Afracin

Afracin

Isoniazid, Rifampicin

Pulmonary and extrapulmonary forms of tuberculosis caused by pathogens sensitive to this combination.

Inside, for adults. The daily dose of Rifinag 150 is 3-4 tablets (equivalent to 450-600 mg of rifampicin and 300-400 mg of isoniazid), Rifinag 300 — 2 tablets (equivalent to 600 mg of rifampicin and 300 mg of isoniazid). The daily dose is taken in one dose in the morning on an empty stomach.

Hypersensitivity, jaundice, acute liver diseases of various origins, severe renal failure.

Epigastric pain, anorexia, nausea, vomiting, constipation, flatulence, tenesmus, diarrhea, increased levels of hepatic transaminases, alkaline phosphatase and bilirubin in plasma, headache, drowsiness, dizziness, asthenia, impaired concentration and vision, paresthesia of the skin of the hands and feet, hyperreflexia, tremor, convulsions, toxic encephalopathy, toxic psychosis, insomnia, neuritis and atrophy of the optic nerve, muscle weakness, pain in the extremities, menstrual disorders, vitamin B deficiency syndrome₆ and nicotinamide, hyperglycemia, hematuria, development of renal failure, acidosis, leukopenia, agranulocytosis, hemolytic sideroblastic and aplastic anemia, thrombocytopenia, eosinophilia, skin rash, itching, urticaria, ulcerative stomatitis and glossitis, lupus and rheumatic syndromes, lymphadenopathy.

It has high activity against mycobacteria, including Micobacterium tuberculosis, and some Gram-positive pathogens. The activity against gram-negative microorganisms is lower. It provides a rapid regression of the tuberculosis process (even in the advanced and widespread form) and leads to a complete cure in a high percentage of cases.

After oral administration, both components are quickly and completely absorbed from the gastrointestinal tract. C_max the active components are reached by the 2nd hour and remain at a detectable level for up to 8 hours, they penetrate well into the body's fluids and tissues, are metabolized in the liver, and are excreted in bile and urine.

• Other synthetic antibacterial agents in combinations

Reduces the effect of indirect anticoagulants, oral hypoglycemic agents, hormonal contraceptives, digitalis preparations, antiarrhythmics (disopyramide, quinidine), glucocorticoids, methadone (when used together, dose adjustments may be required, especially at the beginning and end of treatment). Increases the concentration of diphenylhydantoin in the blood (dose reduction may be required).