Betacom

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]

Pyridoxine HCl (Betacom) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine HCl (Betacom) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Thiamine HCl (Betacom) or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine HCl (Betacom) decomposes if heated. Thiamine HCl (Betacom) was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine HCl (Betacom) plays a key role in intracellular glucose metabolism and it is thought that Thiamine HCl (Betacom) inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine HCl (Betacom) plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine HCl (Betacom) cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

To avoid and correct vitamin deficiency, which may

result from an imbalanced or special diet, impaired

absorption, anorexia, slimming, pathological intestinal

flora, debilitating disease or therapy with drugs acting

as vitamin antagonists.

Nicotinamide (Betacom) syrup meets the increased vitamin requirements

during periods of intensive growth, and as a dietary

supplement in premature and newborn infants.

* Sideroblastic anaemia

* Treatment and prophylaxis of vitamin B6 deficiency states

Oral

Prophylaxis of Riboflavin (Betacom) deficiency

Adult: 1-2 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Riboflavin (Betacom) deficiency

Adult: Up to 30 mg daily in divided doses.

Child: 3-10 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Microcytic anaemia

Adult: Associated with splenomegaly and glutathione reductase deficiency: 10 mg daily for 10 days.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Thiamine HCl (Betacom) Hydrochloride Injection is effective for the treatment of Thiamine HCl (Betacom) deficiency or beriberi whether of the dry (major symptoms related to the nervous system) or wet (major symptoms related to the cardiovascular system) variety. Thiamine HCl (Betacom) Hydrochloride Injection should be used where rapid restoration of Thiamine HCl (Betacom) is necessary, as in Wernicke’s encephalopathy, infantile beriberi with acute collapse, cardiovascular disease due to Thiamine HCl (Betacom) deficiency, or neuritis of pregnancy if vomiting is severe. It is also indicated when giving IV dextrose to individuals with marginal Thiamine HCl (Betacom) status to avoid precipitation of heart failure.

Thiamine HCl (Betacom) Hydrochloride Injection is also indicated in patients with established Thiamine HCl (Betacom) deficiency who cannot take Thiamine HCl (Betacom) orally due to coexisting severe anorexia, nausea, vomiting, or malabsorption. Thiamine HCl (Betacom) Hydrochloride Injection is not usually indicated for conditions of decreased oral intake or decreased gastrointestinal absorption, because multiple vitamins should usually be given.

Pyridoxine HCl (Betacom) is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.

Pyridoxine HCl (Betacom) is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine HCl (Betacom) injection is also used to treat some types of seizure in babies.

Pyridoxine HCl (Betacom) taken by mouth (oral) is available without a prescription. Injectable Pyridoxine HCl (Betacom) must be given by a healthcare professional.

Pyridoxine HCl (Betacom) may also be used for purposes not listed in this medication guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Riboflavin (Betacom) (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. It also makes it possible for oxygen to be used by your body.

Lack of Riboflavin (Betacom) may lead to itching and burning eyes, sensitivity of eyes to light, sore tongue, itching and peeling skin on the nose and scrotum, and sores in the mouth. Your doctor may treat this condition by prescribing Riboflavin (Betacom) for you.

Some conditions may increase your need for Riboflavin (Betacom). These include:

• Alcoholism
• Burns
• Cancer
• Diarrhea (continuing)
• Fever (continuing)
• Illness (continuing)
• Infection
• Intestinal diseases
• Liver disease
• Overactive thyroid
• Serious injury
• Stress (continuing)
• Surgical removal of stomach

In addition, Riboflavin (Betacom) may be given to infants with high blood levels of bilirubin (hyperbilirubinemia).

Increased need for Riboflavin (Betacom) should be determined by your health care professional.

Claims that Riboflavin (Betacom) is effective for treatment of acne, some kinds of anemia (weak blood), migraine headaches, and muscle cramps have not been proven.

Oral forms of Riboflavin (Betacom) are available without a prescription.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Thiamine HCl (Betacom) (vitamin B 1) is needed for the breakdown of carbohydrates.

Some conditions may increase your need for Thiamine HCl (Betacom). These include:

• Alcoholism
• Burns
• Diarrhea (continuing)
• Fever (continuing)
• Illness (continuing)
• Intestinal disease
• Liver disease
• Overactive thyroid
• Stress (continuing)
• Surgical removal of stomach

Also, the following groups of people may have a deficiency of Thiamine HCl (Betacom):

• Patients using an artificial kidney (on hemodialysis)
• Individuals who do heavy manual labor on a daily basis

Increased need for Thiamine HCl (Betacom) should be determined by your health care professional.

Lack of Thiamine HCl (Betacom) may lead to a condition called beriberi. Signs of beriberi include loss of appetite, constipation, muscle weakness, pain or tingling in arms or legs, and possible swelling of feet or lower legs. In addition, if severe, lack of Thiamine HCl (Betacom) may cause mental depression, memory problems, weakness, shortness of breath, and fast heartbeat. Your health care professional may treat this by prescribing Thiamine HCl (Betacom) for you.

Thiamine HCl (Betacom) may also be used for other conditions as determined by your health care professional.

Claims that Thiamine HCl (Betacom) is effective for treatment of skin problems, chronic diarrhea, tiredness, mental problems, multiple sclerosis, nerve problems, and ulcerative colitis (a disease of the intestines), or as an insect repellant or to stimulate appetite have not been proven.

Injectable Thiamine HCl (Betacom) is administered only by or under the supervision of your health care professional. Other forms of Thiamine HCl (Betacom) are available without a prescription.

Once a medicine or dietary supplement has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Thiamine HCl (Betacom) is used in certain patients with the following medical conditions:

• Enzyme deficiency diseases such as encephalomyelopathy, maple syrup urine disease, pyruvate carboxylase, and hyperalaninemia

Oral

Treatment and prophylaxis of nicotinic acid deficiency

Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.

Topical/Cutaneous

Mild to moderate inflammatory acne

Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis:

Cycloserine: 100 to 300 mg/day orally in divided doses.

Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.

Oral contraceptives: 25 to 30 mg/day orally.

Acute Intoxication:

Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.

Usual Adult Dose for Dietary Supplement:

Pyridoxine HCl (Betacom) Deficiency:

10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.

Usual Adult Dose for Anemia:

Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.

If therapeutic response is not obtained after 1 to 2 months of Pyridoxine HCl (Betacom) therapy, a different therapy should be considered.

Usual Adult Dose for Nausea/Vomiting:

Nausea and vomiting of Pregnancy:

25 mg orally every 8 hours.

Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :

Treatment: 10 to 50 mg/day.

Prophylaxis: 1 to 2 mg/kg/day

Acute Intoxication:

Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine HCl (Betacom) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine HCl (Betacom) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.

Usual Pediatric Dose for Dietary Supplement:

Pyridoxine HCl (Betacom) Deficiency:

5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.

Usual Pediatric Dose for Seizures:

Pyridoxine HCl (Betacom)-dependent seizures:

10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule,

Oral:

B-2-400: 400 mg

Generic: 50 mg

Tablet,

Oral:

Generic: 25 mg, 50 mg, 100 mg

Dosing: Adult

Dietary supplement:

Oral: 100 mg once or twice daily

Prevention of migraine headache (off-label use):

Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998)

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of Riboflavin (Betacom) supplementation in pediatric patients; the use of a single-ingredient Riboflavin (Betacom) product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient Riboflavin (Betacom) supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.

Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents:

Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (Riboflavin (Betacom)) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).

Usual Adult Dose for Beriberi

10 to 20 mg IM three times daily for up to 2 weeks. Thereafter, use an oral therapeutic multivitamin preparation containing 5 to 10 mg Thiamine HCl (Betacom) daily for one month. A complete and balanced diet should follow.

Neuritis of pregnancy:

If vomiting severe to preclude oral therapy, give 5 to 10 mg IM daily.

'Wet' with myocardial failure:

Treat as an emergency cardiac condition. Thiamine HCl (Betacom) is administered slowly by the IV route.

Usual Adult Dose for Thiamine HCl (Betacom) Deficiency

If dextrose administered: to patients with marginal Thiamine HCl (Betacom) status, give 100 mg in each of the first few liters of IV fluid to avoid precipitating heart failure.

Usual Adult Dose for Vitamin/Mineral Supplementation

50 to 100 mg orally once a day

Usual Adult Dose for Wernicke's Encephalopathy

100 mg IV as an initial dose followed by 50 to 100 mg/day IM or IV until the patient is on a regular, balanced, diet.

Usual Pediatric Dose for Beriberi

10 to 25 mg IM or IV daily (if critically ill), or 10 to 50 mg orally every day for 2 weeks, then 5 to 10 mg orally daily for 1 month. If collapse occurs: 25 mg IV. Administer with caution.

Usual Pediatric Dose for Thiamine HCl (Betacom) Deficiency

If dextrose administered: to patients with marginal Thiamine HCl (Betacom) status, give 100 mg in each of the first few liters of IV fluid to avoid precipitating heart failure.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Infants: 0.3 to 0.5 mg orally once a day; children: 0.5 to 1 mg orally once a day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

If hypersensitivity to Thiamine HCl (Betacom) is suspected, administer a skin test: one-hundredth of the dose intradermally and observe patient for at least 30 minutes. If no reaction occurs, full dose can be administered.

Precautions

Serious hypersensitivity/anaphylactic reactions have been reported, especially after repeated administration. A skin test should be performed on patients who are suspected of drug allergies or previous reactions to Thiamine HCl (Betacom), and any positive responders should not receive Thiamine HCl (Betacom) by injection.

Deaths have been reported after the use of IV or IM administration of Thiamine HCl (Betacom).

Thiamine HCl (Betacom) injection contains aluminum. Toxic levels of aluminum may occur if prolonged parenteral administration is used in patients with kidney impairment.

Dialysis

Data not available

Other Comments

Oral Thiamine HCl (Betacom) may be given with or without food.

Parenteral Thiamine HCl (Betacom) should be administered IM or by slow IV injection.

Dietary sources of Thiamine HCl (Betacom) include pork, beef, whole grains, yeast, fresh vegetables and legumes.

Recommended Dietary Allowances (RDA) in Adults:

Males: 1.2 mg daily

Female: 1.1 mg daily

Recommended Daily Allowance (RDA) in Pediatrics:

1 to 3 years: 0.5 mg/day

4 to 8 years: 0.6 mg/day

9 to 13 years: 0.9 mg/day

Males -14 to 18 years: 1.2 mg/day

Females - 14 to 18 years: 1.0 mg/day

Average Adequate Intake (AI) for healthy breast-fed infants:

0 to 6 months: 0.2 mg/day

7 to 12 months: 0.3 mg/day

contraindicated in patients with hypersensitivity to any of its components.

See also:
What is the most important information I should know about Pyridoxine HCl (Betacom)?

Contraindications for Vitamin B6 (Pyridoxine HCl (Betacom))

Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.

See also:
What is the most important information I should know about Riboflavin (Betacom)?

None well documented.

See also:
What is the most important information I should know about Thiamine HCl (Betacom)?

A history of sensitivity to Thiamine HCl (Betacom) or to any of the ingredients in this drug is a contraindication.

Use Pyridoxine HCl (Betacom) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pyridoxine HCl (Betacom) (vitamin b6) is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Pyridoxine HCl (Betacom) (vitamin b6) at home, carefully follow the injection procedures taught to you by your health care provider.
• If Pyridoxine HCl (Betacom) (vitamin b6) contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Pyridoxine HCl (Betacom) (vitamin b6) and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pyridoxine HCl (Betacom) (vitamin b6).

A surgeon or other healthcare provider will give you this medicine as part of your corneal collagen crosslinking procedure.

You will be given numbing eyedrops to prepare you for the procedure. You may also be given a sedative or anesthesia to help you relax. Although you will most likely be awake during the procedure, you should feel little or no discomfort. A special device will be placed around your eyelids to keep them open during the procedure.

Your eye surgeon will place Riboflavin (Betacom) ophthalmic drops into your eyes about every 2 minutes during the procedure.

After the procedure, the surgeon will place a contact lens on the treated eye to protect it for a short time.

Call your doctor right away if the contact lens falls out or feels like it is out of place inside your eye.

You may also need to use antibiotic or steroid eyedrops to prevent infection and reduce swelling after your procedure. Carefully follow all after-care instructions and do not miss any follow-up appointments.

Use Thiamine HCl (Betacom) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Thiamine HCl (Betacom) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Thiamine HCl (Betacom) at home, a health care provider will teach you how to use it. Be sure you understand how to use Thiamine HCl (Betacom). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Thiamine HCl (Betacom) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Thiamine HCl (Betacom), contact your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use Thiamine HCl (Betacom).

Nicotinamide (Betacom) is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.

Pyridoxine HCl (Betacom) (vitamin B6) is used to prevent or treat low levels of vitamin B6 in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra vitamin B6. However, some conditions (such as alcoholism, liver disease, overactive thyroid, heart failure) or medications (such as isoniazid, cycloserine, hydralazine, penicillamine) can cause low levels of vitamin B6. Vitamin B6 plays an important role in the body. It is needed to maintain the health of nerves, skin, and red blood cells.

Pyridoxine HCl (Betacom) has been used to prevent or treat a certain nerve disorder (peripheral neuropathy) caused by certain medications (such as isoniazid). It has also been used to treat certain hereditary disorders (such as xanthurenic aciduria, cystathioninuria, hyperoxaluria, homocystinuria).

How to use Pyridoxine HCl (Betacom)

Take this vitamin by mouth with or without food, usually once daily. Follow all directions on the product package, or take as directed by your doctor. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Tell your doctor if your condition persists or worsens. If you think you may have a serious medical problem, seek immediate medical attention.

Riboflavin (Betacom) (Riboflavin (Betacom)) supplementation is used to prevent and treat Riboflavin (Betacom) deficiency. Riboflavin (Betacom) may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Riboflavin (Betacom) is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

Use: Labeled Indications

Treatment of Thiamine HCl (Betacom) deficiency (including Thiamine HCl (Betacom) deficiency in pregnancy associated with neuropathy), beriberi (dry or wet variety), Wernicke encephalopathy, infantile beriberi with acute collapse, cardiovascular disease due to Thiamine HCl (Betacom) deficiency, or when giving IV dextrose to individuals with marginal Thiamine HCl (Betacom) status to avoid precipitation of heart failure; dietary supplement.

Off Label Uses

Alcohol withdrawal syndrome (adjunct)

Data from a limited number of patients studied suggest that Thiamine HCl (Betacom) may be beneficial as an adjunct in the management of alcohol withdrawal syndrome to prevent Wernicke encephalopathy.

Nicotinamide (Betacom): The clearance of primidone and carbamazepine may be reduced with the concomitant use of Nicotinamide (Betacom).

Zinc Oxide: The absorption of quinolones or tetracycline may be decreased with the concomitant use of zinc.

Cupric Oxide: Concomitant use of penicillamine and copper can cause decreased absorption of both substances.

See also:
What other drugs will affect Pyridoxine HCl (Betacom)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this vitamin include: altretamine, cisplatin, phenobarbital, phenytoin.

This vitamin may interfere with certain laboratory tests (including urine test for urobilinogen), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this vitamin.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

See also:
What other drugs will affect Riboflavin (Betacom)?

Interactions for Riboflavin (Betacom) (Riboflavin (Betacom))

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for Riboflavin (Betacom) may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of Riboflavin (Betacom); requirements for Riboflavin (Betacom) may be increased in patients receiving probenecid.

See also:
What other drugs will affect Thiamine HCl (Betacom)?

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of paracetamol.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of paracetamol.

With the simultaneous use of oral contraceptives accelerated excretion of paracetamol from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of paracetamol.

When Thiamine HCl (Betacom) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with paracetamol. A case of severe toxic liver injury.

Described cases of toxic effects of paracetamol, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of paracetamol and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of paracetamol may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of paracetamol and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of paracetamol, with rifampicin, sulfinpyrazone - may increase clearance of paracetamol due to increasing its metabolism in the liver.

At simultaneous application of Thiamine HCl (Betacom) with ethinylestradiol increases absorption of paracetamol from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Allergic sensitization has been reported rarely following oral and parenteral administration of Folic Acid.

At recommended doses, Nicotinamide (Betacom) is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of Nicotinamide (Betacom) or zinc at doses greater than the recommended dose of Nicotinamide (Betacom)

Nicotinamide (Betacom): Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

See also:
What are the possible side effects of Pyridoxine HCl (Betacom)?

Pyridoxine HCl (Betacom) usually has no side effects when used in recommended doses.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Pyridoxine HCl (Betacom) can cause side effects when taken in large doses for a long time. Tell your doctor right away if any of these unlikely but serious side effects occur: headache, nausea, drowsiness, numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Riboflavin (Betacom)?

Adverse Reactions

Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)

See also:
What are the possible side effects of Thiamine HCl (Betacom)?

Applies to Thiamine HCl (Betacom): capsule, solution, tablet, tablet enteric coated

As well as its needed effects, Thiamine HCl (Betacom) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Thiamine HCl (Betacom), check with your doctor immediately:

Rare - Soon after receiving injection only

• Coughing
• difficulty in swallowing
• hives
• itching of skin
• swelling of face, lips, or eyelids
• wheezing or difficulty in breathing