Components:
Dopamine
Dopamine
Method of action:
Adrenomimetic, Cardiac Therapy, Cardiostimulating, Diuretic, Hypertensive, Vasodilator
Adrenomimetic, Cardiac Therapy, Cardiostimulating, Diuretic, Hypertensive, Vasodilator
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Name of the medicinal product

A Si Ke Ding

Qualitative and quantitative composition

Dopamine

Therapeutic indications

The information provided in Therapeutic indications of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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For the correction of haemodynamic imbalances in low-perfusion circulatory insufficiency associated with myocardial infarction, trauma, septicaemia, cardiac failure and open heart surgery.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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The solution must be diluted before administration. Alkaline solutions such as 5% sodium bicarbonate should NOT be added to A Si Ke Ding because the drug will be inactivated. The usual dilution is 1,600 micrograms per ml and this may be achieved by transfer, aseptically of 800mg of A Si Ke Ding to one of the following sterile I.V. solutions: -

Sodium Chloride Injection

5% Glucose Injection

5% Glucose and 0.9% Sodium Chloride Injection

5% Glucose and 0.45% Sodium Chloride Solution

5% Glucose in Ringer Lactate Solution

Sodium Lactate 1/6 Molar Injection

Lactated Ringer's Injection

A suitable metering device is required in the infusion system to control the rate of flow, and this should be adjusted to the optimum patient response and monitored constantly in the light of the individual patient's response.

Adults: Use as large a vein as possible for infusion. The initial rate of infusion is 2 to 5 micrograms per kilogram bodyweight per minute and this may be increased gradually by increments of 5 to 10 micrograms/kg/minute until the optimum dose for the individual is achieved. Up to 50 micrograms/kg/minute may be required, and even higher doses have been used.

Children: The safety and efficacy of A Si Ke Ding therapy in children have not been established.

Contraindications

The information provided in Contraindications of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Dopamine should not be used in patients with –

• Hypersensitivity to dopamine or any of the excipients.

• Phaeochromocytoma or hyperthyroidism

Dopamine should not be used in the presence of uncorrected atrial or ventricular tachyarrhythmias or ventricular fibrillation.

Cyclopropane and halogenated hydrocarbon anaesthetics should be avoided.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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The solution contains an antioxidant, sodium metabisulphite, a sulphite that may cause hypersensitivity reactions including bronchospasm, anaphylaxis and life-threatening episodes in certain susceptible individuals. The prevalence of sulphite-sensitivity in the general population is unknown and is probably low. Sulphite-sensitivity is seen more frequently in persons with a history of asthma or atopic allergy.

Each ampoule of this injection contains 2.42 mg sodium per ml.

Patients who have been treated with MAO inhibitors prior to dopamine should be given reduced doses; the starting dose should be one tenth (1/10th) of the usual dose.

Excess administration of potassium-free solutions may result in significant hypokalaemia.

The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary oedema.

Precautions:

Hypovolaemia should be corrected where necessary prior to dopamine infusion. Low doses should be used in shock due to acute myocardial infarction.

If a disproportionate rise in diastolic pressure (i.e. a marked decrease in pulse pressure) is observed, the infusion rate should be decreased and the patients observed carefully for further evidence of predominant vasoconstriction activity, unless such an effect is desired.

Patients with a history of peripheral vascular disease should be closely monitored for any changes in colour or temperature of the skin of the extremities. If change of skin colour or temperature occurs and is thought to be the result of compromised circulation to the extremities, the benefits of continued dopamine infusion should be weighed against the risk of possible necrosis. These changes may be reversed by decreasing the rate or discontinuing the infusion. IV administration of phentolamine mesylate 5-10 mg may reverse the ischaemia.

A Si Ke Ding in 5% glucose injection should be infused into a large vein whenever possible to prevent the possibility of infiltration of perivascular tissue adjacent to the infusion site. Extravasation of A Si Ke Ding during infusion may cause ischaemic necrosis and sloughing of surrounding tissue. Ischaemia can be reversed by infiltration of the affected area with 10-15 ml of saline containing 5 to 10 mg phentolamine mesylate. A syringe with a fine hypodermic needle should be used to liberally infiltrate the ischaemic area as soon as extravasation is noted.

Administration of A Si Ke Ding should always be under the direct supervision of a physician to whom facilities are available for monitoring cardiovascular and renal indices, including blood volume, cardiac output, blood pressure, electrocardiography and urine flow.

Glucose solutions should be used with caution in patients with known subclinical or overt diabetes mellitus.

When dopamine is used in patients with a history of occlusive vascular disease, particular attention should be paid to the status of blood circulation in the extremities.

The occurrence of undesirable increases in blood pressure or vasoconstriction or decrease in urinary output requires a reduction in dosage of A Si Ke Ding.

The routine use of low-dose A Si Ke Ding in critically ill patients to prevent or treat acute renal failure is not recommended because this may cause adverse effects which could further compromise such patients.

As the effect of dopamine on impaired renal and hepatic function is not known, close monitoring is advised.

Dopamine infusion should be withdrawn gradually, to avoid unnecessary hypotension.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Not applicable in view of the indications for use and the short half-life of the drug.

Undesirable effects

The information provided in Undesirable effects of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Adverse reactions to dopamine are related to its pharmacological action.

More common reactions include-

Cardiovascular: Ectopic heart beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction.

Gastrointestinal: Nausea, vomiting

Nervous System: Headache

Respiratory: Dyspnoea

Less common reactions include-

Biochemical Abnormalities- Azotaemia

Cardiovascular: Aberrant conduction, bradycardia, widened QRS complex, hypertension, gangrene, fatal ventricular arrhythmias have been reported on rare occasions.

Eye Disorders: Mydriasis

Nervous system- Piloerection

Serious or Life-threatening Reactions:

Gangrene of the feet has occurred following doses of 10-14 microgram/kg/min and higher in a few patients with pre-existing vascular disease.

Overdose

The information provided in Overdose of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Excessive elevation of blood pressure and vasoconstriction can occur due to the alpha adrenergic actions of dopamine, especially in patients with a history of occlusive vascular disease. If desired, this condition can be rapidly reversed by dose reduction or discontinuing the infusion, since dopamine has a half-life of less than 2 minutes in the body.

Should these measures fail, an infusion of an alpha adrenergic blocking agent, e.g., phentolamine mesylate, should be considered.

Dopamine at the infusion site can cause local vasoconstriction hence the desirability of infusing into a large vein. The resulting ischaemia can be reversed by infiltration of the affected area with 10-15 ml of saline containing 5 mg to 10 mg phentolamine mesylate. A syringe with a fine hypodermic needle should be used to liberally infiltrate the ischaemic area as soon as extravasation is noted.

Accidental Overdosage:

Accidental overdosage as evidenced by excessive blood pressure elevation can be controlled by dose reduction or discontinuing the dopamine infusion for a short period, since the duration of action of dopamine is short.

Should these measures fail, an infusion of phentolamine mesylate should be considered.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Dopamine (3,4-dihydroxyphenylethylamine) is the third naturally-occurring catecholamine and is a metabolic precursor of noradrenaline and adrenaline. Dopamine is used therapeutically as the hydrochloride and its main effects are seen in the cardiovascular system and the kidneys.

Heart

Dopamine exerts positive inotropic and chronotropic effects on the myocardium, acting as an agonist at beta-adrenergic receptors. In addition to its direct action on beta-adrenergic receptors, dopamine acts indirectly by releasing noradrenaline from sympathetic storage sites.

Blood Vessesls

Depending on the vascular bed being studied and the dose administered, Dopamine can cause relaxation or contraction of vascular smooth muscle.

Dopamine Receptors

Unlike other endogenous catecholamines or sympathomimetic amines, Dopamine caused vasodilatation in renal, coronary, mesenteric and intracerebral arterial vascular beds in anaesthetised dogs. This vasodilator effect is not antagonised by beta-adrenergic blockers, atropine or antihistamines. However, butyrophenones, phenothiazines, apomorphine and bulbocapnine selectively attenuate dopamine-induced vasodilatation, thus suggesting the existence of specific dopamine vascular receptors similar to those in the basal ganglia and other areas in the central nervous system.

Alpha-adrenergic Receptors

Dose response studies indicate that with a sufficiently large dose, the vasoconstrictor effect of dopamine predominates over its vasodilator effect. This dopamine-induced vasoconstrictor effect is antagonised by alpha-adrenoreceptor blocking agents such as phentolamine and phenoxybenzamine, indicating that vasoconstriction results from the action of dopamine on alpha-adrenergic receptors.

Kidney

Intravenous infusions of dopamine (2.6 to 7.1µg/kg/min.) to seven normal subjects increased estimated average renal plasma flow from 507 to 798ml/min., insulin clearance from 109 to 136ml/min. and average sodium excretion from 171 to 571µEq./min. Although the diuretic and natriuretic effects of dopamine may result from vasodilatation in renal vascular bed (vide supra), disassociation between natriuresis and increments in renal blood flow has been observed, suggesting that other mechanisms such as redistribution of intrarenal blood flow may be involved.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Dopamine is inactive when taken orally and its vasoconstrictor properties preclude its administration by subcutaneous or intramuscular injection. A Si Ke Ding is administered by intravenous infusion.

Dopamine is a metabolic precursor of nor-adrenaline and, whereas a proportion is excreted as the metabolic products of nor-adrenaline, the majority is mainly metabolised into 3,4,-Dihydroxyphenylacetic Acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic (HVA) which are rapidly excreted in the urine.

The plasma half-life of dopamine is approximately two minutes.

Preclinical safety data

The information provided in Preclinical safety data of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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No further relevant information other than that which is included in other sections of the Summary of Product Characteristics.

Incompatibilities

The information provided in Incompatibilities of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Iron salts, alkalis or oxidising agents.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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This solution must be diluted before use.

Do not dilute with alkaline solution.

Do not use the injection if it is darker than slightly yellow or discoloured in any other way.

For the preparation of A Si Ke Ding Intravenous Infusion.

Use as directed by the physician.

Keep out of reach of children.

Name of the medicinal product
A Si Ke Ding
Qualitative and quantitative composition
Dopamine
Therapeutic indications
The information provided in Therapeutic indications of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

For the correction of haemodynamic imbalances in low-perfusion circulatory insufficiency associated with myocardial infarction, trauma, septicaemia, cardiac failure and open heart surgery.

Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

The solution must be diluted before administration. Alkaline solutions such as 5% sodium bicarbonate should NOT be added to A Si Ke Ding because the drug will be inactivated. The usual dilution is 1,600 micrograms per ml and this may be achieved by transfer, aseptically of 800mg of A Si Ke Ding to one of the following sterile I.V. solutions: -

Sodium Chloride Injection

5% Glucose Injection

5% Glucose and 0.9% Sodium Chloride Injection

5% Glucose and 0.45% Sodium Chloride Solution

5% Glucose in Ringer Lactate Solution

Sodium Lactate 1/6 Molar Injection

Lactated Ringer's Injection

A suitable metering device is required in the infusion system to control the rate of flow, and this should be adjusted to the optimum patient response and monitored constantly in the light of the individual patient's response.

Adults: Use as large a vein as possible for infusion. The initial rate of infusion is 2 to 5 micrograms per kilogram bodyweight per minute and this may be increased gradually by increments of 5 to 10 micrograms/kg/minute until the optimum dose for the individual is achieved. Up to 50 micrograms/kg/minute may be required, and even higher doses have been used.

Children: The safety and efficacy of A Si Ke Ding therapy in children have not been established.

Contraindications
The information provided in Contraindications of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Dopamine should not be used in patients with –

• Hypersensitivity to dopamine or any of the excipients.

• Phaeochromocytoma or hyperthyroidism

Dopamine should not be used in the presence of uncorrected atrial or ventricular tachyarrhythmias or ventricular fibrillation.

Cyclopropane and halogenated hydrocarbon anaesthetics should be avoided.

Special warnings and precautions for use
The information provided in Special warnings and precautions for use of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

The solution contains an antioxidant, sodium metabisulphite, a sulphite that may cause hypersensitivity reactions including bronchospasm, anaphylaxis and life-threatening episodes in certain susceptible individuals. The prevalence of sulphite-sensitivity in the general population is unknown and is probably low. Sulphite-sensitivity is seen more frequently in persons with a history of asthma or atopic allergy.

Each ampoule of this injection contains 2.42 mg sodium per ml.

Patients who have been treated with MAO inhibitors prior to dopamine should be given reduced doses; the starting dose should be one tenth (1/10th) of the usual dose.

Excess administration of potassium-free solutions may result in significant hypokalaemia.

The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary oedema.

Precautions:

Hypovolaemia should be corrected where necessary prior to dopamine infusion. Low doses should be used in shock due to acute myocardial infarction.

If a disproportionate rise in diastolic pressure (i.e. a marked decrease in pulse pressure) is observed, the infusion rate should be decreased and the patients observed carefully for further evidence of predominant vasoconstriction activity, unless such an effect is desired.

Patients with a history of peripheral vascular disease should be closely monitored for any changes in colour or temperature of the skin of the extremities. If change of skin colour or temperature occurs and is thought to be the result of compromised circulation to the extremities, the benefits of continued dopamine infusion should be weighed against the risk of possible necrosis. These changes may be reversed by decreasing the rate or discontinuing the infusion. IV administration of phentolamine mesylate 5-10 mg may reverse the ischaemia.

A Si Ke Ding in 5% glucose injection should be infused into a large vein whenever possible to prevent the possibility of infiltration of perivascular tissue adjacent to the infusion site. Extravasation of A Si Ke Ding during infusion may cause ischaemic necrosis and sloughing of surrounding tissue. Ischaemia can be reversed by infiltration of the affected area with 10-15 ml of saline containing 5 to 10 mg phentolamine mesylate. A syringe with a fine hypodermic needle should be used to liberally infiltrate the ischaemic area as soon as extravasation is noted.

Administration of A Si Ke Ding should always be under the direct supervision of a physician to whom facilities are available for monitoring cardiovascular and renal indices, including blood volume, cardiac output, blood pressure, electrocardiography and urine flow.

Glucose solutions should be used with caution in patients with known subclinical or overt diabetes mellitus.

When dopamine is used in patients with a history of occlusive vascular disease, particular attention should be paid to the status of blood circulation in the extremities.

The occurrence of undesirable increases in blood pressure or vasoconstriction or decrease in urinary output requires a reduction in dosage of A Si Ke Ding.

The routine use of low-dose A Si Ke Ding in critically ill patients to prevent or treat acute renal failure is not recommended because this may cause adverse effects which could further compromise such patients.

As the effect of dopamine on impaired renal and hepatic function is not known, close monitoring is advised.

Dopamine infusion should be withdrawn gradually, to avoid unnecessary hypotension.

Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
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Not applicable in view of the indications for use and the short half-life of the drug.

Undesirable effects
The information provided in Undesirable effects of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Adverse reactions to dopamine are related to its pharmacological action.

More common reactions include-

Cardiovascular: Ectopic heart beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction.

Gastrointestinal: Nausea, vomiting

Nervous System: Headache

Respiratory: Dyspnoea

Less common reactions include-

Biochemical Abnormalities- Azotaemia

Cardiovascular: Aberrant conduction, bradycardia, widened QRS complex, hypertension, gangrene, fatal ventricular arrhythmias have been reported on rare occasions.

Eye Disorders: Mydriasis

Nervous system- Piloerection

Serious or Life-threatening Reactions:

Gangrene of the feet has occurred following doses of 10-14 microgram/kg/min and higher in a few patients with pre-existing vascular disease.

Overdose
The information provided in Overdose of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Excessive elevation of blood pressure and vasoconstriction can occur due to the alpha adrenergic actions of dopamine, especially in patients with a history of occlusive vascular disease. If desired, this condition can be rapidly reversed by dose reduction or discontinuing the infusion, since dopamine has a half-life of less than 2 minutes in the body.

Should these measures fail, an infusion of an alpha adrenergic blocking agent, e.g., phentolamine mesylate, should be considered.

Dopamine at the infusion site can cause local vasoconstriction hence the desirability of infusing into a large vein. The resulting ischaemia can be reversed by infiltration of the affected area with 10-15 ml of saline containing 5 mg to 10 mg phentolamine mesylate. A syringe with a fine hypodermic needle should be used to liberally infiltrate the ischaemic area as soon as extravasation is noted.

Accidental Overdosage:

Accidental overdosage as evidenced by excessive blood pressure elevation can be controlled by dose reduction or discontinuing the dopamine infusion for a short period, since the duration of action of dopamine is short.

Should these measures fail, an infusion of phentolamine mesylate should be considered.

Pharmacodynamic properties
The information provided in Pharmacodynamic properties of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Dopamine (3,4-dihydroxyphenylethylamine) is the third naturally-occurring catecholamine and is a metabolic precursor of noradrenaline and adrenaline. Dopamine is used therapeutically as the hydrochloride and its main effects are seen in the cardiovascular system and the kidneys.

Heart

Dopamine exerts positive inotropic and chronotropic effects on the myocardium, acting as an agonist at beta-adrenergic receptors. In addition to its direct action on beta-adrenergic receptors, dopamine acts indirectly by releasing noradrenaline from sympathetic storage sites.

Blood Vessesls

Depending on the vascular bed being studied and the dose administered, Dopamine can cause relaxation or contraction of vascular smooth muscle.

Dopamine Receptors

Unlike other endogenous catecholamines or sympathomimetic amines, Dopamine caused vasodilatation in renal, coronary, mesenteric and intracerebral arterial vascular beds in anaesthetised dogs. This vasodilator effect is not antagonised by beta-adrenergic blockers, atropine or antihistamines. However, butyrophenones, phenothiazines, apomorphine and bulbocapnine selectively attenuate dopamine-induced vasodilatation, thus suggesting the existence of specific dopamine vascular receptors similar to those in the basal ganglia and other areas in the central nervous system.

Alpha-adrenergic Receptors

Dose response studies indicate that with a sufficiently large dose, the vasoconstrictor effect of dopamine predominates over its vasodilator effect. This dopamine-induced vasoconstrictor effect is antagonised by alpha-adrenoreceptor blocking agents such as phentolamine and phenoxybenzamine, indicating that vasoconstriction results from the action of dopamine on alpha-adrenergic receptors.

Kidney

Intravenous infusions of dopamine (2.6 to 7.1µg/kg/min.) to seven normal subjects increased estimated average renal plasma flow from 507 to 798ml/min., insulin clearance from 109 to 136ml/min. and average sodium excretion from 171 to 571µEq./min. Although the diuretic and natriuretic effects of dopamine may result from vasodilatation in renal vascular bed (vide supra), disassociation between natriuresis and increments in renal blood flow has been observed, suggesting that other mechanisms such as redistribution of intrarenal blood flow may be involved.

Pharmacokinetic properties
The information provided in Pharmacokinetic properties of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Dopamine is inactive when taken orally and its vasoconstrictor properties preclude its administration by subcutaneous or intramuscular injection. A Si Ke Ding is administered by intravenous infusion.

Dopamine is a metabolic precursor of nor-adrenaline and, whereas a proportion is excreted as the metabolic products of nor-adrenaline, the majority is mainly metabolised into 3,4,-Dihydroxyphenylacetic Acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic (HVA) which are rapidly excreted in the urine.

The plasma half-life of dopamine is approximately two minutes.

Preclinical safety data
The information provided in Preclinical safety data of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

No further relevant information other than that which is included in other sections of the Summary of Product Characteristics.

Incompatibilities
The information provided in Incompatibilities of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

Iron salts, alkalis or oxidising agents.

Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of A Si Ke Ding is based on data of another medicine with exactly the same composition as the A Si Ke Ding of the medicine (Dopamine). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug A Si Ke Ding directly from the package or from the pharmacist at the pharmacy.
more... close

This solution must be diluted before use.

Do not dilute with alkaline solution.

Do not use the injection if it is darker than slightly yellow or discoloured in any other way.

For the preparation of A Si Ke Ding Intravenous Infusion.

Use as directed by the physician.

Keep out of reach of children.

Available in countries
See all
close