Albumina

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Albumina

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Albumina

Understanding Albumin

Albumin is a protein naturally produced by the liver that circulates in the blood plasma. It is the most abundant protein in human blood and plays a fundamental role in maintaining the body's fluid balance and transporting various substances throughout the circulatory system.

Biological Functions

Albumin performs several critical roles within the body:

  • Osmotic Pressure Regulation: Albumin is primarily responsible for maintaining oncotic pressure. This is the pressure required to keep water inside the blood vessels, preventing it from leaking into the surrounding tissues and causing swelling (edema).
  • Transport of Molecules: It acts as a carrier protein, binding to and transporting essential substances that are not easily dissolved in water. This includes hormones, fatty acids, bilirubin, calcium, and various metabolic byproducts.
  • Buffering Capacity: It contributes to the blood's ability to maintain a stable pH level, which is necessary for normal physiological functions.

Clinical Applications

In medical settings, albumin is utilized as a plasma volume expander. It is derived from pooled human venous plasma that has been processed and pasteurized for therapeutic use. Its primary purpose is to restore and maintain circulating blood volume in patients where there is a significant deficiency.

When it is Used

Medical professionals may utilize albumin in various clinical scenarios, including:

  • Volume Depletion: To address acute blood or fluid loss resulting from trauma, surgery, or severe injury.
  • Hypoproteinemia: To manage conditions where albumin levels in the blood are abnormally low, which can occur due to liver failure, kidney disorders, or severe malnutrition.
  • Severe Burns: To replace lost fluids and proteins in the initial stages of burn management.
  • Ascites: To assist in the management of fluid accumulation in the abdominal cavity, often associated with chronic liver disease.

By stabilizing blood volume and ensuring the transport of vital nutrients, albumin support is a key component in the management of critical fluid imbalances.

Regulatory References

  1. NIH Albumin Review
  2. NIH Albumin Review

What side effects are possible with Albumina?

Possible Side Effects and Safety Information

The safety profile of Albumina (Human Albumin) is defined by its role as a plasma volume expander and its nature as a protein derived from human plasma. The general principles of adverse effects are largely related to the body's reaction to protein infusion or the consequences of fluid volume expansion, as documented in official regulatory labeling.

Adverse Reactions and Official Classification

Mild reactions are generally classified as rare according to the European Summary of Product Characteristics (SmPC) framework and include flushing (a reddening of the skin), urticaria (hives), fever (pyrexia), and nausea. These mild effects typically disappear rapidly if the rate of infusion is slowed down or stopped. More frequently cited reactions in regulatory documents include a cluster of effects termed anaphylactoid type reactions, such as rigors (chills), hypotension (decreased blood pressure), tachycardia (increased heart rate), and dyspnea (troubled breathing).

Very rarely, severe reactions may occur, including anaphylactic shock, which is a serious adverse reaction involving the immune system.

Safety Considerations Regarding Fluid Overload

A critical safety consideration for this medicine is the potential for hypervolemia, or excess circulating fluid, which can lead to cardiovascular overload. Signs that may indicate the beginning of this serious adverse reaction include headache, jugular vein congestion, increased blood pressure, and pulmonary edema (fluid in the lungs).

Safety Restrictions and Pre-existing Conditions

Albumina is officially contraindicated in individuals with known hypersensitivity to albumin preparations and in patients with severe anemia or cardiac failure where the intravascular volume is already normal or increased. Caution is required in specific pre-existing conditions where volume expansion could represent a heightened risk, such as decompensated cardiac insufficiency, oesophageal varices, and severe anaemia.

Finally, as a plasma-derived product, there is an extremely remote theoretical risk of transmitting infectious agents, which is managed by stringent manufacturing and testing processes required by regulatory bodies.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory documents define the overdose profile for Albumina (Human Albumin) based on its function as a Plasma Volume Expander. An overdose state results when the rate of infusion or the dose is too high, leading to Circulatory Overload (hypervolaemia).

Documented Manifestations

Overdose manifestations explicitly documented in regulatory labeling include clinical signs of increased fluid volume: headache, dyspnoea (shortness of breath), raised venous pressure, increased blood pressure, and jugular vein congestion. Failure to address these signs may lead to severe outcomes such as Pulmonary Oedema or Cardiac Failure, particularly in susceptible patients.

Mandatory Emergency Action

The authoritative regulatory instruction is to stop the infusion immediately at the first appearance of any clinical signs of cardiovascular overload. Immediate medical attention must be sought when severe or life-threatening symptoms, such as acute breathing difficulty or signs of shock, are observed. There is no specific antidote listed in the official prescribing information; management relies exclusively on symptomatic and supportive treatment and continuous haemodynamic monitoring. Conditions such as decompensated cardiac insufficiency are noted as special risks where the consequences of hypervolaemia are particularly severe.

Therapeutic Uses of Albumina

What Albumina Treats: Main Uses and Benefits

Albumina (Human Albumin) is generally used in clinical settings that involve systemic imbalance or volume deficiency. Its main therapeutic benefit is that it provides support in managing circulating volume. This supportive function may help ease the overall symptom burden across several critical clinical domains.


The medication is applicable within clinical settings that involve acute or disruptive symptom patterns, including those related to fluid and protein imbalances.

Therapeutic Domains

Albumina is relevant when symptoms related to systemic imbalance, such as those that create noticeable physiological strain, appear suddenly or intensify. It is used in situations involving recurrent or episodic manifestations and assists with maintaining functional stability during phases of temporary physiological imbalance. It provides supportive relief when symptoms become temporarily overwhelming.


Quick Fact: Support for Physiological Strain

Eligibility and Restrictions for Use

Albumina (Human Albumin) use is restricted to specific patient populations defined by official regulatory criteria, primarily based on the risk of volume overload due to its function as a plasma volume expander.

Contraindicated Populations

Use is absolutely prohibited in individuals with a history of hypersensitivity to human albumin or any of the product’s excipients. The medicine is also contraindicated in patients with severe anemia or cardiac failure with normal or increased intravascular volume.


Conditional Use and Restrictions

Official labeling mandates caution in several conditions where hypervolemia could pose a special risk. These include:

  • Decompensated cardiac insufficiency and hypertension
  • Pulmonary edema, esophageal varices, and hemorrhagic diathesis
  • Renal and post-renal anuria

Age and Physiological Eligibility Status

Population Official Regulatory Status
Pediatric Use Use is generally established in children, but some formulations are noted for insufficient data in controlled trials.
Geriatric Use Insufficient data exists to determine if older adults (ge 65 years) respond differently.
Pregnancy/Lactation Classified as FDA Pregnancy Category C. Use is advised only if clearly needed due to a lack of controlled safety data.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Albumina (Human Albumin Solution) has an official interaction profile that is primarily defined by restrictions related to its physical and chemical properties as a protein solution, rather than complex systemic drug-drug interactions.

Regulatory documents establish that this medicinal product must not be mixed with or diluted by certain substances due to immediate incompatibility risks. These restrictions include:

  • Physical Incompatibility: Co-administration or mixing with solutions containing alcohol or with Protein Hydrolysates is prohibited. This is due to the documented risk that these substances cause protein precipitation (clumping) within the infusion line or container.
  • Diluent Safety Restriction: The product must not be diluted solely with Water for Injections. Official labeling specifies this restriction because the low ionic strength of the water creates a risk of inducing haemolysis in the recipient.

The regulatory profile is devoid of classical systemic drug-drug interactions involving Cytochrome P450 enzymes or major drug transporters. No mandatory timing-based separation rules are documented for co-administration with other intravenously administered medicinal products. Furthermore, no systemic interactions are officially documented for food, alcohol, or herbal products. Official prescribing information also notes that the use of certain administration materials, such as those associated with TPN, may lead to increased exposure to aluminum through leaching from the materials.

Mechanism of Action

Mechanism of Action: DKK1 Receptor Antagonism

Albumina is a small molecule that operates by modulating the Wnt signaling pathway, a critical regulator of bone homeostasis. The molecule specifically targets the DKK1 receptor, acting as a high-affinity antagonist. DKK1 is an endogenous inhibitor that normally binds to the LRP5/6 co-receptors, thereby preventing beta-catenin stabilization and subsequent Wnt signaling activation.

By occupying and blocking the DKK1 receptor, Albumina prevents this native inhibition of LRP5/6. The resultant stabilization of the beta-catenin complex leads to sustained Wnt signal activation within the bone matrix. This pathway activity specifically increases osteoblast differentiation and activity, promoting the function of these bone-forming cells. The overall physiological modulation is characterized by a net increase in bone mass due to enhanced new bone formation.

Dosage and Administration Information

How to use Albumina — Administration Guidelines

Albumina is a human plasma-derived medicinal product for intravenous use only. The concentration, dose, and infusion rate must be carefully adjusted to the patient's individual requirements and clinical indication, as measures of adequate circulating volume, not plasma albumin levels, are used to determine the required dose. The total daily dose should generally not exceed 2 grams per kilogram of body weight.


Preparation and Procedural Steps

  • Inspection: The solution must be visually inspected for any particulate matter or discoloration before use. Do not use solutions that are cloudy or contain deposits.
  • Warming: If a large volume is to be administered, the product should be warmed to room temperature before infusion.
  • Dilution: Albumina may be administered directly by the intravenous route, or it can be diluted in an isotonic solution such as 0.9% sodium chloride or 5% dextrose (glucose).
  • Restriction: Albumin solutions must not be diluted with sterile water for injection, as this may lead to hemolysis in the recipient.
  • Timing: The infusion must begin within 4 hours of piercing the vial stopper, as the product typically does not contain any antimicrobial preservative.

Administration and Monitoring

During administration, the infusion rate must be adjusted according to the individual patient's hemodynamic and physiological responses, and the patient's condition should be carefully monitored. This monitoring should regularly include the assessment of arterial blood pressure, pulse rate, central venous pressure, and urine output, in addition to the patient's electrolyte status. In cases where large volumes are administered, controls of coagulation and hematocrit are also necessary to ensure adequate substitution of other blood constituents.

Recent Clinical Evidence

Albumina: Recent Clinical Evidence

Research on the administration of human albumin focuses primarily on its role in critical illness and complications of advanced liver disease. Clinical trials have assessed whether albumin provides benefits beyond its established function of maintaining plasma volume and oncotic pressure.


Findings in Specific Conditions

Condition Key Research Focus Study Outcomes Observed
Liver Cirrhosis Complications (e.g., SBP, HRS, large-volume paracentesis) Administration was associated with a reduction in the incidence of paracentesis-induced circulatory dysfunction (PICD) and a decrease in acute kidney injury (AKI) risk during spontaneous bacterial peritonitis (SBP).
Sepsis/Septic Shock Fluid resuscitation and survival Studies evaluated albumin as a second-line fluid in patients who did not respond to crystalloid fluids. Some meta-analyses suggested potential short-term hemodynamic stabilization and a survival advantage in certain septic shock subgroups.
Traumatic Brain Injury Fluid management Early reviews suggested a trend toward increased mortality when albumin was used in patients with severe traumatic brain injury (TBI). Subsequent large trials have continued to explore the optimal fluid regimen in this setting.

Current Consensus and Research Gaps

High-quality evidence from Randomized Controlled Trials (RCTs) supports the use of albumin for specific complications of liver disease. However, its use as a first-line therapy for general hypovolemia or routine nutritional supplementation in critically ill patients is not widely recommended by current guidelines, which stress cost-effectiveness and the limited evidence in non-cirrhotic indications. Ongoing trials aim to clarify the optimal timing and dosing regimen of albumin in critical care and high-risk cardiac surgery to further define its clinical role.

Key Studies & References

  1. EASL Clinical Practice Guidelines for Decompensated Cirrhosis PowerPoint Presentation (Based on 2018 Guidelines)

Frequently Asked Questions (FAQ)

Common questions about Albumina (FAQ)

Q: Is Albumina only used in emergency or critical care situations?

A: According to official product information, Albumina is indicated for both emergency treatment (such as hypovolemic shock) and for specific non-emergency conditions. Non-emergency conditions for which its use is indicated include certain cases of hypoalbuminemia (low albumin levels) related to chronic liver disease or nephrosis.

Q: How long after stopping Albumina will the side effects usually disappear?

A: Regulatory documents state that minor adverse reactions, such as flushing (skin reddening) or fever, typically diminish quickly when the rate of the infusion is slowed down or when the administration is stopped completely.

Q: Can Albumina cause long-term complications or health problems?

A: Official information notes an extremely remote theoretical risk of transmitting infectious agents, including the Creutzfeldt-Jakob disease (CJD) agent. This theoretical risk is addressed through the stringent manufacturing and testing processes required by regulatory bodies.

Q: Can infants or young children receive Albumina, and is the preparation different for them?

A: Yes, Albumina is indicated for use in pediatric patients for conditions such as hypovolemia. Official guidance indicates that the same concentrations may be used, but the specific dosage must always be carefully adjusted based on the child's weight and clinical condition.

Q: Has Albumina received approval from major regulatory bodies like the FDA or EMA?

A: Yes, human albumin solutions like Albumina are licensed and approved biologics (a type of medicine derived from living sources). Their use is regulated by authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), as noted on official labeling.

Q: What is the difference between Albumina and regular nutritional protein supplements?

A: Albumina is a plasma-derived medicinal product (a biologic) used for its ability to maintain colloid osmotic pressure and fluid balance. It is defined by regulatory bodies as a medicinal product and is not indicated for general nutritional use like a protein supplement.

Q: Does Albumina treat the underlying cause of a condition or only the symptoms?

A: The product's primary role is to restore and maintain circulating blood volume, which addresses symptoms related to volume loss or low protein levels. Its effect on low protein levels is temporary unless the underlying disorder is also corrected.

Q: Is it common to feel a little dizzy or lightheaded shortly after receiving Albumina?

A: Dizziness and lightheadedness are reported adverse reactions. These effects are reported and may be related to temporary changes in blood pressure or volume.

Q: Can Albumina cause changes in a person's mood or anxiety levels?

A: A 'confusional state' is listed as a post-marketing adverse reaction for Human Albumin. However, official information does not reliably estimate the frequency of such psychological effects.

Q: Can Albumina be taken with common over-the-counter pain relievers?

A: While the product is generally compatible with certain solutions, it is a transport protein that has the ability to bind to certain pharmaceuticals. Any questions regarding the co-administration of specific over-the-counter pain relievers should be discussed with a healthcare professional.

Q: Can using tobacco or nicotine products affect how Albumina works in the body?

A: Official regulatory labels advise patients to discuss the use of alcohol or tobacco with their healthcare professional. This general guidance is given because these substances may cause interactions to occur with certain medications.

Q: Does Albumina affect the effectiveness of hormonal birth control?

A: No specific interactions with hormonal birth control are cited in the official labeling. However, Albumina is known to bind to and carry a plethora of hydrophobic molecules, which includes hormones.

Q: How quickly should I expect Albumina to start working after administration?

A: The product's effect on oncotic pressure—the mechanism by which it pulls fluid into the blood—is immediate upon infusion. The duration of its overall effect on circulating blood volume can vary based on the patient's condition.

Q: What is the typical length of a treatment course for Albumina?

A: The duration of treatment is highly variable and depends entirely on the specific medical indication being addressed. It may range from a single, acute administration for volume replacement to a therapy administered over several days for conditions like severe burns.

Q: Is it normal to not feel any immediate difference after the first day of using Albumina?

A: This is possible, as there is considerable individual variation in the product's effect on plasma volume. Official documentation notes that in patients with marked dehydration, the effects may be negligible.

Q: Is Albumina the kind of medication that requires continuous, long-term use?

A: Official product information suggests its use is primarily defined by acute medical needs (such as shock or complications of chronic disease) rather than continuous, long-term maintenance therapy.

Q: What are the general criteria that determine eligibility to receive Albumina?

A: Eligibility is determined by specific medical indications such as hypovolemia, shock, severe burns, or certain types of hypoalbuminemia. Contraindications include known hypersensitivity to albumin and severe anemia or heart failure where the blood volume is already increased.

Q: Is Albumina known to be similar to any other widely used medication in terms of its purpose?

A: Albumina's primary purpose is to increase circulating plasma volume. In this role, its function is comparable to other colloid solutions and, in some contexts, to less expensive crystalloid fluids.

How should Albumina be stored and disposed of?

The official storage and disposal requirements for Albumina (Human Albumin Solution) are detailed in regulatory labeling to maintain the stability of this plasma-derived protein solution.

Official Storage Requirements

Condition Regulatory Rule
Temperature Store below 25, C (or 30, C in some regions); Do not freeze.
Protection Keep the container in the original outer carton to protect the solution from light.
Stability The solution must be used immediately after the single-use container is opened. Do not use if the solution appears cloudy or contains particles.
Child Safety Keep out of the sight and reach of children.

Official Disposal Rules

Unused or expired Albumina, which is for single use, must be discarded according to official guidelines. Do not dispose of any medicine via wastewater or household waste. Any waste material must be managed in accordance with local pharmaceutical waste requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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