Components:
Treatment option:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 22.03.2022
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In adults in the complex therapy of the following diseases and conditions:
secondary immunodeficiency states that develop after severe injuries against the background of purulent-septic and purulent-destructive processes,
after extensive surgical procedures,
chronic septic conditions with anergy phenomena,
infectious diseases (viral hepatitis, tuberculosis, chlamydia).
In/m, 100 mcg in 1 ml of water for injection, 1 time per day daily. The course of treatment is 5 injections.
individual intolerance to the drug,
allergic and autoimmune diseases (urticaria, Quincke's edema, Lyell's syndrome, systemic connective tissue diseases),
pregnancy,
lactation period,
children's age.
In some cases, nausea and dizziness may occur. If any of the side effects listed in the instructions are aggravated or the patient has noticed any other side effects not listed in the instructions, you should inform your doctor.
To date, no cases of overdose accompanied by any clinical symptoms have been described. However, as with an overdose of any drug, symptomatic therapy should be carried out with monitoring of the functions of vital organs and regular monitoring of the patient's condition.
Gamma-D-glutamyl-tryptophan sodium is a dipeptide with an immunostimulating effect. It stimulates cellular and humoral immunity. Increases antibacterial and antiviral resistance. The pharmacological effect is determined by increased differentiation and proliferation of T-lymphocyte precursors, stimulation of IL-2 production, increased expression of IL-2 receptors and markers of T-cell differentiation, and restoration of the immunoregulatory index. Application of the drug Bestim® in the complex therapy of diseases accompanied by secondary immunodeficiency, it significantly increases its effectiveness. The drug is effective when included in the complex therapy of viral diseases accompanied by insufficiency of the cellular link of immunity.
The distribution of the drug in the body is limited to the extracellular water phase. The drug is quickly removed from the systemic circulation — the average time of its circulation is 10-11 minutes, the elimination rate is characterized by a high clearance-25-30 ml/kg / min. The drug is excreted from the body in the form of metabolites in the urine and feces.
- Other immunomodulators
In a place protected from light, at a temperature of 2-10 °C.
Keep out of reach of children.
Shelf life of the drug Bestim®2 года.Do not use after the expiration date indicated on the package.
Instructions for medical useBestim®
Instructions for medical use-RU no. R N003335/01
Last modified date: 10.05.2017
Dosage form
Lyophilizate for the preparation of a solution for intramuscular administration
Composition
1 ampoule-active ingredient: "Bestim®"(gamma-D-glutamyl-tryptophan sodium) - 100 mcg, auxiliary components: sodium chloride-1.0 mg, mannitol -9.0 mg.
Description of the dosage form
White powder or porous mass, odorless
Pharmacological Group
Immunostimulating agent
Pharmacodynamics
Gamma-D-glutamyl-tryptophan sodium is a dipeptide with an immunostimulating effect. It stimulates cellular and humoral immunity. Increases antibacterial and antiviral resistance. The pharmacological effect is determined by increased differentiation and proliferation of T-lymphocyte precursors, stimulation of interleukin-2 production, increased expression of interleukin-2 receptors and markers of T-cell differentiation, and restoration of immunoregulatory
the index. Application of the drug Bestim® in the complex therapy of diseases accompanied by secondary immunodeficiency, it significantly increases its effectiveness. The drug is effective when included in the complex therapy of viral diseases accompanied by insufficiency of the cellular link of immunity.
Pharmacokinetics
The distribution of the drug in the body is limited to the extracellular water phase. The drug is quickly removed from the systemic circulation - the average time of its circulation is 10-11 minutes, the elimination rate is characterized by a high clearance-25-30 ml/kg / min. The drug is excreted from the body in the form of metabolites in the urine and feces.
Indications
In adults, in the complex therapy of secondary immunodeficiency conditions that develop after severe injuries against the background of purulent-septic and purulent-destructive processes, after extensive surgical interventions, in chronic septic conditions with anergy phenomena, as well as in infectious diseases (viral hepatitis, tuberculosis, chlamydia).
Contraindications
Individual drug intolerance, allergic and autoimmune diseases (urticaria, Quincke's edema, Lyell's syndrome, systemic connective tissue diseases), pregnancy and lactation, childhood.
Method of administration and dosage
Intramuscularly, 100 mcg in the volume of 1 ml of water for injection 1 time per day daily. The course of treatment is five injections.
Side effects
In some cases, nausea and dizziness may occur. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
To date, no cases of overdose have been described, accompanied by any clinical symptoms. However, as with an overdose of any drug, symptomatic therapy should be performed with monitoring of the functions of vital organs and regular monitoring of the patient's condition.
Interaction
With simultaneous use of Bestim® increases the clinical effectiveness of anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, ethambutol, ciprofloxacin) in the complex therapy of pulmonary tuberculosis, antibiotics of various groups (azithromycin, rovamycin, doxycycline) and antimicrobial drugs of the fluoroquinolone group (lomefloxacin, sparfloxacin) in the complex therapy of urogenital chlamydia, antiviral drug ribavirin in the complex therapy of viral hepatitis C.
Special instructions
Given the possibility of dizziness, you should be careful when driving vehicles and working with precise mechanisms.
Release form
Lyophilizate for the preparation of a solution for intramuscular administration. 100 micrograms in an ampoule of colorless glass. 5 ampoules in a cassette contour cell package. 1 cassette contour cell package together with instructions for use in a pack of cardboard.
Storage conditions
In a place protected from light, at a temperature of 2 to 10 °C. Keep out of reach of children.
Expiration date
2 years.
Do not use after the expiration date.
Conditions of supply of pharmacies
They are released on prescription.
| Lyophilizate for the preparation of a solution for intramuscular administration | 1 amp. |
| active substance: | |
| Bestim® (gamma-D-glutamyl - tryptophan sodium) | 100 mcg |
| excipients: sodium chloride-1 mg, mannitol-9 mg |
Lyophilizate for the preparation of a solution for intramuscular administration. 100 micrograms in an ampoule of colorless glass. 5 amp. in a cassette contour cell package. 1 the cassette contour cell packaging is placed in a cardboard pack.
According to the recipe.
Taking into account the possibility of dizziness, care should be taken when driving vehicles and working with precise mechanisms.
L03AX Other Immunostimulants
- A16. 9 Respiratory tuberculosis of unspecified localization without mention of bacteriological or histological confirmation
- A41. 9 Septicemia, unspecified
- A74. 9 Chlamydia infection, unspecified
- B19 Viral hepatitis, unspecified
- D84. 8 Other specified immunodeficiency disorders
- Z54. 0 Recovery period after surgery
White powder or a porous mass without smell.
