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Albothyl 1.8%

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Albothyl 1.8%

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Treatment option: Vaginitis

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Albothyl 1.8%

Property Description
Active ingredient Policresulen (INN)
Form Hydrophilic Gel / Vaginal Jelly
Pharmacological class Antiseptic and Disinfectant; Astringent
Common use Localized tissue conditioning and cleansing
Origin Synthetic polycondensation product

The Chemical Identity and Pharmacological Class of Albothyl 1.8%

Albothyl 1.8% is a medicinal preparation whose sole active ingredient is Policresulen (INN), which classifies the product primarily as an antiseptic and disinfectant agent used for localized treatment. Policresulen is a synthetic compound, defined as a polycondensation product of metakresolsulfonic acid and formaldehyde. This compound acts locally on mucosal surfaces and is identified under the classification code G01AX03 (Gynecological Antiinfectives and Antiseptics).

Composition and Available Topical Forms of Policresulen

The Albothyl 1.8% concentration is specifically formulated as a hydrophilic gel or jelly utilizing an aqueous base, optimized for topical administration to deliver the Policresulen effectively to mucosal areas. This 1.8% concentration is a standard strength for this delivery method. While Albothyl is a common brand name for Policresulen, the active substance is also available in other topical forms, including concentrated solutions and vaginal suppositories. The primary action of Policresulen involves selective protein coagulation properties, which lead to the removal of damaged tissue.

General Therapeutic Purpose and Selective Action

The general purpose of the medicine is to support the healing of inflammatory lesions and superficial tissue damage by promoting the removal of unhealthy tissue and providing localized cleansing. This is achieved through the mechanism of Policresulen, which enables the selective coagulation and shedding of pathologically altered or necrotic cells, a process that minimizes damage to adjacent healthy cells. Concurrently, the preparation creates an intensely acidic local environment that delivers a broad-spectrum cleansing action against local pathogens, contributing to overall tissue conditioning.

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What side effects are possible with Albothyl 1.8%?

Possible Side Effects and Safety Information

The official safety profile for Policresulen (Albothyl 1.8%) primarily documents localized adverse reactions and potential systemic immune concerns, categorized by their reported frequency as per regulatory standards.

Frequency-Classified Adverse Reactions

The most frequent reactions are generally confined to the application site. Regulatory summaries define the incidence as:

  • Very Common (Affects 1 in 10 users or more): Sensation of dryness in the vagina.
  • Common (Affects 1 to 10 in 100 users): Sensation of burning and the discharge of shreds of mucous membrane (necrotic tissue).
  • Not Known (Cannot be estimated from available data): This category includes systemic effects such as allergic reactions, generalized urticaria (hives), angioedema (swelling beneath the skin), and local effects like pruritus vulvae (itching) and local discomfort.

Serious Safety Considerations and Constraints

Official labeling recognizes the potential for serious systemic allergic reactions, including the risk of anaphylaxis and angioedema, which represent clinically significant concerns classified under Immune System Disorders.

Population-Specific Safety: The medicine is generally contraindicated for cervical treatment during pregnancy, particularly in the third trimester. Use during pregnancy and lactation is permitted only when strictly deemed necessary by a healthcare professional due to limited safety data in humans.

Product Constraints: Concomitant use with other topical vaginal or anorectal products should be avoided. Furthermore, due to the physicochemical properties of Policresulen, the preparation has been noted to potentially stain clothing and materials. The expulsion of altered tissue is often observed at the beginning of treatment as an expected consequence of the therapeutic action.

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Overdose and Emergency Response

The official regulatory profile for Albothyl 1.8% (Policresulen) focuses on the risks associated with accidental non-topical exposure, as regulatory sources report no cases of overdose from appropriate therapeutic use. The drug's classification as an acidic corrosive agent is the basis for the documented risk of severe tissue damage following accidental contact or ingestion.

Documented Manifestations: Accidental ingestion may result in an erosive effect on the mouth, throat, and oesophagus, creating the potential for digestive tract burns. The official classification also notes the risk of serious eye damage and severe burns upon contact or exposure.

When to Seek Urgent Help: Immediate and urgent action is mandated following any accidental ingestion or eye contact. The official instruction requires calling a POISON CENTER or physician immediately and seeking prompt medical examination. The person must be medically examined and treated as quickly as possible.

Required Emergency Actions: Specific first aid protocols are defined in regulatory documents: If swallowed, the individual must immediately drink plenty of water but must NOT induce vomiting to avoid exacerbating corrosive damage. If the substance contacts the eyes, the area must be thoroughly rinsed out at once with water, and an ophthalmologist must be consulted. Treatment for these exposures is strictly symptomatic and supportive.

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Therapeutic Uses of Albothyl 1.8%

What Albothyl 1.8% Treats: Main Uses and Benefits

The therapeutic application of Albothyl 1.8% gel is generally focused on local treatment for conditions involving tissue damage, inflammation, or infection on mucosal and superficial dermal surfaces. The core benefit helps support the natural process of regeneration through targeted cleansing and tissue conditioning.


The primary therapeutic domains include supportive care for gynecological conditions (like vaginitis and cervicitis, as well as cervical erosions), the management of symptoms related to anorectal pathology (including hemorrhoids and anal fissures), and supporting regeneration in superficial wounds and ulcers. This action may assist with easing symptoms such as pathological discharge, local irritation, and minor mucosal bleeding in situations where patients experience heightened discomfort.


Quick Fact: Supportive Care for Inflammatory Symptoms
This preparation supports the management of symptoms related to localized inflammation and tissue breakdown in conditions like anal fissures and cervical lesions.

Regulatory References

  1. DailyMed (NIH)
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Eligibility and Restrictions for Use

Eligibility Profile: Regulatory Statement

Official regulatory documentation defines the eligibility profile for Albothyl 1.8% (Policresulen 1.8%) by establishing explicit contraindications, age limitations, and conditional restrictions. This medicine is formally indicated for use in adult populations.

Absolute Contraindications

Use of Albothyl 1.8% is absolutely prohibited for the following populations, as stated in regulatory labeling:

  • Patients with known hypersensitivity or allergy to the active substance, Policresulen, or any of the product's excipients.
  • Pregnant women, where use is contraindicated, particularly in the later stages of pregnancy.

Age and Conditional Restrictions

Population Group Regulatory Status
Children and Adolescents Not indicated for use in individuals under the age of 18 years due to insufficient clinical data.
Lactating Women Not recommended; use is restricted to cases where the benefit is strictly necessary.
Menstruating Patients Must not be used during the menstrual period.
Older Adults No specific restrictions are documented solely based on age beyond the adult category.

No specific systemic comorbidities, such as hepatic or renal impairment, are listed as absolute contraindications for the topical 1.8% formulation in official regulatory documents.

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What should I know about interactions with other medicines?

Interaction Map: Interactions with other medicines and products — official regulatory information for Albothyl 1.8%

Category Official Regulatory Description
Medicinal product categories with documented interactions Other medicinal products for localized use (specifically vaginal medicinal products)
Specific interacting medicines (if explicitly listed) None explicitly listed by name or specific pharmacological class
Mechanistic basis of interactions (only if stated in label) Local incompatibility or potential for alteration of intended local effects; no systemic pharmacokinetic basis is documented.
Timing-based interaction rules (if applicable) Must not be co-administered simultaneously with other local products
Population-specific interaction notes (if applicable) None documented in the official interaction sections of regulatory sources
Interaction-related restrictions Restriction on simultaneous use with other local agents due to the possibility that local interactions cannot be excluded.

Interaction Classifications (High-Level)

Category Official Regulatory Description
Interaction severity classification (as defined in official documents) General caution against simultaneous use (Local Pharmacodynamic/Administration Restriction)
Regulatory basis (EMA / FDA / etc.) Based on official prescribing information and instruction for usage, consistent across multiple regulatory authorities.
Interaction-context constraints (as defined in official documents) The constraint applies to simultaneous administration and is limited to local medicinal products.

Resulting Interaction Structure

Official interaction statements:

  • The co-administration of Albothyl 1.8% with other medicinal products intended for localized use must be avoided simultaneously.
  • The regulatory documentation notes that interactions between Albothyl 1.8% and other local medicinal products cannot be excluded, necessitating a restriction on their simultaneous use.
  • No systemic pharmacokinetic interactions, such as those involving CYP enzymes or drug transporters, are documented in the official regulatory sections for this product.

Connection to the overall interaction profile (2–4 sentences): The regulatory interaction profile for Policresulen is defined by the absence of documented systemic drug-drug interactions, which is consistent with its highly localized administration and minimal systemic absorption. The only official interaction-related constraint is a timing-based restriction against the simultaneous use of other local medicinal products. This constraint is officially mandated to mitigate the potential for local incompatibility or undesirable alterations to the product's intended effect.

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Mechanism of Action

The action of Albothyl 1.8% is defined by the localized chemical properties of its single active ingredient, Policresulen, which exerts non-receptor-mediated effects entirely at the application site.

Selective Chemical Debridement and Tissue Coagulation

This domain covers the drug's primary interaction with pathologically altered tissue proteins. As an acidic, polymolecular compound, Policresulen chemically precipitates and denatures these proteins, creating a layer of coagulated material (eschar). This structural action results in the natural shedding of the unhealthy tissue, which is the key physiological mechanism for tissue removal and separation.

Localized Antiseptic and Microenvironment Modulation

This focuses on the formulation's high acidity (low pH) and its resulting effect on local microbial life. The acidic environment is hostile to pathogens, disrupting the structure and metabolism of local bacteria and fungi. This physical-chemical modulation of the microbial environment reduces the infectious barrier, supporting a reduced impediment to the natural process of re-epithelialization.

Hemostatic Action and Tissue Renewal Initiation

This domain addresses the drug's effect on capillary blood vessels and plasma proteins. Policresulen directly stimulates small-vessel vasoconstriction while chemically coagulating plasma proteins, contributing to localized hemostasis. By coupling this vascular effect with the debridement process, the mechanism initiates the necessary physiological sequence for successful re-epithelialization and regeneration of healthy underlying tissue. This physiochemical alteration initiates the endogenous cascade of re-epithelialization.

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Dosage and Administration Information

How Albothyl 1.8% is Used: Administration Guidelines

Albothyl 1.8% is administered via the topical route, specifically designed for vaginal application when addressing certain gynecological conditions. The general principle of its use is a short-term, localized, intermittent regimen.


Dosing and Scheduling Principles

Administration follows an intermittent schedule, requiring the application of a single dose to the affected area once every second day (every other day). This schedule is observed for a short-term duration, typically until symptoms have disappeared, but the total course of treatment must not exceed nine days.


Procedural and Population Constraints

For proper administration, the application is performed at night before going to sleep, with the patient positioned supine (lying on the back) to facilitate retention of the product. It is instructed that a sanitary pad be used concurrently to prevent the preparation from soiling clothing. Furthermore, the instructions indicate that the treatment is to be avoided during menstruation.

Usage is restricted for certain groups; the product is not indicated for use in postmenopausal women and is not for use in children and adolescents under 18 years of age for vaginal indications.

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Recent Clinical Evidence

Research evidence / Overview of studies for Albothyl 1.8%


Evidence for use in Gynecological Conditions (Vaginitis and GSM)

Research has explored Policresulen's use for symptoms related to localized inflammation in the vaginal area, such as those associated with vaginitis and Genitourinary Syndrome of Menopause (GSM). Studies include short-term Randomized Controlled Trials (RCTs) conducted on post-menopausal women that compared the product to a non-active control. These studies tracked patient-reported physical discomfort. The evidence is classified as moderate, but limitations include the lack of long-term effects and limited comparative evidence against other active standard treatments.


Evidence for use in Anorectal Pathology (Hemorrhoids and Fissures)

Studies exploring Policresulen for conditions like hemorrhoids and anal fissures rely heavily on large-scale multicenter studies examining outcomes related to perceived discomfort and therapeutic response. Multicenter studies reported that the therapeutic response was often rated favorably by investigators and patients for symptoms of hemorrhoidal pathology. However, the evidence is rated moderate due to the common use of Policresulen as a component of a combination product, making it challenging to isolate its specific contribution.


Research Limitations and Gaps

Specific small-sample controlled trials have explored the topical use of Policresulen in the context of care following procedures like open hemorrhoidectomy, measuring pain intensity post-surgery. Some trials reported that the difference in pain measurements between the Policresulen group and placebo did not reach statistical significance, leading to a low evidence rating for this specific use. Overall research has limited information on long-term outcomes and includes insufficient data for specific groups, such as pediatric patients or those with defined comorbidities, as these groups were often excluded from primary clinical trials.

Key Studies & References

  1. Instruction for Usage of Policresulen Vaginal Suppository (DailyMed/NIH)
  2. WHO Anatomical Therapeutic Chemical (ATC) Classification System for Policresulen (G01AX03)
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Frequently Asked Questions (FAQ)

Common questions about Albothyl 1.8% (FAQ)


Q: What Albothyl 1.8% is used for by most people?

Official regulatory documents indicate that the active ingredient, Policresulen, is used to address localized inflammation, infection, and tissue damage, particularly in the vaginal and cervical areas. It is also officially indicated for treating specific anorectal conditions, such as hemorrhoids and fissures.

Q: Is Albothyl 1.8% an antibiotic?

Albothyl 1.8% is formally classified as an antiseptic and disinfectant agent, not a systemic antibiotic. Its mechanism involves a physical-chemical cleansing action that creates an environment hostile to various pathogens, including both bacteria and fungi, at the site of application.

Q: How quickly does Albothyl 1.8% start working after application?

The product's selective action of chemically changing altered tissue begins immediately upon contact. Regulatory product information notes that the discharge of altered tissue shreds is a documented and common side effect that is observed during treatment, which indicates the localized action is occurring.

Q: What is the difference between the gel and the pessaries form of Albothyl (in general terms)?

The active substance Policresulen is available in different topical preparations. Albothyl 1.8% is a hydrophilic gel or jelly, while other products containing Policresulen may be formulated as vaginal suppositories, also called pessaries. These forms differ in their concentration and delivery vehicle, which determines how they are applied locally.

Q: Can I use Albothyl 1.8% if I have an IUD?

The presence of an IUD (intrauterine device) is not listed as an absolute contraindication in official regulatory documents. Some medical information suggests the product has been used for conditions even with an IUD in place. Information regarding use with an IUD is best discussed with a qualified healthcare professional.

Q: How can I tell if Albothyl 1.8% is working?

The discharge of small shreds of mucous membrane is listed in regulatory documents as a Common side effect. This shedding is an expected physiological consequence of the localized therapeutic action, which involves the removal of unhealthy or necrotic tissue.

Q: Does Albothyl 1.8% affect the natural flora of the body?

The product creates a highly acidic local environment. Official scientific information indicates that studies suggest the localized action does not typically affect the normal, beneficial Döderlein bacterial flora (Lactobacillus) of the area.

Q: Is it safe to use Albothyl 1.8% if I am trying to get pregnant?

Official regulatory documents restrict use during pregnancy and lactation. However, there is no specific regulatory data or restriction information available regarding its use during the pre-conception or fertility-planning period.

Q: Is it okay to have sex while using Albothyl 1.8%?

Official instructions consistently advise that sexual intercourse should be avoided during the treatment period. This constraint is also generally advised to continue for up to seven days following the completion of the treatment course.

Q: Why is Albothyl 1.8% sometimes used for minor skin issues?

The active substance, Policresulen, has a primary therapeutic purpose of localized tissue cleansing and conditioning. Some officially recognized formulations of the ingredient are specifically indicated for buccal use as an oral debriding agent to clean minor wounds and inflammation of the mouth and gums.

Q: Are there any long-term studies on the safety of Albothyl 1.8%?

The official research summaries acknowledge that current clinical evidence, while moderate, has limitations. Specifically, the data base for the product includes limited information regarding long-term outcomes and the duration of effects.

Q: What happens if I use Albothyl 1.8% for longer than recommended?

Official guidelines advise that the treatment course should not exceed nine days. Regulatory safety information indicates that extending use beyond the recommended duration may potentially risk disturbing the natural beneficial flora of the mucosa, which could increase the chance of secondary infection.

Q: Is Albothyl 1.8% indicated for use by men for related conditions?

While the gynecological indications apply to women, the regulatory documents also indicate use for conditions related to anorectal pathology, such as hemorrhoids and anal fissures. The product is generally defined for use in adult populations for these specific localized conditions.

Q: Does the 1.8% concentration refer to the active ingredient strength?

Yes, regulatory documents confirm this. The 1.8% figure specifically refers to the concentration of the sole active ingredient, Policresulen, within the hydrophilic gel or vaginal jelly formulation.

Q: Are there any foods or drinks to avoid while using Albothyl 1.8%?

The official regulatory Interaction Map and statements document no known interactions or contraindications related to the consumption of any specific foods or drinks while using the product.

Q: Is Albothyl 1.8% used for cervical issues?

Yes. Official regulatory documentation explicitly indicates that the product is appropriate for localized inflammation, infection, and tissue damage of both the vagina and the cervix.

Q: Do regulatory documents note the potential for allergic reactions to Albothyl 1.8%?

Yes, the official safety labeling recognizes the potential for systemic effects, including various forms of allergic reactions. These range from localized itching and hives to more serious reactions like angioedema (swelling) and, rarely, anaphylaxis.

Q: Can Albothyl 1.8% be used to treat yeast infections?

The mechanism involves a broad-spectrum cleansing action effective against various pathogens, including fungi such as Candida. Regulatory indications include treatment for secretions and infections caused by these organisms.

Q: What if I experience a side effect not listed on the package?

If any reaction occurs that is not listed in the product information, consultation with a healthcare professional is generally advised. The healthcare professional can provide guidance on reporting the event to the national regulatory agency.

Q: What is the shelf life or expiration date for Albothyl 1.8%?

The expiration date printed on the packaging defines the product's official shelf life. This is the period during which the medicine is guaranteed by the manufacturer to remain effective, safe, and stable, provided it has been stored according to the specified conditions.

Q: Is it true that Albothyl 1.8% can be used for dental/oral issues?

Yes, some officially recognized formulations of the active ingredient Policresulen are specifically indicated for buccal use (in the mouth). This use is primarily as an oral debriding agent to cleanse canker sores, minor wounds, or general gum inflammation.

Q: Can Albothyl 1.8% be used for non-infectious conditions?

Yes. The regulatory indications for the product include treatment for generalized localized tissue damage and certain inflammatory lesions that may be non-infectious in nature. The mechanism focuses on removing damaged tissue and promoting regeneration.

Q: Is Albothyl 1.8% effective against all types of bacteria?

The product is characterized by a broad-spectrum cleansing action, meaning it is active against a wide variety of common Gram-positive and Gram-negative bacteria, as well as fungi. However, official information does not confirm its efficacy against all bacterial species.

Q: Does the effectiveness of Albothyl 1.8% change with the time of day it's used?

The official instructions mandate application at night before going to sleep. This scheduling is primarily intended to facilitate retention of the product when lying down, which maximizes the duration of its localized action rather than affecting the inherent potency of the ingredient itself.

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How should Albothyl 1.8% be stored and disposed of?

How to Store and Dispose of Albothyl 1.8% (Policresulen)

Official regulatory guidelines mandate specific conditions to ensure the stability and safety of Albothyl 1.8%.

Required Storage Conditions

Storage Component Requirement
Temperature Store below 25 °C (controlled room temperature).
Protection Keep in a shading and airtight environment, protected from direct light and moisture.
Handling The container must be kept tightly closed; do not store in the freezer.
Safety Keep out of the reach and sight of children.
Stability Do not use the product after the expiry date stated on the packaging.

Official Disposal Instructions

Expired or unused Albothyl 1.8% must be handled as pharmaceutical waste. Disposal must follow procedures to prevent environmental contamination, primarily by utilizing an approved drug take-back program. The product must not be discharged to sewer systems or flushed. If necessary, follow FDA guidelines for disposal in household trash by mixing the medicine with an undesirable substance and sealing it in a container.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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