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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 14.06.2022
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Oral
Meniere's disease
Adult: As betahistine HCl: Initially, 8-16 mg tid.
Maintenance: 24-48 mg daily. As betahistine mesilate: 6-12 mg tid.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Improvement of memory, concentration and mental alertness.
Prevention of further degeneration of cognitive function, social functioning ability and depressive mood associated with dementia syndromes eg, Alzheimer's and vascular dementia. Tinnitus, vertigo, peripheral arterial occlusive disease, improves blood circulation.
Note: Prior to starting treatment with Ginkgo extract, clarification should be obtained as to whether the pathological symptoms encountered are not based on an underlying disease requiring a specific treatment.
Improvement of the pain-free walking distance in peripheral arterial occlusive disease in Fontaine stage II (intermittent claudication) within the framework of physical therapeutic measures, in particular walking training.
Vertigo of vascular and involutional origin.
Adjuvant treatment in case of tinnitus of vascular and involutional origin.
Frequently occurring dizziness and tinnitus always need to be clarified by a physician.
In case of sudden hearing deficit or hearing loss, patient should immediately consult a physician.
Circulation and memory loss due to brain conditions such as stroke, Alzheimer disease, and dementia. It may also have other uses. Check with your pharmacist for more details regarding the particular brand you use.
Ginkgo biloba is an herbal product. It works by increasing blood flow to the brain.
Recommended Dose and Mode of Action: Adults: 16-mg Tab:24-48 mg divided over the day.
24-mg Tab: 48 mg divided over the day.
The dosage should be individually adapted according to the response. Improvement can sometimes only be observed after a couple of weeks of treatment. The best results are sometimes obtained after a few months. There are indications that treatment from the onset of the disease prevents the progression of the disease and/or the loss of hearing in later phases of the disease.
Pediatric: Betahistine is not recommended for use in children below18 years due to insufficient data on safety and efficacy.
Geriatric: Although there are limited data from clinical studies in this patient group, extensive post-marketing experience suggests that no dose adjustment is necessary in this patient population.
Renal and/or Hepatic Impairment: There are no specific clinical trials available in this patient groups, but according to the post-marketing experience, no dose adjustment appears to be necessary.
Administration: Should be swallowed with water.
Normal
Dosage: 1 tab daily. For more intensive use, 1 tab may be taken twice daily. The intake of Ginkgo Biloba is independent of meals.
Hypersensitivity to betahistine diHCl or to any of the excipients of Betahistine.
Phaeochromocytoma.
See also:
What is the most important information I should know about Ginkgo Biloba?
Hypersensitivity to Ginkgo biloba or to any of the excipients of Ginkgo Biloba.
Use in lactation: It is unknown whether Ginkgo Biloba/metabolites are excreted in human milk. A risk to the newborns/infants cannot be excluded. Ginkgo Biloba should not be used during breastfeeding.
Use ginkgo biloba as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dosing depends on the use and the source of the product.
- Use as directed on the package, unless instructed otherwise by your doctor.
- If you miss taking a dose of ginkgo biloba for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.
Ask your health care provider any questions you may have about how to use ginkgo biloba.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Betahistine is used to treat Meniere's disease, condition which typically causes vertigo (sensation of spinning or rotation),tinnitus (ringing in ears), hearing loss and nausea (urge to vomit).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Cerebrovascular and peripheral activator, dementia.
No in vivo interaction studies have been performed. Based on in vitro data, no in vivo inhibition on cytochrome P-450 enzymes is expected.
In vitro data indicate an inhibition of betahistine metabolism by drugs that inhibit monoamine oxidase (MAO), including MAO subtype B (eg, selegiline). Caution is recommended when using betahistine and MAO inhibitors (including MAO-B selective) concomitantly.
As betahistine is an analogue of histamine, interaction of betahistine with antihistamines may in theory affect the efficacy of one of these drugs.
Incompatibilities: Not applicable.
In case of simultaneous application of Ginkgo Biloba with coagulation-inhibiting drugs (eg, phenprocoumon, warfarin, clopidogrel, acetylsalicylic acid and other nonsteroidal antirheumatics) it cannot be excluded that the effect of these medicines are enhanced.
As for all medicinal preparations, it cannot be excluded that Ginkgo Biloba acts on the metabolization of other different medicinal preparations which may influence the potency and/or duration of the effect of the preparation concerned. There are no sufficient investigations available on these effects. Inform the physician if administering or have recently taken any other medicines including medicines obtained without prescription.
The following undesirable effects have been experienced with the below indicated frequencies in betahistine-treated patients in placebocontrolled clinical trials [very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000)].
Gastrointestinal Disorders: Common: Nausea and dyspepsia.
Nervous System Disorders: Common: Headache.
In addition to those events reported during clinical trials, the following undesirable effects have been reported spontaneously during post-marketing use and in scientific literature. A frequency cannot be estimated from the available data and is therefore classified as "not known".
Immune System Disorders: Hypersensitivity reactions, e.g. anaphylaxis.
Gastrointestinal Disorders: Mild gastric complaints (e.g. vomiting, gastrointestinal pain, abdominal distension and bloating). These can normally be dealt with by taking the dose during meals or by lowering the dose.
Skin and Subcutaneous Tissue Disorders: Cutaneous and subcutaneous hypersensitivity reactions, in particular angioneurotic oedema, urticaria, rash, and pruritus.
See also:
What are the possible side effects of Ginkgo Biloba?
There are no verified data on the frequency of the undesirable effects observed during treatment with Ginkgo biloba-containing preparations, since these adverse effects have become known through single reports from patients, physicians or pharmacists. According to these reports, the following side effects may occur during treatment with Ginkgo Biloba: Nervous System Disorders: Headache.
Vascular Disorders: Bleeding from single organs has been reported.
Gastrointestinal Disorders: Mild gastrointestinal disturbances.
Skin and Subcutaneous Tissue Disorders: Allergic skin reactions (reddening, swelling, itching).
Each tablet contains betahistine dihydrochloride 8 mg.
It also contains the following excipients: β-cyclodextrin, maize starch, microcrystalline cellulose, anhydrous colloidal silica, calcium hydrogen phosphate, povidone, sodium lauryl sulphate, magnesium stearate, purified talc, sodium starch glycolate and purified water.
Each film-coated tablet contains EGb 761® [dry extract from Ginkgo biloba leaves (35-67:1)]; Extraction Agent: Acetone 60% (m/m).
The extract in each film-coated tablet is quantified to flavonoids 26.4-32.4 mg, calculated as flavone glycosides, and terpene lactones 6.48-7.92 mg of which gingkgolides A, B, C 3.36-4.08 mg as well as bilobalide 3.12-3.84 mg, and contains ginkgolic acids <0.6 mcg.
Ginkgo Biloba also contains the following excipients: Croscarmellose sodium, colloidal silica; hypromellose, lactose monohydrate, macrogol 1500; magnesium stearate; maize starch, microcrystalline cellulose, dimethicone, α-octadecyl-ω-hydroxypoly(oxyethylene)-5; talcum; titanium dioxide E171; iron oxide E172.