Belosalic (Mometasone furoate_Salicylic acid)

Belosalic (Mometasone furoate_Salicylic acid)

Mometasone Furoate, Sodium Salicylate

Externally, apply a thin layer of ointment to the affected areas of the skin 2 times a day (morning and evening).

The maximum daily dose is 15 g.

hypersensitivity to mometasone furoate, salicylic acid and other components of the drug,

children's age (up to 12 years),

bacterial, viral (herpes simplex, chickenpox, shingles), fungal skin infections,

pink acne,

perioral dermatitis,

post-vaccination reactions,

tuberculosis,

syphilis.

Mild or moderate burning at the site of application of the ointment, itching, skin atrophy, peeling, irritation, skin maceration, dry skin, folliculitis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, the appearance of atrophic skin bands, sweating, secondary infections, hypertrichosis. In children, in addition, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system, including with the development of Cushing's syndrome.

Prolonged treatment of corticosteroids with excessive topical application can lead to suppression of the hypothalamic-pituitary-adrenal system and to secondary adrenal insufficiency. If there are signs of suppression of the hypothalamic-pituitary-adrenal system, stop using the ointment or reduce the frequency of application.

If there are signs of toxicity caused by salicylic acid, the use of the ointment should be discontinued. To stimulate the excretion of salicylates in the urine, additional fluid administration is recommended. If necessary, oral or intravenous administration of sodium bicarbonate and potassium salts can be prescribed.

Mometasone furoate-GCS. It has anti-inflammatory, antipruritic and vasoconstrictive properties. In general, the mechanism of anti-inflammatory action of topical corticosteroids is unclear. It is believed that GCS induce the release of proteins that inhibit phospholipase A2 and are commonly known as lipocortins. These proteins are thought to control the biosynthesis of such potent inflammatory mediators as PG and LT by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from the membrane phospholipids under the action of phospholipase A2.

In the experiments in vitro It has been shown that mometasone furoate is a powerful inhibitor of the synthesis of 3 cytokines involved in the development of the inflammatory process and its maintenance — IL-1, IL-6 and alpha-factor of tumor necrosis (TNF-alpha,). Salicylic acid causes exfoliation of the stratum corneum of the skin.

After a single topical application of the ointment, approximately 1.5% of the applied dose is subjected to systemic absorption. The drug, which has entered the systemic circulation, is excreted in the urine and feces.

• Glucocorticoid keratolytic agent [Glucocorticosteroids in combinations]

With topical application of the ointment, the presence of small amounts of salicylates in the blood plasma was noted. According to the data on the interaction of salicylates with other substances after ingestion or application to the skin, it is possible to change the effect of the following medicinal compounds: tolbutamide (butamide), methotrexate, heparin, pyrazinamide, agents that promote the excretion of uric acid and drugs such as coumarin. Other corticosteroids and ammonium sulfate may affect the salicylic acid content. These interactions should be kept in mind when prescribing Elok ointment With^® together with these connections.