Components:
Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 17.03.2022
Attention! Information on this page is intended only for medical professionals! Information is collected in open sources and may contain significant errors! Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
headache,
migraine,
toothache,
painful menstruation,
neuralgia,
back pain,
muscle pain,
rheumatic pain,
joint pain,
feverish conditions with flu and colds.
Fever syndrome of various origins, pain syndrome of various etiologies (including sore throat, headache, migraine, toothache, neuralgia, postoperative pain, post-traumatic pain, primary algodismenorrhea), inflammatory and degenerative diseases of the joints and spine (including rheumatoid arthritis, ankylosing spondylitis).
inflammatory and degenerative diseases of the musculoskeletal system: joint syndrome with exacerbation of gout, arthritis (rheumatoid, psoriatic, gouty), brachiopathic periarthritis, ankylosing spondylitis (Bekhterev's disease), deforming osteoarthritis, osteochondrosis with radicular syndrome, sciatica, tendinitis, tendovaginitis, bursitis, lumbago, sciatica,
muscle pain (myalgia) of rheumatic and non-rheumatic origin,
injuries (sports, industrial, domestic) without violating the integrity of the skin (dislocations, sprains or tears of muscles and ligaments, bruises, post-traumatic edema of soft tissues).
Rheumatoid arthritis, osteoarthritis, joint syndrome with exacerbation of gout, psoriatic arthritis, ankylosing spondylitis, spondylosis, neuralgia, myalgia, tendinitis, bursitis, tendovaginitis, Charcot-Marie-Toute neural amyotrophy (peroneal muscle atrophy), sprain, hematomas, sciatica, traumatic damage to soft tissues and the musculoskeletal system, feverish conditions of various origins (including after immunization), with influenza and ARVI.
As an auxiliary agent for infectious and inflammatory diseases of the ENT organs (tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis), pelvic inflammatory processes, adnexitis, algodismenorrhea, postoperative pain syndrome, headache and toothache, panniculitis.
As an antipyretic: for colds, acute respiratory viral infections, influenza, sore throat (pharyngitis), childhood infections accompanied by fever, post-vaccination reactions.
As a painkiller: for toothache, painful teething, headache, migraine, neuralgia, muscle pain, joint pain, injuries and burns.
Rheumatoid arthritis, ankylosing spondylitis, extra-articular rheumatism, osteoarthritis, brachiopathic periarthritis( capsulitis), bursitis, tendinitis, tendosynovitis, lumbar pain, postoperative, traumatic, toothache, headache (including migraine), dysmenorrhea, fever in infectious and inflammatory diseases.
For children from 3 months to 12 years:
as a symptomatic treatment as an antipyretic for acute respiratory infections (including influenza), childhood infections, other infectious and inflammatory diseases and post-vaccination reactions accompanied by an increase in body temperature,
as a symptomatic analgesic for pain of mild or moderate intensity, including toothache, headache, migraine, neuralgia, ear pain, sore throat, sprain pain, muscle pain, rheumatic pain, joint pain and other types of pain.
The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.
Treatment of hemodynamically significant open ductus arteriosus in premature infants with a gestational age of less than 34 weeks.
Inside, washed down with water. Patients with hypersensitivity of the stomach are recommended to take the drug with a meal. For short-term use only. Before taking the drug, you should carefully read the instructions.
Adults and children over 12 years of age: inside 1 table. (200 mg) up to 3-4 times a day. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tablets (400 mg) up to 3 times a day.
Children from 6 to 12 years: 1 table (200 mg) up to 3-4 times a day, the drug can be taken only if the child's body weight is more than 20 kg.
The interval between taking the tablets should be at least 6 hours.
The maximum daily dose for adults is 1200 mg (6 tables).
The maximum daily dose for children from 6 to 18 years is 800 mg (4 tables).
If the symptoms persist or worsen after taking the drug for 2-3 days, you should stop treatment and consult a doctor.
Inside. 1 tablet 2-3 times a day.
Inside.
Tablets-washed down with a glass of water (200 ml), during meals. The initial dose for adults and children over 12 years of age is 400 mg, if necessary — 400 mg every 4-6 hours, the maximum daily dose is 1200 mg. The duration of therapy is no more than 7 days.
Granules - the contents of the bag are dissolved in 50-100 ml of water and taken immediately after cooking during or after a meal. Adults and children over 12 years of age — bags of 200 mg: 4-6 pcs./day, 400 mg-2-3 pcs./day, 600 mg-1-3 pcs./day. The maximum daily dose when using bags of 200 and 400 mg — 1200 mg, 600 mg-2400 mg.
To overcome morning stiffness in patients with arthritis, it is recommended to take the first dose immediately after waking up.
In patients with impaired renal, hepatic, or cardiac function, the dose should be reduced.
Externally.
Cream. Apply to the skin in the area of the painful area 3-4 times a day and rub with light movements until the drug is completely absorbed. A strip of cream with a length of 4-10 cm is used, depending on the area of the affected surface.
The duration of treatment depends on the severity of the disease and the nature of the damage and is on average 2-3 weeks.
Gel. A strip of gel 5-10 cm long is applied to the area of damage and carefully rubbed with light movements until completely absorbed 3-4 times a day.
The duration of treatment depends on the severity of the disease and the nature of the damage and is on average 2-3 weeks.
Inside, after eating, the effervescent tablet should be completely dissolved in a glass of water (the resulting solution is immediately drunk). The dose is prescribed individually so that the desired therapeutic effect is obtained with the use of the lowest possible dose.
Adults and children over 12 years old. For acute pain-200-400 mg every 4-6 hours, for fever-an initial dose of 200 mg every 4-6 hours, if necessary — 400 mg every 4-6 hours, for rheumatoid arthritis-2.4–3.2 g/day in 4-6 doses. The maximum daily dose is 40 mg / kg.
Children from 6 months to 12 years old. With fever-5-10 mg / kg/day in 4-5 doses, treatment should not last more than 3 days without consulting a doctor, with juvenile rheumatoid arthritis, children weighing less than 20 kg-400 mg/day in 4-5 doses, body weight 20-30 kg-600 mg / day, body weight 30-40 kg-800 mg/day, more than 40 kg-dosage as for adults.
Effervescent tablets are recommended for children over 6 years of age and adults.
Inside, after the meal. The average single dose is 5-10 mg/kg of body weight 3-4 times a day. Children aged 6 months-1 year (7-9 kg) - 2.5 ml (50 mg) 3 times a day, the maximum daily dose is 7.5 ml (150 mg). 1-3 years (10-15 kg) - 2.5 ml (50 mg) 3-4 times a day, the maximum daily dose is 7.5-10 ml (150-200 mg). 3-6 years old (16-20 kg) — 5 ml (100 mg) 3 times a day, the maximum daily dose is 15 ml (300 mg). 6-9 years old (21-30 kg) — 5 ml (100 mg) 4 times a day, the maximum daily dose is 20 ml (400 mg). 9-12 years old (31-41 kg) — 10 ml (200 mg) 3 times a day, the maximum daily dose is 30 ml (600 mg). Older than 12 years (more than 41 kg) - 10 ml (200 mg) 4 times a day, the maximum daily dose is 40 ml (800 mg). The dose can be repeated every 6-8 hours.Do not exceed the maximum daily dose. Children from 6 months to 1 g. the drug is prescribed on the recommendation of a doctor.
Inside, after a meal, with a small amount of liquid, in several doses, 2 tablets. at one time 1 time a day (in the evening or before going to bed). In severe conditions, the daily dose is increased by 1 table. for reception in the morning in addition to the evening dose.
Inside. Nurofen® for children-a suspension specially designed for children.
Patients with hypersensitivity of the stomach are recommended to take the drug with a meal.
For short-term use only.
Read the instructions carefully before taking the drug.
Shake the bottle thoroughly before use. To accurately measure the dose of the drug, a convenient measuring syringe is attached. 5 ml of the drug contains 100 mg of ibuprofen or 20 mg of ibuprofen in 1 ml.
Using a measuring syringe
Insert the measuring syringe firmly into the neck of the bottle. Turn the bottle upside down and gently pull the plunger down, drawing the suspension into the syringe to the desired mark. Return the bottle to its original position and remove the syringe by gently turning it. Place the syringe in the oral cavity and slowly press the plunger, gently releasing the suspension.
After use, rinse the syringe in warm water and dry it out of the reach of the child.
Fever (fever) and pain
The dosage for children depends on the age and body weight of the child. The maximum daily dose should not exceed 30 mg / kg with intervals between doses of the drug 6-8 hours. Children under the age of 3-6 months (baby weight from 5 to 7.6 kg) - 2.5 ml (50 mg) up to 3 times for 24 hours, no more than 7.5 ml (150 mg) per day.
Children aged 6-12 months, (child weight 7.7–9 kg): 2.5 ml (50 mg) up to 3-4 times within 24 hours, no more than 10 ml (200 mg) per day. Children aged 1-3 years (child weight 10-16 kg): 5 ml (100 mg) up to 3 times for 24 hours, no more than 15 ml (300 mg) per day.
Children aged 4-6 years (child weight 17-20 kg): 7.5 ml (150 mg) up to 3 times for 24 hours, no more than 22.5 ml (450 mg) per day.
Children aged 7-9 years (child weight 21-30 kg): 10 ml (200 mg) up to 3 times for 24 hours, no more than 30 ml (600 mg) per day.
Children aged 10-12 years, (child weight 31-40 kg): 15 ml (300 mg) up to 3 times for 24 hours, no more than 45 ml (900 mg) per day.
The duration of treatment is no more than 3 days. Do not exceed the specified dose.
If symptoms persist or worsen when taking the drug for 24 hours (in children aged 3-5 months) or for 3 days (in children aged 6 months and older), it is necessary to stop treatment and consult a doctor.
Post-immunization fever
Children under the age of 6 months: 2.5 ml (50 mg) of the drug. If necessary, another 2.5 ml (50 mg) after 6 hours. Do not use more than 5 ml (100 mg) for 24 hours.
In/in.
Treatment with Abfen® It should only be performed in the neonatal intensive care unit under the supervision of an experienced neonatologist. The course of treatment is 3 doses with an interval of 24 hours.
The dose of ibuprofen is selected depending on the body weight:
- 1st injection — 10 mg / kg,
- 2nd and 3rd injections — 5 mg/kg.
Abfen preparation® It is prescribed in the form of a short 15-minute infusion, preferably in undiluted form. If necessary, the injected volume can be adjusted with a sodium chloride solution of 9 mg / ml (0.9%) for injection or a glucose solution of 50 mg/ml (5%) for injection. The remaining unused solution should be discarded.
When determining the total volume of the administered solution, the total daily volume of the prescribed liquid should be taken into account.
If after the 1st or 2nd dose the child develops anuria or obvious oliguria, the next dose is prescribed only after the restoration of normal diuresis. If the ductus arteriosus remains open 24 hours after the last injection or re-opens, a second course consisting of 3 doses may be prescribed, as described above.
If the condition does not change after the second course of treatment, surgical treatment of the open ductus arteriosus may be required.
hypersensitivity to ibuprofen or any of the components that make up the drug,
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including in the anamnesis),
erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or history (two or more confirmed episodes of peptic ulcer disease or ulcerative bleeding),
bleeding or perforation of a gastrointestinal ulcer in the anamnesis, provoked by the use of NSAIDs,
severe liver failure or active liver disease,
severe renal insufficiency (creatinine Cl <30 ml / min), confirmed hyperkalemia,
decompensated heart failure,
the period after coronary artery bypass grafting,
cerebrovascular or other bleeding,
fructose intolerance, glucose-galactose malabsorption, sucrose-isomaltase deficiency,
hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis,
pregnancy (third trimester),
children under 6 years of age.
With caution: concomitant use of other NSAIDs, a history of a single episode of gastric and duodenal ulcer or ulcerative bleeding of the gastrointestinal tract, gastritis, enteritis, colitis, the presence of infection Helicobacter pylori, ulcerative colitis, bronchial asthma or allergic diseases in the acute stage or history-possible development of bronchospasm, systemic lupus erythematosus or mixed connective tissue disease (Sharp's syndrome) - increased risk of aseptic meningitis, kidney failure, t.tsch. dehydration (creatinine Cl <30-60 ml/min), nephrotic syndrome, hepatic insufficiency, cirrhosis of the liver with portal hypertension, hyperbilirubinemia, arterial hypertension and/or heart failure, cerebrovascular diseases, blood diseases of unknown etiology (leukopenia and anemia), severe somatic diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral artery diseases, smoking, frequent alcohol consumption, concomitant use of drugs that may increase the risk of ulcers or bleeding, in particular, oral corticosteroids (in t.tsch. prednisone), anticoagulants (in t.tsch. warfarin), SSRI (in t.tsch. citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (in t.tsch. acetylsalicylic acid, clopidogrel), pregnancy I-II trimesters, breast-feeding, elderly, under 12 years of age
Hypersensitivity to any of the ingredients that make up the drug, as well as to acetylsalicylic acid or other NSAIDs in the anamnesis. Erosive and ulcerative diseases of the gastrointestinal tract (including acute gastric and duodenal ulcers, Crohn's disease, ulcerative colitis), "aspirin" asthma, hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis, bleeding of any etiology, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation, children under 12 years of age, diseases of the optic nerve.
With caution: in the elderly, with heart failure, arterial hypertension, cirrhosis of the liver with portal hypertension, hepatic and / or renal insufficiency, nephrotic syndrome, hyperbilirubinemia, gastric ulcer and duodenal ulcer (in the anamnesis), gastritis, enteritis, colitis, blood diseases of unknown etiology (leukopenia and anemia).
Common for cream and gel
hypersensitivity to ibuprofen, other components of the drug and other NSAIDs,
wet dermatoses, eczema,
violations of the integrity of the skin (including infected abrasions and wounds) at the site of application of the cream/gel.
Optional for cream
pregnancy, lactation,
children under 14 years of age.
Optional for gel
bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid,
pregnancy (third trimester),
children under 12 years of age.
With caution: pregnancy (I-II trimester), lactation period.
Hypersensitivity, erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer, Crohn's disease-non — specific ulcerative colitis), diseases of the optic nerve, scotoma, amblyopia, color vision disorder, hearing loss, vestibular pathology, "aspirin" asthma (provoked by taking acetylsalicylic acid or other NSAIDs), heart failure, edema, arterial hypertension, blood clotting disorders (including hypocoagulation), hemophilia, leukopenia, hemorrhagic diathesis, glucose−6-phosphate dehydrogenase deficiency, pregnancy (third trimester).
Hypersensitivity (including to acetylsalicylic acid or other NSAIDs), peptic ulcer of the stomach and duodenum, severe insufficiency of the liver, kidneys, cardiovascular system, arterial hypertension, hemophilia, hypocoagulation, hemorrhagic diathesis, glucose-6−phosphate dehydrogenase deficiency, bronchospastic reactions after the use of acetylsalicylic acid or other NSAIDs ("aspirin asthma"), edema Quincke, nasal polyps, hearing loss, infancy (up to 6 months, with a body weight of less than 7 kg).
Hypersensitivity, peptic ulcer of the stomach and duodenum," aspirin " triad, attacks of bronchial asthma (including in the anamnesis), childhood (up to 12 years), pregnancy, breast-feeding (suspend).
hypersensitivity to ibuprofen or any of the components that make up the drug,
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid or other NSAIDs,
bleeding or perforation of a gastrointestinal ulcer in the anamnesis, provoked by the use of NSAIDs,
erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in the anamnesis (two or more confirmed episodes of peptic ulcer disease or ulcerative bleeding),
severe liver failure or active liver disease,
severe renal insufficiency (creatinine Cl <30 ml / min), confirmed hyperkalemia,
decompensated heart failure, the period after coronary artery bypass grafting,
cerebrovascular or other bleeding,
hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis,
pregnancy (III trimester of),
fructose intolerance,
the child's body weight is up to 5 kg.
With caution: in the presence of the conditions specified in this section, before using the drug, you should consult a doctor — simultaneous use of other NSAIDs, the presence of a single episode of gastric ulcer or ulcerative bleeding of the gastrointestinal tract, gastritis, enteritis, colitis, the presence of infection Helicobacter pylori, ulcerative colitis, bronchial asthma or allergic diseases in the acute stage or in the anamnesis-possible development of bronchospasm, severe somatic diseases, systemic lupus erythematosus or mixed connective tissue disease (Sharp's syndrome) — increased risk of aseptic meningitis, kidney failure, t.tsch. with dehydration (creatinine Cl 30-60 ml / min), fluid retention and edema, liver failure, hypertension and / or heart failure, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral artery diseases, blood diseases of unknown etiology (leukopenia, anemia), concomitant use of other drugs that may increase the risk of ulcers or bleeding, in particular, oral corticosteroids (in t.tsch. prednisone), anticoagulants (in t.tsch. warfarin), SSRI (in t.tsch. citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (in t.tsch. acetylsalicylic acid, clopidogrel), pregnancy (I-II trimester), breastfeeding, old age
hypersensitivity to ibuprofen or any excipient of the drug,
life-threatening infection,
clinically pronounced bleeding, especially intracranial or gastrointestinal bleeding,
thrombocytopenia or blood clotting disorder,
a significant impairment of renal function,
a congenital heart defect in which an open ductus arteriosus is a prerequisite for satisfactory pulmonary or systemic blood flow (for example, pulmonary artery atresia, severe Fallot tetrad, severe aortic coarctation),
diagnosed or suspected necrotizing enterocolitis.
With caution - in case of suspected infectious diseases.
Use Algidol Ibu 400 capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Algidol Ibu 400 capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Algidol Ibu 400 capsules refilled.
- Take Algidol Ibu 400 capsules by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Swallow Algidol Ibu 400 capsules whole. Do not break, crush, or chew before swallowing.
- Take Algidol Ibu 400 capsules with a full glass of water (8 oz/240 mL) as directed by your doctor.
- If you miss a dose of Algidol Ibu 400 capsules and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about the proper use of Algidol Ibu 400 capsules.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Algidol Ibu 400 is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu. Algidol Ibu 400 is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.
This form of Algidol Ibu 400 is intended for use by children. Do not give this medication to a child younger than 6 months unless directed by the doctor.
Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.
How to use Algidol Ibu 400
Read and follow all directions on the product package before using this medication. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor or the package label, usually every 6 to 8 hours as needed. Shake the bottle well before each dose. Carefully measure the dose using the provided dropper/syringe. Do not use a household spoon because you may not get the correct dose. If you have stomach upset while taking this medication, take it with food or milk.
The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed by your doctor or the package label.
When Algidol Ibu 400 is used by children, the dose is based on the child's weight. Read the package directions to find the proper dose for your child's weight. Consult the pharmacist or doctor if you have questions or if you need help choosing a nonprescription product.
If you are using this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away. If you are using the nonprescription product to treat yourself or a child for fever or pain, consult the doctor right away if fever worsens or lasts more than 3 days, or if pain worsens or lasts more than 10 days.
See also:
What other drugs will affect Algidol Ibu 400?
Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that Algidol Ibu 400 significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when Algidol Ibu 400 and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering Algidol Ibu 400 to patients on anticoagulants.
Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including Algidol Ibu 400, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on Algidol Ibu 400 blood levels. Correlative clinical studies have not been performed.
Methotrexate: Apo-Algidol Ibu 400, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that Algidol Ibu 400 could enhance the toxicity of methotrexate. Caution should be used if Algidol Ibu 400 is administered concomitantly with methotrexate.
H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with Algidol Ibu 400 had no substantive effect on Algidol Ibu 400 serum concentrations.
Furosemide: Clinical studies, as well as random observations, have shown that Algidol Ibu 400 can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with Algidol Ibu 400, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.
Lithium: Apo-Algidol Ibu 400 produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.
This effect has been attributed to inhibition of renal prostaglandin synthesis by Algidol Ibu 400. Thus, when Algidol Ibu 400 and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose necessary to eliminate the symptoms.
In the elderly, there is an increased frequency of adverse reactions against the background of the use of NSAIDs, especially gastrointestinal bleeding and perforation, in some cases with a fatal outcome. Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term administration of ibuprofen at doses not exceeding 1200 mg / day (6 Tables). In the treatment of chronic conditions and long-term use, other adverse reactions may occur.
The frequency of adverse reactions is estimated based on the following criteria: very common (≥1/10), common (≥1/100 to <1/10), infrequent (≥1/1000 to <1/100), rare (≥1/10000 to <1/1000), very rare (<1/10000), frequency unknown (no data available for frequency estimation).
From the blood and lymphatic system: very rarely-hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
On the part of the immune system:
From the gastrointestinal tract: infrequently-abdominal pain, nausea, dyspepsia (including heartburn, bloating), rarely-diarrhea, flatulence, constipation, vomiting, very rarely-peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis, the frequency is unknown-exacerbation of colitis and Crohn's disease.
From the liver and biliary tract: very rarely-impaired liver function, increased activity of hepatic transaminases, hepatitis and jaundice.
From the kidneys and urinary tract: very rarely-acute renal failure (compensated and decompensated), especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.
From the nervous system: infrequently-headache, very rarely-aseptic meningitis.
From the CCC side: the frequency is unknown — heart failure, peripheral edema, with prolonged use, the risk of thrombotic complications (for example, myocardial infarction), increased blood pressure.
From the respiratory system and mediastinal organs: the frequency is unknown — bronchial asthma, bronchospasm, shortness of breath.
Laboratory parameters: hematocrit or Hb (may decrease), bleeding time (may increase), plasma glucose concentration (may decrease), creatinine clearance (may decrease), plasma creatinine concentration (may increase), hepatic transaminase activity (may increase).
If side effects occur, stop taking the drug and consult a doctor.
From the gastrointestinal tract: NSAIDs-gastropathy (abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, flatulence, constipation, rarely — ulceration of the gastrointestinal mucosa, which in some cases are complicated by perforation and bleeding), irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis.
From the side of the hepatobiliary system: hepatitis.
From the respiratory system: shortness of breath, bronchospasm.
On the part of the senses: hearing impairment (hearing loss, ringing or noise in the ears).
From the central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely-aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system: heart failure, tachycardia, increased blood pressure.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous or urticular), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the side of the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
On the part of the visual organs: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dry and irritated eyes, swelling of the conjunctiva and eyelids (allergic origin).
The risk of ulceration of the gastrointestinal mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoid), visual disturbances (color vision disorders, scotomas, optic nerve damage) increases with prolonged use of the drug in large doses.
Changes in laboratory parameters: bleeding time (may increase), serum glucose concentration (may decrease), creatinine clearance (may decrease), hematocrit or hemoglobin (may decrease), serum creatinine concentration (may increase), hepatic transaminase activity (may increase).
Usually the drug is well tolerated. In rare cases, there may be temporary signs of local irritation of the skin in the form of redness, swelling, rashes, itching of the skin, burning and tingling sensations. In the case of hypersensitivity to NSAIDs, bronchospasm may occur. With prolonged use of the drug in particularly sensitive patients, it is possible to develop systemic side effects, if they occur, stop using the drug and consult a doctor.
From the gastrointestinal tract: nausea, vomiting, NSAIDs-gastropathy (decreased appetite, pain and discomfort in the epigastric region, abdominal pain), irritation, dryness of the oral mucosa or pain in the oral cavity, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation/diarrhea, flatulence, digestive disorders, possibly erosive — ulcerative lesions and bleeding from the gastrointestinal tract, impaired liver function.
From the nervous system and sensory organs: headache, drowsiness, anxiety, nervousness, irritability, psychomotor agitation, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases), hearing impairment, tinnitus, reversible toxic amblyopia, blurred vision or double vision, dry and irritated eyes, conjunctival and eyelid edema (allergic origin), scotoma.
From the cardiovascular system and blood (hematopoiesis, hemostasis): heart failure, tachycardia, increased blood pressure, eosinophilia, anemia, including hemolytic, thrombocytopenic purpura, agranulocytosis, leukopenia.
From the respiratory system: shortness of breath, bronchospasm, allergic rhinitis.
From the genitourinary system: edematous syndrome, impaired renal function, acute renal failure, allergic nephritis, polyuria, cystitis.
Allergic reactions: skin rash (erythematous, urticaria), pruritus, urticaria, Quincke's edema, anaphylactic reactions, including anaphylactic shock, multiform exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis.
Other: increased sweating, fever.
From the central nervous system: headache, dizziness, sleep disturbance, anxiety, drowsiness, depression, agitation, visual impairment (reversible toxic amblyopia, blurred vision, or double vision).
From the side of the hematopoietic organs: heart failure, tachycardia, increased blood pressure, anemia, thrombocytopenia, agranulocytosis, leukopenia.
From the gastrointestinal tract: nausea, vomiting, decreased appetite, heartburn, abdominal pain, diarrhea, constipation, flatulence, impaired liver function, peptic ulcers, stomach bleeding.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: itching, rash, bronchospastic syndrome, allergic rhinitis, Quincke's edema, Stephen-Johnson syndrome, Lyell's syndrome.
Dyspeptic disorders, gastrointestinal bleeding, thrombocytopenia, allergic reactions.
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose necessary to eliminate the symptoms.
Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term administration of ibuprofen at doses not exceeding 1200 mg / day. In the treatment of chronic conditions and with prolonged use, other adverse reactions may occur.
The frequency of adverse reactions is estimated based on the following criteria: very common (≥1/10), common (≥1/100 to <1/10), infrequent (≥1/1000 to <1/100), rare (≥1/10000 to <1/1000), very rare (<1/10000), frequency unknown (no data available for frequency estimation).
From the blood and lymphatic system: very rare-hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
On the part of the immune system: infrequently-hypersensitivity reactions-non-specific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, t.tsch. its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, in t.tsch. toxic epidermal necrolysis, Lyell's syndrome, Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia, very rare-severe hypersensitivity reactions, in t.tsch. edema of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock)
From the gastrointestinal tract: infrequently-abdominal pain, nausea, dyspepsia, rarely-diarrhea, flatulence, constipation, vomiting, very rarely-peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, ulcerative stomatitis, gastritis, frequency unknown-exacerbation of ulcerative colitis and Crohn's disease.
From the liver and biliary tract: very rarely-liver function disorders.
From the kidneys and urinary tract: very rarely-acute renal failure (compensated and decompensated), especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, papillary necrosis.
From the nervous system: infrequently-headache, very rarely-aseptic meningitis (in patients with autoimmune diseases).
From the CCC side: the frequency is unknown — heart failure, peripheral edema, with prolonged use, the risk of thrombotic complications (for example, myocardial infarction, stroke), increased blood pressure.
From the respiratory system and mediastinal organs: the frequency is unknown — bronchial asthma, bronchospasm, shortness of breath.
Other: very rarely — edema, including peripheral.
Laboratory parameters: hematocrit or Hb (may decrease), bleeding time (may increase), plasma glucose concentration (may decrease), creatinine clearance (may decrease), plasma creatinine concentration (may increase), hepatic transaminase activity (may increase). If side effects occur, stop taking the drug and consult a doctor.
From the blood system: blood clotting disorders that lead to bleeding, such as intestinal and intracranial bleeding, respiratory disorders, and pulmonary bleeding.
From the digestive system: obstruction and perforation of the intestine.
The part of the kidney: decrease in the volume of formed urine, the presence of blood in the urine. Currently, data are available for approximately 1,000 premature newborns, found in the ibuprofen literature and obtained in clinical trials of the drug Abfen®. The causes of adverse events observed in premature newborns are difficult to assess, since they can be associated with both the hemodynamic consequences of an open ductus arteriosus and the direct effects of ibuprofen.
The described adverse events are listed below, classified by organ system and frequency. The frequency of events was determined as follows: very often (>1/10), often (>1/100, <1/10), rarely (>1/1000, <1/100).
From the circulatory and lymphatic system: very often — thrombocytopenia, neutropenia.
From the nervous system: often-intraventricular hemorrhage, periventricular leukomalacia.
From the respiratory system, chest and mediastinal organs: very often — bronchopulmonary dysplasia, often-pulmonary bleeding, rarely-hypoxemia (occurred within 1 hour after the first infusion with normalization of the condition within 30 minutes after inhalation with nitric oxide).
From the kidneys and urinary tract: often-oliguria, fluid retention, hematuria, rarely-acute renal failure.
Gastrointestinal disorders: often-necrotizing enterocolitis, perforation of the intestine, rarely-gastrointestinal bleeding.
Deviations from the norm of laboratory research data: very often-an increase in the concentration of creatinine in the blood, a decrease in the concentration of sodium in the blood.
In children, symptoms of overdose may occur after taking a dose exceeding 400 mg/kg. In adults, the dose-dependent effect of overdose is less pronounced. T1/2 the drug in case of overdose is 1.5–3 hours.
Symptoms: nausea, vomiting, epigastric pain, or less commonly, diarrhea, tinnitus, headache, and gastrointestinal bleeding. In more severe cases, there are manifestations from the central nervous system: drowsiness, rarely-agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased PV, renal failure, damage to liver tissue, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, an exacerbation of this disease is possible.
Treatment: symptomatic, with mandatory airway patency, ECG monitoring and basic vital signs until the patient's condition is normalized. Oral administration of activated charcoal or gastric lavage for 1 hour after taking a potentially toxic dose of ibuprofen is recommended. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to remove the acidic ibuprofen derivative by the kidneys, forced diuresis. Frequent or prolonged seizures should be stopped by intravenous administration of diazepam or lorazepam. When bronchial asthma worsens, the use of bronchodilators is recommended
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (only within an hour after ingestion), administration of activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of acid-base state, blood pressure).
Cases of overdose of cream or gel are not described.
Treatment: In case of accidental ingestion, it is necessary to clear the stomach (induce vomiting, prescribe activated charcoal) and consult a doctor. Further treatment, if necessary, is symptomatic.
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, low blood pressure, brady/tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (only within 1 hour after ingestion), activated charcoal, alkaline drink, forced diuresis, symptomatic therapy (correction of SCC, blood pressure).
Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, hemorrhagic diathesis, decreased blood pressure, acute renal failure, impaired liver function, tachycardia, bradycardia, atrial fibrillation, convulsions, apnea and coma (especially characteristic of children under 5 years of age).
Treatment: gastric lavage, administration of activated charcoal, alkaline drinking, symptomatic therapy (correction of CSF, blood pressure).
In children, symptoms of overdose may occur after taking a dose exceeding 400 mg/kg. In adults, the dose-dependent effect of overdose is less pronounced. T1/2 the drug in case of overdose is 1.5–3 hours.
Symptoms: nausea, vomiting, epigastric pain, or, less commonly, diarrhea, tinnitus, headache, and gastrointestinal bleeding. In more severe cases, there are manifestations from the central nervous system: drowsiness, rarely-agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased PV, renal failure, damage to liver tissue, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, an exacerbation of this disease is possible.
Treatment: symptomatic, with mandatory airway patency, ECG monitoring and basic vital signs until the patient's condition is normalized.
Oral administration of activated charcoal or gastric lavage for 1 hour after taking a potentially toxic dose of ibuprofen is recommended. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to remove the acidic ibuprofen derivative by the kidneys, forced diuresis. Frequent or prolonged seizures should be stopped by intravenous administration of diazepam or lorazepam. When bronchial asthma worsens, the use of bronchodilators is recommended.
There are no known cases of overdose associated with intravenous administration of ibuprofen to premature newborns.
However, an overdose has been described in children treated with ibuprofen for oral administration.
Symptoms: central nervous system depression, convulsions, gastrointestinal disorders, bradycardia, hypotension, shortness of breath, impaired renal function and hematuria. Cases of massive overdose (after taking doses of more than 1000 mg/kg), accompanied by coma, metabolic acidosis and passing renal failure, have been described. One case of fatal overdose was reported: after taking a dose of 469 mg / kg in a 16-month-old child due to respiratory arrest, the development of convulsive syndrome and subsequent aspiration pneumonia.
Treatment: symptomatic therapy. After the standard treatment, all patients recovered.
Ibuprofen
However, we will provide data for each active ingredient