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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 22.03.2022
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Cefadol
Cefamandole
Abdominal and gynecological infections, sepsis, meningitis, endocarditis, infections of the urinary tract, BONES, joints, skin and soft tissues. Prevention of postoperative infectious complications.
V / m or V / V. For intravenous administration of the drug (0.5 or 1 g) is dissolved in 3 ml of water for injection or in 3 ml of isotonic solution of sodium chloride. For intravenous administration, dissolve 1 g of the drug in 10 ml of water for injection or in 10 ml of isotonic sodium chloride solution. For intravenous administration, the dissolved drug is mixed with a 10% glucose solution or isotonic sodium chloride solution.
Adults-0.5-1 g every 4-8 hours, with diseases of the urinary tract - 0.5 g (in severe cases - 1 g) every 8 hours, with severe infections — up to 2 g every 4 hours (12 g / day). Children - 50-150 mg / kg / day (with severe infections — up to 150 mg / kg / day) with an interval between injections — 4-8 no.with infections caused by beta-hemolytic streptococcus, treatment is continued for at least 10 days. For the prevention of postoperative infectious complications for 30-60 minutes before the intervention, adults are administered - 1-2 g, children - 50-100 mg / kg, followed by the use of the same doses for 24-48 hours
In case of violation of kidney function, the dosage regimen is established taking into account creatinine Cl. The first dose is the same for all patients and is 1-2 G. At cl creatinine 50-80 ml / min: for the treatment of severe infections - 2 g every 4 hours, for the treatment of moderate infections-1.5 g every 6 hours or 2 g every 8 hours. At cl creatinine 25-50 ml / min: for the treatment of severe infections - 1.5 g every 4 hours or 2 g every 6 hours, for the treatment of moderate infections-1.5 g every 8 hours. At cl creatinine 10-25 ml / min: for the treatment of severe infections - 1 g every 6 hours or 1.25 g every 8 hours, for the treatment of moderate infections - 1 g every 8 hours. At cl creatinine 2-10 ml / min: for the treatment of severe infections-670 mg every 8 hours or 1 g every 12 hours, for the treatment of moderate infections — 500 mg every 8 hours or 750 mg every 12 hours. When Creatinine cl is less than 2 ml / min: for the treatment of severe infections - 500 mg every 8 hours or 750 mg every 12 hours, for the treatment of moderate infections — 500 mg every 12 hours.patients on hemodialysis - in / or / m 1 g every 12 hours (if injected in / m, then after completion of hemodialysis additionally administered 1 / 3-1 / 2 doses).
Hypersensitivity to cephalosporins, penicillins, carbapenems.
From the cardiovascular system and blood (Hematopoiesis, hemostasis): leukopenia, thrombocytopenia, neutropenia, thrombophlebitis (with/in the introduction).
On the part of the gastrointestinal organs: nausea, vomiting, pseudomembranous colitis, persistent hepatitis, cholestatic jaundice, dysbacteriosis.
Allergic reactions: rash, urticaria, eosinophilia, medicinal fever, in rare cases — bronchospasm, Quincke's edema, anaphylactic shock.
And others: superinfection, pain and infiltration at the site of intravenous administration, positive Coombs test, decrease in creatinine Cl, increase in urea nitrogen in the blood (in patients with renal insufficiency), transient increase in the activity of liver transaminases and alkaline phosphatase.
Has a wide spectrum of antibacterial action. Active against many Gram-negative and Gram-positive microorganisms: Escherichia coli, Enterobacter spp., Klebsiella spp. (may acquire resistance), Haemophilus influenzae, Proteus mirabilis, Providencia rettgeri, Morganella morganii, certain strains of Proteus vulgaris, Staphylococcus aureus (including methicillin-resistant and resistant strains), Staphylococcus epidermidis, Streptococcus spp. Gram-positive and Gram-negative anaerobes (Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Fusobacterium spp.).
After intravenous administration at a dose of 0.5 or 1 g Cmax reached after 30-120 minutes and is 13 µg / ml and 25 µg/ml, respectively. With / in the introduction of 1, 2 and 3 g after 10 min, the plasma concentration is 139, 240 and 533 µg/ml (at the therapeutic level is maintained for 6 h). You1/2 after intravenous administration - 32 min, after I / m - 60 min. Therapeutic concentrations are created in pleural and joint fluids, bile, BONES. It is excreted in the urine in unchanged form (for 8 hours 65-85% is excreted). After intravenous administration of 0.5 and 1 g in the urine is 254 and 1357 µg/ml, with/in administration at a dose of 1 and 2 g — 750 and 1380 µg / ml, respectively. In case of renal failure, the excretion of the drug slows down.
- Cephalosporin
There is a synergy of antibacterial action with simultaneous use with aminoglycoside antibiotics. Increases the nephrotoxicity of diuretics and aminoglycosides, prolongs the effect of alcohol (causes a Disulfiram-like reaction). Aminoglycosides increase antibacterial activity. Probenecid slows the excretion of the drug, doubles the duration of action. Anticoagulants, thrombolytics and NSAIDs increase the risk of bleeding. Pharmaceutically incompatible with solutions of aminoglycosides (can not be mixed in one syringe).