×
Components:
Folic Acid
Method of action:
Antianemic, Compensating Deficiency Of Folic Acid, Hematopoietic, Metabolic, Nutritive Agent
Available in countries
See all
close
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 2019.09.22

Name of the medicinal product

Acide Folique CCD

Qualitative and quantitative composition

Folic Acid

Therapeutic indications

The information provided in Therapeutic indications of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

1. Folate deficient megaloblastic anaemia

2. Folate deficient megaloblastic anaemia in infants

3. Treatment of folate deficiency in malabsorption syndromes (parenteral administration of Acide Folique CCD may need to be considered if oral treatment is not effective)

3.1 Tropical sprue. Tropical sprue responds to folate supplements in the early stages of the disease but cobalamin status must also be checked, particularly later.

3.2 Coeliac disease. The necessity of supplementation with folate ceases once a gluten free diet is introduced.

3.3 Non-tropical sprue. In congenital folate malabsorption, oral treatment may not be effective and parental folate may therefore be required.

4. Megaloblastic anaemia in pregnancy

5. Megaloblastic anaemia associated with alcoholism

6. Megaloblastic anaemia associated with anti-convulsant therapy

7. Acide Folique CCD deficiency/megaloblastic anaemia associated with haemolytic anaemia e.g. Sickle Cell Anaemia

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

For oral administration only.

Children (persons aged 12 years and younger):

May be given 5 mg to 15 mg daily, in divided doses, according to the severity of the deficiency state.

Adults:

Initial dose of 10 mg to 20 mg daily, in divided doses, for 14 days or until a haemopotoietic response has been obtained.

Maintenance dose is 2.5 mg to 10 mg daily.

Prophylactic dose in pregnancy 0.5 mg (1ml) daily.

Elderly:

As for adults.

Contraindications

The information provided in Contraindications of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

Known hypersensitivity to Acide Folique CCD.

Known hypersensitivity to hydroxybenzoate esters.

Patients with malignant disease, unless megaloblastic anaemia due to Acide Folique CCD deficiency.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

Acide Folique CCD should not be administered for treatment of pernicious anaemia or undiagnosed megaloblastic anaemia without sufficient amounts of cyanocobalamin (vitamin B12) as Acide Folique CCD alone will not prevent and may precipitate development of subacute combined degeneration of the spinal cord. Therefore a full clinical diagnosis should be made before initiating treatment.

Folate should not be routinely used in patients receiving coronary stents.

Caution should be exercised when administering Acide Folique CCD to patients who may have folate dependent tumours.

Acide Folique CCD is removed by haemodialysis.

Contains methyl- ethyl- and propyl- p-hydroxybenzoates; may cause allergic reactions (possibly delayed).

Contains 0.75 mmol (or 17.4mg) sodium per 20 ml dose, and is therefore essentially 'sodium-free'.

Contains phenylalanine. May be harmful for people with phenylketonuria.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

There are no known effects of this preparation on the ability to drive or use machines.

Undesirable effects

The information provided in Undesirable effects of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

Acide Folique CCD is generally well tolerated, although the following side effects have been reported:

Blood and lymphatic system disorders:

Acide Folique CCD may worsen the symptoms of co-existing vitamin B12 deficiency and should never be used to treat anaemia without a full investigation of the cause.

Immune system disorders:

Allergic reactions to Acide Folique CCD have been reported.

Gastrointestinal disorder:

Abdominal distension, flatulence, anorexia and nausea.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.

Overdose

The information provided in Overdose of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

No cases of acute overdosage appear to have been reported, but even extremely high doses are unlikely to cause harm to patients. No special procedures or antidote are likely to be needed.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

ATC Code: B03B B

After conversion into co-enzyme forms it is concerned in single carbon unit transfers in the synthesis of purines, pyrimidines and methionine.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

About 70 - 80 % of a 2 mg oral solution of Acide Folique CCD is absorbed. Larger doses are probably equally well absorbed. It is distributed into plasma and extracellular fluid. In plasma, folate is bound weakly to albumin (70 %). There is a further high affinity binder for folate but this has a very low capacity and is barely detectable in normal sera. About 70 % of small doses of folate (about 1 mg) are retained and the rest excreted into the urine. With larger doses most is excreted into the urine. With a 5 mg dose of folate, urinary excretion will be complete in about five hours. There is an enterohepatic circulation of folate. The retained folate is taken into cells and reduced by dihydrofolate to tetrahydrofolate. Acide Folique CCD is a relatively poor substrate for folate reduction, the normal substrate being dihydrofolate.

Acide Folique CCD itself does not occur in natural materials, it is entirely a pharmacological form of the compound. Once reduced, folate has additional glutamic acid residues added, a folate pentaglutamate being the dominant intracellular analogue. These polyglutamates are the active co-enzymes.

Preclinical safety data

The information provided in Preclinical safety data of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

Acide Folique CCD is a drug on which extensive clinical experience has been obtained. Relevant information for the prescriber is provided elsewhere in the Summary of Product Characteristics.

Incompatibilities

The information provided in Incompatibilities of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

None stated.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Acide Folique CCD is based on data of another medicine with exactly the same composition as the Acide Folique CCD of the medicine (Folic Acid). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Acide Folique CCD directly from the package or from the pharmacist at the pharmacy.
more... close

Not applicable.