Licotin

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Licotin

Treatment option: Cough

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Licotin

Quick Facts

Property Description
Active ingredient Dextromethorphan Hydrobromide (DXM)
Form Oral (Syrup, Tablet, Capsule, Lozenge)
Pharmacological class Antitussive (Cough Suppressant)
Common use Symptomatic relief of non-productive cough
Origin Synthetic Morphinan Derivative

What is Licotin?

Licotin is a synthetic pharmaceutical product used for the symptomatic relief of cough, classified chemically as a morphinan derivative. Its composition centers around the single active compound, Dextromethorphan Hydrobromide (DXM), which acts as a centrally operating antitussive agent. The primary purpose of Licotin is to suppress the cough reflex, offering temporary respite from disruptive, non-productive coughing associated with minor irritations.


What Type of Medicine is Licotin? (Identity and Classification)

Licotin is classified as an antitussive, or cough suppressant, a type of medicine that targets the neurological pathways controlling the cough reflex. The active ingredient, Dextromethorphan Hydrobromide, is a synthetic compound derived from the morphinan class, yet it is specifically recognized as a non-narcotic agent. Dextromethorphan is characterized as a non-opioid central-acting antitussive. This non-narcotic classification is critical because, unlike older opioid antitussives, Licotin primarily suppresses the cough impulse without possessing significant analgesic effects at recommended therapeutic levels, ensuring focused action on the cough center in the medulla oblongata.


Licotin: Forms, Composition, and General Purpose

Licotin is prepared for oral use and is commonly supplied in several dosage forms, including oral syrup, tablet, capsule, lozenge, and solution. The high-level composition involves the active ingredient combined with a suitable base, such as an aqueous or hydroalcoholic solution for liquids, or various pharmaceutical excipients for solid preparations. Dextromethorphan is recognized for its efficacy in managing the cough symptom. This highlights the medicine's clinical relevance in providing relief from dry, irritating coughs. While it can be used as a single-ingredient product, its availability across multiple forms, including extended-release variants, allows for selection based on desired duration of effect. The overall benefit is the centralized suppression of the cough reflex, which minimizes the frequency and severity of dry, irritating coughs.

Regulatory References

  1. MedlinePlus Drug Information
  2. WHO Essential Medicines Lists
  3. Dextromethorphan (StatPearls - NCBI Bookshelf)

What side effects are possible with Licotin?

Possible Side Effects and Safety Information

Licotin's safety profile, based on official regulatory documents, outlines potential side effects primarily involving the Nervous System and Gastrointestinal System. At standard therapeutic doses, these adverse reactions are often classified as Uncommon, meaning they occur in a limited number of patients according to the regulatory frequency framework. Common officially documented effects include drowsiness, dizziness, and mild nausea or vomiting.


Serious Adverse Reactions and Safety Constraints

The regulatory safety profile explicitly identifies Serotonin Syndrome as a potentially serious adverse reaction, particularly when Licotin is used concurrently with specific serotonergic agents like MAOIs or SSRIs. Other serious concerns documented at high exposure levels include the risk of convulsions and dystonias.

Official safety labeling mandates restrictions concerning use in specific patient populations. Caution is advised for individuals with moderate to severe hepatic impairment due to the drug's metabolism. Furthermore, the medicine is often contraindicated for use in pediatric populations below certain age limits, depending on the regulatory region and formulation. The medicine is also typically restricted in cases of known hypersensitivity and in patients with or at risk of respiratory failure.

Overdose and Emergency Response

The official regulatory documents state that acute overdose of Licotin (Dextromethorphan Hydrobromide) may lead to a broad spectrum of clinical manifestations, primarily affecting the central nervous system. Documented signs include confusion, somnolence, agitation, nystagmus (rapid eye movement), and ataxia (unsteady walk), alongside gastrointestinal effects such as nausea and vomiting. Cardiovascular effects, including tachycardia and fluctuations in blood pressure, may also occur.

Life-threatening outcomes officially reported include respiratory depression, coma, seizures, and the risk of developing Serotonin Syndrome. Regulators require that immediate medical attention be sought for any suspected overdose. Emergency services must be called without delay if the affected person has trouble breathing, collapses, has a seizure, or cannot be awakened.

Treatment management, as described in official labeling, is typically symptomatic and supportive. This includes the potential use of Activated Charcoal (if administered within one hour of ingestion) and the consideration of Naloxone to manage severe CNS or respiratory depression. Continuous monitoring of vital signs and an Electrocardiogram (ECG) may be required for observation.


Note on Special Populations: Regulatory information indicates that breathing problems may be more severe in young children, and a dose reduction may be necessary for patients with pre-existing hepatic or renal impairment.

Therapeutic Uses of Licotin

Main Uses and Benefits of Licotin

Licotin is a pharmacological treatment primarily utilized in the management of specific nutritional deficiencies and associated metabolic conditions. Its therapeutic profile focuses on stabilizing micronutrient levels and supporting physiological functions related to its active components.

Core Indications

The administration of Licotin is generally centered on the following clinical areas:

  • Nutritional Deficiencies: It is indicated for the correction of documented vitamin and mineral imbalances that cannot be managed through dietary changes alone.
  • Supportive Metabolic Therapy: The preparation assists in maintaining cellular metabolism, particularly in patients with increased physiological demand or impaired absorption.
  • Convalescence: It may be used as adjunctive support during recovery from illness or surgery to facilitate the restoration of nutritional homeostasis.

Physiological Benefits

When utilized according to clinical guidance, Licotin provides several physiological benefits aimed at improving overall health status:

  • Correction of Micronutrient Levels: By providing concentrated forms of essential nutrients, it helps reverse symptoms associated with specific deficiencies.
  • Cellular Function Support: The components of Licotin play a role as cofactors in enzymatic reactions, contributing to efficient energy production and tissue repair.
  • Antioxidant Properties: Certain elements within the formulation may assist in protecting cells from oxidative stress, thereby supporting long-term cellular integrity.

Therapeutic Goals

The primary objective of treatment with Licotin is to restore the patient to a state of nutritional adequacy. By addressing underlying deficiencies, the medication helps mitigate secondary symptoms such as fatigue or weakened physical resilience that often accompany sub-optimal nutrient levels. It serves as a targeted intervention to bridge the gap between systemic requirements and current biological availability.

Regulatory References

  1. MedlinePlus Drug Information

Eligibility and Restrictions for Use

Who Can and Cannot Use Licotin?

Licotin (Dextromethorphan Hydrobromide) eligibility is determined by specific regulatory criteria concerning age, concurrent medication use, and underlying medical conditions. This information is derived strictly from official government labeling.


Contraindications and Absolute Prohibitions

Licotin is absolutely contraindicated for patients who are currently taking or have stopped taking a Monoamine Oxidase Inhibitor (MAOI) within the last 14 days, due to the risk of severe drug interaction. Use is also prohibited for individuals with a known hypersensitivity to any component in the formulation. For Over-The-Counter products, Licotin is not recommended for use in children under 4 years of age, and is often contraindicated under 2 years in regulatory documents.


Special Populations and Restricted Use

Population Group Regulatory Restriction or Condition
Chronic Cough Must not be administered if cough is chronic, persistent, or involves excessive secretions, unless directed by a healthcare provider.
Hepatic Impairment Caution is required in patients with moderate to severe liver dysfunction due to the drug's metabolism.
Pregnancy/Lactation Alcohol-containing Licotin formulations must be avoided during both pregnancy and breastfeeding.

Standard use is established for adults and adolescents 12 years of age and older, with conditional use established for children aged 4 to less than 12 years.

What should I know about interactions with other medicines?

The official interaction profile for Licotin (Dextromethorphan) is governed by both its metabolic pathway and its central pharmacodynamic effects. Co-administration with Monoamine Oxidase Inhibitors (MAOIs) is formally contraindicated due to the serious risk of Serotonin Syndrome. This mandatory regulatory restriction requires a 14-day washout period after stopping an MAOI before Licotin can be administered. The primary metabolic route for Licotin involves the Cytochrome P450 2D6 (CYP2D6) enzyme. Co-administration with potent CYP2D6 inhibitors, such as quinidine, fluoxetine, and paroxetine, results in a regulatory-documented significant increase in Licotin plasma exposure and reduced clearance. The resulting higher concentrations can lead to exaggerated effects.

Other serotonergic agents (e.g., SSRIs, SNRIs) also pose a risk of Serotonin Syndrome through additive pharmacodynamic effects. The profile also notes additive depressant effects on the Central Nervous System (CNS) when combined with substances like alcohol or other CNS depressants. Furthermore, individuals identified as poor CYP2D6 metabolizers exhibit inherently higher exposure and prolonged effects, similar to the interaction with an enzyme inhibitor. These regulatory constraints focus on administration timing, pharmacokinetic alteration, and pharmacodynamic risk.

Mechanism of Action

How Licotin Works

Licotin's mechanism is defined by its selective action within the microbial cell. The drug functions as a specific inhibitor by targeting the essential 50S ribosomal subunit of susceptible bacteria . This ribosomal structure is necessary for protein production, and the binding of Licotin to its active site initiates the mechanistic cascade.

Upon binding, Licotin physically obstructs the translocation step required for the ribosome to move along the messenger RNA (mRNA) strand. This interference prevents the addition of new amino acids to the growing polypeptide chain, effectively halting protein synthesis. This molecular disruption leads to a fundamental change in the organism's viability: the arrest of the microbial population growth (bacteriostasis). The resulting physiological state is characterized by non-replicating microbial populations, allowing for the host's natural clearance processes to occur without being overwhelmed by exponential proliferation.

Dosage and Administration Information

Licotin, which contains the active ingredient Dextromethorphan Hydrobromide, is authorized for use exclusively via the oral route of administration. The medicine is supplied in several forms, including oral syrups, tablets, capsules, and lozenges, and must be ingested according to the specific procedural instructions for each form.

The standard administration schedule for adults (12 years and older) involves a single dose typically ranging from 10 mg to 60 mg, depending on whether the formulation is immediate- or extended-release. Administration frequency is dictated by the formulation; immediate-release products are generally repeated every four hours, while extended-release forms allow for dosing intervals of six to eight hours. A strict constraint limits the total dose to a maximum of 120 mg in any 24-hour period.

Use is categorized as short-term and intermittent, intended only for the temporary phase of symptoms, with official guidance generally restricting use beyond seven days. The medicine may be taken without regard to food. Specific forms require particular handling: lozenges must be allowed to dissolve slowly in the mouth, and extended-release capsules or tablets must not be crushed, chewed, or divided before swallowing. Dosing for pediatric patients aged 6 to under 12 years is subject to distinct, lower dose ranges that must not exceed 60 mg daily.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Licotin


Evidence for Managing Acute, Non-Productive Cough

Licotin was studied for acute, non-productive cough—the dry, hacking cough associated with conditions like the common cold—primarily through randomized controlled trials (RCTs). These short-term studies have been applied in research exploring how symptoms change over time, typically comparing the active ingredient against an inactive substance (placebo). Researchers monitored outcomes related to physical discomfort, such as cough severity, as well as patient-reported outcomes describing perceived discomfort.

Findings describe patterns observed in the studies but have often been mixed. Some trials reported differences in objective cough frequency measurements when compared to the placebo group. However, other studies exploring patient-reported experiences described subjective outcomes reflecting daily functioning or activity level that were similar to those reported by participants receiving placebo. Scientific reviews frequently note that studies conducted during periods of increased symptom activity can face the challenge of a high spontaneous resolution rate and a significant placebo effect.


Review of Follow-up and Long-Term Data

The available evidence for Licotin is primarily derived from short-term studies. Follow-up durations were limited, reflecting the acute use of the medicine. Consequently, long-term effects are not fully established. There is limited information for long-term outcomes or how the medicine might be associated with symptom patterns over periods longer than the acute phase.


Research in Specific Age Groups and Subpopulations

Evidence from RCTs is most prevalent in adults experiencing acute respiratory symptoms. Dedicated research was also explored in children, specifically those in older pediatric groups. However, data for certain groups remain insufficient: there is a documented lack of well-controlled studies for use in very young children (e.g., those under four to six years old). Clinical guidelines have highlighted this as a significant area where specific research data is missing.

Key Studies & References Dextromethorphan Hydrobromide: Drug Information

Frequently Asked Questions (FAQ)

Common questions about Licotin (FAQ)

Q: How does Licotin differ from other common medicines prescribed for the same condition?

A: Licotin is classified as a non-narcotic, central-acting antitussive, meaning it works to suppress the cough reflex without being an opioid. The active ingredient, Dextromethorphan, is a synthetic morphinan derivative. This classification highlights the focused action on the cough center compared to older, opiate-derived cough medicines.

Q: What are the general ways that drug-drug interactions with Licotin might be noticed?

A: Interactions can potentially cause very high levels of Licotin in the body, leading to exaggerated effects. Interactions resulting in high levels of Licotin are described in official documents as potentially being associated with symptoms such as confusion, hallucinations, or uncontrolled trembling, which are signs of exaggerated effects.

Q: Do the side effects of Licotin get worse when taking higher amounts?

A: Regulatory documents state that serious adverse reactions, such as convulsions and a movement disorder known as dystonia, are documented at high exposure levels of Licotin. This information indicates that risks and effects are documented to increase when the medicine is used at high exposure levels.

Q: Is Licotin cleared for use in pediatric patients (children)?

A: Official guidance on Licotin's active ingredient in OTC products states that use is typically not recommended for children under 4 years old and is contraindicated for children under 2 years old. Eligibility is based on regulatory criteria concerning the specific age group and formulation.

Q: Was Licotin studied in large clinical trials for its main uses?

A: Studies examining Licotin for acute cough relief were primarily conducted through randomized controlled trials (RCTs). These short-term trials explored the changes in outcomes like cough severity and patient-reported discomfort. Scientific reviews have indicated that the findings from these studies have often been mixed.

Q: Does Licotin have a generic version available in the US?

A: Yes, the active ingredient in Licotin, Dextromethorphan Hydrobromide, is widely available. It is found in many generic and store-brand forms in the US, providing alternatives to the brand-name product.

Q: Are there any activities to avoid while taking Licotin, such as driving?

A: Official product information notes that caution is advised when engaging in activities requiring full alertness. Because Licotin may cause common side effects like drowsiness and dizziness, caution is advised when operating machinery or driving until a person knows how the medicine affects their alertness.

Q: Which over-the-counter (OTC) pain relievers should be mentioned to a doctor when taking Licotin?

A: In general, official information indicates that Licotin can be taken with common OTC pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil). However, regulatory sources emphasize caution when using combination cough/cold products, as they may contain additional ingredients that interact.

Q: Are there specific vitamins or herbal supplements known to interact with Licotin?

A: Official documents contain a statement advising patients to inform their healthcare provider about all prescription, non-prescription, and herbal products or supplements being taken. This is due to the potential for some supplements to interact with Licotin’s metabolic pathways.

Q: Is Licotin considered a controlled substance by government agencies?

A: The U.S. Drug Enforcement Administration (DEA) has confirmed that Licotin’s active ingredient, Dextromethorphan Hydrobromide, is not classified as a controlled substance under the Controlled Substances Act (CSA). This means it is generally not subject to the strict federal regulations applied to narcotics.

Q: Can Licotin be stored at room temperature or does it need refrigeration?

A: Official regulatory guidelines specify that Licotin must be stored at a Controlled Room Temperature, typically 20 C to 25 C (68 F to 77 F). The product must be protected from excessive heat and moisture, and official labeling explicitly states that it must not be frozen.

Q: What are the signs that Licotin is considered to be working as intended?

A: Licotin's common use is defined as the symptomatic relief of non-productive cough. The medicine is considered to be working as intended when it helps to suppress the cough reflex, leading to a reduction in the frequency and severity of dry, irritating coughs.

Q: Does Licotin affect a person's mood or emotional state, such as anxiety?

A: The safety profile notes potential effects on the Nervous System. Changes in mood or mental status, such as confusion or hallucinations, are listed as potential serious effects when the medicine is used at high exposure levels.

Q: Is it normal to feel a change in energy levels after starting Licotin?

A: A change in energy levels may be noted, as drowsiness and dizziness are listed in official documents as common, though uncommon overall, potential side effects. These effects relate to the medicine's central nervous system activity.

Q: Can taking Licotin cause difficulties with concentration or memory?

A: Licotin’s safety profile includes potential effects on the Nervous System, with side effects like drowsiness and dizziness described as potential concerns.

Q: What specific type of healthcare provider typically prescribes Licotin?

A: Licotin is primarily available as an over-the-counter (OTC) medicine and can be purchased without a prescription. When the active ingredient is included in stronger combination products, its use may be assessed or prescribed by a licensed healthcare provider, such as a clinician or physician.

How should Licotin be stored and disposed of?

Storage and Disposal Requirements for Licotin

Official regulatory guidelines strictly define the conditions necessary to maintain Licotin (Dextromethorphan Hydrobromide) stability and ensure safety.


Required Storage and Protection

Licotin must be stored at Controlled Room Temperature, which is typically 20 C to 25 C (68 F to 77 F), protected from excessive heat and moisture. The medicine must remain in its original container and be kept tightly closed. It is explicitly required to not freeze the product.


Child Safety and Disposal

All forms of Licotin must be stored out of the sight and reach of children and pets. For disposal, unused or expired medication should be taken to a drug take-back program. If no program is available, the product should be mixed with an unappealing substance, sealed in a bag, and placed in the household trash. The product must not be flushed down the toilet or poured down a sink.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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