Аевит

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Аевит

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Аевит

What is Aevit? A Combined Vitamin Preparation

Property Description
Active Ingredients Retinol (Vitamin A), Tocopherol (Vitamin E)
Form Soft gelatin capsule, Oily solution
Pharmacological Class Vitamin Complex / Essential Nutrient Supplement
Common Use Management of Vitamin A and E Deficiency (Hypovitaminosis)
Origin Derived (Synthetic/Semi-synthetic forms of essential nutrients)

Defining Aevit: A Combined Vitamin Preparation

Aevit (Аевит) is structurally defined as a multivitamin preparation and an Essential nutrient supplement intended to manage deficiencies of two specific fat-soluble vitamins. It is defined as a combination product that synergistically delivers Vitamin A (Retinol) and Vitamin E (Tocopherol) within a single pharmaceutical entity. Belonging to the high-level pharmacological class of Vitamin complexes, its identity is distinct from single-ingredient supplements, focusing on the simultaneous replenishment of both essential nutrients. The preparation is typically presented as a soft gelatin capsule containing an oily solution suitable for the oral route of administration, although the oily solution may also be prepared for parenteral use.

Composition, Synergism, and General Purpose

The core active ingredients of Aevit are Retinol Palmitate (a stable form of Vitamin A) and Alpha-Tocopherol Acetate (a stable form of Vitamin E), which are suspended in an oily vehicle to ensure proper bioavailability. The general purpose of this specific combined composition is to provide comprehensive support against concurrent hypovitaminosis (deficiency states) of both Vitamin A and Vitamin E. The formulation’s effect relies on the synergism between the two vitamins: Vitamin E provides powerful antioxidant protection to cellular structures, while Vitamin A supports tissue regeneration and the healthy differentiation of epithelial cells. Consequently, the preparation is fundamentally beneficial for maintaining cellular integrity and supporting the body's natural antioxidant defenses.

What side effects are possible with Аевит?

Possible Side Effects and Safety Information

The safety profile of Аевит is primarily determined by its Vitamin A (retinol) content, which is a fat-soluble vitamin stored in the liver. Side effects are dose-dependent and typically linked to excessive intake, leading to hypervitaminosis A.

Serious Safety Considerations

  • Teratogenicity (Birth Defects): The most critical safety risk is the potential for severe congenital malformations in a developing fetus, particularly during the first trimester of pregnancy. For this reason, intake of high-dose Vitamin A (retinol/retinyl esters) supplements, especially those exceeding 10,000 International Units (IU) daily, is contraindicated during or immediately preceding pregnancy.
  • Acute and Chronic Toxicity: Prolonged or extremely high intake can lead to systemic toxicity, which includes: increased intracranial pressure (manifested by severe headache, nausea, and vomiting), liver injury (e.g., hepatomegaly, elevated liver enzymes, or, in chronic cases, fibrosis), and significant bone and joint pain.

Common and Dose-Related Adverse Reactions

Side effects that may occur with chronic overconsumption of Vitamin A include:

System-Organ Class Reactions
Skin & Subcutaneous Dryness, fissuring, cheilitis (dry, cracked lips), hair loss, pruritus (itching).
Nervous System Headache, dizziness, fatigue, irritability.
Gastrointestinal Nausea, vomiting, abdominal discomfort, loss of appetite.

Safety Monitoring and Restrictions

Due to the risks of accumulation, all sources of Vitamin A intake (dietary and supplemental) must be considered to prevent exceeding the established safe upper limits. The risk of bleeding may be a consideration at very high doses of the Vitamin E component, particularly in individuals concurrently taking anticoagulant or antiplatelet medications.

Overdose and Emergency Response

Overdose and When to Seek Help

This section outlines the officially documented overdose manifestations and required emergency actions for a combination of Vitamin A (Retinol) and Vitamin E (Tocopherol), based strictly on government regulatory documents.

Officially Documented Manifestations

Overdose Type Common Manifestations (as documented)
Acute Toxicity (Vitamin A) Headache, dizziness, irritability, somnolence, nausea, vomiting, blurred vision, muscular incoordination.
Chronic Toxicity (Vitamin A) Dry/cracked skin, hair loss, fatigue, loss of appetite, bone/joint pain, and potential liver enlargement (hepatomegaly).
High-Dose (Vitamin E) Nausea, diarrhea, abdominal pain, muscle weakness, and fatigue.

Severe Outcomes and Required Actions

Official labeling indicates that two primary severe risks exist: a haemorrhage risk linked to high doses of Vitamin E, which can increase bleeding tendency, and the potential for increased intracranial pressure from severe Vitamin A toxicity.

When to Seek Urgent Medical Help

Regulatory authorities require the immediate cessation of the supplement upon suspicion of overdose. Urgent medical attention must be sought for substantial acute overdose, any severe symptoms, or the occurrence of active bleeding or signs of neurological complications.

Specific Overdose Considerations

Patients with pre-existing renal or liver disease may be at higher risk for Vitamin A toxicity. Furthermore, due to teratogenic risk, high Vitamin A doses during pregnancy are associated with birth defects.

Therapeutic Uses of Аевит

The therapeutic application of Aevit, a combination of Vitamin A (Retinol) and Vitamin E (Tocopherol), is commonly used to help with deficiency states (hypovitaminosis) and is applied in addressing the resulting symptoms across key physiological domains. This nutritional support is relevant for critical body functions.

Aevit is relevant in contexts involving heightened systemic burden, such as during periods of convalescence after long and severe illnesses, or in situations where fat malabsorption syndromes are present. It is applied in addressing symptom clusters including impaired vision like night blindness (nyctalopia), excessive skin dryness (xerosis), and general fatigue (asthenia).

“This supportive function assists with maintaining functional stability and may help patients cope more steadily with symptom fluctuations.”

This preparation is commonly used to help with conditions characterized by periods of heightened symptoms, supporting epithelial health and addressing deficiency-related ocular dysfunction. By addressing the nutritional deficit, it contributes to improved comfort and helps maintain a sense of stability when symptoms are more noticeable.


Quick Fact: Relief for Epithelial Symptoms
Aevit is applied in addressing symptoms related to impaired epithelial health, such as hyperkeratosis and skin xerosis, supporting cell renewal and dermal integrity.

Eligibility and Restrictions for Use

Aevit is a combination preparation of Retinol Palmitate (Vitamin A) and Alpha-Tocopheryl Acetate (Vitamin E), and its eligibility profile is defined by strict regulatory contraindications related to the high doses of these fat-soluble vitamins.

Eligibility Status Excluded Populations/Conditions (Contraindications)
Do Not Use Hypervitaminosis A and/or D (pre-existing vitamin excess)
Do Not Use Severe renal impairment (nephritis, chronic glomerulonephritis)
Do Not Use Acute inflammatory diseases (e.g., acute pancreatitis, acute cholecystitis)
Do Not Use Thyrotoxicosis; chronic heart failure (decompensation stage)
Do Not Use Acute myocardial infarction; increased risk of thrombosis
Do Not Use Hypersensitivity/Allergy to any component of the formulation
Do Not Use Pregnancy (especially the first trimester) and lactation
Do Not Use Children under 14 years of age

Use of Aevit is additionally restricted and requires special caution in individuals with conditions such as cholecystitis, chronic pancreatitis, and severe hepatic impairment. The regulatory labeling strictly excludes populations who have pre-existing vitamin excess or specific acute and chronic organ diseases.

What should I know about interactions with other medicines?

Interactions with Other Medicines and Products

Аевит (containing retinol acetate, Vitamin A, and alpha-tocopherol acetate, Vitamin E) can interact with several types of medications and supplements. It is essential to consult a healthcare professional about all current drugs and supplements to safely manage potential interactions.


Major Interaction Concerns

Interacting Substance Potential Effect
Oral Anticoagulants (e.g., Warfarin) High doses of Vitamin E can increase the risk of bleeding by inhibiting platelet aggregation.
Retinoids (e.g., Isotretinoin, Acitretin) Co-administration may lead to an excessive accumulation of Vitamin A (hypervitaminosis A), increasing the risk of adverse effects like liver toxicity and increased intracranial pressure.

Other Significant Interactions

  • Mineral Oil and Orlistat: These agents can decrease the absorption of the fat-soluble vitamins (A and E) found in Аевит, potentially reducing their effectiveness. Dosing should be separated by several hours.
  • High-Dose Vitamin A Supplements: Taking additional Vitamin A supplements should be avoided to prevent Vitamin A toxicity.
  • Tetracycline Antibiotics: Concomitant use with high-dose Vitamin A may increase the risk of a condition called pseudotumor cerebri (increased pressure around the brain).

Mechanism of Action

Nuclear Modulation of Epithelial Structure

The action of Aevit is governed by two complementary mechanistic domains: the gene-regulating activity of Retinol and the antioxidant defense of Alpha-Tocopherol, operating in a synergistic relationship. The Retinol mechanism is defined by its active metabolite, All-trans Retinoic Acid ( ATRA), which functions as a ligand agonist for the nuclear RAR and RXR transcription factors. This binding modulates gene expression to control cellular differentiation and proliferation. The resulting physiological effect is the regulation of epithelial structure formation and cellular maturation throughout the body.

Chain-Breaking Protection Against Oxidative Stress

This complementary mechanism relies on Alpha-Tocopherol acting as a fat-soluble, chain-breaking antioxidant integrated within cell membranes. It rapidly neutralizes lipid peroxyl radicals ( LOOcdot) by donating a hydrogen atom, thereby terminating the destructive lipid peroxidation cascade. This action minimizes structural and functional alteration of cellular membranes by free radical species. The two components work together via a reciprocal protection mechanism: Alpha-Tocopherol provides a protective barrier against the oxidative degradation of Retinol, which maintains the necessary substrate concentration for the gene-regulation pathway.

Dosage and Administration Information

Official Administration Guidelines

Aevit is a high-dose combination of Vitamin A (Retinol Palmitate) and Vitamin E (Alpha-Tocopherol Acetate), primarily regulated in certain national pharmacopeias.

1. Route and Form

The standard approved formulation is the oral soft gel capsule, which must be swallowed whole with water. Some jurisdictions may also approve an oily solution for intramuscular (IM) injection as an alternative route of administration.

2. Dosing Schedule and Timing

The standard dosage is typically one capsule once daily (q.d.) or as specifically prescribed. Due to the fat-soluble nature of the vitamins, the capsule must be taken with food or immediately after a meal to ensure adequate absorption.

3. Course Duration and Limitations

Treatment with Aevit is strictly time-limited and is not intended for continuous use. Official guidelines specify a typical treatment course duration (e.g., 20 to 40 days). Following completion of the course, a mandatory break period (e.g., several months) is required before treatment can be repeated. This is a crucial procedural constraint to mitigate the risk of fat-soluble vitamin accumulation (hypervitaminosis).

4. Population and Missed Dose

Aevit is typically restricted in use for pediatric patients due to the high concentration of Vitamin A. If an oral dose is missed, it should be taken as soon as remembered, unless it is nearly time for the next scheduled dose, in which case the missed dose should be skipped; do not double the dose to compensate. Adherence to the stated limits for daily intake and course duration is mandatory.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Aevit


Evidence for Use in Severe Vitamin Deficiency States

Research for the combined use of high-dose Vitamin A (Retinol) and Vitamin E (Tocopherol) was studied for use in patients with severe deficiency states (known as hypovitaminosis). This severe deficiency often results from conditions that cause fat malabsorption syndromes, where the body struggles to absorb these essential fat-soluble nutrients.

The research in this area largely consists of long-term observational studies and case series. Large-scale randomized controlled trials (RCTs) are limited. Researchers used these methods to examine how the combined preparation affected biomarker measurements (tracking the return of vitamin blood levels to expected ranges) and to monitor functional outcomes like neurological health and visual capacity over defined time intervals.

Studies consistently reported measurements of elevated serum retinol and tocopherol levels in these specific patient groups. However, evidence remains limited for the general population with mild or non-syndromic hypovitaminosis, as the focus has been on rare, severe cases.


Evidence for Ocular Dysfunction in Specific Inherited Conditions

The combined preparation was evaluated in research exploring its role in managing specific inherited eye diseases, such as Retinitis Pigmentosa. This research included a large, multi-year randomized controlled trial (RCT). The research examined the administration of high-dose Vitamin A and Vitamin E, both separately and combined.

The main outcomes measured were functional measures of vision, specifically monitoring the patterns of change in retinal function. The core RCT reported patterns of slower rates of decline in certain visual parameters for the study group receiving the high-dose Vitamin A component alone. However, the trial indicated that the findings were mixed regarding the Vitamin E component in the combination.


Research Gaps and Unanswered Questions

There are several key limitations in the research and areas where certainty remains low. The overall evidence quality varies across studies, with limited availability of large-scale, placebo-controlled RCTs for the primary use of the combination in general deficiency states. Comparative evidence is lacking regarding whether the combined preparation has been studied against using single, targeted vitamin supplements.

Frequently Asked Questions (FAQ)

Common questions about Аевит (FAQ)


Q: Does the time of day I take Аевит matter (morning vs. evening)?

A: Official administration guidelines state that the capsule must be taken with food or immediately after a meal due to the fat-soluble nature of the vitamins, which aids in absorption. However, the regulatory documents do not specify whether the morning or evening is a required time for administration.


Q: Can Аевит be taken with food, or should it be on an empty stomach?

A: According to official administration guidelines, Аевит must be swallowed whole with food or immediately following a meal. This is a requirement in the official procedure for use and is intended to support the adequate absorption of the fat-soluble vitamins (A and E) contained in the capsule.


Q: What are the main potential side effects mentioned in official product information for Аевит?

A: Official product information lists several common dose-related adverse reactions primarily linked to high Vitamin A intake. These include skin issues like dryness and itching, nervous system reactions such as headache and fatigue, and gastrointestinal reactions like nausea and abdominal discomfort.


Q: Can Аевит be used by people with diabetes?

A: The official eligibility section lists several chronic health conditions, such as severe renal impairment and chronic heart failure, as contraindications for use. However, diabetes mellitus is not listed among the specific conditions that contraindicate use of the product.


Q: Is it okay to take another multivitamin while using Аевит?

A: Official guidance warns against taking additional high-dose Vitamin A supplements to prevent toxicity. Since Аевит itself is a high-concentration product, intake from other multivitamins is an important factor for consideration to manage the risk of exceeding safe limits and causing excessive vitamin accumulation.


Q: Why is Аевит sometimes recommended for eye-related issues?

A: The combined preparation has been evaluated in research exploring its role in managing specific inherited eye diseases, such as Retinitis Pigmentosa. This is an example of the specific deficiency and therapeutic areas where the product has been studied, as described in official research overviews.


Q: Can taking Аевит cause changes to skin color or texture?

A: Official documentation lists several dose-related skin reactions that may occur with chronic overconsumption. These include dryness, fissuring, cheilitis (dry, cracked lips), and hair loss, which relate to changes in skin texture, although changes to skin color are not explicitly listed.


Q: What is the main difference between Аевит and taking separate vitamin A and vitamin E supplements?

A: Аевит is defined as a specific high-concentration combination product whose composition addresses concurrent deficiencies of both Vitamin A and Vitamin E. Its formulation is based on a concept of synergism, where Vitamin E protects Vitamin A from degradation.


Q: Is Аевит considered a general-purpose vitamin supplement?

A: Official documents define it as a high-dose Vitamin Complex defined for use in the management of specific deficiency states (hypovitaminosis). Regulatory guidelines also indicate that treatment is strictly time-limited and not intended for continuous, general use.


Q: Are there any common reasons why a doctor would prescribe or recommend Аевит?

A: Research evidence examines the combined use for patients with severe deficiency states of both Vitamin A and E. These severe deficiencies often result from medical conditions that lead to fat malabsorption syndromes, which represents a common area of use examined in research.


Q: Is it true that Аевит is sometimes used for skin conditions or beauty?

A: The mechanism of the Vitamin A component is defined by its role in regulating epithelial structure and cellular differentiation. While the safety profile lists skin-related issues (dryness, hair loss), official sources focus the product's indications on deficiency, and do not list cosmetic or general skin health uses.


Q: Is Аевит safe to use for teenagers?

A: The regulatory label strictly contraindicates the use of the product for children under 14 years of age. Populations aged 14 and older are not explicitly excluded, but the product is a high-dose treatment whose use is defined by the necessity of addressing a specific deficiency.


Q: Why are the vitamins A and E combined in one capsule in Аевит?

A: The two vitamins are combined because they work in a synergistic relationship. Vitamin E acts as a chain-breaking antioxidant, which in turn provides a reciprocal protective barrier that minimizes the oxidative degradation of the Vitamin A component.


Q: Is there a risk of overdose with Аевит?

A: The official documentation indicates a risk of toxicity due to the high Vitamin A content. Official warnings state that prolonged or extremely high intake can lead to systemic toxicity, which is known as hypervitaminosis A.


Q: Can men and women use Аевит for the same purposes?

A: The eligibility profile contraindicates use for women who are pregnant (especially in the first trimester) or lactating due to the critical risk of birth defects from high-dose Vitamin A. No gender-based differences in use conditions are mentioned for non-reproductive populations.


Q: Does official research evidence exist to support the common uses of Аевит?

A: Official research evidence has evaluated the use in severe deficiency states and specific inherited eye diseases. However, the documentation notes that large-scale randomized controlled trials (RCTs) are limited, and comparative evidence against using single vitamin supplements is lacking.


Q: Is it common to feel slightly nauseous when first starting Аевит?

A: Nausea, vomiting, and abdominal discomfort are listed among the common and dose-related adverse reactions. These reactions are typically associated with the chronic overconsumption or accumulation of the Vitamin A component.


Q: Is it true that people sometimes use the oil from the Аевит capsule topically?

A: The standard approved formulations and routes of administration described in official documents are limited to the oral soft gel capsule, which is swallowed, and the oily solution for intramuscular injection. Official documents do not describe or authorize a topical route of administration.


Q: Can Аевит cause insomnia or affect sleep patterns?

A: Official documentation lists adverse reactions under the Nervous System, including headache, dizziness, fatigue, and irritability. However, specific changes like insomnia or general sleep pattern disturbances are not explicitly named in the official safety profile.


Q: How does the concentration of Vitamin A and E in Аевит compare to daily recommended intake levels?

A: Аевит is defined as a high-dose combination product. Official safety sections highlight that intake of high-dose Vitamin A, especially exceeding 10,000 International Units (IU) daily, is a critical safety consideration due to the risk of accumulation.


Q: Do studies suggest any potential long-term risks associated with Аевит use?

A: A potential long-term risk mentioned in official safety sections is the possibility of vitamin accumulation in the body. This is due to the nature of fat-soluble vitamins and requires safety monitoring to mitigate the risk of chronic toxicity (hypervitaminosis).


Q: Why might a user feel tired when starting a course of Аевит?

A: Fatigue is listed as one of the common and dose-related adverse reactions that may affect the nervous system. These reactions are often associated with the chronic overconsumption or accumulation of the high-dose Vitamin A component.


Q: Does the medicine come in forms other than capsules?

A: Yes. The product is approved in two standard formulations and routes of administration: the oral soft gel capsule, which is swallowed, and an oily solution prepared for intramuscular (IM) injection.


Q: What is the difference between Аевит and just high-dose Vitamin E?

A: Аевит is officially defined as a specific combination product that delivers both Retinol (Vitamin A) and Alpha-Tocopherol (Vitamin E) together in a synergistic formula. High-dose Vitamin E, by contrast, is a single-ingredient supplement.


Q: How is the research evidence for Аевит generally characterized by medical bodies?

A: Official documents characterize the evidence quality as varying across studies, with a general limitation being the lack of large-scale, placebo-controlled randomized controlled trials (RCTs) for general deficiency states. Comparative evidence against single supplements is also noted as lacking.


Q: Does Аевит help with hair health?

A: Official documentation lists hair loss as a potential adverse reaction under the Skin and Subcutaneous system, which is linked to the high-dose Vitamin A component. The product's official therapeutic indications do not include hair health benefits.


Q: Is there any official information about Аевит and its use in treating acne?

A: The mechanism of the Vitamin A component involves modulating gene expression to regulate cellular differentiation, including in epithelial structure. However, the product’s official therapeutic indications do not explicitly name acne treatment.


Q: How quickly is Аевит typically absorbed by the body?

A: To ensure adequate absorption of the fat-soluble vitamins, official administration guidelines require the product to be taken with food or immediately after a meal. No specific absorption time is described in the core product information.


Q: What should a person do if they suspect an interaction with another medicine?

A: Official guidance emphasizes the importance of consulting a healthcare professional about all current drugs and supplements, including over-the-counter and herbal products, to safely identify and manage any potential interactions.


Q: Is the packaging of Аевит child-proof?

A: Official storage rules strictly mandate a safety rule to keep the product out of the sight and reach of children. This required instruction addresses the need for child safety.


Q: Why do some people experience dry skin after using Аевит?

A: Dryness and fissuring of the skin are listed as potential side effects in the official safety profile. These reactions are associated with the chronic overconsumption or accumulation of the high-dose Vitamin A component in the body.

How should Аевит be stored and disposed of?

Official Storage and Disposal Instructions

Regulatory documentation defines strict environmental conditions for storing Aevit capsules to maintain the stability of the vitamin complex.

Storage Requirement Specification
Temperature Range Store between 15 C and 25 C.
Environmental Control Protect from light and store in a dry place.
Packaging Rule Must be kept in the original packaging (box and blister).
Child Safety Keep out of the sight and reach of children (mandatory safety rule).
Stability Do not use the product after the official expiry date.

Storage outside of the required 15 C to 25 C range is prohibited, which includes cold storage like refrigeration or freezing. The requirement to protect the product from light and moisture ensures the integrity of the fat-soluble components and the soft gelatin capsule.

For disposal, unused or expired Aevit must be discarded according to local pharmaceutical waste collection procedures and should not be disposed of in household trash or wastewater, although no specific environmental handling rules are mandated on the product label.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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