Asmadol

Bronchial asthma: the threat of an attack or an acute attack (in adults and children), bronchitis with a spastic component, bronchospasm of various origins, chronic emphysema of the lungs.

The threat of premature birth (as a continuation of infusion therapy).

Tablets: inside, 30 minutes before meals, with a small amount of liquid, adults — 1 tab. 3 times a day, if necessary — 2 tab. 3 times a day or 1 tab. every 4 hours, children 3-6 months — 0.25 tab. 1-2 times a day, 6-12 months — 0.25 tab. 1-3 times a day, 1-3 years — 0.25–0.5 tab. 1-3 times a day, 3-6 years — 0.5 tab. 1-3 times a day, 6-10 years — 1 tab. 1-3 times a day day.

Aerosol: inhaled, the injection is made during inhalation (holding the mouthpiece of the inhaler with your lips), adults and children over 3 years old-1-2 doses for an acute attack of suffocation, if necessary, the inhalation is repeated, but not earlier than 30 minutes.

Solution for injection: intravenous injection (slowly, at a rate of 1 ml/min) or infusion (diluted with isotonic sodium chloride solution or 5% glucose solution), adults with acute bronchospasm — 2 ml, with severe difficulty breathing — 3 ml, maximum — 4 ml, with asthmatic status, if necessary, 2 ml 3-4 times within 24 hours, children (1-3 times a day) 3-6 months — 1 mcg, 6-12 months — 2 mcg, 1-3 years — 2-3 mcg, 3-10 years — 3-4 mcg.

Inside, washed down with a small amount of water.

In the absence of other recommendations, the specified dosage should be strictly observed.

The threat of premature birth: 1-2 hours before the end of the Asmadol infusion^® start taking tablets at a dose of 0.5 mg (1 table.) every 3 hours, then every 4-6 hours (Table 4-8). per day).

Hypersensitivity, hyperthyroidism, severe liver and kidney diseases, angle-closure glaucoma, heart diseases (myocarditis, mitral valve defects), aortic stenosis of unknown origin, tachycardia, hypertension, and conditions after a recent myocardial infarction.

hypersensitivity (especially in patients suffering from bronchial asthma and hypersensitivity to sulfites),

thyrotoxicosis,

cardiovascular diseases, especially heart rhythm disorders, occurring with tachycardia, myocarditis, mitral valve disease and aortic stenosis,

CHD,

arterial hypertension,

severe liver and kidney diseases,

angle-closure glaucoma,

premature detachment of the placenta, uterine bleeding, intrauterine infection,

pregnancy (first trimester),

lactation period.

Anxiety, dizziness, tremor, sweating, tachycardia, nausea, vomiting, increased blood sugar (due to glycogenolytic action). With bronchial asthma and hypersensitivity to sulfates, diarrhea, difficulty breathing, an attack of bronchial asthma, impaired or loss of consciousness, anaphylactic shock are possible.

Dizziness, anxiety, slight tremor of the fingers, increased sweating, tachycardia, headache, increased activity of liver enzymes.

It is possible to reduce blood pressure, especially diastolic. In some cases, nausea and vomiting develop.

In rare cases-ventricular extrasystole, pain in the heart (cardialgia). These symptoms quickly disappear after discontinuation of the drug.

The blood sugar level increases due to the glycogenolytic effect of the drug (especially in diabetes).

Diuresis at the beginning of treatment is reduced. In patients with a tendency to fluid retention in the tissues, this can lead to edema.

During treatment with Asmadol^® the intensity of intestinal peristalsis may decrease (it is necessary to pay attention to the regularity of the stool).

In newborns-hypoglycemia, acidosis, bronchospasm, anaphylactic shock.

Expands the bronchi, relaxing the smooth muscles (since cAMP reduces the concentration of intracellular calcium), prevents the release of biologically active substances (histamine, leukotriene D₄ etc.), has tocolytic properties (stimulates beta₂-adrenergic receptors of the muscles of the uterus). When used in medium therapeutic doses, it does not have a pronounced effect on heart rate.

It relaxes the muscles of the uterus, reduces the frequency and intensity of contractions, and inhibits spontaneous and oxytocin-induced labor contractions. During childbirth, it normalizes the strength and regularity of contractions, suppresses (in most cases) premature contractions and promotes the extension of pregnancy to the normal term of delivery. It has a slight effect on the cardiovascular system of the pregnant woman and the fetus.

• Beta-adrenomimetics

• Beta₂- selective adrenomimetic [Beta-adrenomimetics]
• Beta₂- selective adrenomimetic [Tocolytics]

The effect is reduced by non-selective beta-blockers, enhanced by methylxanthines (theophylline). Other sympathomimetics (some cardiovascular and anti-asthmatic) increase the effect of Asmadol on the heart and can lead to overdose phenomena. Reduces the effectiveness of oral antidiabetic agents and the accumulation of glycogen in the liver under the action of glucocorticoids.

A number of drugs that reduce blood pressure (beta-blockers) weaken the effect of Asmadol^® or neutralize it.

Methylxanthines (e.g. theophylline) enhance the effect of Asmadol^®.

The effect of oral hypoglycemic agents on the background of Asmadol therapy.^® weakens.

Drugs for general anesthesia (halothane) and adrenostimulants (cardiovascular and anti-asthmatic drugs) increase the side effects of the cardiovascular system.

Asmadol^® it is incompatible with ergot alkaloid, MAO inhibitors, tricyclic antidepressants, as well as with mineralocorticoids, dihydrotachisterol, and preparations containing calcium and vitamin D.