Adalat CC

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Adalat CC

Quick Facts

Property Description
Active ingredient Nifedipine
Form Extended-release tablet (Long-acting)
Pharmacological class Dihydropyridine Calcium Channel Blocker (CCB)
Common use Management of high blood pressure and chest pain
Origin Synthetic compound

The Core Identity: Adalat CC and the Calcium Channel Blocker Class

Adalat CC is a specific branded pharmaceutical preparation whose active ingredient is nifedipine, a substance that is manufactured as a synthetic compound. Nifedipine is classified within the major pharmacological class of Calcium Channel Blockers (CCBs), and more specifically, it is a Dihydropyridine (DHP) calcium ion antagonist. This group of medicines is defined by its ability to influence the movement of calcium ions across cell membranes.

As a CCB, Adalat CC's primary function is to relieve cardiovascular strain by addressing conditions stemming from excessive vascular tension. Its general therapeutic purpose is for the chronic management of hypertension (high blood pressure) and angina pectoris (chest pain), often used when continuous control of peripheral arterial resistance is required. The medication helps to widen blood vessels to reduce the pressure on the heart.

Composition and the Significance of the Extended-Release Formulation

The medication is an oral product presented as an extended-release tablet, a specialized long-acting form designed for once-daily administration. The proprietary "CC" designation signifies this unique controlled-release delivery system, which differentiates it from standard immediate-release nifedipine forms and ensures a stable, consistent therapeutic profile. This particular single active ingredient preparation is crucial because it maintains consistent therapeutic concentrations of nifedipine throughout the day, preventing the fluctuations commonly associated with shorter-acting drugs.

The extended-release characteristic is designed for a sustained-release over 24 hours, supporting continuous control. The formulation is composed of the active compound integrated within solid excipients and matrix materials that govern the controlled-release mechanism necessary for its 24-hour efficacy.

What side effects are possible with Adalat CC?

Possible side effects and safety information

The safety profile for nifedipine extended-release (Adalat CC) is formally documented by regulatory authorities, classifying adverse reactions by frequency and physiological system affected. These reactions primarily stem from the medicine’s vasodilatory effects.

Frequency-Classified Adverse Reactions

Adverse reactions are grouped based on the frequency observed in clinical data:

Classification Examples of Reactions
Very Common (geq10%) Headache, Oedema (peripheral swelling)
Common (geq1% to <10%) Dizziness, Flushing, Constipation, Fatigue, Nausea, Palpitations
Uncommon (geq0.1% to <1%) Hypotension, Tachycardia, Allergic reactions, Visual disturbances, Gastrointestinal pain

Serious Adverse Reactions and Safety Constraints

Official prescribing information notes rare, but clinically important, safety concerns. The potential for increased angina and/or acute myocardial infarction is documented, particularly upon starting treatment or increasing the dosage. The extended-release form also carries rare reports of serious gastrointestinal obstruction. Caution is advised in patients with severe hypotension or poor cardiac reserve.

Specific safety considerations are mandated for certain groups. Patients with hepatic impairment may require close monitoring and possible dose reduction, with use not recommended in severe cases. Furthermore, ingestion of grapefruit or grapefruit juice is officially restricted while taking this medicine due to the risk of enhanced blood pressure-lowering effects.

Side effects like dizziness and hypotension are noted in regulatory documents as being more likely to occur when beginning the medicine or when the dose is increased.

Overdose and Emergency Response

Overdose and when to seek help

Suspected overdosage of Adalat CC (nifedipine extended-release) is formally documented in regulatory materials as potentially leading to severe, life-threatening outcomes. The primary documented manifestations are consequences of profound hemodynamic instability, specifically marked and prolonged hypotension (severe low blood pressure) and significant alterations in heart rate, which may present as bradycardia (slow heart rate) or reflex tachycardia (rapid heart rate).

Beyond cardiovascular signs, official prescribing information lists systemic effects such as dizziness, confusion, somnolence, and the potential progression to loss of consciousness. Severe cases are classified by regulators as risking cardiogenic shock, cardiac failure, asystole, and death. Metabolic disturbances like hyperglycemia and metabolic acidosis are also documented physiological findings.

Regulators mandate immediate action upon any suspected overdose. The official instruction is to seek immediate medical attention or contact emergency services without delay. Management protocols detailed in official documents specify symptomatic and supportive treatment, including gastric decontamination and the use of pharmaceutical agents such as calcium and vasopressors to stabilize cardiovascular function. Extended and continuous monitoring, often in an Intensive Care Unit setting, is required for observed or suspected massive ingestions. It is officially stated that no specific antidote is known for nifedipine.

Therapeutic Uses of Adalat CC

Adalat CC is commonly used to help with managing symptoms related to systemic imbalance, specifically the persistent elevation of blood pressure and the discomfort of recurrent chest pain. The medication is utilized for the management of high blood pressure and is relevant for easing symptoms of angina.

The medication is relevant for addressing symptom clusters associated with two primary conditions: essential hypertension and Angina Pectoris, including both chronic stable angina and vasospastic angina. The general clinical context involves long-term management and is applied when supportive symptom management is appropriate.

The primary benefit contributes to maintaining a sense of stability when blood pressure is more noticeable. The core benefit for angina is that it supports the patient during difficult episodes by helping to ease the overall symptom burden. The medication assists with maintaining functional stability during symptomatic periods.


Quick Fact: Relief for Chronic Cardiovascular Symptoms

This medication is generally used to help address conditions characterized by periods of heightened physiological activity and episodic or fluctuating manifestations. It plays a role in managing symptoms that create noticeable functional strain, and supports general well-being during symptomatic phases of cardiovascular conditions.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Adalat CC is officially approved for use in adult patients for the management of hypertension and angina pectoris. Eligibility is strictly defined by regulatory documents, which establish clear contraindications and limitations for other population groups.

Populations for Whom Use is Prohibited (Contraindications)

Category Regulatory Status
Cardiogenic Shock Contraindicated
Hypersensitivity Contraindicated (to nifedipine or any tablet component)
Recent Myocardial Infarction Contraindicated (within one month)
Strong CYP3A4 Inducers Contraindicated (e.g., Rifampin)
Severe GI Narrowing Contraindicated (risk of obstruction)

Restricted and Non-Recommended Use

Age-Related Eligibility

  • Pediatric Patients: Use is not recommended; safety and efficacy have not been established in children and adolescents.
  • Older Adults: Use is permitted, but caution is advised due to the higher likelihood of age-related organ impairment, which may necessitate careful monitoring.

Physiological and Comorbidity Restrictions

  • Pregnancy: Use is generally contraindicated by some regulators; FDA labeling states use is only if the potential benefit justifies the risk.
  • Lactation (Breastfeeding): Use is not recommended as the medication is excreted in human milk.
  • Severe Hepatic Impairment: Use requires caution and close monitoring due to potential for slower clearance.
  • Poor Cardiac Reserve: Use requires caution as the condition may potentially deteriorate.

Regulatory documents establish that while the medicine is approved for use in adults, the population eligible to take Adalat CC is limited by formal contraindications concerning acute cardiovascular instability (e.g., unstable angina) and certain drug interactions (e.g., Rifampin). The profile further defines restricted use in populations with specific organ dysfunction and in developmental states such as pregnancy, outlining the official boundaries for who can and cannot use the drug.

What should I know about interactions with other medicines?

Adalat CC (nifedipine) interacts with other medicines and certain food products due to its metabolism through the body's Cytochrome P450 3A4 (CYP3A4) enzyme system. Altering the activity of this enzyme can affect how much nifedipine remains in the bloodstream.

Interacting Substances and Categories

  • CYP3A4 Inducers: Medicines that increase the activity of this enzyme can reduce the amount of nifedipine in the blood, potentially making it less effective. Co-administration with strong inducers, such as Rifampin, is considered inappropriate.
  • CYP3A4 Inhibitors: Medicines that block the activity of this enzyme can increase nifedipine levels, raising the risk of unwanted effects. Examples include certain antifungal agents (like ketoconazole, itraconazole), antibiotics (clarithromycin, erythromycin), and certain antiviral drugs. A reduced dose of Adalat CC may be necessary when combined with these inhibitors.
  • Beta-blockers: Combining Adalat CC with a beta-blocker is generally done with careful clinical monitoring, as the combined blood pressure-lowering effect may be enhanced, especially in certain surgical settings.
  • Grapefruit Juice: Ingestion of grapefruit or grapefruit juice should be avoided while taking this medication. The juice can inhibit the CYP3A4 enzyme in the digestive tract, which can significantly increase the concentration of nifedipine in the body.

Mechanism of Action

How Adalat CC Works


Blocking the L-Type Calcium Channel

The mechanism of action of Nifedipine (the active ingredient in Adalat CC) is its function as a specific antagonist of the L-type Voltage-Dependent Calcium Channel ( L-VDCC). These channels are predominantly located in the membranes of vascular smooth muscle cells. By binding to the channel, Nifedipine prevents the influx of extracellular calcium ions ( Ca^2+) into the cytosol. This molecular event interrupts the cascade required for muscle contraction, directly causing the relaxation of arterial walls and initiating systemic vasodilation.


Reducing Systemic Vascular Resistance

The widespread relaxation of arterial smooth muscle causes a reduction in Total Peripheral Resistance ( TPR). This physiological change reduces the pressure gradient throughout the systemic circulation. By lessening the physical opposition to blood flow, this mechanism lowers the afterload and consequently reduces the myocardial workload. Nifedipine also acts on the coronary circulation, causing dilation of the coronary arteries, influencing the relationship between the heart's oxygen demand and its oxygen supply.

Dosage and Administration Information

Instruction Map: How to use Adalat CC — Administration Characteristics

This structure outlines the administration profile for Adalat CC (Nifedipine Extended-Release). It defines the standardized approach for use as established by standard pharmaceutical parameters.


Administration Scope

Instruction Entity Detail
Route of administration Oral (tablet only).
Dosing schedule Initial adult dosing is typically 30 mg or 60 mg once daily. The standard maintenance dose range is 30 mg to 90 mg once daily.
Timing in relation to meals The medication should be administered on an empty stomach. Co-administration with grapefruit or grapefruit juice is avoided.
Preparation requirements The extended-release tablet must be swallowed whole; it is not to be bitten, crushed, or divided, as this disrupts the controlled-release mechanism.
Age-group administration rules Patients with hepatic impairment may require lower initial doses due to altered metabolism of the drug.
Missed-dose rules If a dose is missed, it is skipped if it is almost time for the next scheduled dose. A double dose is not taken to compensate.
Special procedural conditions Gradual dosage adjustments typically proceed over a 7-to-14 day period to assess therapeutic response. Discontinuation of therapy is accomplished by decreasing the dosage gradually.

Instruction Classifications (High-Level)

Classification Detail
Administration method type Oral (swallow whole).
Frequency pattern Once daily (every 24 hours).
Basis of use Established prescribing information.
Use-context constraints Administered on an empty stomach, avoiding grapefruit products.

Resulting Procedural Structure

Administration sequence:

  • Administer the extended-release tablet orally once every 24 hours on an empty stomach.
  • Swallow the tablet whole, ensuring it is not crushed, chewed, or divided.
  • Avoid taking the dose with grapefruit or grapefruit juice.

Connection to the overall use protocol: The instructions define a controlled protocol intended to maintain consistent concentrations of the medication. The once-daily schedule and the requirement to maintain the tablet's physical form ensure the integrity of the specialized 24-hour release system, which is critical for the drug's intended action.

Recent Clinical Evidence

Recent Clinical Evidence

Clinical Trial Data

Adalat CC is an extended-release formulation of nifedipine, a calcium channel blocker used to manage hypertension (high blood pressure) and chronic stable angina (chest pain). Clinical evidence for this formulation is grounded in double-blind, randomized, placebo-controlled trials.

Studies involving hundreds of patients with essential hypertension evaluated Adalat CC at various once-daily doses (e.g., 30 mg, 60 mg, 90 mg) over several weeks. These investigations consistently reported dose-related changes in both systolic and diastolic blood pressure across the treatment periods. The reduction in blood pressure was observed when Adalat CC was administered as a single therapy (monotherapy) and when it was added to existing therapy, such as a beta-blocker.

Pharmacokinetics and Tolerability

The extended-release delivery system is designed to provide sustained plasma concentrations of nifedipine over 24 hours with minimal fluctuation, a feature intended to support once-daily dosing. The pharmacokinetic profile, including drug absorption and metabolism, has been evaluated in various populations, including elderly subjects.

In terms of tolerability, data from clinical trials indicate that the reported adverse events, such as headache and peripheral edema (swelling), were generally comparable to those noted with other long-acting calcium channel blockers.

Specialized Populations

While Adalat CC is indicated for hypertension and angina, research has also explored the use of extended-release nifedipine in specialized patient groups, such as those with chronic kidney disease (CKD) and uncontrolled hypertension, to assess the drug's effectiveness and tolerability in these complex patient settings.

Key Studies & References

  1. Nifedipine Extended-release Tablets (Procardia XL) U.S. Prescribing Information (used for general nifedipine extended-release clinical context)

Frequently Asked Questions (FAQ)

Common questions about Adalat CC (FAQ)


Q: Is the empty tablet shell sometimes appearing in stool a sign that the medicine did not work?

A: Official information indicates that Adalat CC is an extended-release tablet designed to release the medicine slowly. This uses a specialized shell or matrix that controls the release over 24 hours. The empty shell may pass into the stool; regulatory sources confirm that this is a normal occurrence and does not mean that the medicine failed to work or was not absorbed.


Q: What kind of common side effects are usually experienced with Adalat CC?

A: The most commonly reported side effects, as documented in official prescribing information, are related to the medicine's effect of widening blood vessels, which is called vasodilation. These often include a headache, a feeling of flushing (warmth or redness), dizziness, and peripheral swelling (oedema), usually in the feet or ankles.


Q: Is swelling in the ankles or feet a common side effect of Adalat CC?

A: Yes, peripheral swelling (oedema), particularly in the feet or ankles, is noted in clinical data as a very common side effect of nifedipine extended-release. This effect occurs because the medicine causes the blood vessels to relax and widen.


Q: Is it normal to experience dizziness or lightheadedness when first starting Adalat CC?

A: Dizziness and lightheadedness are common side effects of this medication. Official safety documents specifically state that these effects, including the potential for low blood pressure, are most likely to occur when treatment is first started or when the dose is increased.


Q: Can Adalat CC cause heart palpitations or a change in heart rate?

A: Official safety data lists palpitations (a fluttering or thumping sensation in the chest) as a common side effect, and an increased heart rate, known as tachycardia, as an uncommon adverse reaction associated with the use of nifedipine.


Q: Are there any common interactions between Adalat CC and herbal supplements like St. John's Wort?

A: Regulatory and official interaction guidelines caution against taking certain herbal supplements. St. John's Wort is officially noted as an enzyme inducer that can decrease the amount of nifedipine in the blood, which may reduce the medicine's overall effectiveness. Regulatory sources indicate that co-administration may require monitoring.


Q: What does 'calcium channel blocker' mean in simple terms for Adalat CC?

A: Adalat CC is classified as a calcium channel blocker. This means it works by inhibiting the movement of calcium ions into the muscle cells of your blood vessels. This action causes the blood vessels to relax and widen, which lowers blood pressure and reduces the workload on the heart.


Q: Can taking Adalat CC be associated with a risk of worsening congestive heart failure symptoms?

A: Caution is noted in official documents for patients with pre-existing heart conditions, such as poor cardiac reserve. Nifedipine has been documented to exert effects on the heart muscle, and its use is sometimes restricted in patients with severe heart failure.


Q: What is the difference between Adalat CC and other nifedipine extended-release tablets?

A: Adalat CC is a brand-name extended-release formulation of nifedipine. The 'CC' refers to a specific proprietary delivery system (a coat-and-core tablet) used by the manufacturer to control the release of the medicine over a 24-hour period. This specialized formulation dictates the administration and release profile.


Q: Is Adalat CC primarily for high blood pressure or for chest pain (angina)?

A: According to the official product indications, Adalat CC is equally approved and used for the long-term management of both hypertension (high blood pressure) and chronic stable angina (chest pain). Regulatory documents recognize both as primary indications.


Q: How long does it typically take for Adalat CC to start lowering blood pressure?

A: Official studies show that the amount of medicine in the blood usually reaches its peak concentration within 2.5 to 5 hours after taking the tablet on an empty stomach. This peak concentration generally aligns with when the initial blood pressure-lowering effect begins.


Q: Why does Adalat CC sometimes cause facial flushing or redness?

A: Flushing is a common side effect that is directly linked to the medicine's main mechanism. Adalat CC is a vasodilator, meaning it causes blood vessels to widen. This widening action near the skin's surface, especially in the face, causes the increase in blood flow that results in the feeling of warmth or redness.


Q: Can Adalat CC be used by people with a history of liver problems?

A: Adalat CC is metabolized (processed) by the liver. Official documents advise that patients with any level of hepatic (liver) impairment may require close monitoring. For those with severe liver problems, use requires significant caution and a possible dosage reduction.


Q: Is it safe to drink alcohol while taking Adalat CC?

A: Official patient information advises limiting alcoholic beverages. Alcohol may increase the blood pressure-lowering effect of Adalat CC, which could increase the risk of side effects like dizziness, lightheadedness, and fainting.


Q: Does Adalat CC have a risk of causing gum swelling or tenderness?

A: Yes, gingival hyperplasia, which is a condition involving the swelling or tenderness of the gums, is a rare but documented adverse event associated with the active ingredient, nifedipine.


Q: Can Adalat CC affect or worsen constipation?

A: Constipation is formally listed in regulatory documents as a common gastrointestinal side effect of Adalat CC.


Q: Is Adalat CC considered safe for long-term use?

A: Adalat CC is approved for the chronic (long-term) management of both high blood pressure and stable angina. Clinical studies and regulatory approval support its suitability for sustained use to help control these ongoing conditions.


Q: Does Adalat CC interact with antibiotics or antifungal medicines?

A: Yes. Regulatory documents note that certain antifungal agents (e.g., ketoconazole) and certain antibiotics (e.g., erythromycin) can interfere with the way the body processes nifedipine. This may significantly raise the concentration of the medicine in the blood and increase the risk of unwanted effects.


Q: Are there common differences in how Adalat CC affects younger versus older adult patients?

A: Official information advises caution for older adults due to the higher likelihood of age-related changes in organ function. Pharmacokinetic studies have also noted that the time it takes for the body to eliminate the medicine may be longer in elderly subjects.


Q: What are some very rare but serious side effects associated with Adalat CC?

A: Official warnings note a few rare but clinically important safety concerns. These include the potential for a temporary increase in the frequency or severity of chest pain (angina) or severe hypotension (very low blood pressure) when treatment is initiated or the dose is adjusted.


Q: Does Adalat CC cause mental or mood changes, such as depression or nervousness?

A: Yes, official safety documents and adverse event reports note that mental or mood changes, including feelings of nervousness and depression, have been reported as rare side effects associated with nifedipine.


Q: Is a decreased libido or sexual problem listed as a potential side effect of Adalat CC?

A: Official adverse event reports associated with nifedipine include mentions of sexual problems, such as decreased libido (sex drive) and erectile dysfunction.


Q: Can Adalat CC affect blood sugar levels for people with diabetes?

A: Yes, official safety documents note that hyperglycemia (high blood sugar) is a rare, reported side effect associated with nifedipine use. Caution and monitoring may be advised for patients who have diabetes.


Q: Does Adalat CC work instantly to stop an attack of chest pain (angina)?

A: No. Adalat CC is an extended-release product and is specifically indicated for the chronic, long-term management of stable angina. It is not approved or designed for the immediate treatment or relief of an acute or sudden attack of chest pain.


Q: What should a person do if they notice worsening chest pain after starting Adalat CC?

A: Official warnings note the potential for a temporary worsening of chest pain upon starting treatment or increasing the dose. Regulatory safety information states that an individual experiencing this symptom should obtain immediate medical assistance.


Q: How quickly should common side effects like headache or flushing go away after starting the medication?

A: Official information does not specify an exact timeline for when side effects will resolve. However, it is noted that common effects like headache, dizziness, and flushing are more likely to occur during the initial phase of treatment or immediately following a dose increase.


Q: Is Adalat CC used for conditions other than high blood pressure or angina, such as Raynaud's phenomenon?

A: Adalat CC is only officially approved (indicated) for high blood pressure and chronic stable angina. However, its active ingredient, nifedipine, is often recognized in medical literature for its blood vessel-widening properties, and may be discussed in clinical guidelines for conditions like Raynaud's phenomenon.


Q: Is it true that Adalat CC may contain lactose?

A: Yes, official drug listings that detail the components of the tablet confirm that lactose is included as one of the inactive ingredients used in the extended-release formulation of Adalat CC.


Q: Is there a maximum dose of Adalat CC that is usually prescribed?

A: Regulatory documents establish an official maximum recommended dosage for Adalat CC for adult patients.


Q: Are there any specific foods, other than grapefruit, that interact with Adalat CC?

A: Official interaction warnings are specifically focused on grapefruit and grapefruit juice, which must be completely avoided. While the medicine must be taken on an empty stomach, no other specific foods have an official contraindication documented.


Q: Is it necessary to avoid driving or operating machinery until I know how Adalat CC affects me?

A: Official patient safety information documents caution due to the potential for side effects like dizziness and lightheadedness, which may temporarily impair the ability to drive or operate hazardous machinery.

How should Adalat CC be stored and disposed of?

How to Store and Dispose of Adalat CC (Nifedipine Extended-Release Tablets)

Adalat CC must be stored at controlled room temperature, specifically between 20°C and 25°C (68°F and 77°F). It is mandatory to protect the medication from light and moisture and to keep it from freezing or exceeding the maximum recommended temperature.

Requirement Official Condition
Temperature 20°C to 25°C (Controlled Room Temperature)
Protection Keep tightly closed; protect from light and moisture
Safety Keep out of the reach of children

The medication must remain in its original, tightly closed container to maintain the stability of the extended-release formulation. Disposal of unused or expired Adalat CC requires following applicable local regulations or utilizing a drug take-back program. If a program is unavailable, government guidelines advise mixing the product with an undesirable substance before discarding it in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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