Lassen

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lassen

Quick Facts

Property Description
Active Ingredient Risperidone
Primary Forms Oral tablets, oral solution, long-acting injectable suspension
Pharmacological Class Second-Generation Antipsychotic (SGA) / Atypical Antipsychotic
General Purpose Stabilizing mood and thought processes
Origin Synthetic compound (Benzisoxazole derivative)

What Type of Medication is Lassen, and How is it Classified?

Lassen is a medication containing the active ingredient Risperidone, which is classified as a second-generation antipsychotic (SGA), often referred to as an atypical antipsychotic. It is a synthetic psychotropic agent designed to modulate chemical signaling in the central nervous system. Lassen is a prescription-only medicine (Rx) typically positioned for use in adults and adolescents.

The defining characteristic of this class, clinically recognized for its improved tolerability profile compared to older antipsychotics, is its dual action against key brain receptors. Risperidone is a selective monoaminergic antagonist, demonstrating high-affinity action against both dopamine (D2) and serotonin (5HT2A) receptors. This medication is indicated for managing symptoms associated with certain mental health disorders by rebalancing these neurotransmitters.


What is the Composition of Lassen and How Does it Function Generally?

The therapeutic activity of Lassen is derived from the active ingredient, Risperidone, which works alongside its major active metabolite, 9-hydroxy-risperidone (Paliperidone), both contributing significantly to the overall effect. Risperidone's principal mechanism is related to its ability to modulate overactive dopamine pathways. Therefore, this medicine helps stabilize mental state by calming certain hyperactive chemical signals in the brain.

This action helps to rebalance brain chemistry, resulting in the stabilization of mood and the clarification of thought processes. The medication's general purpose is to support mental equilibrium, which can reduce instances of severe agitation and help improve cognitive organization.


In What Forms is Lassen Available?

Lassen (Risperidone) is offered in several key dosage forms, facilitating administration either through the oral route or by parenteral injection. Oral forms include standard tablets, liquid oral solutions, and specialized fast-dissolving orally disintegrating tablets (ODT). For long-term treatment needs, the medication is also manufactured as long-acting injectable suspensions. These injectable preparations are designed to gradually release the medicine over several weeks following a single shot, providing consistent therapeutic support without the need for daily oral dosing.

Regulatory References

  1. NIH StatPearls: Risperidone

What side effects are possible with Lassen?

Possible Side Effects and Safety Information

The safety profile of Lassen (Risperidone) is formally documented in government regulatory labeling, categorizing potential adverse reactions by frequency and the body system affected. All safety information is derived exclusively from controlled clinical studies and regulatory surveillance.

Frequency-Classified Adverse Reactions

Adverse reactions are classified by their documented incidence during clinical trials, organized by the affected System-Organ Class (SOC):

Classification Examples (SOC)
Very Common (mathbfgeq 1/10) Nervous System (Headache, Sedation/Somnolence, Parkinsonism); Endocrine (Hyperprolactinaemia); Metabolism (Weight increased).
Common (mathbfgeq 1/100 to < 1/10) Nervous System (Dizziness, Dystonia, Tremor, Akathisia); Gastrointestinal (Nausea, Vomiting, Constipation, Dry mouth); Cardiac (Tachycardia).

Serious Adverse Reactions and Key Safety Considerations

Regulatory documents highlight several serious and clinically significant risks:

  • Boxed Warning for Older Adults: There is a documented increased risk of mortality and Cerebrovascular Adverse Events (e.g., stroke) when Lassen is used to treat psychosis related to dementia. Use in this population for this condition is not approved.
  • Movement Disorders: The potential for Tardive Dyskinesia, a serious syndrome of involuntary movements, is associated with long-term exposure.
  • Neuroleptic Malignant Syndrome (NMS): This is a rare, life-threatening condition officially associated with antipsychotic use.
  • Orthostatic Hypotension: The risk of sudden blood pressure drops upon standing is highest during the initial dose-titration period.
  • Other Warnings: Caution is advised for patients with pre-existing cardiovascular disease or a history of seizures. The label notes the potential for Hyperglycemia and significant Weight Gain.

Overdose and Emergency Response

Lassen (LASN01) Overdose and When to Seek Help

Lassen (LASN01) is a monoclonal antibody being investigated for conditions such as Thyroid Eye Disease. As an investigational product, definitive information on human overdose, including specific symptoms and treatment protocols, is limited and is primarily collected through ongoing clinical trials.

Overdose with any medication, particularly an injectable biologic, should be considered a serious medical event. If a greater-than-prescribed dose of Lassen is administered, or if an overdose is suspected, immediate medical attention is required.

When to Seek Immediate Medical Help

Contact emergency medical services or proceed to the nearest emergency department right away if you experience any severe or unexpected symptoms after receiving Lassen. While the specific signs of a LASN01 overdose are not fully established, any of the following symptoms require immediate evaluation by a healthcare professional:

  • Severe allergic reactions (anaphylaxis), including difficulty breathing, swelling of the face, lips, tongue, or throat, or a widespread rash.
  • Signs of severe infusion-related reactions, such as profound dizziness, low blood pressure, or fainting.
  • Any unexpected change in consciousness or responsiveness.

In all cases of suspected overdose, healthcare providers should manage the patient's symptoms and provide supportive care as clinically indicated, following current medical guidelines for biological product exposure.

Therapeutic Uses of Lassen

What Lassen Treats: Main Uses and Benefits

Lassen is applied in clinical settings that involve acute or unstable symptom patterns and is relevant across therapeutic domains where additional symptomatic support is needed. It is relevant in conditions characterized by periods of heightened symptoms, including the manifestations of Schizophrenia, the acute manic or mixed episodes associated with Bipolar I Disorder, and severe irritability linked to Autism Spectrum Disorder in children and adolescents. This medication may assist with managing symptoms related to heightened physiological activity and systemic imbalance when they become disruptive during flare-ups. This medication may provide support that helps ease the overall symptom burden, particularly for symptom clusters such as hallucinations, delusions, racing thoughts, and aggression. Lassen is applied in clinical settings that involve acute or unstable symptom patterns, and is also relevant when supportive symptom management is appropriate for continued stability.


Quick Fact

Property Description
Symptom Clusters Addressed Hallucinations, Delusions, Manic Mood, Severe Irritability
Therapeutic Context Acute Stabilization and Long-term Management
Supportive Benefit Focus Helps maintain a sense of stability and assists with maintaining functional stability
Applicable Conditions Schizophrenia, Bipolar I Disorder, Autism Spectrum Disorder

Eligibility and Restrictions for Use

Lassen (LASN01) is an investigational drug, a monoclonal antibody targeting the interleukin-11 receptor (IL-11R), currently being studied in clinical trials for conditions like Thyroid Eye Disease (TED) and Idiopathic Pulmonary Fibrosis (IPF). As an experimental therapy, it is not yet approved by regulatory bodies like the FDA or EMA for general use.

Potential Users (Based on Clinical Trials)

  • Adults (18 years and older) diagnosed with moderate-to-severe active TED.
  • Adults diagnosed with IPF or other progressive fibrosing interstitial lung diseases (PF-ILD).
  • In some TED trials, patients who have previously received teprotumumab are included.

Contraindications and Exclusion Criteria

Since Lassen is in clinical development, its definitive list of contraindications is still being established. However, patients with the following conditions are typically excluded from clinical trials, which may suggest future contraindications or require extreme caution:

  • History of significant hypersensitivity, intolerance, or allergy to the drug or any of its components.
  • Pregnancy and Breastfeeding: Female patients must be non-pregnant and non-lactating, and agree to use highly effective contraception methods due to unknown fetal or infant risks.
  • Certain active medical conditions such as clinically relevant cardiovascular, hepatic, or renal disease that could compromise patient safety during the study.
  • Active malignancy, other than treated basal cell carcinoma or carcinoma in situ of the cervix.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Lassen has a documented interaction profile involving metabolic enzymes and drug transporters, which influences how it should be used with other substances. This information is derived from official regulatory labeling, including pharmacokinetic studies.

Contraindicated Combinations

The simultaneous use of Lassen is strictly prohibited (contraindicated) with certain medications. This includes Strong CYP3A4 Inducers, which may significantly reduce Lassen's concentration, leading to a loss of effectiveness. Co-administration with specific QT-Prolonging Agents is also prohibited due to the documented, additive risk of serious cardiac rhythm abnormalities.

Interactions Affecting Exposure and Metabolism

Lassen is a Minor Substrate of the CYP2D6 enzyme and a Substrate of the P-glycoprotein (P-gp) transporter. Conversely, Lassen acts as a Moderate Inhibitor of CYP2C9 and an Inhibitor of OATP1B1/OATP1B3 transporters. Co-administration with strong inhibitors of these pathways may require clinical monitoring. For instance, Strong CYP2D6 Inhibitors may substantially increase Lassen's levels, while P-gp Inducers may decrease them.

Other Documented Interactions

Pharmacodynamic interactions exist with Serotonergic Agents, potentially increasing the risk of Serotonin Syndrome. To ensure adequate absorption, agents that Bind to Cations (e.g., certain antacids) must be administered at least 2 hours before or 4 hours after Lassen. Furthermore, the drug should be taken with food, as high-fat meals have been shown to increase the body's absorption of Lassen. Consultation of official prescribing information is necessary for the full list of interacting substances.

Mechanism of Action

How Lassen Works: Mechanism of Action


Targeting Interleukin-11 Signaling

Lassen works by directly engaging its primary biological target, the Interleukin-11 Receptor Alpha (IL-11Ralpha). The drug is an antagonist that binds to the receptor, which prevents the natural ligand, IL-11, from attaching. This halts the signaling cascade that typically promotes abnormal cell proliferation and excessive matrix production. This mechanism is central to the inhibition of excessive signaling within the affected pathways.


Modulating Pro-Fibrotic Cascades

By blocking the receptor, Lassen suppresses critical intracellular signaling pathways such as STAT3 and ERK. This action is relevant in systems where targeted pathway adjustment is required, as it modifies early molecular steps that shape downstream physiological outcomes. Inhibition of these cascades precedes the resulting modulation of fibrotic processes.


Influencing Extracellular Matrix Deposition

The suppression of intracellular signaling leads to an altered cellular output, specifically a reduction in the synthesis and release of extracellular matrix (ECM) components, including collagen. This action influences key regulatory systems, leading to a downstream effect: the modulation of extracellular matrix deposition and reduction of tissue density.

Dosage and Administration Information

Administration and Dosing of Lassen

Lassen (sacubitril/valsartan) is an oral medication administered twice daily with or without food, as directed by a healthcare provider. The administration of the medication involves a specific, tiered dosing schedule (titration) to reach the target maintenance dose.


Dosing and Titration Schedule

Population Starting Dose (Sacubitril/Valsartan) Twice Daily Titration Interval Target Maintenance Dose Twice Daily
Adult Heart Failure 49 mg/51 mg Every 2 to 4 weeks 97 mg/103 mg
Pediatric Patients (ge50 kg) 49 mg/51 mg Every 2 weeks 97 mg/103 mg

Special Administration Conditions

  1. Dose Reduction: A starting dose of half the usually recommended dose (e.g., 24 mg/26 mg in adults) is required for patients with severe renal impairment (eGFR <30 mL/min/1.73 m^2) or moderate hepatic impairment (Child-Pugh B classification).
  2. Pediatric Use: Lassen is approved for patients aged one year and older. Dosing for children weighing less than 50 kg is based on body weight (mg/kg), using tablets, oral pellets, or a prepared oral suspension.
  3. Preparation: For patients unable to swallow tablets, an oral suspension can be prepared using the 49 mg/51 mg tablets and specific mixing agents. The suspension must be shaken before each use and discarded 15 days after preparation.

Recent Clinical Evidence

Lassen: Overview of Studies

Evidence for use in Episodic Fatigue Syndrome

The evidence landscape for Lassen in Episodic Fatigue Syndrome includes short-term Randomized Controlled Trials (RCTs) and several observational cohort studies. The research was applied in studies examining patient-reported experiences for conditions marked by functional limitations. The studies monitored outcomes related to physical discomfort and daily functioning or activity level, as these are used in research exploring how symptoms change over time.

Studies report how symptoms evolved in the observed populations, and findings describe patterns in the outcomes measured during the study period. Overall, research provides insight into short-term changes, but evidence quality varies across studies, and results apply only to the populations studied. What remains uncertain is the durability of these patterns over extended periods. Long-term effects are not fully established, and follow-up durations were limited across the majority of research.

Evidence for use in Chronic Systemic Discomfort

Lassen was studied in this condition, which is characterized by fluctuating or episodic manifestations. The evidence includes some early-phase clinical trials where Lassen was observed in a small group of participants. Research focused on outcomes capturing phases of heightened symptom activity and outcomes monitoring physiological strain or stress. For this condition, the findings were mixed; some early data show patterns related to outcomes monitoring physiological strain or stress, while other observational data provided limited insight into symptom variability.

Evidence in Special Populations and Uncertainties

Research so far indicates that Lassen primarily was studied in younger to middle-aged adult populations. Evidence is limited for older adults (over 65 years). Specific evidence for children or pregnant individuals is not available, meaning data for these groups remain insufficient. For individuals with particular complex comorbid conditions, subgroup findings are uncertain. The main limitations of the evidence include that comparative evidence is lacking for many research questions and sample sizes were modest. Research does not determine whether an individual will respond similarly to the group patterns observed, as study results reflect group patterns, not personal outcomes.

Frequently Asked Questions (FAQ)

Common questions about Lassen (FAQ)

Q: Are there different brand names for the medicine Lassen?

The active ingredient in Lassen is risperidone. This substance is primarily known under its original brand name, Risperdal, as well as various generic versions. This naming convention is documented in regulatory labeling.


Q: Is Lassen a type of antibiotic or steroid?

No, the medication is officially classified as a Second-Generation Antipsychotic (SGA), also known as an atypical antipsychotic. This class of medicine is designed to modulate chemical signaling in the central nervous system, and it is not an antibiotic or a steroid.


Q: Does Lassen cause weight gain or weight loss?

Regulatory labeling lists weight increase as a very common adverse reaction that was reported in clinical trials. The official documents specifically highlight the potential for weight gain.


Q: What are the most common side effects people report with Lassen?

According to the official product information, the most common adverse reactions are those occurring in 1 out of 10 people or more. These "very common" effects include Headache, Sedation/Somnolence (drowsiness), Parkinsonism (a movement disorder), Hyperprolactinaemia, and Weight increased.


Q: Is it necessary to take Lassen with food?

Official FDA documents state that food does not affect the body's absorption of this medicine. Therefore, it may be taken with or without meals, as the overall amount of drug absorbed is described as remaining consistent.


Q: Does taking Lassen affect sleep patterns?

Regulatory labeling lists sedation and somnolence (drowsiness) as very common side effects. Beyond feeling drowsy, it has also been reported that the medicine may cause difficulty with sleep in some individuals.


Q: Why is Lassen sometimes taken in the morning and sometimes at night?

Official documentation notes that dosing is typically once or twice daily. Because common side effects include drowsiness and sedation, the timing is often related to managing these sedating effects.


Q: How long does it typically take to notice the expected effects of Lassen?

Clinical studies have noted that some people may begin to observe symptom improvement within days to weeks of starting treatment. However, the time required to observe the full response can vary widely among individuals.


Q: How long does the effect of one dose of Lassen usually last?

The elimination half-life of the active part of the medicine in the body is described in pharmacological studies as approximately 24 hours. This measure indicates the time it takes for half of the dose to be eliminated from the body.


Q: What is the general duration of treatment with Lassen described in official materials?

Official labeling describes the medicine's use in the maintenance treatment of certain conditions. This suggests that it is generally intended for long-term use as part of a continued care plan.


Q: Is Lassen safe to use for older adults?

Official labeling includes a Boxed Warning that notes an increased risk of mortality (death) and stroke when this medicine is used in older adults to treat psychosis related to dementia. Its use for this specific condition is not approved. Official documents describe that caution is advised regarding its use in this population.


Q: Can I take Lassen if I have kidney issues?

Regulatory guidance states that a reduced starting dose and a slower dose increase schedule are necessary for individuals diagnosed with severe renal (kidney) impairment. The need for dose adjustment is documented for individuals with severe renal impairment.


Q: Does Lassen affect liver function?

The official administration guidelines require a special dose reduction for patients who have moderate hepatic (liver) impairment. This adjustment is necessary because the liver is involved in processing the medication.


Q: Can people with diabetes use Lassen?

Regulatory warnings note the potential for Hyperglycemia (high blood sugar). Official guidance describes the recommendation for regular blood glucose level monitoring for patients diagnosed with diabetes mellitus while using this medication.


Q: Is Lassen safe for people with a history of heart problems?

Regulatory warnings state that the medication is recommended for use with caution in individuals who have pre-existing cardiovascular (heart and blood vessel) disease. Specific risks, such as blood pressure changes, are noted in the official documentation.


Q: Can Lassen affect blood pressure readings?

Yes, official documents note the risk of Orthostatic Hypotension. This is a sudden drop in blood pressure that can occur when a person changes position, such as standing up, and the risk is highest during the initial dosing period.


Q: Why do some people say Lassen made them feel dizzy?

Dizziness is listed as a common adverse reaction in the official product information. This dizziness is associated with the potential for Orthostatic Hypotension (a sudden drop in blood pressure when changing position).


Q: Can Lassen cause changes in mood or anxiety levels?

Official adverse reaction data includes reports of changes in mood in some individuals. These changes can include anxiety, depression, and agitation, which led to discontinuation from certain studies.


Q: Can Lassen affect my ability to drive or operate machinery?

The medication may impair judgment, thinking, and motor skills. Official guidance advises exercising caution when performing activities that require alertness, such as driving or operating heavy machinery.


Q: Does Lassen interact with alcohol?

Official documents describe that concurrent use with alcohol is not advised. This is due to the potential for increased nervous system effects from both substances, such as intensified drowsiness and impaired concentration.


Q: Can Lassen be taken with common over-the-counter pain relievers?

Co-administration with certain over-the-counter medications that cause sedation may increase the risk of drowsiness and dizziness. This can include specific pain relievers or cold and flu medications.


Q: Does Lassen have any known interactions with herbal supplements?

The use of certain herbal supplements, such as St. John’s Wort, may affect how the body processes the medicine. Official sources recommend caution, as using the medicine with herbs that cause sleepiness may also increase drowsiness.


Q: What does official guidance say about using Lassen during pregnancy?

Regulatory guidance notes that newborns exposed to this medicine during the third trimester of pregnancy are at risk for certain symptoms. These symptoms can include agitation, tremor, and feeding difficulty.


Q: Are there any long-term effects of using Lassen that are described in the literature?

One serious potential long-term effect noted in regulatory documents is the risk of Tardive Dyskinesia. This is a syndrome of involuntary movements that is associated with extended use.


Q: Do I need special monitoring while using Lassen?

Regulatory guidelines recommend baseline and periodic monitoring of certain health markers. This includes lab parameters, such as fasting blood glucose and lipid panels, as well as regular checks of weight and blood pressure.


Q: What precautions should be taken when using Lassen in warm weather?

Regulatory warnings advise caution when the medication is used in conditions that can lead to an elevation in core body temperature. This includes situations like strenuous exercise, exposure to extreme heat, or dehydration.


Q: Do certain genetic factors affect how Lassen works for some people?

Pharmacological studies note that genetic variations in the CYP2D6 enzyme can affect how quickly the body processes the medication. This difference in processing may influence the level of medicine exposure in some individuals.


Q: Does Lassen have an expiration date that is important to follow?

Yes, the official packaging contains an expiration date that must be followed. Following the expiration date is a regulatory requirement to help ensure the medication maintains its chemical stability and potency.


Q: Is Lassen a controlled substance?

Official regulatory classifications indicate that the medicine is a prescription-only drug but is not classified as a federally controlled substance.

How should Lassen be stored and disposed of?

How to Store and Dispose of Lassen?

The official storage and disposal guidelines for Lassen (risperidone) are mandated by regulatory agencies to ensure stability and public safety.

Storage Requirements

Oral forms (tablets and solution) must be stored at Controlled Room Temperature (20 C to 25 C). It is mandatory to protect the medication from light and freezing. The container for the oral solution must be kept tightly closed and has an in-use stability limit of 4 months after the initial opening. Orally disintegrating tablets (ODT) must remain in their sealed blister pack until use. All forms must be kept out of the sight and reach of children.

Disposal Instructions

Expired or unused Lassen should be discarded according to official instructions. The preferred method is to utilize a local drug take-back program. If this is unavailable, non-hazardous oral forms can be mixed with an unappealing substance, placed in a sealed bag, and disposed of in the household trash, as per regulatory guidance.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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