Bisolvon Linctus

The frequency of adverse reactions listed below was determined according to the following criteria: very common (≥10%), common (≥1% to <10%), infrequent (≥0.1% to <1%), rare (≥0.01% to <0.1%), very rare (<0.01%), frequency unknown (cannot be estimated based on available data).

On the part of the immune system: rarely-hypersensitivity reactions, the frequency is unknown-anaphylactic reactions, including anaphylactic shock, angioedema, itching.

From the gastrointestinal tract: infrequently-nausea, abdominal pain, vomiting, diarrhea, rarely-exacerbation of gastric ulcer and duodenal ulcer.

From the skin and subcutaneous tissue: rarely-rash, urticaria, frequency unknown-severe skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis).

From the nervous system: rarely-dizziness, headache.

From the liver and biliary tract: very rarely — an increase in the activity of hepatic transaminases in blood plasma.

General well-being: infrequently-fever, allergic reaction (suffocation).

Life-threatening overdoses when using the drug Bromhexin 8 in humans are unknown.

Symptoms: as a rule, there are no signs of the disease that go beyond the usual side effects.

Treatment for acute overdose: artificial vomiting, gastric lavage, symptomatic therapy.

Bromhexin 8 has a mucolytic (secretolytic), expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mucoprotein and mucopolysaccharide fibers, increases the serous component of bronchial secretions), activates the ciliated epithelium, increases the volume and improves the discharge of sputum.

When taken orally, bromhexine is almost completely (99%) absorbed into the gastrointestinal tract within 30 minutes. Bioavailability is 80% due to the effect of the first pass through the liver. Bromhexine in plasma binds to proteins, penetrates through the BBB and the placental barrier. In the liver, bromhexine undergoes demethylation and oxidation, and some of the resulting metabolites (ambroxol) remain active. T_1/2 is 15 h due to slow reverse diffusion from the tissues. C_max the blood level is reached approximately 1 hour after administration. It is excreted by the kidneys. In CRF, the release of bromhexine metabolites is disrupted. With repeated use, bromhexine can accumulate.

• Secretolytics and stimulants of motor function of the respiratory tract

Bromhexin 8 can be prescribed simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexin 8 is not prescribed simultaneously with antitussive agents (including those containing codeine), because they can make it difficult to cough up liquefied sputum.

Bromhexin 8 promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs into the bronchial secretions in the first 4-5 days of antimicrobial therapy.