of visual field defects), therefore, with more than 7 days of use of drugs containing corticosteroids, IOP should be regularly measured,

- development of posterior subcapsular cataracts (especially with frequent instillation),

- thinning of the cornea or sclera, which can lead to perforation,

- the addition of a secondary (fungal) infection.

Symptoms: prolonged and intensive topical use can lead to systemic effects. If you swallow the contents of one bottle (up to 10 ml of solution), it is unlikely to develop serious side effects.

Treatment: symptomatic.

Framycetin sulfate-an antibiotic from the group of aminoglycosides, acts bactericidal. It has a wide spectrum of antibacterial action, is active against Gram-positive microorganisms, including Staphylococcus aureus, and most clinically significant Gram-negative microorganisms (Escherichia coli, dysentery bacillus, proteus, etc.). It is ineffective against streptococci. It does not affect pathogenic fungi, viruses, and anaerobic flora. Resistance of microorganisms to framycetin sulfate develops slowly.

Gramicidin has a bactericidal and bacteriostatic effect, expands the spectrum of antimicrobial action of framycetin due to its activity against streptococci and anaerobic microorganisms. It enhances the effects of framycetin against staphylococci, because it also has an anti-staphylococcal effect.

Dexamethasone-GCS, which has a pronounced anti-inflammatory, anti-allergic and desensitizing effect.

Dexamethasone suppresses inflammatory processes by inhibiting the release of inflammatory mediators, mast cell migration, and reducing capillary permeability.

When instilled in the eyes, it reduces pain, burning, lacrimation, photophobia. When instilled in the ears, it reduces the symptoms of otitis media of the outer ear (redness of the skin, pain, itching, burning in the external auditory canal, a feeling of stuffiness of the ear).

When applied topically, systemic absorption is low.

Framycetin sulfate can be absorbed through inflamed skin or open wounds. When it enters the systemic circulation, it is quickly excreted by the kidneys in an unchanged form. T_1/2 framycetin sulfate is 2-3 hours.

When taken orally, dexamethasone can be rapidly absorbed from the gastrointestinal tract. T_1/2 is 190 min.

• Glucocorticosteroid for topical use antibiotics (aminoglycoside and cyclic polypeptide) [Glucocorticosteroids in combination]
• Glucocorticosteroid for topical use antibiotics (aminoglycoside and cyclic polypeptide) [Ophthalmic agents in combinations]

Do not use framycetin sulfate together with other antibiotics that have ototoxic and nephrotoxic effects (streptomycin, monomycin, kanamycin, gentamicin).