Teotard

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Teotard

Quick Facts

Property Description
Active ingredient Choline Theophyllinate (Oxtriphylline)
Form Sustained-release capsules (Modified-release preparation)
Pharmacological class Bronchodilator, Xanthine derivative
Common use Relief of symptoms associated with chronic obstructive airway diseases
Origin Synthetic compound (Salt of Theophylline and Choline)

Teotard: Definition and Pharmaceutical Classification

Teotard is a prescription-only medicine whose active ingredient is Choline Theophyllinate, a synthetic compound chemically classified as a xanthine derivative. Functionally, this medication is placed within the pharmacological class of anti-asthmatic agents and is specifically a bronchodilator. The active substance, also known as Oxtriphylline, is a derivative salt of the core compound theophylline combined with choline. This structure is clinically recognized to maintain the necessary systemic action for chronic respiratory management.

Composition and Sustained-Release Formulation

The main dosage form for Teotard is the sustained-release capsule, categorized as a modified-release preparation intended for oral administration. The design of this specialized sustained-release formulation is engineered to ensure the gradual and consistent release of Choline Theophyllinate over an extended duration. This sustained profile is crucial for maximizing the prophylactic use of the medication in long-term therapy, as opposed to formulations that release the active ingredient rapidly.

General Purpose: What Does Teotard Help Achieve?

The primary therapeutic purpose of Teotard is to achieve bronchodilation through its action as a bronchial smooth muscle relaxant. By reducing the tension in the smooth muscles that surround the airways, the medicine allows the air passages to widen. This physiological action offers essential systemic action to maintain open airways, providing support by helping to alleviate the obstruction that causes breathing difficulty in chronic respiratory conditions.

What side effects are possible with Teotard?

Possible Side Effects and Safety Information

Teotard (Theophylline) has a narrow therapeutic index, meaning the effective dose is close to the dose that causes serious side effects. The risk of adverse reactions is strongly dose-dependent, increasing significantly when the concentration in the bloodstream exceeds 20 mu g/mL.


Common and Expected Adverse Reactions

Side effects frequently documented in regulatory information often involve the central nervous system and gastrointestinal tract. These include:

  • Central Nervous System: Headache, insomnia, restlessness, tremors, and irritability.
  • Gastrointestinal Tract: Nausea, vomiting, and epigastric pain.
  • Other: Palpitations and increased urination (diuresis).

Serious Adverse Reactions

The regulatory labeling highlights the potential for severe, life-threatening events, which may occur without being preceded by milder symptoms:

  • Cardiovascular: Life-threatening ventricular arrhythmias.
  • Neurological: Seizures (generalized convulsions), which can lead to permanent neurological damage or death.
  • Systemic: Circulatory failure or peripheral vascular collapse.

Population-Specific Safety Considerations

The drug's clearance can be altered in certain groups, increasing the risk of toxicity:

  • Hepatic Impairment: Patients with liver disease (e.g., cirrhosis) have decreased clearance, necessitating close monitoring and dose reduction.
  • Older Adults: Increased sensitivity and decreased clearance may necessitate careful dosing.
  • Pediatric Use: Specific caution is advised in children under 1 year of age due to higher risk of serious effects.

Safety Monitoring and Restrictions

Due to the narrow safety margin, official regulatory texts emphasize the necessity of monitoring serum theophylline concentrations. This practice is critical because serious adverse effects are directly linked to high serum levels and may occur suddenly.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory profile for Teotard overdose is defined by the systemic toxicity of its active component, Theophylline, a xanthine derivative. Seek immediate medical attention for the onset of any signs consistent with toxicity, such as persistent or repetitive vomiting, severe headache, agitation, or tremor. The dose must be immediately withheld if symptoms develop.

Initial manifestations of overdose commonly involve the gastrointestinal system, presenting as nausea, vomiting, or diarrhea. Neurological effects often include tremor, restlessness, and agitation. However, toxicity can rapidly escalate to life-threatening complications requiring immediate hospitalization.

Severe or life-threatening outcomes documented in regulatory sources include seizures (convulsions), severe ventricular arrhythmias, and significant metabolic disturbances, notably profound hypokalemia and metabolic acidosis.

No specific antidote is known for this overdose. Management focuses on supportive treatment and decontamination. Officially described procedures include administering activated charcoal to reduce absorption and using hemodialysis or hemoperfusion for severe, life-threatening cases where serum concentrations are extremely high.

Population-specific notes state that elderly patients and individuals with conditions that impair drug clearance (e.g., liver disease, heart failure) are documented to be at increased risk of severe toxicity, including cardiac dysrhythmias and seizures, at concentrations lower than those typically seen in acute overdose.

Therapeutic Uses of Teotard

What Teotard Treats: Main Uses and Benefits

Teotard, a form of extended-release Theophylline, is used in situations involving certain distressing symptoms associated with chronic lung conditions. Its therapeutic use is relevant for conditions such as chronic asthma, emphysema, and chronic bronchitis.


Managing Acute and Fluctuating Symptoms

This medicine is commonly used to help address symptom clusters related to physical discomfort that may become intense or disruptive, in situations where symptoms may intensify temporarily. It is applied across conditions presenting with acute episodes and provides support that helps ease the overall symptom burden. When symptoms create noticeable interference with daily functioning, this medication assists with maintaining functional stability when supportive symptom management is appropriate.


Supporting Comfort During Symptomatic Periods

Teotard is applied across domains where additional symptomatic support is needed. It contributes to improved comfort during periods of heightened symptoms, and supports general well-being during symptomatic phases.

Quick Fact: Relief for Respiratory Discomfort
This medication may assist with symptoms related to systemic imbalance, often used when symptoms create noticeable physiological strain.

Regulatory References

  1. Official FDA Drug Label for Theophylline Extended-Release Tablets

Eligibility and Restrictions for Use

Teotard, which contains the active ingredient theophylline, is a bronchodilator used to treat chronic obstructive lung diseases. Its use is determined by a patient's underlying health conditions and age.

Teotard must be avoided by patients with a known hypersensitivity or allergy to theophylline or other xanthine derivatives like caffeine and theobromine. It is also generally contraindicated in patients with a recent or active stomach ulcer or a pre-existing seizure disorder (epilepsy).


Special Populations

Population Consideration for Use
Children Caution is advised in children, particularly infants under 1 year, who metabolize theophylline more slowly. Dosing requires careful adjustment and frequent blood monitoring.
Elderly Older adults may experience increased sensitivity to effects due to slower clearance, necessitating a lower maximum daily dose.
Pregnancy/Breastfeeding Use during pregnancy is category C, meaning potential benefits may warrant use despite risks. Theophylline is excreted into breast milk and may cause infant irritability or mild toxicities, especially in newborns. Use should be considered acceptable but requires monitoring.
Underlying Conditions Use with extreme caution in patients with severe heart conditions (e.g., arrhythmia, cor pulmonale), liver disease, acute fever, hypothyroidism, or uncontrolled hypertension, as these conditions can alter the drug's metabolism and increase the risk of toxicity.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Teotard, whose active ingredient is Choline Theophyllinate, has an interaction profile determined by the core compound, theophylline. The official interaction structure is based on pharmacokinetic (PK) clearance modification and pharmacodynamic (PD) effects, as documented in regulatory sources.


Official Interaction Profile

Co-administration with Riociguat and Febuxostat is formally classified as contraindicated by regulatory authorities. Certain medicines are documented to alter theophylline concentration significantly.

Interaction Type Interacting Substances/Examples
Increased Plasma Levels (Reduced Clearance) Quinolone antibiotics (e.g., Ciprofloxacin), Cimetidine, Macrolide antibiotics (e.g., Erythromycin), and Allopurinol.
Decreased Plasma Levels (Increased Clearance) Antiepileptics (e.g., Phenytoin, Carbamazepine), and Rifampicin.

Administration Constraints and Co-occurring Conditions

Pharmacodynamic interactions are documented with medicines such as Beta-blockers, which can antagonize the bronchodilator effect. Co-administration with Beta2-agonists or Diuretics is noted to increase the risk of hypokalaemia.

Specific administration rules state that Dipyridamole must be separated by 24 hours prior to certain testing. Non-medicinal substances, including tobacco smoking and the herbal product St. John's Wort, are documented to increase theophylline clearance. Furthermore, conditions such as hepatic impairment (liver disease) or fever (ge 102 F for ge 24 hours) are officially recognized to decrease theophylline clearance, thereby increasing the risk of accumulation from all interactions.

Mechanism of Action

The mechanism of action for Teotard is driven by the active moiety Theophylline, which acts through a complex, non-selective engagement of molecular targets, resulting in the modulation of muscle tone and cellular inflammatory pathways.

The primary mechanism involves the non-selective competitive inhibition of Phosphodiesterase (PDE) enzymes, particularly PDE3, within the bronchial smooth muscle cells. This inhibition prevents the degradation of the cellular messenger cyclic AMP (cAMP), causing its internal concentration to rise. The resulting cAMP elevation leads to a reduction in intracellular calcium, triggering the relaxation of bronchial smooth muscle (bronchodilation) and enhancing the contractility of the diaphragm, resulting in decreased airway smooth muscle tension.


The molecule also modulates inflammatory responses through engagement with nuclear enzymes. It enhances the activity of the nuclear enzyme Histone Deacetylase 2 (HDAC2) and blocks the activity of Adenosine receptors. HDAC2 enhancement suppresses the gene transcription necessary for producing inflammatory proteins, while the Adenosine antagonism interferes with signaling that triggers mediator release (like histamine) from immune cells. These actions result in the modulation of biological factors contributing to airway hyper-responsiveness and associated inflammatory processes.

Dosage and Administration Information

How Teotard is Used: Administration Guidelines

Administration Procedure and Route

Teotard, in its sustained-release form, is strictly approved for oral administration only. The capsule or tablet must be swallowed whole and should not be crushed, broken, or chewed under any circumstances. This procedural requirement is mandatory to preserve the integrity of the modified-release formulation and ensure the gradual, consistent release of the active ingredient over time, supporting the medicine's long-term maintenance pattern of use.

Dosing and Schedule

The medicine is used as part of a long-term plan for chronic management. Dosing is individualized and requires careful titration based on measured drug levels in the blood. The typical initial adult daily dose is between 300 mg and 400 mg, and the dose is adjusted slowly to achieve a goal serum concentration range, generally between 10 to 15 mcg/mL. The total daily dose usually should not exceed 600 mg.

The standard dosing frequency is twice daily (every 12 hours), though clinical protocols may permit a once-daily schedule for certain patients. Dosage adjustments must be spaced by an interval of no less than three days to allow the drug concentration to reach a steady state before further modifications are made.

Contextual and Population Instructions

Teotard may be taken with or without food; however, specific instructions require that administration remains consistent with respect to meals, as consuming the dose immediately after a high-fat meal may increase the drug's absorption rate. Dose reduction and close monitoring are explicitly required for older adults (over 60 years) and individuals with hepatic impairment due to reduced clearance. No specific dose adjustment is generally necessary for adult patients with renal impairment.

Recent Clinical Evidence

Research evidence / Overview of studies

Overview of Key Studies

Studies investigated the compound's effect on certain biological markers, such as the activity of phosphodiesterase (PDE) enzymes and histone deacetylases (HDACs). The research aimed to connect the findings on biological markers to potential use in certain chronic conditions, particularly those characterized by reduced HDAC activity.

Studies on Combination Approach

Clinical studies compared the compound, when used alongside a standard therapeutic agent (such as an inhaled corticosteroid or beta-agonist), to other treatments. Studies evaluated changes in established clinical endpoints over time for the combination approach.

Clinical studies have included participants with chronic pain, inflammatory markers, and Chronic Obstructive Pulmonary Disease (COPD). Safety studies examined the compound's profile in participants, including those with pre-existing heart conditions.

Findings from Investigations

Research investigated the compound’s activity within specific participant groups, often focusing on lung function and respiratory symptoms.

Head-to-Head Comparison

The study design included a comparison group receiving monotherapy (treatment with a single agent). This research focused on measuring differences in established outcome parameters, such as forced expiratory volume in one second (FEV1), arterial blood gas tensions, mobility scores, and patient-reported quality of life.

The studies evaluated measurements of pain and inflammation using standardized clinical tools. Overall, research findings provide descriptive data on the compound in controlled settings, indicating a modest effect on lung function and blood gas parameters in moderate-to-severe COPD.

Key Studies & References

  1. Theophylline - StatPearls - NCBI Bookshelf (NIH)
  2. THEOPHYLLINE Extended Release Capsules, USP - DailyMed (FDA Labeling)

Frequently Asked Questions (FAQ)

Common questions about Teotard (FAQ)


Q: Is Teotard considered a rescue inhaler or a long-term control medicine?

Teotard is classified in official labeling as a long-term control or maintenance medicine. It is intended for the chronic management of symptoms to help prevent them over time. It is not designed to provide quick relief for an acute breathing attack.


Q: Is Teotard a steroid drug?

No, Teotard is not classified as a steroid drug. Official product information describes it as a bronchodilator and a xanthine derivative, which is a different pharmacological class of medication that works by relaxing the airway muscles.


Q: Why do doctors prescribe Teotard when there are newer medicines for asthma and COPD?

Official guidance documents describe Teotard's role in cases where other inhaled treatments may not be possible or effective, or in research studies that examined its use alongside other standard therapeutic agents for chronic respiratory conditions.


Q: Are side effects like nausea or headache normal when starting Teotard?

Nausea and headache are documented in regulatory labeling as common adverse reactions associated with this medicine. Regulatory information documents that these effects are common, but does not provide guarantees regarding their duration or resolution.


Q: Is it common to experience trouble sleeping (insomnia) while taking Teotard?

Yes, official product information lists insomnia (trouble sleeping) as a common adverse reaction related to the central nervous system. This effect is documented in regulatory labeling.


Q: What are the signs of having too much Teotard in the body (toxicity)?

Symptoms of toxicity documented in regulatory labeling can range from persistent vomiting, rapid heart rate, confusion, and tremors. In severe cases, high concentrations may lead to serious neurological events like seizures or life-threatening ventricular arrhythmias (irregular heart rhythms).


Q: Why are regular blood tests necessary while taking Teotard?

Regular blood tests are necessary because the drug has a narrow therapeutic index. This means the dose that is effective for most people is close to the level where serious adverse effects can occur, making the periodic monitoring of serum concentrations a critical factor.


Q: What is the target therapeutic range for Teotard blood levels?

Official documents describe the serum concentration range for maximum therapeutic benefit while minimizing risk as generally between 10 to 15 mcg/mL. This range is a reference point used for the therapeutic monitoring of theophylline concentration.


Q: How long does it typically take for Teotard to start working after beginning treatment?

Teotard is a long-term management medication, not an immediate reliever. Official administration instructions emphasize that dosing changes must be spaced by an interval of no less than three days. This period allows the drug concentration to reach a steady state in the body, which is the consistent level required for chronic, long-term effect.


Q: Is Teotard a maintenance medication or an on-demand treatment?

Official product information confirms that Teotard is used as a maintenance or prophylactic treatment. It is part of a long-term plan for managing chronic respiratory symptoms, rather than being used for acute, on-demand relief.


Q: What should I do if my symptoms get worse while taking Teotard?

Official labeling highlights the potential for serious adverse effects, such as seizures or life-threatening arrhythmias, which may occur without warning. The regulatory warnings emphasize this risk, suggesting the need for prompt medical attention if such severe symptoms are experienced.


Q: Is it necessary to continue taking Teotard even if my breathing feels better?

The medication is intended for long-term maintenance and prophylactic use to consistently help maintain open airways. It is used as part of a long-term chronic management plan as described in the official product information.


Q: Can a high-fat meal change how the body absorbs Teotard?

Yes, official administration instructions specifically note that consuming a dose immediately following a high-fat meal may change how the body absorbs the drug. This effect may increase the drug's absorption rate.


Q: What are some of the less common side effects of Teotard, such as skin rash or itching?

Less common side effects reported in regulatory documents may include abdominal pain, diarrhea, and other reactions such as a rash or itching. This information is based on the official safety profile.


Q: Do pregnant women have different considerations when taking Teotard?

Yes, the use of Teotard during pregnancy is designated as Category C. While potential benefits may warrant its use despite risks, careful monitoring of the drug's blood levels is needed due to potential changes in drug clearance during pregnancy.


Q: How is Teotard different from other common asthma/COPD medications?

Teotard's active ingredient is classified as a xanthine derivative bronchodilator. This pharmacological class has different molecular actions than other common respiratory medications like inhaled steroids, which target inflammation, or inhaled beta-agonists, which act through different receptor pathways.


Q: Does Teotard help with wheezing and shortness of breath?

Yes, official information states that Teotard is used to help control symptoms of chronic obstructive lung diseases, which can include wheezing and shortness of breath. It achieves this by acting as a bronchodilator to help open air passages in the lungs.


Q: How does the extended-release formula of Teotard work?

The extended-release capsule or tablet is engineered with a specialized design to ensure the gradual and consistent release of the active ingredient over an extended duration. This sustained profile is maintained by swallowing the capsule or tablet whole, which ensures the consistent, gradual release needed for long-term control.


Q: Does Teotard cause anxiety or tremors/shaking?

Yes, regulatory labeling lists both tremors and restlessness as common side effects affecting the central nervous system. Feelings of anxiety are also reported as a possible nervous system effect.


Q: Are there any specific dietary or food restrictions with Teotard?

Regulatory information notes that significant changes in diet can alter the body's clearance of theophylline. Specifically, both high carbohydrate/low protein diets and low carbohydrate/high protein diets are documented to affect how the body processes the medication.


Q: Is Teotard safe for use in children?

Dosage information is described for children 1 year of age and older, often based on body weight. Official labeling advises specific caution for infants under 1 year due to a higher documented risk of serious adverse effects.


Q: What happens if I miss a dose of Teotard?

Regulatory information advises that if a dose is missed, the dose should be skipped entirely, with the next dose taken at the normal scheduled time. This principle is consistent with maintaining stable drug concentrations.


Q: If I switch Teotard brands, do I need to notify my doctor?

Due to the narrow therapeutic index, consistent dosing is important. Regulatory documents note that any change in specific brand or generic may be a circumstance that calls for a review of drug blood levels, due to documented differences in how various sustained-release formulations behave.


Q: Does alcohol consumption affect the safety or effectiveness of Teotard?

Official regulatory information states that using alcohol with this medicine may cause interactions to occur or result in a sudden change in theophylline levels in the body, which can increase the risk of adverse effects.


Q: Can Teotard affect the results of certain medical tests?

Yes, regulatory and official information notes that high levels of theophylline in the blood can be associated with altered results in other medical tests. These changes can include elevated blood sugar levels or decreased potassium levels.


Q: Why might Teotard dosage need to be changed if a patient recently stopped smoking?

Smoking tobacco increases the body's clearance (or removal) of the drug. Regulatory guidance states that when a patient stops smoking, the dosage is often monitored and may be adjusted to avoid a sudden increase in drug levels and the corresponding risk of toxicity.


Q: Can Teotard cause stomach irritation or upset stomach?

Yes, official information documents that Teotard may potentially act as a local gastrointestinal irritant. Common side effects reported include stomach pain or cramping, nausea, and vomiting.


Q: Is it true that a high-protein, low-carbohydrate diet can affect Teotard levels?

Yes, regulatory documentation states that a low carbohydrate/high protein diet is documented to affect the body's clearance of theophylline. This change can potentially be associated with lower drug levels, which is a factor considered during therapeutic drug monitoring.


Q: Does Teotard have a diuretic effect (increasing urination)?

Yes, increased urination (diuresis) is documented in regulatory labeling as a common adverse reaction associated with the use of this medication.

How should Teotard be stored and disposed of?

How to Store and Dispose of Teotard

The following instructions reflect the official storage and disposal requirements for Teotard (Theophylline extended-release).

Storage Conditions

Teotard must be stored at Controlled Room Temperature, which is defined as 20 C to 25 C (68 F to 77 F). The medication must be kept in its tightly closed, original container and stored in a cool, dry place, protected from light and moisture. As a mandatory requirement, Teotard must be stored out of the sight and reach of children and pets.

Disposal Instructions

Unused or expired Teotard should be disposed of through an authorized drug take-back program. If a take-back location is unavailable, the medicine should be mixed with an undesirable substance, placed in a sealed bag, and discarded in the household trash. The product should not be flushed down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Teotard found in:

A-Z Index: