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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 10.04.2022
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31.12.1899 8:01:00
Piperacillin, Tazobactam
Infections (moderate and severe) of the lower respiratory tract, abdominal, skin and soft tissues (including cellulite, abscess, infected trophic ulcers), pelvic organs (including endometritis), bacterial infection in patients with neutropenia, septicemia, severe infectious and inflammatory diseases before identification of the pathogen.
In/in (2.25 g is dissolved in 5 ml of saline solution or 5% dextrose solution, or sterile water for injection), slowly, for 30 minutes. Adults and children over 12 years of age — 2.25 g every 6 hours or 4.5 g every 8 hours (the average daily dose is 12 g of piperacillin and 1.5 g of tazobactam), patients on hemodialysis-2.25 g every 8 hours. The course is 7-10 days.
Hypersensitivity (including to other penicillins, cephalosporins and carbopenems).
Nausea, vomiting, diarrhea, allergic reactions (skin rash, itching, urticaria, erythema), rarely-a transient increase in the blood of hepatic transaminases, alkaline phosphatase.
Active against (including beta-lactamase-producing) gram-negative aerobic bacteria (E. coli, Citrobacter, Klebsiella, Enterobacter, Proteus, Pseudomonas aeruginosa and other Pseudomonas, N. gonorrhoeae, Haemophilus inf.), gram-positive streptococci (S. pneumoniae, S. pyogenes, S. bovis, S. groups C and G), enterococci (E. faecalis, E. faecium), staphylococci (St. aureus, St. epidermidis), anaerobic microorganisms (Bacteroides, B. fragilis, B. ovatus, Fusobacteria).
- Penicillins in combinations
