Special precautions for disposal and other handling

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Influenza, Diarrhea, Infection, Infection,Urinary Tract, Middle Ear Infection, Nocardiosis, COPD,Acute, Pneumonitis, Pneumonia, Pneumocystis Carinii Pneumonia, Prevent Infections, Toxoplasmosis, Chronic Middle Ear Infection, Bronchitis, Shigellosis, Enteritis

Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 26.06.2023

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Special precautions for disposal and other handling

Trimethoprim interferes with assays for serum methotrexate when dihydrofolate reductase from Lactobacillus casei is used in the assay. No interference occurs if methotrexate is measured by radioimmuno assay.

Trimethoprim may interfere with the estimation of serum/plasma creatinine when the alkaline picrate reaction is used. This may result in overestimation of serum/plasma creatinine of the order of 10%. Functional inhibition of the renal tubular secretion of creatinine may produce a spurious fall in the estimated rate of creatinine clearance.

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