Tarac

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Tarac

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Tarac

Quick Facts

Property Description
Active ingredient Tazarotene (a prodrug)
Form Topical preparation (gel or cream)
Pharmacological class Retinoid
General purpose Normalizes skin cell growth and reduces inflammation
Origin Synthetic

What Type of Medicine is Tarac (Tazarotene)?

Tarac is a synthetic, single-ingredient, prescription-only medicinal product containing the active compound Tazarotene. It is formally classified as a topical retinoid within the broader retinoid pharmacological class, chemically derived from Vitamin A. Tazarotene is recognized as a third-generation acetylenic retinoid. This classification highlights its unique chemical structure compared to older analogues.

Tazarotene functions specifically as an acetylenic retinoid prodrug, meaning the molecule is initially inactive and must be converted by the body into its active therapeutic form, tazarotenic acid, once absorbed by the skin. This distinction supports its reputation as a potent, molecularly targeted treatment.


Composition and Available Forms of Tarac

The drug is supplied as a topical preparation intended solely for topical administration to the skin surface. The primary active component is Tazarotene, which is incorporated into an aqueous or emollient base to create the final dosage forms, typically supplied as a gel or a cream. Tazarotene possesses a high selective affinity for specific Retinoic Acid Receptors (RARs), a feature that differentiates it from less selective retinoids. The formulation as a cream or a gel is designed to suit different skin types and affected areas, ensuring the localized delivery of the active agent.


General Purpose and Action of Tarac

The overall purpose of Tarac is to resolve primary abnormal processes in the skin that are characterized by excessive cell proliferation. The active tazarotenic acid metabolite initiates its action by binding selectively to RARs within skin cells, acting as a molecular regulator. This action helps to achieve the key therapeutic goal of normalization of keratinocyte differentiation and a controlled reduction of cell hyperproliferation. By correcting these fundamental cellular irregularities at a molecular level, the treatment provides the general benefit of facilitating the clearing of lesions and an improvement of skin texture associated with the underlying condition.

What side effects are possible with Tarac?

Possible Side Effects and Safety Information

The officially documented safety profile of Tarac (Tazarotene) is primarily defined by local application site reactions and specific population safety constraints, as classified in regulatory documents.


Application Site and Frequency Classification

The majority of documented adverse events involve the area where the medicine is applied. These effects are classified by frequency in regulatory labeling:

  • Very Common (Occurring in ge 10%): Pruritus (itching), Erythema (redness), Burning Sensation, Desquamation (peeling), Dry Skin, Skin Irritation.
  • Common (1% to <10%): Stinging, Skin Pain, Dermatitis, Fissuring.

Local adverse reactions, such as irritation and burning, are explicitly documented to be most frequent during the initial mathbf2 to mathbf4 weeks of therapy, which is a recognized pattern for this pharmacological class.


Serious Safety Constraints

The drug carries a critical, non-local safety constraint related to its classification as a retinoid.

Constraint Regulatory Classification Summary
Embryo-Fetal Toxicity The medicine is contraindicated in pregnancy due to the recognized risk of fetal harm. Females of reproductive potential require effective contraception during use.
Photosensitivity Risk The official label requires the avoidance of excessive exposure to sunlight, sunlamps, or tanning beds due to the potential for severe sunburn and photosensitivity reactions.

Use on compromised skin, such as eczematous or sunburned areas, is avoided as this may lead to severe local reactions.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory profile for Tarac (Tazarotene) overdose addresses two primary situations: accidental oral ingestion and excessive topical application.

When to Seek Immediate Medical Help

Accidental oral ingestion of the topical preparation may cause systemic harm and requires an immediate emergency response. If the medication is swallowed, official regulatory guidance mandates that you seek emergency medical attention or contact the Poison Help line right away.

Manifestations and Management of Topical Overdose

Overuse or application of an excessive amount of Tarac can lead to a local overdose presentation classified as severe skin irritation. Documented manifestations include excessive pruritus, a severe burning sensation, pronounced skin redness (erythema), and noticeable skin peeling (desquamation), which may progress to blistering. In these cases, the required action is the immediate discontinuation of the medication until the skin integrity is restored. Supportive management includes temporarily interrupting treatment or reducing the frequency of application. No specific antidote is documented for Tazarotene overdose.

Population-Specific Risk

Due to the potential for systemic absorption, which is dependent on the body surface area treated, a severe risk of embryofetal toxicity is associated with this retinoid class. Therefore, females of reproductive potential must follow mandated precautions, including the use of effective contraception, as stated in the prescribing information.

Therapeutic Uses of Tarac

Tarac is commonly used across multiple dermatological domains, including the management of acne and psoriasis. It is applied in addressing conditions marked by increased physiological stress, primarily chronic plaque psoriasis, active acne vulgaris, and symptomatic support for sun-induced skin changes.

For plaque psoriasis, the treatment provides support that helps ease the overall symptom burden by contributing to the moderation of plaque size and roughness. In the case of acne, it is relevant for managing symptom clusters that may become intense or disruptive, including both inflammatory and non-inflammatory lesions, and helps improve day-to-day comfort by promoting supportive relief that helps ease the prominence of lesions. The medication may be part of symptomatic management when symptoms interfere with daily functioning.

“The medicine provides supportive relief when symptoms interfere with routine activities and helps maintain a sense of stability when symptoms are more noticeable.”

Quick Fact: Support for Inflammatory Skin Changes

This supportive management is relevant across domains involving inflammatory or irritative processes, assisting with maintaining comfort during symptomatic periods.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Eligibility for Tarac (Tazarotene Topical)

Official regulatory documents define strict criteria for who can and cannot use Tarac. Eligibility is determined primarily by reproductive status, age, and the condition of the skin.


Classification Eligibility Rule (Official Wording)
Absolute Contraindication Pregnancy or being a woman who is planning to become pregnant. Use is also prohibited for individuals with a known hypersensitivity to tazarotene or any excipient in the formulation.
Restricted/Conditional Use Females of childbearing potential must use effective contraception during treatment and have a negative pregnancy test prior to starting therapy. Patients must minimize exposure to sunlight and sunlamps and use sunscreen due to increased photosensitivity.
Contraindicated Skin Condition The medicine must not be applied to skin that is eczematous, severely sunburned, cut, or abraded.
Age-Related Status Use is not established in children under 12 years for most indications (though some products are approved for age 9+ for acne). Safety for plaque psoriasis has not been established in those under 18.
Lactation Status Use is not recommended while breastfeeding, and a decision to discontinue nursing or the drug must be made.

Tarac is allowed for use in adults and in adolescents typically starting at age 12 (for acne) or 18 (for psoriasis), but only if all mandated restrictions, especially those related to pregnancy prevention and sun protection, are strictly followed as defined by regulators.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation for Tarac (Tazarotene) focuses on preventing cumulative skin irritation, augmented photosensitivity, and product degradation. The drug's active metabolite, tazarotenic acid, is highly protein-bound, and the official label does not document any systemic pharmacokinetic interactions involving CYP enzymes or drug transporters that would alter exposure when used as directed.

Documented Interaction Categories

Category Interacting Agents/Substances Official Regulatory Constraint
Augmented Photosensitivity Oral photosensitizers, including certain Thiazides, Tetracyclines, Fluoroquinolones, Phenothiazines, and Sulfonamides. Co-administration should be used with caution due to the increased risk of severe photosensitivity (sunburn) reactions.
Cumulative Irritation Topical preparations with strong drying or irritant effects, such as Salicylic acid, Sulfur, and high concentrations of Benzoyl peroxide or other retinoids. Concomitant use must be avoided to prevent excessive local irritation, peeling, or burning of the treated skin.
Chemical Incompatibility Oxidizing agents, primarily Benzoyl peroxide (when applied topically). If co-use is necessary, the agents must be applied at different times of the day to prevent chemical degradation of Tazarotene.

Contraindicated Combination

The physiological state of pregnancy is a formal contraindication for Tazarotene due to the known risks of systemic retinoid exposure and embryofetal toxicity. No other medicinal product combinations are formally classified as contraindicated based on interaction risk.

Mechanism of Action

Tarac (4'-thio-beta-D-arabinofuranosylcytosine, T-araC) is a nucleoside analog requiring intracellular metabolic activation. It is phosphorylated sequentially by cellular kinases, primarily deoxycytidine kinase, to form its active triphosphate metabolite, T-araCTP. T-araCTP acts as a competitive substrate for cellular replicative DNA polymerases, competing with the endogenous nucleoside triphosphate pool. The triphosphate metabolite is incorporated into the growing 3'-terminus of DNA strands. The incorporated T-araCMP acts as a chain terminator, inhibiting the extension capacity of the DNA polymerases. This incorporation and subsequent DNA elongation arrest leads to the accumulation of DNA strand breaks and replication stress. The disruption of DNA synthesis and genomic integrity ultimately triggers downstream intracellular signaling cascades resulting in programmed cell death.

Dosage and Administration Information

Tarac is an inactive brand name and its specific instructions are generally tied to its active ingredient, which may be chlorprothixene. For safe and effective use, all patients must strictly follow the directions provided by a qualified healthcare professional and the official product labeling. Chlorprothixene is an antipsychotic medication, and proper administration is critical due to its effects on the central nervous system.

Dosage and Administration

Administration details, including dose strength (e.g., 10 mg, 25 mg, 100 mg), frequency, and duration of use, are highly individualized based on the specific condition being treated, the patient's age, and their response to therapy. The medication is typically taken orally in tablet form.

  • Oral Use: Swallow tablets whole with water. They may be taken with or without food. Never crush, chew, or divide the tablets unless specifically instructed to do so by a healthcare provider.
  • Consistency: Take the medication at the same time each day to maintain steady therapeutic levels in the bloodstream.
  • Missed Dose: If a dose is missed, take it as soon as you remember. If it is nearly time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses simultaneously to compensate for a missed dose, as this increases the risk of side effects.

Important Safety Information

Chlorprothixene, like other medications in its class, requires careful monitoring. Abruptly stopping this medication can lead to withdrawal symptoms or a return of the original condition. Therefore, any discontinuation or change in dosage must be gradual and supervised by a healthcare provider to manage the risk of adverse reactions.

Due to the potential for drowsiness, patients are advised to exercise caution when operating machinery or driving until they know how the medication affects them.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Tarac (Tazarotene)

This section provides a factual overview of the clinical research conducted on Tarac, focusing on the types of studies performed, the patient groups examined, and the general findings and limitations described by researchers, without offering any medical or treatment advice.


Evidence for Use in Chronic Plaque Psoriasis

The foundational research for Tarac in psoriasis involved short-term (12-week) Randomized Controlled Trials (RCTs). These studies primarily focused on adults diagnosed with stable plaque psoriasis that covered up to 20% of their total body surface area. The research explored outcomes by measuring characteristics of plaques, specifically monitoring traits like scaling, redness (erythema), and elevation (induration). Findings describe patterns related to the change in plaque characteristics observed during the study period.

Evidence for Use in Active Acne Vulgaris

The study landscape for acne vulgaris is built upon short-term (12-week) Randomized Controlled Trials (RCTs) that compared Tarac against an inactive vehicle. These studies were designed to explore short-term symptom changes in populations of adolescents and adults with moderate-to-severe facial acne. Research examined specific outcomes related to inflammatory or irritative states, focusing on the number of both inflammatory and non-inflammatory lesions. Findings describe patterns related to the changes recorded during the study period.

Evidence for Addressing Sun-Induced Skin Changes (Photoaging)

For sun-induced skin changes, the research involved intermediate to long-term controlled intervention studies, often lasting up to 52 weeks. Research examined complex endpoints by recording measurements of fine wrinkling, tactile roughness, and mottled hyperpigmentation. The findings describe group patterns related to the recorded change in the measured signs of chronic sun exposure.


Key Evidence Gaps and Areas of Uncertainty

A consistent limitation across the body of evidence is the limited follow-up duration of the core randomized trials, which affects understanding symptom patterns beyond the short term. Comparative evidence is lacking for many direct comparisons against other specific medications within the same class. Furthermore, the results apply only to the populations studied (e.g., localized plaque psoriasis or moderate-to-severe facial acne), and the research does not readily provide context for patient groups with much more extensive or severe disease presentations. Research is ongoing to provide further insight into these areas.

Key Studies & References

  1. Tazarotene (Topical) Monograph: U.S. National Library of Medicine

Frequently Asked Questions (FAQ)

Common questions about Tarac (FAQ)

Q: How quickly can I expect to notice the effects of Tarac?

A: Clinical efficacy is commonly evaluated over a 12-week treatment period in studies. Some early changes in symptoms, such as the reduction of scaling in psoriasis, have been noted in research as early as the first week of treatment.

Q: Is Tarac considered a long-term treatment?

A: Official information indicates the duration of use is at the discretion of the prescribing healthcare provider. Clinical studies have evaluated treatment for acne and psoriasis over 12 weeks, and research for sun-induced skin changes has extended up to 52 weeks, supporting its use in intermediate-term regimens.

Q: Are there any common, mild side effects of Tarac that usually go away?

A: Common local adverse events, such as itching, burning, and redness at the application site, are frequently reported when starting treatment. Official regulatory documents note that these effects are most frequent and noticeable during the initial two to four weeks of therapy.

Q: Is it normal to feel dizzy or tired when first starting Tarac?

A: Regulatory documents primarily focus on the local skin reactions associated with topical Tarac. Systemic effects like dizziness or tiredness are generally not listed as common adverse reactions in the main clinical trial data for this topical application.

Q: What happens if I stop taking Tarac suddenly?

A: Since Tarac is a topical medication, sudden discontinuation usually does not cause the severe systemic withdrawal symptoms associated with oral medications in this class. Changes to or cessation of treatment should always be performed under the guidance of a healthcare professional.

Q: Are there any known serious but rare side effects of Tarac?

A: The most significant safety constraints documented in official labeling include Embryo-Fetal Toxicity (risk of fetal harm if used during pregnancy) and the potential for severe Photosensitivity reactions. Postmarketing surveillance reports have also included rare instances of more serious reactions like blistering or severe allergic responses.

Q: Does Tarac affect blood pressure or heart rate?

A: Based on clinical trial data, changes in blood pressure or heart rate are not commonly listed as adverse reactions for the topical product. The low systemic absorption of the drug suggests it does not often cause these types of systemic effects.

Q: Can Tarac be crushed or split if swallowing is difficult?

A: Tarac is a topical preparation for external use only. It is not an oral medication and is therefore not intended to be swallowed, crushed, or split.

Q: Why is Tarac sometimes prescribed in combination with another drug?

A: Clinical studies indicate Tazarotene has been evaluated for co-administration with other treatments, such as topical corticosteroids, often to manage local irritation. While the label cautions against combining it with other strong topical irritants, combination regimens are sometimes used under medical supervision.

Q: Do elderly patients experience different side effects with Tarac?

A: Official information regarding the use of Tarac in geriatric patients (65 and over) is limited. Clinical trials often do not provide specific data on whether this age group responds differently compared to younger adults, and the appropriate use in this population is determined by the prescribing healthcare professional.

Q: What are the signs that Tarac is working effectively?

A: In clinical trials, effectiveness was evaluated by specific changes in the treated condition. This includes the mitigation of fine wrinkling, reduction of mottled hyperpigmentation, and the clearing or reduction of specific lesions associated with acne and psoriasis.

Q: How long does Tarac stay in the system after the last dose?

A: Pharmacokinetic data indicate that the active metabolite of Tarac has a half-life of approximately 16 to 18 hours after topical application, which determines how long it may remain detectable.

Q: Can taking Tarac affect my sleep?

A: Based on official clinical trial data for the topical formulation, insomnia or other sleep disturbances are not commonly listed as adverse reactions.

Q: Does Tarac affect driving or operating machinery?

A: The official product label does not typically include a specific warning regarding impaired driving or operating machinery because systemic absorption is low. Patients should, however, remain mindful of any potential systemic effects they might personally experience.

Q: Have there been any recent studies on the long-term safety of Tarac?

A: Regulatory documents include a summary of the long-term safety profile derived from studies lasting up to one year for certain indications. This information is continually updated as new research, including data on combination products, becomes available.

Q: Is it possible for Tarac to stop working over time?

A: Clinical trial data typically show a sustained effect throughout the duration of the controlled studies. The regulatory documentation does not commonly describe a loss of effect, known as tachyphylaxis, within the periods evaluated.

Q: What does the clinical research say about Tarac's efficacy vs. placebo?

A: Clinical research demonstrated that Tarac showed better results compared to the inactive vehicle (often referred to as a placebo) in treating the indicated conditions. The drug was evaluated in randomized, vehicle-controlled clinical trials.

Q: Is there a generic version of Tarac available?

A: Yes, the active ingredient Tazarotene is available in generic topical formulations. These formulations have been approved by regulatory bodies, such as the FDA, through the Abbreviated New Drug Application (ANDA) process.

How should Tarac be stored and disposed of?

How to Store and Dispose of Tarac (Tazarotene)

Tarac (tazarotene) must be stored and handled according to specific conditions to maintain stability and ensure safety.


Storage Requirements

Detail Requirement
Temperature Store at 25 C (77 F). Permitted excursions are between 15 C and 30 C (59 F and 86 F).
Handling Do not freeze and protect from excessive heat, moisture, and direct light.
Container Keep the medicine in its original container with the cap tightly closed.
Child Safety Must be kept out of the sight and reach of children.

Disposal Instructions

Unused or expired Tarac should not be flushed down the toilet or poured down a sink. The preferred method for disposal is using an authorized drug take-back program. If a take-back program is unavailable, mix the medicine with an undesirable substance (e.g., dirt) in a sealed container and dispose of it in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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