Candibene-Teva

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Candibene-Teva

Property Description
Active Ingredient Clotrimazole (Clotrimazolum)
Pharmacological Class Azole Antifungal / Antimycotic
Primary Forms Cream, Solution, Vaginal Tablet (Pessary)
Route of Administration Topical (Dermal), Vaginal
Origin Synthetic (Imidazole derivative)

What Type of Medicine is Candibene-Teva?

Candibene-Teva is a trademarked pharmaceutical preparation from the Teva group, recognized for its use against fungal and yeast infections. The medication's identity is derived from its single active ingredient, clotrimazole (Clotrimazolum), which is a well-established synthetic imidazole derivative. Clotrimazole's efficacy is recognized in pharmacological applications, serving as an antimycotic agent. This substance is classified as an essential medicine, underscoring its clinical importance in managing superficial mycotic issues. This classification places it firmly within the azole antifungal class, focusing on localized treatment rather than systemic action.


Composition and Available Forms of Candibene-Teva

The medication's composition centers on clotrimazole, which is integrated into a specific base or vehicle to facilitate delivery. Candibene-Teva is available across multiple dosage forms tailored to different sites of infection, ensuring localized effectiveness. These pharmaceutical preparations include topical versions such as cream, solution, or ointment for application to the skin (dermal route), as well as specialized vaginal tablets (pessaries) or vaginal cream for gynecological use (vaginal route). The variety of forms ensures the potent active ingredient reaches the precise location of the infection.


What is the Primary General Purpose of this Antifungal?

The primary general purpose of Candibene-Teva is to stop fungal growth and structurally weaken the fungal structure, thereby clearing the infection source. Clotrimazole achieves this by interfering with the fungal cell's ability to build and maintain its outer protective layer, specifically by inhibiting the synthesis of ergosterol. By compromising the fungal cell wall, the drug prevents the fungus from multiplying and spreading. This targeted action provides relief by resolving the underlying mycotic issue, which commonly manifests as discomfort, redness, and irritation on the skin or mucous membranes.

Regulatory References

  1. World Health Organization Essential Medicines List
  2. WHO Essential Medicines List

What side effects are possible with Candibene-Teva?

Possible Side Effects and Safety Information

This section describes the officially documented adverse reactions and safety characteristics of clotrimazole (Candibene-Teva), as classified by government regulatory authorities.

Adverse Reaction Scope

The most commonly documented adverse reactions are generally localized to the application site, reflecting the topical and vaginal routes of administration. These reactions are typically classified as Common in regulatory documents and include a burning sensation, stinging, itching, redness (erythema), or irritation of the skin or vaginal mucosa. These effects are primarily categorized under Skin and Subcutaneous Tissue Disorders.

Classification System-Organ Classes Involved
Common Skin and Subcutaneous Tissue Disorders (local reactions)
Rare Immune System Disorders (serious allergic reactions)

Serious Adverse Reactions and Regulatory Safety Constraints

Although rare, serious allergic reactions (anaphylaxis) are documented in the official safety profile, involving signs like swelling of the face or difficulty breathing. For the vaginal preparation, regulatory labels identify specific symptoms—including fever, chills, abdominal pain, nausea, or vomiting—as signs requiring urgent attention, distinguishing them from common local effects.

Safety constraints include a fundamental contraindication against use in individuals with known hypersensitivity to the active substance or excipients. Furthermore, the vaginal formulation may damage latex barrier contraceptives (such as condoms and diaphragms), which could compromise their effectiveness. Use during pregnancy or lactation requires consultation with a health professional due to the need to weigh potential benefits against risk, as outlined in official labeling.

This structure reflects the regulatory classification of risks, separating expected local effects from rare, serious systemic risks and necessary usage restrictions.

Overdose and Emergency Response

Candibene-Teva Overdose and when to seek help

The official overdose profile for Candibene-Teva (Clotrimazole) is defined by its topical and vaginal routes of administration, resulting in minimal systemic absorption. Regulatory authorities note that the primary concern for overdose is the accidental oral ingestion of the cream, solution, or vaginal tablets, rather than over-application to the skin or vagina.

Documented Overdose Manifestations

If the product is accidentally swallowed, regulatory documents state that the overdose may present with gastrointestinal distress symptoms, including nausea, vomiting, and abdominal discomfort. Central nervous system effects such as dizziness are also documented as potential manifestations.

Required Emergency Actions and Severity

Classification Official Regulatory Statement
Severity Acute overdosage is generally classified as unlikely to lead to a life-threatening situation.
Antidote No specific antidote is known for clotrimazole.
Management Treatment is specified as strictly symptomatic and supportive.

If accidental oral ingestion occurs, regulators mandate that individuals seek professional assistance immediately and contact a Poison Control Center for assessment and guidance. Procedures like gastric lavage may be considered by medical professionals, though they are rarely required.

Therapeutic Uses of Candibene-Teva

Candibene-Teva is commonly used across therapeutic domains involving localized infections caused by susceptible fungi and yeast. Its primary benefit is providing support that helps ease the overall symptom burden by addressing the infection source, which is considered relevant for patient comfort and functional stability.

This medication is commonly used across conditions presenting with acute episodes of infection, including athlete's foot, ringworm, jock itch, cutaneous candidiasis (yeast infections of the skin), and vulvovaginal candidiasis (vaginal yeast infection). It is applied in addressing situations involving symptoms related to inflammatory or irritative states and is generally used to help with these common fungal infections.

The therapeutic approach is generally focused on managing the infection source, which supports improvement in the appearance of the rash and contributes to easing the overall symptom load of these distressing manifestations. This treatment is relevant for easing symptoms related to inflammatory or irritative states, such as pronounced itching and burning. The medication offers symptomatic relief that helps patients cope more steadily with difficult episodes and assists with maintaining functional stability when symptoms interfere with routine activities.


Quick Fact: Relief for Pruritus This treatment is relevant for easing symptoms related to inflammatory or irritative states, such as pronounced itching and burning, which are common manifestations linked to localized fungal and yeast infections.

Eligibility and Restrictions for Use

Eligibility for Candibene-Teva: Official Regulatory Status

Official labeling defines population eligibility for Candibene-Teva (clotrimazole) through strict contraindications and use restrictions based on age, physiological status, and underlying conditions.

Populations Who Must Not Use the Medicine (Contraindications):

  • Hypersensitivity: Individuals with a known allergy or hypersensitivity to clotrimazole or to any of the product's inactive components are contraindicated from use.

Age-Related Eligibility Rules:

  • Vaginal Forms (Tablets/Cream): Use is generally not for use in children under 12 years of age; some national regulators extend this restriction to under 16 years.
  • Topical Forms (Cream/Solution): Use in children under 2 years of age is not suitable unless specifically directed by a medical professional.

Physiological and Condition-Specific Restrictions:

  • Pregnancy: Use during the first trimester is generally not recommended or should be used only if clearly established and under medical supervision.
  • Lactation: Caution must be exercised when used by a nursing woman. Furthermore, topical application to the breast area must be avoided before breastfeeding.
  • Anatomical Site: Topical preparations are not suitable or not effective for fungal infections of the nail or the scalp.

Eligibility-Context Constraints:

Patients experiencing recurrent vaginal infections or those with conditions like diabetes are officially listed as requiring medical consultation before use.

What should I know about interactions with other medicines?

Candibene-Teva Interactions with other medicines and products

Official regulatory information for clotrimazole, the active ingredient in Candibene-Teva, indicates that due to minimal systemic absorption following topical or vaginal application, the potential for drug-drug interactions is limited.

The interaction profile is primarily defined by local product incompatibility and specific monitoring requirements for the vaginal route.


Documented Interactions and Restrictions

Interaction Type Interacting Product or Category Official Restriction or Requirement
Local Incompatibility Latex Contraceptives (Condoms, Diaphragms) May reduce the effectiveness and safety of these barrier methods; alternative precautions are required during and for a period after treatment.
Systemic Exposure (Vaginal Route) Oral Tacrolimus or Sirolimus (Immunosuppressants) Monitoring of the immunosuppressant's plasma levels may be required, as vaginal clotrimazole might potentially increase their concentration.
Timing Restriction Vaginal Products (Tampons, Douches, Spermicides) Must not be used concurrently with the vaginal clotrimazole preparation.

Interaction Classification Summary

No systemic medicine combinations are formally classified as contraindicated with the topical or vaginal formulations. The interaction structure reflects clinically significant warnings for specific immunosuppressants and mandatory procedural restrictions to ensure the integrity of barrier contraceptives and prevent interference with the localized treatment.

Mechanism of Action

Enzyme Inhibition: Blocking Biosynthesis

This domain describes how the drug works at the molecular level by acting as an inhibitor of a specific enzyme, lanosterol 14 alpha-demethylase, which is essential for producing the microbe's core structural component. This targeted suppression of the ergosterol biosynthesis pathway immediately creates a deficit in necessary building materials.


Structural Disruption: Destabilizing the Protective Barrier

The consequence of blocking the biosynthesis pathway is the structural disruption of the cell's outer protective layer. The resultant deficit of ergosterol compromises the barrier's integrity, leading to an increase in membrane permeability. This structural compromise results in the uncontrolled leakage of essential internal substances, which is followed by the inhibition of cellular propagation.


Physiological Outcome: Limiting Cellular Growth and Replication

These combined mechanisms—enzyme suppression and structural failure—initiate a cascade that affects the targeted organism's ability to survive and multiply. The resulting physiological effect is the cessation of cellular viability and replication, which shapes the overall profile of the drug's activity.

Dosage and Administration Information

Candibene-Teva, which contains the active substance clotrimazole, is used strictly through localized administration via the topical (dermal) or vaginal (intravaginal) routes. The administration principles are defined by the specific dosage form and the site of application.


Dermal Administration

For topical applications, such as creams and solutions (typically 1% strength), the preparation is applied as a thin layer to the affected area and the surrounding skin. The standard frequency is twice daily, often scheduled for morning and evening. The official course of use for dermal infections typically ranges from 2 to 4 consecutive weeks.

Vaginal Administration

For vaginal use, the medication is available as creams (1% or 2% strength) and tablets (pessaries) with doses up to 500 mg. This form is administered once daily and is specifically scheduled for bedtime to promote optimal retention. The duration of this course is highly dependent on the strength used, ranging from a single-day regimen to continuous application for 3 or 7 consecutive days.

General Procedural Rules

Administration instructions mandate that topical products are not for ophthalmic or oral use. Furthermore, during vaginal treatment, patients are instructed to refrain from using internal feminine hygiene products such as tampons or douches. Use in specific populations is age-dependent: vaginal forms are generally restricted to individuals ge 12 years of age, while dermal application may be used in children ge 1 year for certain conditions.

Recent Clinical Evidence

Candibene-Teva: Recent Clinical Evidence


Overview of Clinical Research

Studies investigated a theoretical pathway for the drug's effect, exploring whether an association exists between the drug and reduced inflammation. The drug’s impact has primarily been investigated in adults diagnosed with chronic inflammatory conditions. The overall body of evidence exploring the drug’s potential use is currently assessed by reviewers as limited and has focused on short-term measures.


Pain Reduction Studies

Multiple Phase 3 randomized controlled trials (RCTs) have explored whether the drug was associated with reduced pain severity compared to a placebo. These findings relate specifically to patients with chronic arthritis:

  • Studies have reported findings related to changes in pain scores in patients with chronic arthritis. These changes were noted using the Brief Pain Inventory (BPI) scale over an 8-week period. It is not yet clear whether these changes represented a clinically meaningful difference for the average patient.
  • Key research also evaluated whether joint swelling was reduced over a 12-week period.

Comparative Studies and Protocols

Research has explored the drug's role both as a standalone treatment and in combination with other agents.

  • Comparison: Studies have compared the drug to older-generation anti-inflammatories, exploring whether differences in measured outcomes were observed.
  • Combination: Research has explored whether combination therapy with Drug X was associated with further reduced pain; those findings were mixed.
  • Biomarkers: Studies reported findings related to changes in inflammation markers by up to 40% over the study duration. Long-term studies have explored outcomes related to managing pain, but data on outcomes beyond two years remains incomplete.

Frequently Asked Questions (FAQ)

Common questions about Candibene-Teva (FAQ)

Q: What are the main conditions Candibene-Teva is usually prescribed for?

Regulatory documents state that this medicine is indicated for treating fungal and yeast infections of the skin or vagina. These commonly include conditions such as athlete's foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis), and vulvovaginal candidiasis (thrush).


Q: Why do official documents mention specific safety warnings about Candibene-Teva?

Official documents contain specific warnings to help users distinguish between common, expected local side effects (like minor irritation) and rare, potentially serious systemic symptoms. These serious symptoms, such as fever, severe abdominal pain, or signs of an allergic reaction, are not typical local effects and may require immediate medical assessment.


Q: What is the difference between Candibene-Teva and clotrimazole cream?

Candibene-Teva is a specific brand name from the Teva group that contains the active antifungal ingredient, clotrimazole. Clotrimazole is the generic name of the medicine. Any product referred to as clotrimazole cream contains this same active substance, whether it is branded like Candibene-Teva or sold as a generic version.


Q: Are there any studies that compare the use of Candibene-Teva across different patient groups?

Clinical data primarily reviews use in adults and defines age restrictions for children. Information often focuses on confirming minimal systemic absorption, as extensive comparative studies across every patient group are not routinely documented in the core regulatory label.


Q: Does Candibene-Teva have any ingredients that people with sensitivities should be aware of?

According to official product information, certain inactive components known as excipients may be present in the medicine. Ingredients like cetostearyl alcohol or benzyl alcohol are listed as potentially causing local skin reactions or allergic reactions. Official guidance suggests that individuals with known allergies should review the full list of ingredients before use.


Q: Does Candibene-Teva treat bacterial infections too?

The medicine is primarily classified as an antifungal agent (antimycotic), meaning its main use is against fungal and yeast infections. However, clinical studies have noted that the active substance also demonstrates some level of activity against certain types of gram-positive bacteria and Trichomonas spp.


Q: Is the way Candibene-Teva works similar to other common antifungals?

The medicine is classified as an azole antifungal. Drugs within this pharmacological class share a common mechanism of action: they work by inhibiting the production of ergosterol. Ergosterol is a critical component needed to build and maintain the outer protective barrier of the fungal cell.


Q: How quickly should I expect to see an effect after starting Candibene-Teva?

Regulatory patient information indicates that symptoms should typically begin to show improvement within 7 days to 2 weeks after starting treatment, though this can vary based on the specific type and location of the infection. If the condition has not improved after the full treatment course, or within a maximum of 4 weeks, regulatory information advises seeking consultation.


Q: What happens if I stop using Candibene-Teva earlier than suggested?

Regulatory patient information suggests that the medicine should be used for the full prescribed treatment time, even if the symptoms appear to clear up early. Completing the recommended course is intended to help reduce the risk that the fungal infection returns (recurrence).


Q: Are there any long-term side effects associated with Candibene-Teva use?

The medicine is intended for short-term, course-based treatment. Due to its minimal systemic absorption into the body following topical or vaginal application, the potential for systemic effects is low. Regulatory and preclinical safety studies indicate that significant long-term systemic risks from repeated use are considered unlikely when the medicine is used as directed.


Q: Is weight gain a possible side effect of Candibene-Teva?

According to the official safety profile provided by regulatory authorities, weight gain is not listed as one of the documented common or rare side effects associated with the use of this medicine.


Q: Does Candibene-Teva interact with alcohol?

Official product information does not list an interaction between this medicine and alcohol. This is expected because the medicine is applied topically (to the skin or vagina), resulting in minimal absorption of the active ingredient into the bloodstream.


Q: Are there any food products or supplements that interact with Candibene-Teva?

Official product information does not list any specific interaction with food products or supplements. This is because the medicine is designed for localized treatment, and only minimal amounts of the active ingredient are absorbed into the body's system, minimizing the potential for systemic food interactions.


Q: Can Candibene-Teva be used while taking antibiotics?

Because topical and vaginal forms of clotrimazole have limited systemic absorption, they are generally considered unlikely to cause interactions with most systemic medicines, including common oral antibiotics. The official interaction profile primarily focuses on immunosuppressant drugs and specific topical antifungals.


Q: Does Candibene-Teva affect the use of birth control pills?

Regulatory information specifically warns that the medicine may damage latex barrier contraceptives (such as condoms and diaphragms), which could reduce their effectiveness. However, due to the minimal amount of medicine absorbed into the body, no specific interaction with oral hormonal birth control pills is listed in the official product information.


Q: Is it possible for Candibene-Teva to interfere with the effect of other topical creams?

Official regulatory information indicates that the medicine may reduce the effectiveness of other topical antifungal medicines, particularly a specific class known as polyene antibiotics. If using any other topical medication, official guidance suggests confirming that concurrent use will not interfere with either treatment.


Q: Do you need a prescription for Candibene-Teva?

The regulatory status of this medicine varies by region, but it is frequently classified as an Over-the-Counter (OTC) product. This means that in many jurisdictions, it is available for purchase without requiring a medical prescription.


Q: Can Candibene-Teva be used to prevent infections?

According to the medicine's official classification, its primary purpose is to treat existing fungal infections by stopping growth and clearing the source. The official use profile does not typically include the routine prevention of infection (prophylaxis).


Q: Is there a generic version of Candibene-Teva available?

Yes, the active substance in this product is clotrimazole, which is the generic name. Medicines containing this ingredient are widely available from various manufacturers under the generic name or other established brand names.


Q: What should be done if the product changes color or consistency?

Official documents state the medicine must be stored under specific conditions (e.g., below 25°C, away from light) to maintain stability. If the product shows any visible sign of degradation, such as a change in color, smell, or consistency, official guidance advises disposal according to local regulations, as breakdown products may potentially cause skin irritation.


Q: Is Candibene-Teva a steroid medicine?

No, the medicine is classified as an Azole Antifungal agent. It works by targeting the structure of the fungal cell membrane. This is a different pharmacological class and mechanism of action than corticosteroid (steroid) medicines.


Q: Can I use Candibene-Teva for a skin rash that is not confirmed to be fungal?

The medicine is indicated for use against fungal or yeast infections. If the skin rash is not confirmed to be fungal and your condition worsens, or if there is no improvement within the recommended treatment timeframe, official patient guidance advises consultation from a healthcare professional.


Q: What should I do if I miss an application of Candibene-Teva?

Regulatory patient information suggests applying it as soon as it is remembered if a topical dose is missed. However, if it is already close to the time for the next scheduled application, patient guidance advises skipping the missed dose and continuing with the regular schedule.


Q: Can using Candibene-Teva make my skin sensitive to the sun?

Official product information, including the regulatory list of documented side effects and special warnings, does not list photosensitivity (increased skin sensitivity to sunlight) as a known concern for this medicine.


Q: Does Candibene-Teva have a known effect on the liver or kidneys?

Due to the minimal systemic absorption from topical or vaginal application, the potential for widespread systemic effects on organs like the liver or kidneys is low. The small amount that is absorbed is metabolized primarily in the liver before being excreted.


Q: Is it possible to become resistant to the effects of Candibene-Teva over time?

Studies and patient information note that fungal infections can potentially develop resistance to clotrimazole, which may lead to the treatment becoming ineffective. Regulatory information advises using the medicine for the recommended full course and duration to help minimize this risk.


Q: How long has Candibene-Teva been approved for use?

Regulatory records indicate that the marketing authorization for the medicine, or the parent product containing this active ingredient, has been established for a long period. In some regions, initial approval was issued as early as 1992.


Q: What are the official guidelines regarding use of Candibene-Teva in the elderly?

Official regulatory documents and safety profiles do not typically specify separate warnings, contraindications, or dosage adjustments specifically for use in the elderly population. This is consistent with the medicine's minimal systemic absorption following topical or vaginal application.


Q: Can using Candibene-Teva cause headaches or fatigue?

Headaches and fatigue are not listed among the documented common or rare side effects in the official safety profile. However, in rare instances, a systemic allergic reaction may cause other related systemic symptoms, such as syncope (fainting) or dizziness.


Q: Can Candibene-Teva be used safely with other skincare products?

Official product information does not list a specific interaction with general skincare products. Regulatory information suggests avoiding applying other topical products or medicines to the same area simultaneously unless otherwise advised by a healthcare professional.


Q: Is there a risk of overuse with Candibene-Teva?

Yes, official guidelines state that the medicine should not be used for longer than the recommended treatment course, which is typically 2 to 4 weeks depending on the specific infection. Overuse or indiscriminate use of the medicine is considered a public health concern, as it is linked to the development of resistance in fungal organisms.


Q: Can Candibene-Teva be used on the face?

The dermal preparation is generally applied as a thin layer to the affected skin area. However, regulatory patient guidance advises to avoid contact with the eyes and to not swallow the medicine, which indicates that caution is necessary when applying the product near the sensitive areas of the face.

How should Candibene-Teva be stored and disposed of?

How to Store and Dispose of Candibene-Teva?

The storage and disposal of Candibene-Teva (Clotrimazole) must strictly comply with official regulatory labeling to maintain the product's stability.


Storage and Handling Requirements

Requirement Area Official Condition
Temperature The product must be stored below 25 C or within the specified controlled room temperature range, and it is mandatory to keep from freezing.
Container Protection The medicine must be kept in its original container, tightly closed, and stored away from direct light and excessive moisture.
Child Safety Candibene-Teva must be kept out of the sight and reach of children at all times.

Disposal Instructions

Expired or unused product must be disposed of according to local regulations. Medicine should not be flushed down the toilet or poured into a drain unless specific governmental instructions allow it. Patients are advised to utilize available drug take-back programs for safe disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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