Components:
Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 10.06.2022
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Top 20 medicines with the same components:
used to treat symptoms caused by the common cold, flu, allergies, hay fever, or other breathing illnesses (e.g., sinusitis, bronchitis). Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) is a cough suppressant that affects a certain part of the brain (cough center), reducing the urge to cough. Decongestants help relieve stuffy nose symptoms. Antihistamines relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) and hydrocodone is used to treat cough and reduce chest congestion caused by the common cold, flu, or allergies.
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) is used to treat a cough.
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) will not treat a cough that is caused by smoking, asthma, or emphysema.
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) may also be used for purposes not listed in this medication guide.
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is used to reduce chest congestion caused by the common cold, flu, or chronic bronchitis.
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
There are many brands and forms of Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) available. Not all brands are listed on this leaflet.
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) may also be used for purposes not listed in this medication guide.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral, as hydrobromide:
Robafen Cough: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]
Robitussin Lingering CoughGels: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, polyethylene glycol, propylene glycol]
Gel,
Oral, as hydrobromide:
ElixSure Cough: 7.5 mg/5 mL (120 mL) [alcohol free; contains carbomer 934p, propylene glycol, propylparaben; cherry bubblegum flavor]
Liquid,
Oral, as hydrobromide:
Buckleys Cough: 12.5 mg/5 mL (118 mL) [alcohol free, sugar free; contains butylparaben, menthol, propylparaben, saccharin sodium]
Little Colds Cough Formula: 7.5 mg/mL (30 mL) [alcohol free, dye free, saccharin free; contains sodium benzoate; grape flavor]
PediaCare Childrens Long-Act: 7.5 mg/5 mL (118 mL) [contains brilliant blue fcf (fd&c blue #1), saccharin sodium, sodium benzoate]
Robitussin Lingering LA Cough: 15 mg/5 mL (118 mL [DSC]) [contains alcohol, usp, fd&c red #40, menthol, saccharin sodium, sodium benzoate]
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold): 10 mg/5 mL (480 mL [DSC], 3780 mL [DSC]) [alcohol free, dye free, fructose free, sodium free, sorbitol free, sugar free]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL) [alcohol free, dye free, pseudoephedrine free; contains benzoic acid, propylene glycol]
Lozenge, Mouth/Throat, as hydrobromide:
Hold: 5 mg (10 ea)
Hold: 5 mg (10 ea) [cherry flavor]
Trocal Cough Suppressant: 7.5 mg (1 ea [DSC])
Strip,
Oral, as hydrobromide:
Triaminic Long Acting Cough: 7.5 mg (14 ea, 16 ea) [contains alcohol, usp, fd&c red #40; cherry flavor]
Triaminic Long Acting Cough: 7.5 mg (14 ea) [contains alcohol, usp, fd&c red #40, isopropyl alcohol]
Suspension Extended Release,
Oral:
Cough DM: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite; orange flavor]
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold): Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), disodium edta, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; grape flavor]
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold): Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; orange flavor]
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) Cough Childrens: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), edetate disodium, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; grape flavor]
Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) Cough Childrens: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; orange flavor]
GoodSense Cough DM: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
GoodSense Cough DM Childrens: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 (quinoline yellow), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough
Child: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Generic: Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex [equivalent to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) hydrobromide 30 mg/5 mL] (89 mL)
Syrup,
Oral, as hydrobromide:
Creomulsion
Adult: 20 mg/15 mL (118 mL [DSC])
Creomulsion for Children: 5 mg/5 mL (118 mL [DSC]) [cherry flavor]
Robitussin Childrens Cough LA: 7.5 mg/5 mL (118 mL) [alcohol free; contains fd&c red #40, propylene glycol, saccharin sodium, sodium benzoate; fruit punch flavor]
Silphen DM Cough: 10 mg/5 mL (118 mL) [contains alcohol, usp; strawberry flavor]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL [DSC]) [alcohol free, dye free; contains benzoic acid, edetate disodium, propylene glycol]
Dosing: Adult
Cough suppressant:
Oral: 10 to 20 mg every 4 hours
or
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Safety and efficacy for the use of cough and cold products in infants and young children limited; the AAP warns against the use of these products for respiratory illnesses in infants and young children (AAP 2018; FDA 2017).
Cough suppressant:
Oral:
Oral syrup (immediate release):
Children 2 to <6 years: 5 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children 6 to <12 years: 10 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children ≥12 years and Adolescents: 20 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Long-acting liquid: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Oral capsule: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Extended-release suspension (Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) polistirex):
Children 4 to <6 years: 15 mg every 12 hours as needed; do not exceed 30 mg in 24 hours.
Children 6 to <12 years: 30 mg every 12 hours as needed; do not exceed 60 mg in 24 hours.
Children ≥12 years and Adolescents: 60 mg every 12 hours as needed; do not exceed 120 mg in 24 hours.
ORGANIDIN® NR (Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold))
Tablets — Adults and children 12 years of age and older: One to 2 tablets (200 mg to 400 mg) every four hours, not to exceed 2400 mg (12 tablets) in 24 hours.
PATIENTS SHOULD BE ADVISED TO KEEP THESE AND ALL DRUGS OUT OF THE REACH OF CHILDREN AND TO SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY IN CASE OF ACCIDENTAL OVERDOSE.
How supplied
ORGANIDIN® NR (Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold))
Tablets — Each round, scored, rose-colored tablet contains 200 mg Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) USP—available in bottles of 100 (NDC 0037-4312-01)
Storage
Store at controlled room temperature 20°-25°C (68°-77°F). Protect tablets from moisture. Keep bottle tightly closed.
To report SUSPECTED ADVERSE REACTIONS, contact Meda Pharmaceuticals Inc. at 1-800-526-3840 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Meda Pharmaceuticals Inc. Somerset, New Jersey 08873-4120. Rev. 11/09
See also:
What is the most important information I should know about Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold)?
Do not use Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) before the MAO inhibitor has cleared from your body.
Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold).
See also:
What is the most important information I should know about Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)?
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Ask a doctor or pharmacist before using any other cough or cold medicine. Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) or other decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) or a decongestant.
Do not use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
Use Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) orally disintegrating strips as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) orally disintegrating strips by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not remove the strip from the pouch until you are ready to take Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) orally disintegrating strips. Be sure that your hands are dry when you touch the strip.
- Remove the strip from the pouch and place it onto the tongue. The strip dissolves quickly and can be swallowed with saliva. It may be taken with or without water.
- Use the strip right away after you open the pouch. Do not store it for future use.
- If you miss a dose of Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) orally disintegrating strips and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) orally disintegrating strips.
Use Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets by mouth with or without food.
- Drinking extra fluids while you are taking Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets is recommended. Check with your doctor for instructions.
- Swallow Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (e.g., sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold). It is a cough suppressant that works by decreasing the feeling of needing to cough.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold)
Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.
Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.
If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Improper use of this medication (abuse) may result in serious harm (e.g., brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.
Tell your doctor if your symptoms persist or worsen after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is used to treat coughs and congestion caused by the common cold, bronchitis, and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier.
If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold. To decrease the risk for side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use 2/G
Take this medication by mouth with or without food, as directed by your doctor, usually every 4 hours. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) may have a bitter taste. Do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
For powder packets, empty the entire contents of the packet onto the tongue and swallow. To prevent a bitter taste, do not chew.
Dosage is based on your age, medical condition, and response to treatment. Do not take more than 6 doses in a day. Do not increase your dose or take this drug more often than directed.
Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.
Tell your doctor if your cough is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem. Seek immediate medical attention if you think you may have a serious medical problem.
See also:
What other drugs will affect Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold)?
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) Lafayette Pharmaceutical Laboratory may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
See also:
What other drugs will affect Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold)?
In vitro results suggest that methadone undergoes hepatic N-demethylation by cytochrome P450 enzymes, principally CYP3A4, CYP2B6, CYP2C19 and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with CYP inducers of these enzymes may result in a more rapid metabolism and potential for decreased effects of methadone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadones effects. Although antiretroviral drugs such as efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir+ritonavir combination are known to inhibit CYPs, they are shown to reduce the plasma levels of methadone, possibly due to their CYP induction activity. Therefore, drugs administered concomitantly with methadone should be evaluated for interaction potential; clinicians are advised to evaluate individual response to drug therapy.
Opioid Antagonists, Mixed Agonist/Antagonists, and Partial Agonists
As with other mu-agonists, patients maintained on methadone may experience withdrawal symptoms when given opioid antagonists, mixed agonist/antagonists, and partial agonists. Examples of such agents are naloxone, naltrexone, pentazocine, nalbuphine, butorphanol, and buprenorphine.
Anti-retroviral Agents
Abacavir, amprenavir, efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir+ritonavir combination - Coadministration of these anti-retroviral agents resulted in increased clearance or decreased plasma levels of methadone. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold)-maintained patients beginning treatment with these antiretroviral drugs should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Didanosine and Stavudine - Experimental evidence demonstrated that methadone decreased the AUC and peak levels for didanosine and stavudine, with a more significant decrease for didanosine. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) disposition was not substantially altered.
Zidovudine - Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result in toxic effects.
Cytochrome P450 Inducers
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold)-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly. The following drug interactions were reported following coadministration of methadone with inducers of cytochrome P450 enzymes:
Rifampin - In patients well-stabilized on methadone, concomitant administration of rifampin resulted in a marked reduction in serum methadone levels and a concurrent appearance of withdrawal symptoms.
Phenytoin - In a pharmacokinetic study with patients on methadone maintenance therapy, phenytoin administration (250 mg b.i.d. initially for 1 day followed by 300 mg QD for 3 to 4 days) resulted in an approximately 50% reduction in methadone exposure and withdrawal symptoms occurred concurrently. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin administration.
St. Johns Wort, Phenobarbital, Carbamazepin/strong>Administration of methadone along with other CYP3A4 inducers may result in withdrawal symptoms. Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would be increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.g., ketoconazole) and macrolide antibiotics (e.g., erythromycin), with methadone should be carefully monitored and dosage adjustment should be undertaken if warranted. Some selective serotonin reuptake inhibitors (SSRIs) (e.g., sertraline, fluvoxamine) may increase methadone plasma levels upon coadministration with methadone and result in increased opiate effects and/or toxicity. Voriconazole - Repeat dose administration of oral voriconazole (400mg Q12h for 1 day, then 200mg Q12h for 4 days) increased the Cmax and AUC of (R)-methadone by 31% and 47%, respectively, in subjects receiving a methadone maintenance dose (30 to 100 mg QD). The Cmax and AUC of (S)-methadone increased by 65% and 103%, respectively. Increased plasma concentrations of methadone have been associated with toxicity including QT prolongation. Frequent monitoring for adverse events and toxicity related to methadone is recommended during coadministration. Dose reduction of methadone may be needed. Monoamine Oxidase (MAO) Inhibitors - Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. Similar reactions thus far have not been reported with methadone. However, if the use of methadone is necessary in such patients, a sensitivity test should be performed in which repeated small, incremental doses of methadone are administered over the course of several hours while the patients condition and vital signs are under careful observation. Desipramine - Blood levels of desipramine have increased with concurrent methadone administration. Extreme caution is necessary when any drug known to have the potential to prolong the QT interval is prescribed in conjunction with methadone. Pharmacodynamic interactions may occur with concomitant use of methadone and potentially arrhythmogenic agents such as class I and III antiarrhythmics, some neuroleptics and tricyclic antidepressants, and calcium channel blockers. Caution should also be exercised when prescribing methadone concomitantly with drugs capable of inducing electrolyte disturbances (hypomagnesemia, hypokalemia) that may prolong the QT interval. These drugs include diuretics, laxatives, and, in rare cases, mineralocorticoid hormones. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) may be expected to have additive effects when used in conjunction with alcohol, other opioids or CNS depressants, or with illicit drugs that cause central nervous system depression. Deaths have been reported when methadone has been abused in conjunction with benzodiazepines. Anxiety - Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients who are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals. The physician should not confuse such symptoms with those of narcotic abstinence and should not attempt to treat anxiety by increasing the dose of methadone. The action of methadone in maintenance treatment is limited to the control of narcotic withdrawal symptoms and is ineffective for relief of general anxiety. Acute Pain - Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should be administered analgesics, including opioids, in doses that would otherwise be indicated for non-methadone-treated patients with similar painful conditions. Due to the opioid tolerance induced by methadone, when opioids are required for management of acute pain in methadone patients, somewhat higher and/or more frequent doses will often be required than would be the case for non-tolerant patients. Abrupt opioid discontinuation can lead to development of opioid withdrawal symptoms. Presentation of these symptoms have been associated with an increased risk of susceptible patients to relapse to illicit drug use and should be considered when assessing the risks and benefit of methadone use. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy. If methadone is abruptly discontinued in a physically dependent patient, an abstinence syndrome may occur. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. In general, chronically administered methadone should not be abruptly discontinued. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) should be given with caution and the initial dose reduced in certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addisons disease, prostatic hypertrophy, or urethral stricture. The usual precautions appropriate to the use of parenteral opioids should be observed and the possibility of respiratory depression should always be kept in mind. See also: Applies to Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold): oral capsule, oral capsule extended release, oral elixir, oral liquid, oral packet, oral solution, oral syrup, oral tablet, oral tablet extended release In addition to its needed effects, some unwanted effects may be caused by Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) (the active ingredient contained in Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) LA). In the event that any of these side effects do occur, they may require medical attention. Some of the side effects that can occur with Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: Less common or rare: See also: Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in DOLOPHINE. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute bronchial asthma or hypercarbia. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is contraindicated in any patient who has or is suspected of having a paralytic ileus. Relieving minor pain caused by conditions such as arthritis, backache, bruising, bursitis, cramping, muscle strains or sprains, and tendonitis. It may also be used for other conditions as determined by your doctor. Menthol (Benylin DM-D-E Extra Strength Cough and Cold) lotion is a topical analgesic. It works by temporarily relieving minor pain. Nasal congestion; Throat irritation Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly. Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly. Muscular aches and pains Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily. Use Menthol (Benylin DM-D-E Extra Strength Cough and Cold) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions. Ask your health care provider any questions you may have about how to use Menthol (Benylin DM-D-E Extra Strength Cough and Cold) spray. Pharmaceutical Aid Menthol (Benylin DM-D-E Extra Strength Cough and Cold) is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of Menthol (Benylin DM-D-E Extra Strength Cough and Cold) occurring in nature is (-)-Menthol (Benylin DM-D-E Extra Strength Cough and Cold), which is assigned the (1R,2S,5R) configuration. Menthol (Benylin DM-D-E Extra Strength Cough and Cold) has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Nasal congestion; Throat irritation Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly. Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly. Muscular aches and pains Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily. Tell your doctor of any over-the-counter or prescription medication you may take including: blood thinners. Do not start or stop any medicine without doctor or pharmacist approval. See also: May cause hypersensitivity reactions such as cutaneous dermatitis. Ingestion of large amount of Menthol (Benylin DM-D-E Extra Strength Cough and Cold) may cause GI effects such as severe abdominal pain, nausea, vomiting, vertigo, ataxia, drowsiness and coma. See also: Not to be used in No known conditions. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) (Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes. Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) may also be used for purposes not listed in this medication guide. Temporary relief of symptoms of upper respiratory tract disorders such as sinusitis, vasomotor rhinitis, and hay fever; temporary relief of coughs associated with respiratory tract infections and related conditions such as sinusitis, pharyngitis, bronchitis, and asthma when tenacious mucus and/or mucus plugs and congestion complicate these conditions. Use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets (24 hour) as directed by your doctor. Check the label on the medicine for exact dosing instructions. Ask your health care provider any questions you may have about how to use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) sustained-release tablets (24 hour). Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) is used for the temporary relief of stuffy nose and sinus pain/pressure caused by infection (such as the common cold, flu) or other breathing illnesses (such as hay fever, allergies, bronchitis). Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) is a decongestant (sympathomimetic). It works by narrowing the blood vessels to decrease swelling and congestion. If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product in children younger than 6 years unless specifically directed by the doctor. Long-acting tablets/capsules are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely. These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar decongestants. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray). OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Your doctor may direct you to use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) to decrease pain and swelling in the ear or to help "open up" the ear canal when there is a change in air pressure (such as during air travel, underwater diving). Follow your doctor's directions carefully. If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, ask your doctor or pharmacist. If your doctor has prescribed this medication, take it as directed. Take this medication by mouth with or without food, usually every 4-6 hours, as directed by the product package or by your doctor. Do not take more than 4 doses in a day. Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age. If you are using the chewable tablets, chew each tablet well and swallow. If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/cup. Do not use a household spoon because you may not get the correct dose. There are many brands and forms of Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) available. Some tablets should be swallowed with plenty of water. Check your product package for specific directions. Read the dosing instructions carefully for each product because the amount of Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) may be different between products. Do not take more Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) than recommended. Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine. If your symptoms do not improve after 7 days, if they worsen or return, if you develop fever, rash, or a persistent headache, or if you think you may have a serious medical problem, seek immediate medical attention. Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) has been withdrawn in Canada. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug. Immediate release: 30 to 60 mg orally every 4 to 6 hours as needed 12-hour extended- release: 120 mg orally every 12 hours as needed 24-hour extended-release: 240 mg orally every 24 hours as needed Maximum dose: 240 mg per day Comment: Recommended doses should not be exceeded. Uses: -Temporarily relieves nasal congestion due to the common cold, hay fever, or other upper respiratory allergies. -Temporarily relieve sinus congestion and pressure. 4 to 5 years: Immediate release: 15 mg orally every 4 to 6 hours as needed Maximum dose: 60 mg in 24 hours 6 to 12 years: Immediate release: 30 mg orally every 4 to 6 hours as needed Maximum dose: 120 mg in 24 hours 12 years or older: Immediate release: 30 to 60 mg orally every 4 to 6 hours as needed 12-hour extended- release: 120 mg orally every 12 hours as needed 24-hour extended-release: 240 mg orally every 24 hours as needed Maximum dose: 240 mg in 24 hours Comments: -Recommended doses should not be exceeded. -Giving more than 1 cough and cold medicine to a child could result in overdose; there are many products that have similar names and it is critical to identify the active ingredients in the product to ensure the correct dosage is being used. Uses: -Temporarily relieves nasal congestion due to the common cold, hay fever, or other upper respiratory allergies. -Temporarily relieve sinus congestion and pressure. Severe renal impairment: Use caution, especially in patients with concurrent cardiovascular disease. Severe hepatic impairment: Use caution, especially in patients with concurrent cardiovascular disease. On March 9, 2006, The Combat Methamphetamine Epidemic Act of 2005 was enacted which requires sellers of this drug ensure that: employees have been trained; records of the training are being maintained; sales limits are being enforced; products are being stored appropriately; and a written or electronic logbook is being maintained. The law requires that retailers place Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) products where customers do not have direct access to such products before a sale is made. The FDA defines Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) as an OTC drug in accordance with the monograph and FDA regulations. The US FDA strongly recommends that over- the- counter (OTC) cough and cold products not be used in children younger than 2 years of age because serious and potentially life-threatening side effects can occur including death, convulsions, rapid heart rates, and decreased levels of consciousness. OTC cough and cold products include decongestants, expectorants, antihistamines, and antitussives. Safety and efficacy have not been established in patients younger than 2 years. Consult WARNINGS section for additional precautions. Data not available Administration advice: -Use only with enclosed measuring device or measuring devices specifically designed for measuring drugs. Extended-release tablets: -Swallow whole; do not divide crush, chew, or dissolve Storage requirements: -Protect from light General: -Over the counter cough and cold products can be harmful if more than the recommended amount is consumed; this may happen if more than 1 product containing the same active ingredient is used. Patient advice: -Patients should be instructed to pay close attention to drugs labels, particularly to the active ingredients section to ensure they are not receiving duplicate therapy. -Adult cough and cold products should not be used for children; appropriate measuring devices should be used with liquid products. -Patients should check with their health care provider if they are receiving concomitant medications. -Patients should understand that over the counter cough and cold medications do not cure or shorten the duration of the common cold, these products are for the management of symptoms. See also: The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring. To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval. Some products that may interact with this drug include: stimulants (such as caffeine, dextroamphetamine, methamphetamine, herbal products like ephedra/ma huang), terbutaline. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) may decrease the effectiveness of blood pressure medications (such as beta blockers, calcium channel blockers, reserpine, guanethidine, methyldopa). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain similar ingredients (decongestants such as phenylephrine). Ask your pharmacist about using those products safely. This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems. See also: Applies to Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold): oral capsule, oral capsule extended release, oral capsule liquid filled, oral liquid, oral solution, oral suspension, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release Along with its needed effects, Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) (the active ingredient contained in Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur while taking Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold):Cytochrome P450 Inhibitors
Others
Potentially Arrhythmogenic Agents
Interactions with Alcohol and Drugs of Abuse
Risk of Relapse in Patients on Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) Maintenance Treatment of Opioid Addiction
Tolerance and Physical Dependence
Special-Risk Patients
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) side effects
What are the possible side effects of Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold)?Minor Side Effects
Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) contraindications
What is the most important information I should know about Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold)?What is Menthol (Benylin DM-D-E Extra Strength Cough and Cold)?
Menthol (Benylin DM-D-E Extra Strength Cough and Cold) indications
Oral
Topical/Cutaneous
How should I use Menthol (Benylin DM-D-E Extra Strength Cough and Cold)?
Uses of Menthol (Benylin DM-D-E Extra Strength Cough and Cold) in details
Menthol (Benylin DM-D-E Extra Strength Cough and Cold) description
Menthol (Benylin DM-D-E Extra Strength Cough and Cold) dosage
Oral
Topical/Cutaneous
Menthol (Benylin DM-D-E Extra Strength Cough and Cold) interactions
Menthol (Benylin DM-D-E Extra Strength Cough and Cold) side effects
What are the possible side effects of Menthol (Benylin DM-D-E Extra Strength Cough and Cold)?Menthol (Benylin DM-D-E Extra Strength Cough and Cold) contraindications
What is the most important information I should know about Menthol (Benylin DM-D-E Extra Strength Cough and Cold)?What is Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)?
Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) indications
How should I use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)?
Uses of Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) in details
How to use Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)
Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) description
Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) dosage
Usual Adult Dose for Nasal Congestion
Usual Pediatric Dose for Nasal Congestion
Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis
Other Comments
Oral Liquid:
Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) interactions
What other drugs will affect Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)?Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) side effects
What are the possible side effects of Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold)?Rare
- more common with high doses
Symptoms of Overdose
- Convulsions (seizures)
- fast breathing
- hallucinations (seeing, hearing, or feeling things that are not there)
- increase in blood pressure
- irregular heartbeat (continuing)
- shortness of breath or troubled breathing (severe or continuing)
- slow or fast heartbeat (severe or continuing)
- unusual nervousness, restlessness, or excitement
Some side effects of Pseudoephedrine (Benylin DM-D-E Extra Strength Cough and Cold) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More Common
- Nervousness
- restlessness
- trouble in sleeping
Less Common
- Difficult or painful urination
- dizziness or light-headedness
- fast or pounding heartbeat
- headache
- increased sweating
- nausea or vomiting
- trembling
- unusual paleness
- weakness
See also:
What are the possible side effects of Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold)?
Applies to Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold): oral capsule, oral capsule liquid filled, oral elixir, oral liquid, oral lozenge/troche, oral solution, oral suspension, oral suspension extended release, oral syrup, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) (the active ingredient contained in Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) HBr Adult Formula). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold), check with your doctor or nurse as soon as possible:
Symptoms of overdose:
- Blurred vision
- confusion
- difficulty in urination
- drowsiness or dizziness
- nausea or vomiting (severe)
- shakiness and unsteady walk
- slowed breathing
- unusual excitement, nervousness, restlessness, or irritability (severe)
Minor Side Effects
Some of the side effects that can occur with Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common or rare:
- Confusion
- constipation
- dizziness (mild)
- drowsiness (mild)
- headache
- nausea or vomiting
- stomach pain
The d-isomer of the codeine analog of levorphanol. Dextromethorphan (Benylin DM-D-E Extra Strength Cough and Cold) shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Guaifenesin (Benylin DM-D-E Extra Strength Cough and Cold) is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)