Openvas

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Openvas

Property Description
Active Ingredient Olmesartan Medoxomil
Form Oral Tablets
Pharmacological Class Angiotensin II Receptor Blocker (ARB)
General Purpose Systemic Blood Pressure Reduction
Origin Synthetic Compound (Prodrug)

Openvas is a prescription medication whose active ingredient is Olmesartan Medoxomil, a synthetic compound belonging to the class of Angiotensin II Receptor Blockers (ARBs). This pharmacological category is clinically recognized as a foundation of maintenance therapy aimed at achieving systemic blood pressure reduction in individuals with high blood pressure, formally termed Essential Hypertension. Olmesartan is used in treating hypertension in adults.

Composition, Form, and Unique Chemical Nature

The medication is typically administered as a single-ingredient product in the form of Oral Tablets for convenient oral use. Its active substance, Olmesartan Medoxomil, is chemically classified as a prodrug—an inactive precursor that is metabolized rapidly in the body into its therapeutically active compound, Olmesartan. This design ensures efficient intestinal absorption and bioavailability. Openvas is further distinguished as a non-peptide antagonist, making it structurally suitable for oral administration.

How Openvas Relates to Blood Pressure Management

Openvas's general purpose is to promote Vasodilation (widening of blood vessels). It achieves this by acting as a highly selective antagonist that prevents the potent natural vasoconstrictor, Angiotensin II, from signaling blood vessel walls to tighten. This blockade reduces the resistance to blood flow, leading to the desired lowering of arterial pressure. This sustained reduction of vascular strain is the essential therapeutic benefit, serving as a critical strategy for mitigating the long-term cardiovascular risks associated with chronic high blood pressure.

What side effects are possible with Openvas?

Possible Side Effects and Safety Information

The safety profile of Openvas (Olmesartan Medoxomil) is formally documented by regulatory agencies and organized into categories based on the frequency and system affected. Reactions are classified using standardized terms such as Common (may affect up to 1 in 10 people), Uncommon, Rare, and Very Rare.


Key Adverse Reactions and Organ Systems

Common adverse reactions documented in the regulatory labeling include dizziness, headache, back pain, bronchitis, cough, diarrhoea, and peripheral oedema (swelling). These effects are generally associated with the Nervous System Disorders, Musculoskeletal and Connective Tissue Disorders, and Gastrointestinal Disorders categories.


Serious Safety Considerations

The official documents describe several serious safety concerns. Angioedema (swelling of the face, lips, or throat) is a rare but documented reaction. A Very Rare but serious gastrointestinal issue, Sprue-like enteropathy (severe, chronic diarrhea), has been noted as a potential late-onset event, developing months to years after treatment initiation.

Official labeling includes a Boxed Warning regarding Fetal Toxicity due to the risk of injury and death to the developing fetus, resulting in a contraindication during the second and third trimesters of pregnancy.


Population and Contextual Constraints

Safety notes specify that hypotension (low blood pressure) and dizziness may be more pronounced at the start of treatment. The drug is formally contraindicated in specific groups, notably for use with the medicine Aliskiren in patients with diabetes. Caution is also advised for use in patients with pre-existing volume or salt depletion due to an increased risk of symptomatic hypotension.

Overdose and Emergency Response

The regulatory information for Openvas (Olmesartan Medoxomil) strictly defines documented overdose manifestations and required emergency actions, noting that only limited human data are available.

Overdose Scope

Property Official Regulatory Statement
Documented overdose presentations The most likely effect of overdosage is hypotension (low blood pressure), representing an exaggerated pharmacological effect.
Physiological systems affected (as stated in label) Cardiovascular system (profound hypotension); Renal system (oliguria, renal failure in exposed infants).
Dose-related or exposure-related factors (if applicable) Overdose risk is tied to excessive dosing or, specifically, in utero exposure, which poses a severe risk to the fetus/neonate.
Population-specific overdose notes (if applicable) Infants/Neonates exposed in utero must be closely observed for hypotension, oliguria, and hyperkalemia.
Emergency-response statements (as written in official documents) Treatment is mandated to be supportive and symptomatic; immediate medical attention must be sought.
When immediate medical help is required (label-derived phrasing only) Urgent medical help is required when symptomatic hypotension or severe consequences are suspected.

Overdose Classifications (High-Level)

Property Official Regulatory Statement
Severity classification (as defined in official documents) Associated with the potential for profound hypotension and life-threatening neonatal injury from in utero exposure.
Regulatory basis (EMA / FDA / etc.) Information derived from FDA Prescribing Information and regulatory labels.
Overdose-context constraints (as defined in official documents) No specific antidote is known, and no information is available regarding the dialysability of olmesartan.

Resulting Overdose Structure

Official Overdose Statements:

  • The primary manifestation of Olmesartan Medoxomil overdose is hypotension.
  • Management is strictly supportive and symptomatic; specific guidance includes placing the patient in the supine position and administering an intravenous infusion of normal saline for symptomatic hypotension.
  • Infants exposed in utero may require specialized interventions like exchange transfusion or dialysis to manage hypotension and disordered renal function.

Connection to the overall overdose profile (2–4 sentences): Regulatory documentation defines the overdose profile based on the risk of severe blood pressure reduction, which dictates the requirement to seek immediate medical attention for mandated supportive care and stabilization. The label highlights this risk, along with the specific, life-threatening risk associated with exposure during pregnancy, requiring close monitoring and defined procedures.

Therapeutic Uses of Openvas

Supportive medicines are generally relevant in contexts marked by increased discomfort or tension. Openvas is applied across domains where additional symptomatic support is needed, aiming to provide supportive relief when symptoms interfere with routine activities. It is commonly used across conditions involving episodic or fluctuating manifestations and those with **acute or unstable symptom patterns.

Addressing Symptom Clusters

This medicine may assist with managing symptoms related to physical discomfort and symptoms that interfere with daily functioning. Applied in clinical settings that involve acute or disruptive symptom patterns, Openvas is relevant for easing distressing symptoms that may become intense or disruptive. As a patient-oriented benefit, it contributes to easing the overall symptom load during periods of heightened symptoms.

“Openvas provides support that helps ease the overall symptom burden when symptoms are more noticeable.”

Openvas is relevant in situations where symptoms cluster into patterns requiring supportive management, and may assist with symptoms that become more disruptive during flare-ups.

Quick Fact: Supportive Assistance for Flare-ups

Regulatory References

  1. NIH MedlinePlus overview of drug information

Eligibility and Restrictions for Use

Who Can and Cannot Use Openvas (Olmesartan Medoxomil)

The official eligibility criteria for Openvas, an Angiotensin II Receptor Blocker (ARB), are strictly defined by regulatory documents, categorizing populations as permitted, restricted, or contraindicated.

Contraindicated and Restricted Populations

Absolute prohibitions (contraindications) prevent use in specific groups due to severe, documented risks:

  • Pregnancy: Contraindicated during the second and third trimesters due to the high risk of fetal injury and death. Use in the first trimester is not recommended.
  • Hypersensitivity: Contraindicated in patients with known sensitivity to Olmesartan Medoxomil or its components.
  • Biliary Obstruction: Use is contraindicated based on regulatory labeling in certain regions.
  • Diabetes and Aliskiren: Contraindicated for concurrent use with Aliskiren in patients with Diabetes Mellitus.

Age- and Condition-Based Eligibility

Category Regulatory Status
Adults Approved for the treatment of hypertension.
Children/Adolescents Approved for hypertension in ages 6 to under 18 years.
Infants (< 1 year) Prohibited from receiving the medicine.
Severe Organ Impairment Not recommended in cases of severe hepatic or severe renal impairment (CrCl < 20 mL/min or 30 mL/min).
Lactation Not recommended; a decision must be made to discontinue nursing or the drug.

Eligibility is conditional upon the absence of these restrictions. Furthermore, use requires caution in patients with conditions like volume depletion or renal artery stenosis.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents detail specific constraints regarding the co-administration of Openvas with certain other medicinal products. These interactions are categorized based on their mechanism, primarily focusing on effects on drug exposure (pharmacokinetic) and compounding effects on the body (pharmacodynamic).

Interaction Domains and Constraints

Interaction Domain Practical Regulatory Implication
Metabolizing Enzyme Inhibitors Co-administration with strong inhibitors of the drug's primary metabolic pathway is typically either avoided or requires stringent clinical monitoring to manage the risk of significantly increased drug exposure and potential toxicity.
Other CYP450 Substrates/Inducers Use with medicines that are substrates or inducers of the same metabolizing enzyme systems requires checking for potential adjustments to maintain the efficacy of Openvas or prevent altered exposure of the co-administered medicine.
Pharmacodynamic Agents Concurrent use with other agents that share a similar key physiological effect may result in additive or synergistic effects, necessitating careful patient monitoring and potential modification of therapy to manage the combined effect.

Official Interaction Structure

Regulatory agencies define the product's interaction profile by its role as a substrate for specific drug-metabolizing enzymes. The official section emphasizes necessary precautions, such as avoiding or closely monitoring combinations with strong inhibitors of these enzymes. The documented constraints are defined by the requirement to manage the drug’s systemic exposure and its potential for compounding effects with other agents, structuring the official interaction section around these pharmacokinetic and pharmacodynamic classifications.

Mechanism of Action

The drug acts as a competitive antagonist, binding selectively to the Angiotensin II Type 1 ( AT1) receptors primarily located in vascular smooth muscle, the heart, kidneys, and adrenal glands. This interaction blocks the normal signaling pathway initiated by the endogenous ligand, Angiotensin II, a major vasoconstrictor and mediator of water and salt retention. The mechanism targets and regulates the Renin-Angiotensin-Aldosterone System (RAAS). By inhibiting the AT1 receptor, the drug prevents Angiotensin II from activating downstream intracellular processes, including Ca^2+ mobilization and the MAPK/ERK cascade. This results in the suppression of Angiotensin II-mediated pressor and trophic signaling. The key physiological consequence is a reduction in vasoconstrictive tone, leading to vasodilation, and a decrease in renal water and salt reabsorption, which modulates the systemic fluid balance.

Dosage and Administration Information

Openvas (Olmesartan Medoxomil) is exclusively administered via the oral route as a film-coated tablet for use in systemic blood pressure management. Usage protocols define standard regimens and specific adjustments for vulnerable populations. The tablet must be swallowed whole with fluid and is administered independent of food intake.

The standard adult usage pattern involves taking the medicine once daily, at approximately the same time each day. The typical starting dose is 20 mg once daily, with the ability to adjust the dosage up to a maximum recommended daily dose of 40 mg. A period of approximately two weeks is observed between any dose increases to allow the full response to manifest. Full antihypertensive effect is generally achieved after about eight weeks of continuous therapy, making this a long-term maintenance protocol.


Official Dosing Adjustments

Population Constraint Official Administration Rule
Moderate Renal or Hepatic Impairment The maximum daily dose is required to be reduced, typically to 20 mg once daily.
Volume Depletion Initiation of treatment may require a lower starting dose and close medical supervision.
Older Adults No initial dosage adjustment is generally required.

This administration protocol ensures consistent, long-term use.

Recent Clinical Evidence

Openvas: Recent Clinical Evidence

Evidence for Use in Essential Hypertension

Research examining Olmesartan Medoxomil for use in Essential Hypertension (high blood pressure) primarily consists of randomized controlled trials (RCTs). Many of these trials are short-term and compare the medicine to an inactive substance or to other active blood pressure medications. The main focus of these studies was to measure changes in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) over defined time periods, often assessed by office readings and 24-hour Ambulatory Blood Pressure Monitoring (ABPM). The trials examined blood pressure changes and reported that the measurements for both SBP and DBP were lower at the end of the monitored treatment periods compared to baseline. Because many definitive trials are short-term (e.g., 6 to 12 weeks), there is limited direct evidence from these specific studies on the medicine’s absolute, long-term incidence of major cardiovascular events like heart attack or stroke.


Evidence for Use in High Blood Pressure with Type 2 Diabetes

Olmesartan Medoxomil was studied for use in patients with high blood pressure who also have co-existing Type 2 Diabetes Mellitus, particularly in large, long-term RCTs, such as the ROADMAP study. These trials monitored outcomes, such as the time to the first occurrence of microalbuminuria (a marker related to kidney changes). Long-term trials monitored the onset of microalbuminuria in the diabetic population studied. However, regulators reviewed findings from these long-term studies concerning cardiovascular mortality that was tracked in specific, high-risk subgroups of diabetic patients. The review was prompted by the findings related to cardiovascular outcomes tracked in these long-term studies, as noted by regulators.


Key Limitations and Areas of Research Uncertainty

The body of research for Olmesartan Medoxomil, while extensive for blood pressure measurements, still contains specific gaps and areas of uncertainty. One major limitation is that many original efficacy studies had follow-up durations that were limited to only a few weeks. Furthermore, the findings concerning cardiovascular mortality in specific high-risk diabetic subgroups remain uncertain and complex, indicating that evidence quality varies across specific patient groups.

Frequently Asked Questions (FAQ)

Common questions about Openvas (FAQ)

Q: How long does it typically take to notice the effects of Openvas?

Studies indicate that measurable changes in blood pressure can be seen as early as two weeks after starting treatment. The full antihypertensive effect is generally assessed after about eight weeks of continuous daily use, according to regulatory data.

Q: Does Openvas make you gain weight?

Unusual weight gain is noted in regulatory documents as one of the less commonly reported effects during clinical studies. It is important to note that in rare instances, a severe, chronic diarrhea that results in weight loss (known as Sprue-like enteropathy) has also been documented.

Q: Can Openvas be taken with common over-the-counter pain relievers?

Regulatory information states that concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of the medication in lowering blood pressure. The concurrent use of these agents requires medical oversight to manage risks, as it is also documented to increase the potential risk of developing kidney problems.

Q: Does Openvas interact with grapefruit?

Official documents detailing the specific drug interaction profile of the medication do not typically list a specific warning or interaction with grapefruit products.

Q: Are there any known interactions between Openvas and vitamins/supplements?

The official product information addresses the risk of high potassium levels (hyperkalemia) in the blood. Regulatory information cautions against the use of potassium-containing salt substitutes or potassium supplements, as this may increase potassium levels in the blood.

Q: Does Openvas have a generic version available?

Yes, the active substance in the medication, Olmesartan Medoxomil, is chemically available under its generic name.

Q: Do you always get side effects from Openvas?

No, the classification of side effects is based on how often they were reported in clinical studies. Regulatory documents categorize reactions by frequency, such as Common (1% to 10%) or Rare, indicating that many individuals do not experience adverse effects.

Q: Can Openvas cause hair loss, or is that a myth?

Hair loss, formally called alopecia, has been noted in the post-marketing experience for this medication. However, official regulatory documents classify the frequency of this specific effect as not known.

Q: Is it true that Openvas can affect sleep?

Yes, difficulty sleeping, known as insomnia, is listed in the official documents as a common side effect reported by individuals taking the medication.

Q: Can Openvas make you feel dizzy or lightheaded?

Dizziness is a commonly reported side effect documented in official safety information. Lightheadedness may also occur, particularly when treatment is initiated or when moving quickly from a sitting or lying position.

Q: Do other medications stop Openvas from working correctly?

Official documents show that some other medicines can interfere with the blood pressure lowering effect. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) are documented as potentially leading to a loss of the medication's intended effect.

Q: Is Openvas approved in countries other than the US?

The medication and its components have been reviewed and approved for use by several governmental health authorities internationally. This includes organizations such as the European Medicines Agency (EMA).

Q: Does Openvas need to be taken long-term for some conditions?

Yes, the drug is described in administration protocols as a long-term maintenance treatment for chronic conditions like high blood pressure. Continued use is often required to sustain the therapeutic benefit, as it is classified as a long-term maintenance protocol.

Q: How long does Openvas stay in your system after you stop taking it?

The mean terminal elimination half-life of the active substance in the body is documented to be between 12 and 18 hours. This pharmacokinetic value is used as a measure of the time it takes for half of the drug to be eliminated from the body.

Q: Is Openvas considered an addictive drug?

No, the drug is classified as an Angiotensin II Receptor Blocker (ARB) for managing high blood pressure. It is not classified as a controlled substance and does not carry an abuse potential.

Q: Can Openvas affect the results of blood tests?

Yes, official safety notes indicate that the medication can affect the levels of certain substances in the blood, such as potassium (serum electrolytes). Due to this potential effect, periodic monitoring may be required during treatment.

Q: What happens if I stop taking Openvas suddenly?

Clinical studies examining the medication reported no evidence of rebound high blood pressure (hypertension) after discontinuing the treatment following one year of therapy.

Q: Does Openvas cause problems with driving?

Because dizziness is a documented common side effect, official warnings suggest that individuals should exercise caution when driving or operating machinery until they understand how the medicine affects them.

Q: Is Openvas suitable for people who have liver disease?

Official eligibility criteria indicate that use is generally not recommended for people with severe liver impairment. The dosage may also be adjusted for moderate liver impairment, according to regulatory guidelines.

Q: Are there different brand names for the same drug, Openvas?

Yes, the drug containing the active ingredient Olmesartan Medoxomil is available under the brand name Openvas. It is also available under other recognized brand names, such as Benicar.

Q: Can Openvas be used to treat anxiety?

Regulatory agencies have approved this medication exclusively for its therapeutic indication, which is the treatment of high blood pressure, formally known as hypertension. It is not approved for the treatment of anxiety.

Q: How does the body get rid of Openvas?

After the prodrug is converted into the active substance, the body eliminates it through natural processes. The active substance is primarily excreted through the feces (approximately 60%) and, to a lesser extent, through the urine (approximately 35% to 50%).

Q: Can women use Openvas for the same conditions as men?

Clinical trial data indicated that the medication’s efficacy in lowering blood pressure was observed regardless of the patient's gender.

Q: Does Openvas lose its effectiveness over time?

Clinical studies have shown that the effectiveness of the medication in lowering blood pressure was successfully maintained for at least one year of continuous use.

Q: What is the duration of action for one dose of Openvas?

The blood pressure lowering effect from a single dose is maintained throughout the full 24-hour dosing interval. This characteristic supports the medicine's administration as a once-daily treatment.

Q: Do certain races or ethnicities respond differently to Openvas?

Regulatory documents report that while the blood pressure-lowering effect was observed in all racial groups studied, the effect was found to be somewhat less pronounced in Black patients.

Q: Is Openvas considered a high-risk medication?

Official labeling includes a Boxed Warning regarding the risk of fetal injury and death during the second and third trimesters of pregnancy. This designation highlights specific, serious safety concerns detailed in the label.

Q: Why did the FDA approve Openvas?

The FDA approved the medication for the treatment of high blood pressure (hypertension) in adults and in children. This approval was based on clinical studies that demonstrated a reduction in blood pressure and provided data on the medicine’s safety profile.

Q: What is the half-life of Openvas?

The mean terminal elimination half-life of the active substance is documented to be between 12 and 18 hours. This is a measure of the time it takes for half of the drug to be eliminated from the body.

Q: Is Openvas the same as [other similar drug name]?

The medication contains the active ingredient Olmesartan Medoxomil and is available under the brand name Openvas, as well as other brand names (like Benicar). This information allows for clarification of drug identity.

How should Openvas be stored and disposed of?

How to Store and Dispose of Openvas?

The storage and disposal of Openvas (Olmesartan Medoxomil) must follow conditions defined in official regulatory labeling to ensure product integrity and public safety.


Mandatory Storage Conditions

Openvas tablets must be stored at room temperature, generally defined as below 30 C. The product must be protected from light and moisture to maintain its stability. For this reason, it is required to keep the medicine in its original container or blister packaging, with the container tightly closed.


Disposal and Child Safety

All medicines, including Openvas, must be kept out of the sight and reach of children. When disposing of unused or expired tablets, do not throw them in household trash or flush them down the toilet. Instead, return the product to a pharmacist or use an official drug take-back program to ensure proper pharmaceutical waste disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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